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PDXDC1 pyridoxal-dependent decarboxylase domain containing 1 [ Homo sapiens (human) ]

Gene ID: 23042, updated on 26-May-2016
Official Symbol
PDXDC1provided by HGNC
Official Full Name
pyridoxal-dependent decarboxylase domain containing 1provided by HGNC
Primary source
HGNC:HGNC:28995
See related
Ensembl:ENSG00000179889 HPRD:13789; MIM:614244; Vega:OTTHUMG00000166304
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
LP8165
Orthologs
Location:
16p13.11
Exon count:
26
Annotation release Status Assembly Chr Location
107 current GRCh38.p2 (GCF_000001405.28) 16 NC_000016.10 (14974591..15139349)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (15068448..15131552)

Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene polycystin 1, transient receptor potential channel interacting pseudogene 3 Neighboring gene microRNA 6770-1 Neighboring gene nuclear pore complex interacting protein family member A1 Neighboring gene KIAA2013 pseudogene Neighboring gene microRNA 1972-1 Neighboring gene N-terminal asparagine amidase Neighboring gene RRN3 homolog, RNA polymerase I transcription factor Neighboring gene uncharacterized LOC100505915 Neighboring gene nuclear pore complex interacting protein pseudogene 1 Neighboring gene polycystin 1, transient receptor potential channel interacting pseudogene 6 Neighboring gene PKD1P6-NPIPP1 readthrough Neighboring gene microRNA 6511b-2 Neighboring gene microRNA 3180-4 Neighboring gene uncharacterized LOC105371096

NHGRI GWAS Catalog

Description
A genome-wide association study in 19 633 Japanese subjects identified LHX3-QSOX2 and IGF1 as adult height loci.
NHGRI GWA Catalog
An atlas of genetic influences on human blood metabolites.
NHGRI GWA Catalog
Discovery and refinement of loci associated with lipid levels.
NHGRI GWA Catalog
Genetic loci associated with plasma phospholipid n-3 fatty acids: a meta-analysis of genome-wide association studies from the CHARGE Consortium.
NHGRI GWA Catalog
Genome-wide association study identifies multiple loci influencing human serum metabolite levels.
NHGRI GWA Catalog
Genome-wide association study identifies novel loci associated with circulating phospho- and sphingolipid concentrations.
NHGRI GWA Catalog
Genome-wide association study of plasma N6 polyunsaturated fatty acids within the cohorts for heart and aging research in genomic epidemiology consortium.
NHGRI GWA Catalog
Genome-wide meta-analysis identifies 56 bone mineral density loci and reveals 14 loci associated with risk of fracture.
NHGRI GWA Catalog
Human metabolic individuality in biomedical and pharmaceutical research.
NHGRI GWA Catalog
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Clone Names

  • KIAA0251

Gene Ontology Provided by GOA

Function Evidence Code Pubs
carboxy-lyase activity IEA
Inferred from Electronic Annotation
more info
 
pyridoxal phosphate binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
carboxylic acid metabolic process IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
Golgi apparatus IDA
Inferred from Direct Assay
more info
 
intracellular membrane-bounded organelle IDA
Inferred from Direct Assay
more info
 
Preferred Names
pyridoxal-dependent decarboxylase domain-containing protein 1
NP_001272373.1
NP_001272374.1
NP_001272376.1
NP_001272377.1
NP_001272378.1
NP_001272379.1
NP_055842.2

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001285444.1NP_001272373.1  pyridoxal-dependent decarboxylase domain-containing protein 1 isoform 2

    See identical proteins and their annotated locations for NP_001272373.1

    Status: VALIDATED

    Source sequence(s)
    BC042104, BC053946, BC060871, BM997114, BX647809, HY036748
    Consensus CDS
    CCDS66954.1
    UniProtKB/Swiss-Prot
    Q6P996
    Related
    ENSP00000455070, OTTHUMP00000250199, ENST00000569715, OTTHUMT00000422426
    Conserved Domains (1) summary
    cl18945
    Location:145367
    AAT_I; Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the ...
  2. NM_001285445.1NP_001272374.1  pyridoxal-dependent decarboxylase domain-containing protein 1 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AK299111, BC042104, BC053946, BC060871, BM997114, D87438, HY036748
    Consensus CDS
    CCDS66955.1
    UniProtKB/Swiss-Prot
    Q6P996
    Related
    ENSP00000486662, OTTHUMP00000278730, ENST00000627450, OTTHUMT00000482784
    Conserved Domains (1) summary
    cl18945
    Location:144366
    AAT_I; Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the ...
  3. NM_001285447.1NP_001272376.1  pyridoxal-dependent decarboxylase domain-containing protein 1 isoform 4

    See identical proteins and their annotated locations for NP_001272376.1

    Status: VALIDATED

    Source sequence(s)
    AK295168, BC033748, BC042104, BC060871, BM997114, DA775396
    UniProtKB/Swiss-Prot
    Q6P996
    UniProtKB/TrEMBL
    B4DHL7
    Conserved Domains (1) summary
    cl18945
    Location:157379
    AAT_I; Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the ...
  4. NM_001285448.1NP_001272377.1  pyridoxal-dependent decarboxylase domain-containing protein 1 isoform 5

    Status: VALIDATED

    Source sequence(s)
    AK299799, BC042104, BC060871, BM997114, DA321929
    Consensus CDS
    CCDS66957.1
    UniProtKB/Swiss-Prot
    Q6P996
    Related
    ENSP00000391147, ENST00000450288
    Conserved Domains (1) summary
    cl18945
    Location:81303
    AAT_I; Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the ...
  5. NM_001285449.1NP_001272378.1  pyridoxal-dependent decarboxylase domain-containing protein 1 isoform 6

    See identical proteins and their annotated locations for NP_001272378.1

    Status: VALIDATED

    Source sequence(s)
    BC045554, CD370048, HY036748
    Consensus CDS
    CCDS73830.1
    UniProtKB/TrEMBL
    Q86XE2
    Related
    ENSP00000437835, OTTHUMP00000250195, ENST00000535621, OTTHUMT00000422421
    Conserved Domains (1) summary
    cl18945
    Location:172394
    AAT_I; Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the ...
  6. NM_001285450.1NP_001272379.1  pyridoxal-dependent decarboxylase domain-containing protein 1 isoform 7

    Status: VALIDATED

    Source sequence(s)
    AC138932, BC033748, BC053946, CA423507, HY036748
    Consensus CDS
    CCDS73831.1
    UniProtKB/Swiss-Prot
    Q6P996
    Related
    ENSP00000406703, OTTHUMP00000250197, ENST00000455313, OTTHUMT00000422423
    Conserved Domains (1) summary
    cl18945
    Location:172371
    AAT_I; Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the ...
  7. NM_001324019.1NP_001310948.1  pyridoxal-dependent decarboxylase domain-containing protein 1 isoform 8

    Status: VALIDATED

    Source sequence(s)
    AC138932
  8. NM_001324020.1NP_001310949.1  pyridoxal-dependent decarboxylase domain-containing protein 1 isoform 9

    Status: VALIDATED

    Source sequence(s)
    AC138932, AC139256
  9. NM_001324021.1NP_001310950.1  pyridoxal-dependent decarboxylase domain-containing protein 1 isoform 10

    Status: VALIDATED

    Source sequence(s)
    AC138932, AC139256
  10. NM_015027.3NP_055842.2  pyridoxal-dependent decarboxylase domain-containing protein 1 isoform 1

    See identical proteins and their annotated locations for NP_055842.2

    Status: VALIDATED

    Source sequence(s)
    AY203955, BC042104, BC060871, BM997114, DB019664, HY036748
    Consensus CDS
    CCDS32393.1
    UniProtKB/Swiss-Prot
    Q6P996
    UniProtKB/TrEMBL
    Q6XYB5
    Related
    ENSP00000379691, OTTHUMP00000232564, ENST00000396410, OTTHUMT00000389065
    Conserved Domains (1) summary
    cl18945
    Location:172394
    AAT_I; Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the ...

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 107 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p2 Primary Assembly

Genomic

  1. NC_000016.10 Reference GRCh38.p2 Primary Assembly

    Range
    14974591..15139349
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005255173.1XP_005255230.1  

    See identical proteins and their annotated locations for XP_005255230.1

    UniProtKB/TrEMBL
    H3BND4
    Related
    ENSP00000454791, OTTHUMP00000250192, ENST00000563679, OTTHUMT00000422418
    Conserved Domains (1) summary
    cl18945
    Location:190412
    AAT_I; Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the ...
  2. XM_011522428.1XP_011520730.1  

    See identical proteins and their annotated locations for XP_011520730.1

    Conserved Domains (1) summary
    cl18945
    Location:190412
    AAT_I; Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the ...
  3. XM_006720865.2XP_006720928.2  

    Conserved Domains (1) summary
    cl18945
    Location:130352
    AAT_I; Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the ...
  4. XM_005255176.2XP_005255233.1  

    See identical proteins and their annotated locations for XP_005255233.1

    Conserved Domains (1) summary
    cl18945
    Location:157379
    AAT_I; Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the ...

Reference GRCh38.p2 ALT_REF_LOCI_1

Genomic

  1. NT_187607.1 Reference GRCh38.p2 ALT_REF_LOCI_1

    Range
    814085..888476
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate CHM1_1.1

Genomic

  1. NC_018927.2 Alternate CHM1_1.1

    Range
    15334311..15408702
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)