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Npr2 natriuretic peptide receptor 2 [ Mus musculus (house mouse) ]

Gene ID: 230103, updated on 28-May-2016
Official Symbol
Npr2provided by MGI
Official Full Name
natriuretic peptide receptor 2provided by MGI
Primary source
MGI:MGI:97372
See related
Ensembl:ENSMUSG00000028469 Vega:OTTMUSG00000007021
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
cn; pwe; GC-B; GC-B2; GC-B3; mNPR-B
Orthologs
Location:
4 B1; 4 23.05 cM
Exon count:
22
Annotation release Status Assembly Chr Location
105 current GRCm38.p3 (GCF_000001635.23) 4 NC_000070.6 (43630332..43651437)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 4 NC_000070.5 (43644807..43664116)

Chromosome 4 - NC_000070.6Genomic Context describing neighboring genes Neighboring gene RAB6A GEF compex partner 1 Neighboring gene microseminoprotein, prostate associated Neighboring gene predicted gene, 42279 Neighboring gene sperm associated antigen 8 Neighboring gene histidine triad nucleotide binding protein 2 Neighboring gene small EDRK-rich factor 2 pseudogene Neighboring gene family with sequence similarity 221, member B Neighboring gene small EDRK-rich factor 2 pseudogene

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Associated conditions

Description Tests
achondroplasia
GeneReviews: Not available

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
ATP binding ISO
Inferred from Sequence Orthology
more info
 
GTP binding ISO
Inferred from Sequence Orthology
more info
 
guanylate cyclase activity IDA
Inferred from Direct Assay
more info
PubMed 
guanylate cyclase activity ISO
Inferred from Sequence Orthology
more info
 
hormone binding ISO
Inferred from Sequence Orthology
more info
 
identical protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
lyase activity IEA
Inferred from Electronic Annotation
more info
 
natriuretic peptide receptor activity IDA
Inferred from Direct Assay
more info
PubMed 
natriuretic peptide receptor activity ISO
Inferred from Sequence Orthology
more info
 
nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
peptide hormone binding ISO
Inferred from Sequence Orthology
more info
 
phosphorus-oxygen lyase activity IEA
Inferred from Electronic Annotation
more info
 
protein kinase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
bone development IMP
Inferred from Mutant Phenotype
more info
PubMed 
cGMP biosynthetic process IDA
Inferred from Direct Assay
more info
PubMed 
cGMP biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
cyclic nucleotide biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
intracellular signal transduction IEA
Inferred from Electronic Annotation
more info
 
negative regulation of meiotic cell cycle IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of oocyte maturation IMP
Inferred from Mutant Phenotype
more info
PubMed 
ossification IEA
Inferred from Electronic Annotation
more info
 
protein phosphorylation IEA
Inferred from Electronic Annotation
more info
 
receptor guanylyl cyclase signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
 
receptor guanylyl cyclase signaling pathway ISO
Inferred from Sequence Orthology
more info
 
single organism reproductive process IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
guanylate cyclase complex, soluble IBA
Inferred from Biological aspect of Ancestor
more info
 
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
membrane IEA
Inferred from Electronic Annotation
more info
 
plasma membrane ISO
Inferred from Sequence Orthology
more info
 
plasma membrane TAS
Traceable Author Statement
more info
PubMed 
Preferred Names
atrial natriuretic peptide receptor 2
Names
ANP-B
ANPR-B
NPR-B
Nppb receptor
atrial natriuretic peptide receptor type B
guanylate cyclase B
guanylyl cyclase-B
natriuretic peptide receptor B type
NP_776149.1

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_173788.3NP_776149.1  atrial natriuretic peptide receptor 2 precursor

    See identical proteins and their annotated locations for NP_776149.1

    Status: PROVISIONAL

    Source sequence(s)
    AL732626
    Consensus CDS
    CCDS18105.1
    UniProtKB/Swiss-Prot
    Q6VVW5
    Related
    ENSMUSP00000030191, OTTMUSP00000007443, ENSMUST00000030191, OTTMUST00000016249
    Conserved Domains (6) summary
    cd07302
    Location:8601036
    CHD; cyclase homology domain
    smart00044
    Location:8251009
    CYCc; Adenylyl- / guanylyl cyclase, catalytic domain
    pfam01094
    Location:44397
    ANF_receptor; Receptor family ligand binding region
    pfam07701
    Location:799846
    HNOBA; Heme NO binding associated
    cd14042
    Location:518792
    PK_GC-A_B; Pseudokinase domain of the membrane Guanylate Cyclase receptors, GC-A and GC-B
    cl10011
    Location:26421
    Periplasmic_Binding_Protein_Type_1; Type 1 periplasmic binding fold superfamily

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 105 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p3 C57BL/6J

Genomic

  1. NC_000070.6 Reference GRCm38.p3 C57BL/6J

    Range
    43630332..43651437
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006537833.2XP_006537896.1  

    UniProtKB/Swiss-Prot
    Q6VVW5
    Conserved Domains (6) summary
    cd07302
    Location:8351011
    CHD; cyclase homology domain
    smart00044
    Location:800984
    CYCc; Adenylyl- / guanylyl cyclase, catalytic domain
    pfam01094
    Location:44397
    ANF_receptor; Receptor family ligand binding region
    pfam07701
    Location:774821
    HNOBA; Heme NO binding associated
    cd14042
    Location:486767
    PK_GC-A_B; Pseudokinase domain of the membrane Guanylate Cyclase receptors, GC-A and GC-B
    cl10011
    Location:26421
    Periplasmic_Binding_Protein_Type_1; Type 1 periplasmic binding fold superfamily

RNA

  1. XR_390318.2 RNA Sequence

Alternate Mm_Celera

Genomic

  1. AC_000026.1 Alternate Mm_Celera

    Range
    43666379..43685849
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)