Sign in to NCBI

Display Settings:

Format

Send to:

Choose Destination
We are sorry, but NCBI web applications do not support your browser and may not function properly. More information

    XPO7 exportin 7 [ Homo sapiens (human) ]

    Gene ID: 23039, updated on 5-May-2013
    Official Symbol
    XPO7provided by HGNC
    Official Full Name
    exportin 7provided by HGNC
    Primary source
    HGNC:14108
    See related
    Ensembl:ENSG00000130227; HPRD:05846; MIM:606140; Vega:OTTHUMG00000163789
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    EXP7; RANBP16
    Summary
    The transport of protein and large RNAs through the nuclear pore complexes (NPC) is an energy-dependent and regulated process. The import of proteins with a nuclear localization signal (NLS) is accomplished by recognition of one or more clusters of basic amino acids by the importin-alpha/beta complex; see MIM 600685 and MIM 602738. The small GTPase RAN (MIM 601179) plays a key role in NLS-dependent protein import. RAN-binding protein-16 is a member of the importin-beta superfamily of nuclear transport receptors.[supplied by OMIM, Jul 2002]
    Location :
    8p21
    Sequence :
    Chromosome: 8; NC_000008.10 (21777180..21864096)
    See XPO7 in Epigenomics, MapViewer

    Chromosome 8 - NC_000008.10Genomic Context describing neighboring genes Neighboring gene olfactory receptor, family 6, subfamily R, member 2 pseudogene Neighboring gene docking protein 2, 56kDa Neighboring gene nucleophosmin/nucleoplasmin 2 Neighboring gene fibroblast growth factor 17

    Go to nucleotideGraphics FASTA GenBank

    Go to reference sequence details

    Related articles in PubMed

    1. A census of human soluble protein complexes. Havugimana PC, et al. Cell, 2012 Aug 31. PMID 22939629.
    2. A high-throughput approach for measuring temporal changes in the interactome. Kristensen AR, et al. Nat Methods, 2012 Sep. PMID 22863883.
    3. The proteomic analysis of endogenous FAT10 substrates identifies p62/SQSTM1 as a substrate of FAT10ylation. Aichem A, et al. J Cell Sci, 2012 Oct 1. PMID 22797925.
    4. Functional proteomics establishes the interaction of SIRT7 with chromatin remodeling complexes and expands its role in regulation of RNA polymerase I transcription. Tsai YC, et al. Mol Cell Proteomics, 2012 May. PMID 22586326.
    5. Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition. Udeshi ND, et al. Mol Cell Proteomics, 2012 May. PMID 22505724.

    See all (18) citations in PubMed

    See citations in PubMed for homologs of this gene provided by HomoloGene

    GeneRIFs: Gene References Into Functions What's a GeneRIF?

    1. These biochemical and functional data reveal RANBP16 and RANBP17 as novel regulators of E2A protein action, and demonstrate specific interaction of E12 with RANBP17.
      Title: Identification of RANBP16 and RANBP17 as novel interaction partners for the bHLH transcription factor E12.
    2. STRADalpha facilitates nuclear export of LKB1 by serving as an adaptor between LKB1 and exportins CRM1 and exportin7.
      Title: STRADalpha regulates LKB1 localization by blocking access to importin-alpha, and by association with Crm1 and exportin-7.
    3. Exportin 7-dependent nuclear export signals differ fundamentally from the leucine-rich, CRM1-dependent ones
      Title: Exportin 7 defines a novel general nuclear export pathway.
    Submit: New GeneRIF Correction

    Review eQTL and phenotype association data in this region using PheGenI

    Products Interactant Other Gene Complex Source Pubs Description
    Q9UIA9 Q9UMR2 DDX19B    HPRD  PubMed  
    Q9UIA9 P45984 MAPK9    HPRD  PubMed  
    Q9UIA9 P49790 NUP153    HPRD  PubMed  
    Q9UIA9 O43592 XPOT    HPRD  PubMed  
    BioGRID:116678 BioGRID:106672 AP2B1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:116678 BioGRID:120578 BRF2    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:116678 BioGRID:121015 C20orf24    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:116678 BioGRID:115760 CARM1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:116678 BioGRID:107283 CARS    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:116678 BioGRID:107876 CTNNA1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:116678 BioGRID:116426 DDX19B    BioGRID  PubMed Two-hybrid 
    BioGRID:116678 BioGRID:109569 DNAJB1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:116678 BioGRID:108142 DPYSL2    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:116678 BioGRID:108291 EIF4B    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:116678 BioGRID:116298 FAF1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:116678 BioGRID:108887 GARS    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:116678 BioGRID:108888 GART    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:116678 BioGRID:108941 GFPT1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:116678 BioGRID:114053 HIRIP3    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:116678 BioGRID:113955 HIST1H4A    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:116678 BioGRID:116022 HSPH1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:116678 BioGRID:116817 JMJD6    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:116678 BioGRID:111587 MAPK9    BioGRID  PubMed Two-hybrid 
    BioGRID:116678 BioGRID:110758 NARS    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:116678 BioGRID:115297 NUP153    BioGRID  PubMed Reconstituted Complex 
    BioGRID:116678 BioGRID:111048 OSBP    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:116678 BioGRID:111196 PDPK1    BioGRID  PubMed Two-hybrid 
    BioGRID:116678 BioGRID:111367 PLOD2    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:116678 BioGRID:111491 PPM1G    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:116678 BioGRID:115491 PRMT3    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:116678 BioGRID:116327 PTP4A3    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:116678 BioGRID:111837 RAN    BioGRID  PubMed Affinity Capture-MS; Reconstituted Complex 
    BioGRID:116678 BioGRID:114070 RANBP3    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:116678 BioGRID:117436 SAMHD1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:116678 BioGRID:115747 SEC23A    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:116678 BioGRID:114991 SEC24C    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:116678 BioGRID:116589 SEPHS1    BioGRID  PubMed Co-fractionation 
    BioGRID:116678 BioGRID:113368 SF1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:116678 BioGRID:119602 SIRT7    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:116678 BioGRID:113188 SUMO1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:116678 BioGRID:115717 TAB1    BioGRID  PubMed Two-hybrid 
    BioGRID:116678 BioGRID:117420 THUMPD3    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:116678 BioGRID:115206 TLK1    BioGRID  PubMed Co-fractionation 
    BioGRID:116678 BioGRID:116201 TLK2    BioGRID  PubMed Co-fractionation 
    BioGRID:116678 BioGRID:112616 TROVE2    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:116678 BioGRID:113116 TTC1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:116678 BioGRID:113164 UBC    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:116678 BioGRID:115791 UBD    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:116678 BioGRID:113177 UBE2I    BioGRID  PubMed Co-fractionation 
    BioGRID:116678 BioGRID:113866 USP11    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:116678 BioGRID:114551 USP14    BioGRID  PubMed Co-fractionation 
    BioGRID:116678 BioGRID:122836 VPS37B    BioGRID  PubMed Co-fractionation 
    BioGRID:116678 BioGRID:113348 XPO1    BioGRID  PubMed Co-fractionation 
    BioGRID:116678 BioGRID:116483 XRN2    BioGRID  PubMed Co-fractionation 

    Markers

    Genotypes

    Homology

    Clone Names

    • KIAA0745

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    nuclear export signal receptor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    mRNA transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    protein export from nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    nuclear pore IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Preferred Names
    exportin-7
    Names
    exportin-7
    RAN binding protein 16

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_015024.4 → NP_055839.3  exportin-7

      Status: VALIDATED

      Source sequence(s)
      AF064729, BC014219, CN479571, DB460798
      Consensus CDS
      CCDS47818.1
      UniProtKB/Swiss-Prot
      Q9UIA9
      Related
      ENSP00000252512, OTTHUMP00000224893, ENST00000252512, OTTHUMT00000375494
      Conserved Domains (1) summary
      smart00913
      Location:30 – 96
      Blast Score: 151
      IBN_N; Importin-beta N-terminal domain

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 104

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh37.p10 Primary Assembly

    Genomic

    1. NC_000008.10 Reference GRCh37.p10 Primary Assembly

      Range
      21777180..21864096
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate HuRef

    Genomic

    1. AC_000140.1 Alternate HuRef

      Range
      20319885..20406819
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate CHM1_1.0

    Genomic

    1. NC_018919.1 Alternate CHM1_1.0

      Range
      22031012..22117895
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001100161.1: Suppressed sequence

      Description
      NM_001100161.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.

    2. NM_001100162.1: Suppressed sequence

      Description
      NM_001100162.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.
    Nucleotide Protein
    Heading Accession and Version
    genomic ABBA01005497.1 (190..87124) None
    genomic AC087363.17 None
    genomic AC091171.15 (9612..55946) None
    genomic AMYH01018562.1 (877900..964783) None
    genomic CH471080.2 EAW63733.1
      EAW63734.1
      EAW63735.1
      EAW63736.1
    mRNA AB018288.1 BAA34465.1
    mRNA AF064729.1 AAF21771.1
    mRNA AK291472.1 BAF84161.1
    mRNA AK299848.1 BAG61710.1
    mRNA AK311616.1 None
    mRNA AL597247.1 None
    mRNA BC014219.2 AAH14219.1
    mRNA BC030785.1 AAH30785.1
    mRNA CN479571.1 None
    mRNA DB460798.1 None
    mRNA DC332379.1 None
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9UIA9.3 GenPept UniProtKB/Swiss-Prot:Q9UIA9

    Additional Links

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Medical
    Molecular Biology Databases
    Research Materials
    Tools
    Miscellaneous

      Supplemental Content

      Table of contents

      Related information

      • Order cDNA clone
        Order cDNA clone
      • BioAssay
        Related PubChem BioAssays
      • BioProjects
        BioProjects related to a gene
      • CCDS
        Links from Gene to CCDS are established if a gene encodes a protein sequence that is a member of a Consensus CDS (CCDS).
      • Conserved Domains
        Conserved Domain Database Links between Entrez Gene and Conserved Domain Database (CDD) are calculated from the domains annotated by the CDD group on Reference Sequence proteins.
      • dbVar
        Link from Gene to dbVar
      • EST
        Link to related EST entry
      • Full text in PMC
        PMC links
      • Full text in PMC_nucleotide
        Full text in PubMedCentral identified from shared sequence links
      • Genome
        Genome records having the gene annotated on corresponding genomic reference sequence.
      • GEO Profiles
        Related GEO
      • HomoloGene
        Links between HomoloGene and Gene are provided by the HomoloGene group when a gene is included in a HomoloGene record.
      • Map Viewer
        These links are maintained by the Map Viewer group and are provided when a GeneID is annotated on a map for the same species.
      • Nucleotide
        Link to related Nucleotide entry
      • OMIM
        Links between OMIM and Gene are calculated by Gene based on MIM numbers included in the summary and phenotype sections of the Gene record.
      • Probe
        Related Probe entry
      • Protein
        Link to related protein entry
      • PubChem Compound
        PubChem Compounds
      • PubChem Substance
        PubChem Substances
      • PubMed
        Links between Gene and PubMed are the result of the following: 1. Manual curation within NCBI. Part of the process of generating a REVIEWED RefSeq is an analysis of the current literature. Papers that are seminal in defining the gene, its sequence, and its function are added to the record at that time. Alert users point out gaps or errors in papers associated with a Gene record. These messages are reviewed and implemented as required. 2. Integration of information from other public databases. Gene integrates gene-citation from resources external to NCBI such as model organism-specific databases, Gene Ontology (GO), groups curating interactions, and sequence databases. The assumption in using these source is that they report citations specific to a gene in a known species. Gene does not process citations from OMIM automatically, because many of citations in OMIM refer to studies of genes in species other than human.
      • PubMed (GeneRIF)
        GeneRIF -- Gene Reference Into Function Staff of the Index Section in the National Library of Medicine review the current literature. When they find articles focused on the structure and function of a gene, they write a brief summary of the impact of the paper and make the connection between the citation (PubMed) and Gene. An interface exists for interested users to submit such data as well. http://www.ncbi.nlm.nih.gov/projects/GeneRIF/GeneRIFhelp.html
      • PubMed (OMIM)
        Links are provided when Gene has a link to a record in OMIM, and OMIM explicitly cites these publications in PubMed.
      • PubMed(nucleotide/PMC)
        Citations in PubMed identified from shared sequence and PMC links.
      • RefSeq Proteins
        Link to Protein RefSeqs
      • RefSeq RNAs
        Link to Nucleotide RefSeq RNAs
      • SNP
        Related SNP records
      • SNP: GeneView
        SNPs linked from GeneView
      • SNP: Genotype
        Gene Genotype Report
      • Taxonomy
        Link to related taxonomy entry
      • UniGene
        Links are provided between Gene and UniGene when both databases calculate links to the same mRNA record (gi).
      • UniSTS
        Related UniSTS records

      Links to other resources

      General information

      Related sites

      Feedback

      Subscription

      Recent activity

      Clear Turn Off Turn On

      Your browsing activity is empty.

      Activity recording is turned off.

      Turn recording back on

      See more...