ALDOC aldolase C, fructose-bisphosphate [Homo sapiens] - Gene

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Summary

Official Symbol: ALDOCprovided by HGNC
Official Full Name: aldolase C, fructose-bisphosphateprovided by HGNC
Primary source: HGNC:418
See related: Ensembl:ENSG00000109107; HPRD:02386; MIM:103870; Vega:OTTHUMG00000132605
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: ALDC
Summary: This gene encodes a member of the class I fructose-biphosphate aldolase gene family. Expressed specifically in the hippocampus and Purkinje cells of the brain, the encoded protein is a glycolytic enzyme that catalyzes the reversible aldol cleavage of fructose-1,6-biphosphate and fructose 1-phosphate to dihydroxyacetone phosphate and either glyceraldehyde-3-phosphate or glyceraldehyde, respectively. [provided by RefSeq, Jul 2008]

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Genomic context

Location :: 17cen-q12

Sequence :: Chromosome: 17; NC_000017.10 (26900133..26903951, complement)

See ALDOC in Epigenomics, MapViewer

Chromosome 17 - NC_000017.10 Genomic Context describing neighboring genes

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Genomic regions, transcripts, and products

Genomic Sequence

Go to nucleotideGraphics FASTA GenBank

Go to reference sequence details

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Bibliography

GeneRIFs: Gene References Into Functions What's a GeneRIF?

This protein has been found differentially expressed in the anterior cingulate cortex in men patients with schizophrenia.
Title: Sex-specific proteome differences in the anterior cingulate cortex of schizophrenia.
Results identified fructose bisphospate aldolase C that showed elevated levels of protein carbonyls in inferior parietal lobule (IPL) from subjects with early stage-Alzheimer's disease.
Title: Redox proteomic analysis of carbonylated brain proteins in mild cognitive impairment and early Alzheimer's disease.
This protein has been found differentially expressed in the Wernicke's Area from patients with schizophrenia.
Title: Proteome analysis of schizophrenia patients Wernicke's area reveals an energy metabolism dysregulation.
This protein has been found differentially expressed in the dorsolateral prefrontal cortex from patients with schizophrenia.
Title: Proteomic analysis of dorsolateral prefrontal cortex indicates the involvement of cytoskeleton, oligodendrocyte, energy metabolism and new potential markers in schizophrenia.
This protein has been found differentially expressed in the temporal lobe from patients with schizophrenia.
Title: Alterations in oligodendrocyte proteins, calcium homeostasis and new potential markers in schizophrenia anterior temporal lobe are revealed by shotgun proteome analysis.
Diverse ALDOC promoter regions are required to direct specific LacZ expression in the hippocampus and Purkinje cells if transgenic mice.
Title: Diverse human aldolase C gene promoter regions are required to direct specific LacZ expression in the hippocampus and Purkinje cells of transgenic mice.

Submit: New GeneRIF Correction

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Phenotypes

Review eQTL and phenotype association data in this region using PheGenI

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Products	Interactant	Other Gene	Source	Pubs	Description
P09972	O14939	PLD2	HPRD	PubMed
BioGRID:106731	BioGRID:107012	ATP6V1E1	BioGRID	PubMed	Two-hybrid
BioGRID:106731	BioGRID:113164	UBC	BioGRID	PubMed	Affinity Capture-MS

Function	Evidence Code	Pubs
cytoskeletal protein binding	IDA Inferred from Direct Assay more info	PubMed
fructose-bisphosphate aldolase activity	IDA Inferred from Direct Assay more info	PubMed
lyase activity	IEA Inferred from Electronic Annotation more info
protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
aging	IEA Inferred from Electronic Annotation more info
apoptotic process	IEA Inferred from Electronic Annotation more info
carbohydrate metabolic process	TAS Traceable Author Statement more info
fructose 1,6-bisphosphate metabolic process	IDA Inferred from Direct Assay more info	PubMed
fructose metabolic process	TAS Traceable Author Statement more info	PubMed
gluconeogenesis	TAS Traceable Author Statement more info
glucose metabolic process	TAS Traceable Author Statement more info
glycolysis	TAS Traceable Author Statement more info
organ regeneration	IEA Inferred from Electronic Annotation more info
protein heterotetramerization	IEA Inferred from Electronic Annotation more info
protein homotetramerization	IEA Inferred from Electronic Annotation more info
response to hypoxia	IEA Inferred from Electronic Annotation more info
response to organic cyclic compound	IEA Inferred from Electronic Annotation more info
response to organic nitrogen	IEA Inferred from Electronic Annotation more info
small molecule metabolic process	TAS Traceable Author Statement more info

Component	Evidence Code	Pubs
axon	IEA Inferred from Electronic Annotation more info
cytoplasm	IEA Inferred from Electronic Annotation more info
cytoskeleton	IC Inferred by Curator more info	PubMed
cytosol	TAS Traceable Author Statement more info
mitochondrion	IEA Inferred from Electronic Annotation more info

General protein information

Preferred Names: fructose-bisphosphate aldolase C

Names: fructose-bisphosphate aldolase C; aldolase 3; fructoaldolase C; brain-type aldolase; fructose-1,6-biphosphate triosephosphate lyase

NP_005156.1

EC 4.1.2.13

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NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_005165.2 → NP_005156.1 fructose-bisphosphate aldolase C

Status: REVIEWED

Source sequence(s)

AC005726, AF054987, BF345067

Consensus CDS

CCDS11236.1

UniProtKB/Swiss-Prot

P09972

Related

ENSP00000226253, OTTHUMP00000163435, ENST00000226253, OTTHUMT00000255839

Conserved Domains (1) summary

cd00948
Location:13 – 343
Blast Score: 1556

FBP_aldolase_I_a; Fructose-1,6-bisphosphate aldolase

RefSeqs of Annotated Genomes: Build 37.3

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh37.p5 Primary Assembly

Genomic

NC_000017.10 Reference GRCh37.p5 Primary Assembly

Range

26900133..26903951, complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Alternate HuRef

Genomic

AC_000149.1 Alternate HuRef

Range

23108999..23112817, complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

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Related Sequences

Nucleotide		Protein
Heading	Accession and Version	Protein
genomic	AC005726.1 (80878..84697)	None
genomic	CH471159.1	EAW51104.1
		EAW51105.1
genomic	HI574194.1	CBX47586.1
genomic	X05196.1	CAA28825.1
genomic	X07292.1	CAA30270.1
mRNA	AF054987.1	AAC09348.1
mRNA	AK293453.1	BAH11512.1
mRNA	AK293623.1	BAH11551.1
mRNA	AK293693.1	BAH11572.1
mRNA	AK294091.1	BAH11668.1
mRNA	AK294157.1	BAH11685.1
mRNA	AK296039.1	BAH12243.1
mRNA	AK296053.1	BAH12245.1
mRNA	AK312281.1	BAG35210.1
mRNA	BC003613.2	AAH03613.3
mRNA	BC065565.1	AAH65565.2
mRNA	BC103760.1	AAI03761.1
mRNA	BC106925.1	AAI06926.1
mRNA	BC106926.1	AAI06927.1
mRNA	BF345067.1	None
mRNA	BT007006.1	AAP35652.1
mRNA	CR541862.1	CAG46660.1
mRNA	CR541881.1	CAG46679.1