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Usp1 ubiquitin specific peptidase 1 [ Mus musculus (house mouse) ]

Gene ID: 230484, updated on 8-May-2016
Official Symbol
Usp1provided by MGI
Official Full Name
ubiquitin specific peptidase 1provided by MGI
Primary source
MGI:MGI:2385198
See related
Ensembl:ENSMUSG00000028560 Vega:OTTMUSG00000008702
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
Summary
This gene encodes a member of the ubiquitin-specific peptidase family. The encoded protein acts as a catalytic subunit in a heterodimeric deubiquitinating enzyme complex that deubiquitinates Fanconi anemia, complementation group D2, and plays a role in homologous recombination-mediated DNA repair. Disruption of this gene is associated with a Fanconi anemia-like phenotype and genomic instability. Alternative splicing results in multiple transcript variants. Pseudogenes of this gene have been defined on chromosomes 3, 12, and 15. [provided by RefSeq, Aug 2014]
Orthologs
Location:
4; 4 C6
Exon count:
9
Annotation release Status Assembly Chr Location
105 current GRCm38.p3 (GCF_000001635.23) 4 NC_000070.6 (98923622..98935543)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 4 NC_000070.5 (98590501..98602224)

Chromosome 4 - NC_000070.6Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA I0C0044D17 gene Neighboring gene predicted gene 12851 Neighboring gene dedicator of cytokinesis 7 Neighboring gene angiopoietin-like 3 Neighboring gene ribosomal protein S4, X-linked pseudogene

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Clone Names

  • MGC25559

Gene Ontology Provided by MGI

Function Evidence Code Pubs
cysteine-type peptidase activity IEA
Inferred from Electronic Annotation
more info
 
hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
peptidase activity IEA
Inferred from Electronic Annotation
more info
 
thiol-dependent ubiquitin-specific protease activity ISO
Inferred from Sequence Orthology
more info
 
thiol-dependent ubiquitinyl hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
DNA repair IEA
Inferred from Electronic Annotation
more info
 
cellular response to DNA damage stimulus IEA
Inferred from Electronic Annotation
more info
 
monoubiquitinated protein deubiquitination ISO
Inferred from Sequence Orthology
more info
 
protein deubiquitination ISO
Inferred from Sequence Orthology
more info
 
proteolysis IEA
Inferred from Electronic Annotation
more info
 
regulation of DNA repair ISO
Inferred from Sequence Orthology
more info
 
response to UV ISO
Inferred from Sequence Orthology
more info
 
skeletal system development IMP
Inferred from Mutant Phenotype
more info
PubMed 
ubiquitin-dependent protein catabolic process IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
nucleus ISO
Inferred from Sequence Orthology
more info
 
Preferred Names
ubiquitin carboxyl-terminal hydrolase 1
Names
deubiquitinating enzyme 1
ubiquitin specific protease 1
ubiquitin thioesterase 1
ubiquitin thiolesterase 1
ubiquitin-specific-processing protease 1
usp1
NP_001288343.1
NP_666256.2

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001301414.1NP_001288343.1  ubiquitin carboxyl-terminal hydrolase 1

    See identical proteins and their annotated locations for NP_001288343.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    AK080882, BG083613, BY713495
    Consensus CDS
    CCDS18381.1
    UniProtKB/Swiss-Prot
    Q8BJQ2
    Related
    ENSMUSP00000088917, OTTMUSP00000009051, ENSMUST00000091358, OTTMUST00000019756
    Conserved Domains (3) summary
    cd02671
    Location:423598
    Peptidase_C19O; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...
    pfam00443
    Location:80598
    UCH; Ubiquitin carboxyl-terminal hydrolase
    cl02553
    Location:82253
    Peptidase_C19; Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl group of the C-terminal Gly ...
  2. NM_146144.4NP_666256.2  ubiquitin carboxyl-terminal hydrolase 1

    See identical proteins and their annotated locations for NP_666256.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    AK080882, BG083613
    Consensus CDS
    CCDS18381.1
    UniProtKB/Swiss-Prot
    Q8BJQ2
    Related
    ENSMUSP00000030289, OTTMUSP00000009052, ENSMUST00000030289, OTTMUST00000019757
    Conserved Domains (3) summary
    cd02671
    Location:423598
    Peptidase_C19O; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...
    pfam00443
    Location:80598
    UCH; Ubiquitin carboxyl-terminal hydrolase
    cl02553
    Location:82253
    Peptidase_C19; Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl group of the C-terminal Gly ...

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 105 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p3 C57BL/6J

Genomic

  1. NC_000070.6 Reference GRCm38.p3 C57BL/6J

    Range
    98923622..98935543
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006502939.2XP_006503002.1  

    See identical proteins and their annotated locations for XP_006503002.1

    Conserved Domains (3) summary
    cd02671
    Location:369544
    Peptidase_C19O; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...
    pfam00443
    Location:26544
    UCH; Ubiquitin carboxyl-terminal hydrolase
    cl02553
    Location:28199
    Peptidase_C19; Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl group of the C-terminal Gly ...

Alternate Mm_Celera

Genomic

  1. AC_000026.1 Alternate Mm_Celera

    Range
    97290878..97302607
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)