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FNBP1 formin binding protein 1 [ Homo sapiens (human) ]

Gene ID: 23048, updated on 12-May-2016
Official Symbol
FNBP1provided by HGNC
Official Full Name
formin binding protein 1provided by HGNC
Primary source
HGNC:HGNC:17069
See related
Ensembl:ENSG00000187239 HPRD:10446; MIM:606191; Vega:OTTHUMG00000020800
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
FBP17
Summary
The protein encoded by this gene is a member of the formin-binding-protein family. The protein contains an N-terminal Fer/Cdc42-interacting protein 4 (CIP4) homology (FCH) domain followed by a coiled-coil domain, a proline-rich motif, a second coiled-coil domain, a Rho family protein-binding domain (RBD), and a C-terminal SH3 domain. This protein binds sorting nexin 2 (SNX2), tankyrase (TNKS), and dynamin; an interaction between this protein and formin has not been demonstrated yet in human. [provided by RefSeq, Jul 2008]
Orthologs
Location:
9q34
Exon count:
18
Annotation release Status Assembly Chr Location
107 current GRCh38.p2 (GCF_000001405.28) 9 NC_000009.12 (129887187..130043194, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 9 NC_000009.11 (132649458..132805473, complement)

Chromosome 9 - NC_000009.12Genomic Context describing neighboring genes Neighboring gene chromosome 9 open reading frame 78 Neighboring gene ubiquitin specific peptidase 20 Neighboring gene microRNA 6855 Neighboring gene G protein-coupled receptor 107 Neighboring gene uncharacterized LOC401554

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Clone Names

  • KIAA0554, MGC126804

Gene Ontology Provided by GOA

Function Evidence Code Pubs
ARF guanyl-nucleotide exchange factor activity IBA
Inferred from Biological aspect of Ancestor
more info
 
identical protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
lipid binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
endocytosis IEA
Inferred from Electronic Annotation
more info
 
positive regulation of GTPase activity IEA
Inferred from Electronic Annotation
more info
 
vesicle-mediated transport IBA
Inferred from Biological aspect of Ancestor
more info
 
Component Evidence Code Pubs
cell cortex IEA
Inferred from Electronic Annotation
more info
 
coated pit IEA
Inferred from Electronic Annotation
more info
 
cytoplasmic, membrane-bounded vesicle IEA
Inferred from Electronic Annotation
more info
 
cytoskeleton IEA
Inferred from Electronic Annotation
more info
 
lysosome IEA
Inferred from Electronic Annotation
more info
 
plasma membrane IEA
Inferred from Electronic Annotation
more info
 
trans-Golgi network IBA
Inferred from Biological aspect of Ancestor
more info
 
Preferred Names
formin-binding protein 1
Names
formin-binding protein 17

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_033946.1 RefSeqGene

    Range
    5001..161008
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_015033.2NP_055848.1  formin-binding protein 1

    See identical proteins and their annotated locations for NP_055848.1

    Status: REVIEWED

    Source sequence(s)
    AB011126, AL158207, AW575478, CK005680
    Consensus CDS
    CCDS48040.1
    UniProtKB/Swiss-Prot
    Q96RU3
    Related
    ENSP00000413625, OTTHUMP00000022353, ENST00000446176, OTTHUMT00000054630
    Conserved Domains (3) summary
    cd07676
    Location:5257
    F-BAR_FBP17; The F-BAR (FES-CIP4 Homology and Bin/Amphiphysin/Rvs) domain of Formin Binding Protein 17
    cd11629
    Location:407483
    HR1_FBP17; Protein kinase C-related kinase homology region 1 (HR1) Rho-binding domain of Formin Binding Protein 17
    cl17036
    Location:553608
    SH3; Src Homology 3 domain superfamily

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 107 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p2 Primary Assembly

Genomic

  1. NC_000009.12 Reference GRCh38.p2 Primary Assembly

    Range
    129887187..130043194 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005251834.2XP_005251891.1  

    See identical proteins and their annotated locations for XP_005251891.1

    UniProtKB/TrEMBL
    B7ZL14
    Related
    ENSP00000389117, ENST00000443566
    Conserved Domains (3) summary
    cd07676
    Location:5257
    F-BAR_FBP17; The F-BAR (FES-CIP4 Homology and Bin/Amphiphysin/Rvs) domain of Formin Binding Protein 17
    cd11629
    Location:341417
    HR1_FBP17; Protein kinase C-related kinase homology region 1 (HR1) Rho-binding domain of Formin Binding Protein 17
    cl17036
    Location:487542
    SH3; Src Homology 3 domain superfamily
  2. XM_005251826.2XP_005251883.1  

    See identical proteins and their annotated locations for XP_005251883.1

    UniProtKB/TrEMBL
    B7ZL13
    Conserved Domains (3) summary
    cd07676
    Location:5257
    F-BAR_FBP17; The F-BAR (FES-CIP4 Homology and Bin/Amphiphysin/Rvs) domain of Formin Binding Protein 17
    cd11629
    Location:397473
    HR1_FBP17; Protein kinase C-related kinase homology region 1 (HR1) Rho-binding domain of Formin Binding Protein 17
    cl17036
    Location:543598
    SH3; Src Homology 3 domain superfamily
  3. XM_005251824.2XP_005251881.1  

    See identical proteins and their annotated locations for XP_005251881.1

    UniProtKB/Swiss-Prot
    Q96RU3
    Related
    ENSP00000407548, ENST00000420781
    Conserved Domains (3) summary
    cd07676
    Location:5257
    F-BAR_FBP17; The F-BAR (FES-CIP4 Homology and Bin/Amphiphysin/Rvs) domain of Formin Binding Protein 17
    cd11629
    Location:402478
    HR1_FBP17; Protein kinase C-related kinase homology region 1 (HR1) Rho-binding domain of Formin Binding Protein 17
    cl17036
    Location:548603
    SH3; Src Homology 3 domain superfamily
  4. XM_011518402.1XP_011516704.1  

    Conserved Domains (3) summary
    cd07676
    Location:5257
    F-BAR_FBP17; The F-BAR (FES-CIP4 Homology and Bin/Amphiphysin/Rvs) domain of Formin Binding Protein 17
    cd11629
    Location:435511
    HR1_FBP17; Protein kinase C-related kinase homology region 1 (HR1) Rho-binding domain of Formin Binding Protein 17
    cd12071
    Location:581636
    SH3_FBP17; Src Homology 3 domain of Formin Binding Protein 17
  5. XM_011518401.1XP_011516703.1  

    Conserved Domains (3) summary
    cd07676
    Location:5257
    F-BAR_FBP17; The F-BAR (FES-CIP4 Homology and Bin/Amphiphysin/Rvs) domain of Formin Binding Protein 17
    cd11629
    Location:435511
    HR1_FBP17; Protein kinase C-related kinase homology region 1 (HR1) Rho-binding domain of Formin Binding Protein 17
    cd12071
    Location:582637
    SH3_FBP17; Src Homology 3 domain of Formin Binding Protein 17
  6. XM_005251833.1XP_005251890.1  

    Conserved Domains (3) summary
    cd07676
    Location:5257
    F-BAR_FBP17; The F-BAR (FES-CIP4 Homology and Bin/Amphiphysin/Rvs) domain of Formin Binding Protein 17
    cd11629
    Location:341417
    HR1_FBP17; Protein kinase C-related kinase homology region 1 (HR1) Rho-binding domain of Formin Binding Protein 17
    cl17036
    Location:487542
    SH3; Src Homology 3 domain superfamily
  7. XM_005251832.1XP_005251889.1  

    Conserved Domains (3) summary
    cd07676
    Location:5257
    F-BAR_FBP17; The F-BAR (FES-CIP4 Homology and Bin/Amphiphysin/Rvs) domain of Formin Binding Protein 17
    cd11629
    Location:341417
    HR1_FBP17; Protein kinase C-related kinase homology region 1 (HR1) Rho-binding domain of Formin Binding Protein 17
    cl17036
    Location:488543
    SH3; Src Homology 3 domain superfamily
  8. XM_005251831.1XP_005251888.1  

    Conserved Domains (3) summary
    cd07676
    Location:5257
    F-BAR_FBP17; The F-BAR (FES-CIP4 Homology and Bin/Amphiphysin/Rvs) domain of Formin Binding Protein 17
    cd11629
    Location:346422
    HR1_FBP17; Protein kinase C-related kinase homology region 1 (HR1) Rho-binding domain of Formin Binding Protein 17
    cl17036
    Location:493548
    SH3; Src Homology 3 domain superfamily
  9. XM_005251830.1XP_005251887.1  

    Conserved Domains (3) summary
    cd07676
    Location:5257
    F-BAR_FBP17; The F-BAR (FES-CIP4 Homology and Bin/Amphiphysin/Rvs) domain of Formin Binding Protein 17
    cd11629
    Location:373449
    HR1_FBP17; Protein kinase C-related kinase homology region 1 (HR1) Rho-binding domain of Formin Binding Protein 17
    cl17036
    Location:520575
    SH3; Src Homology 3 domain superfamily
  10. XM_005251829.1XP_005251886.1  

    UniProtKB/Swiss-Prot
    Q96RU3
    Related
    ENSP00000347907, OTTHUMP00000022354, ENST00000355681, OTTHUMT00000054631
    Conserved Domains (3) summary
    cd07676
    Location:5257
    F-BAR_FBP17; The F-BAR (FES-CIP4 Homology and Bin/Amphiphysin/Rvs) domain of Formin Binding Protein 17
    cd11629
    Location:378454
    HR1_FBP17; Protein kinase C-related kinase homology region 1 (HR1) Rho-binding domain of Formin Binding Protein 17
    cl17036
    Location:524579
    SH3; Src Homology 3 domain superfamily
  11. XM_006717016.1XP_006717079.1  

    Conserved Domains (3) summary
    cd07676
    Location:5257
    F-BAR_FBP17; The F-BAR (FES-CIP4 Homology and Bin/Amphiphysin/Rvs) domain of Formin Binding Protein 17
    cd11629
    Location:406482
    HR1_FBP17; Protein kinase C-related kinase homology region 1 (HR1) Rho-binding domain of Formin Binding Protein 17
    cl17036
    Location:553608
    SH3; Src Homology 3 domain superfamily
  12. XM_005251828.1XP_005251885.1  

    Related
    ENSP00000415602, OTTHUMP00000022355, ENST00000449089, OTTHUMT00000054632
    Conserved Domains (3) summary
    cd07676
    Location:5257
    F-BAR_FBP17; The F-BAR (FES-CIP4 Homology and Bin/Amphiphysin/Rvs) domain of Formin Binding Protein 17
    cd11629
    Location:392468
    HR1_FBP17; Protein kinase C-related kinase homology region 1 (HR1) Rho-binding domain of Formin Binding Protein 17
    cl17036
    Location:538593
    SH3; Src Homology 3 domain superfamily
  13. XM_005251827.1XP_005251884.1  

    Conserved Domains (3) summary
    cd07676
    Location:5257
    F-BAR_FBP17; The F-BAR (FES-CIP4 Homology and Bin/Amphiphysin/Rvs) domain of Formin Binding Protein 17
    cd11629
    Location:392468
    HR1_FBP17; Protein kinase C-related kinase homology region 1 (HR1) Rho-binding domain of Formin Binding Protein 17
    cl17036
    Location:539594
    SH3; Src Homology 3 domain superfamily
  14. XM_005251825.1XP_005251882.1  

    Conserved Domains (3) summary
    cd07676
    Location:5257
    F-BAR_FBP17; The F-BAR (FES-CIP4 Homology and Bin/Amphiphysin/Rvs) domain of Formin Binding Protein 17
    cd11629
    Location:397473
    HR1_FBP17; Protein kinase C-related kinase homology region 1 (HR1) Rho-binding domain of Formin Binding Protein 17
    cl17036
    Location:543598
    SH3; Src Homology 3 domain superfamily
  15. XM_005251815.1XP_005251872.1  

    Conserved Domains (3) summary
    cd07676
    Location:5257
    F-BAR_FBP17; The F-BAR (FES-CIP4 Homology and Bin/Amphiphysin/Rvs) domain of Formin Binding Protein 17
    cd11629
    Location:425501
    HR1_FBP17; Protein kinase C-related kinase homology region 1 (HR1) Rho-binding domain of Formin Binding Protein 17
    cl17036
    Location:572627
    SH3; Src Homology 3 domain superfamily
  16. XM_005251823.1XP_005251880.1  

    UniProtKB/Swiss-Prot
    Q96RU3
    Conserved Domains (3) summary
    cd07676
    Location:5257
    F-BAR_FBP17; The F-BAR (FES-CIP4 Homology and Bin/Amphiphysin/Rvs) domain of Formin Binding Protein 17
    cd11629
    Location:402478
    HR1_FBP17; Protein kinase C-related kinase homology region 1 (HR1) Rho-binding domain of Formin Binding Protein 17
    cl17036
    Location:548603
    SH3; Src Homology 3 domain superfamily
  17. XM_005251822.1XP_005251879.1  

    Conserved Domains (3) summary
    cd07676
    Location:5257
    F-BAR_FBP17; The F-BAR (FES-CIP4 Homology and Bin/Amphiphysin/Rvs) domain of Formin Binding Protein 17
    cd11629
    Location:402478
    HR1_FBP17; Protein kinase C-related kinase homology region 1 (HR1) Rho-binding domain of Formin Binding Protein 17
    cl17036
    Location:549604
    SH3; Src Homology 3 domain superfamily
  18. XM_005251821.1XP_005251878.1  

    Conserved Domains (3) summary
    cd07676
    Location:5257
    F-BAR_FBP17; The F-BAR (FES-CIP4 Homology and Bin/Amphiphysin/Rvs) domain of Formin Binding Protein 17
    cd11629
    Location:407483
    HR1_FBP17; Protein kinase C-related kinase homology region 1 (HR1) Rho-binding domain of Formin Binding Protein 17
    cl17036
    Location:553608
    SH3; Src Homology 3 domain superfamily
  19. XM_005251820.1XP_005251877.1  

    Conserved Domains (3) summary
    cd07676
    Location:5257
    F-BAR_FBP17; The F-BAR (FES-CIP4 Homology and Bin/Amphiphysin/Rvs) domain of Formin Binding Protein 17
    cd11629
    Location:407483
    HR1_FBP17; Protein kinase C-related kinase homology region 1 (HR1) Rho-binding domain of Formin Binding Protein 17
    cl17036
    Location:554609
    SH3; Src Homology 3 domain superfamily
  20. XM_011518403.1XP_011516705.1  

    Conserved Domains (3) summary
    cd07676
    Location:5257
    F-BAR_FBP17; The F-BAR (FES-CIP4 Homology and Bin/Amphiphysin/Rvs) domain of Formin Binding Protein 17
    cd11629
    Location:430506
    HR1_FBP17; Protein kinase C-related kinase homology region 1 (HR1) Rho-binding domain of Formin Binding Protein 17
    cl17036
    Location:577632
    SH3; Src Homology 3 domain superfamily
  21. XM_011518400.1XP_011516702.1  

    Conserved Domains (3) summary
    cd07676
    Location:5257
    F-BAR_FBP17; The F-BAR (FES-CIP4 Homology and Bin/Amphiphysin/Rvs) domain of Formin Binding Protein 17
    cd11629
    Location:435511
    HR1_FBP17; Protein kinase C-related kinase homology region 1 (HR1) Rho-binding domain of Formin Binding Protein 17
    cd12071
    Location:581636
    SH3_FBP17; Src Homology 3 domain of Formin Binding Protein 17
  22. XM_011518399.1XP_011516701.1  

    Conserved Domains (3) summary
    cd07676
    Location:5257
    F-BAR_FBP17; The F-BAR (FES-CIP4 Homology and Bin/Amphiphysin/Rvs) domain of Formin Binding Protein 17
    cd11629
    Location:435511
    HR1_FBP17; Protein kinase C-related kinase homology region 1 (HR1) Rho-binding domain of Formin Binding Protein 17
    cd12071
    Location:582637
    SH3_FBP17; Src Homology 3 domain of Formin Binding Protein 17

Alternate CHM1_1.1

Genomic

  1. NC_018920.2 Alternate CHM1_1.1

    Range
    132798466..132954640 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)