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Tmeff1 transmembrane protein with EGF-like and two follistatin-like domains 1 [ Mus musculus (house mouse) ]

Gene ID: 230157, updated on 3-Apr-2024

Summary

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Official Symbol
Tmeff1provided by MGI
Official Full Name
transmembrane protein with EGF-like and two follistatin-like domains 1provided by MGI
Primary source
MGI:MGI:1926810
See related
Ensembl:ENSMUSG00000028347 AllianceGenome:MGI:1926810
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Tr1; TR-1; M7365; A830033E11
Summary
Predicted to be involved in several processes, including animal organ morphogenesis; neuromuscular junction development; and receptor clustering. Predicted to be located in plasma membrane. Is expressed in several structures, including alimentary system; brain; ganglia; genitourinary system; and sensory organ. Orthologous to several human genes including MSANTD3-TMEFF1 (MSANTD3-TMEFF1 readthrough). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in CNS E18 (RPKM 70.4), CNS E14 (RPKM 69.8) and 12 other tissues See more
Orthologs
human all
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Genomic context

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Location:
4 B1; 4 26.15 cM
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (48585064..48663136)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (48585071..48663132)

Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene inversin Neighboring gene testis expressed gene 10 Neighboring gene STARR-positive B cell enhancer ABC_E6178 Neighboring gene STARR-seq mESC enhancer starr_10161 Neighboring gene STARR-seq mESC enhancer starr_10162 Neighboring gene STARR-seq mESC enhancer starr_10163 Neighboring gene STARR-seq mESC enhancer starr_10164 Neighboring gene Myb/SANT-like DNA-binding domain containing 3 Neighboring gene STARR-seq mESC enhancer starr_10167 Neighboring gene predicted gene 12439 Neighboring gene caveolae associated 4

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. The expression pattern of tomoregulin-1 in urodele limb regeneration and mouse limb development. Morais da Silva S, et al. Mech Dev, 2001 Jun. PMID 11404089
  2. Roles of miR-592-3p and Its Target Gene, TMEFF1, in the Nucleus Accumbens During Incubation of Morphine Craving. Xie B, et al. Int J Neuropsychopharmacol, 2022 May 27. PMID 35020881, Free PMC Article
  3. Expression of the follistatin/EGF-containing transmembrane protein M7365 (tomoregulin-1) during mouse development. Eib DW, et al. Mech Dev, 2000 Oct. PMID 11025219
  4. Expression patterns of follistatin and two follistatin-related proteins during mouse development. De Groot E, et al. Int J Dev Biol, 2000 Apr. PMID 10853830
  5. Tomoregulin-1 prevents cardiac hypertrophy after pressure overload in mice by inhibiting TAK1-JNK pathways. Bao D, et al. Dis Model Mech, 2015 Aug 1. PMID 26092120, Free PMC Article

See all (25) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Roles of miR-592-3p and Its Target Gene, TMEFF1, in the Nucleus Accumbens During Incubation of Morphine Craving.
    Title: Roles of miR-592-3p and Its Target Gene, TMEFF1, in the Nucleus Accumbens During Incubation of Morphine Craving.
  2. A possible mechanism by which tomoregulin-1 regulates the development of cardiac hypertrophy in TAC-induced cardiac hypertrophy is through inhibiting TGFbeta non-canonical (TAK1-JNK) pathways in the myocardium.
    Title: Tomoregulin-1 prevents cardiac hypertrophy after pressure overload in mice by inhibiting TAK1-JNK pathways.
  3. The double-fluorescent immunohistochemical analysis revealed that addicsin and tomoregulin-1 were coexpressed in neurons
    Title: Identification of tomoregulin-1 as a novel addicsin-associated factor.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Process Evidence Code Pubs
acts_upstream_of_or_within multicellular organism development IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
tomoregulin-1
Names
transmembrane protein with EGF-like and one follistatin-like domain

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001356272.2 → NP_001343201.1  tomoregulin-1 isoform 1 precursor

    Status: VALIDATED

    Source sequence(s)
    AL772151, AL807771
    UniProtKB/TrEMBL
    A0A0A0MQL0
    Related
    ENSMUSP00000121740.2, ENSMUST00000130834.8
    Conserved Domains (2) summary
    smart00280
    Location:91 → 135
    KAZAL; Kazal type serine protease inhibitors
    cl28647
    Location:268 → 304
    PHA02887; EGF-like protein; Provisional

  2. NM_001426181.1 → NP_001413110.1  tomoregulin-1 isoform 3 precursor

    Status: VALIDATED

    Source sequence(s)
    AL772151, AL807771

  3. NM_021436.4 → NP_067411.1  tomoregulin-1 isoform 2 precursor

    See identical proteins and their annotated locations for NP_067411.1

    Status: VALIDATED

    Source sequence(s)
    AL772151, AL807771
    Consensus CDS
    CCDS18168.1
    UniProtKB/Swiss-Prot
    A2AJN3, Q6PFE7, Q8BRP7, Q8C536, Q9JJS1
    UniProtKB/TrEMBL
    A0A0A0MQL0
    Related
    ENSMUSP00000030032.7, ENSMUST00000030032.13
    Conserved Domains (2) summary
    PHA02887
    Location:267 → 303
    PHA02887; EGF-like protein; Provisional
    smart00280
    Location:91 → 135
    KAZAL; Kazal type serine protease inhibitors

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000070.7 Reference GRCm39 C57BL/6J

    Range
    48585064..48663136
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006537838.2 → XP_006537901.1  tomoregulin-1 isoform X2

    UniProtKB/TrEMBL
    A0A0A0MQL0
    Conserved Domains (2) summary
    PHA02887
    Location:265 → 301
    PHA02887; EGF-like protein; Provisional
    smart00280
    Location:91 → 135
    KAZAL; Kazal type serine protease inhibitors
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q6PFE7.1 GenPept UniProtKB/Swiss-Prot:Q6PFE7

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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