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ABCF1 ATP-binding cassette, sub-family F (GCN20), member 1 [ Homo sapiens (human) ]

Gene ID: 23, updated on 5-Apr-2015
Official Symbol
ABCF1provided by HGNC
Official Full Name
ATP-binding cassette, sub-family F (GCN20), member 1provided by HGNC
Primary source
HGNC:HGNC:70
See related
Ensembl:ENSG00000204574; HPRD:09139; MIM:603429; Vega:OTTHUMG00000031094
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ABC27; ABC50
Summary
The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the GCN20 subfamily. Unlike other members of the superfamily, this protein lacks the transmembrane domains which are characteristic of most ABC transporters. This protein may be regulated by tumor necrosis factor-alpha and play a role in enhancement of protein synthesis and the inflammation process. [provided by RefSeq, Jul 2008]
Orthologs
See ABCF1 in MapViewer
Location:
6p21.33
Exon count:
25
Annotation release Status Assembly Chr Location
107 current GRCh38.p2 (GCF_000001405.28) 6 NC_000006.12 (30571393..30591532)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (30539170..30559309)

Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene major histocompatibility complex, class I, E Neighboring gene guanine nucleotide binding protein-like 1 Neighboring gene proline rich 3 Neighboring gene microRNA 877 Neighboring gene protein phosphatase 1, regulatory subunit 10 Neighboring gene mitochondrial ribosomal protein S18B Neighboring gene alpha tubulin acetyltransferase 1 Neighboring gene prothymosin, alpha pseudogene 1

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

NHGRI GWAS Catalog

Description
Identification of independent risk loci for Graves' disease within the MHC in the Japanese population.
NHGRI GWA Catalog

Protein interactions

Protein Gene Interaction Pubs
Rev rev HIV-1 Rev interacting protein, ATP-binding cassette, sub-family F (ABCF1), is identified by the in-vitro binding experiments involving cytosolic or nuclear extracts from HeLa cells. The interaction of Rev with ABCF1 is increased by RRE PubMed

Go to the HIV-1, Human Interaction Database

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
ATP binding IDA
Inferred from Direct Assay
more info
PubMed 
ATP binding IEA
Inferred from Electronic Annotation
more info
 
ATPase activity IEA
Inferred from Electronic Annotation
more info
 
poly(A) RNA binding IDA
Inferred from Direct Assay
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
ribosome binding IDA
Inferred from Direct Assay
more info
PubMed 
translation activator activity IDA
Inferred from Direct Assay
more info
PubMed 
translation factor activity, RNA binding TAS
Traceable Author Statement
more info
PubMed 
Process Evidence Code Pubs
inflammatory response TAS
Traceable Author Statement
more info
PubMed 
positive regulation of translation IDA
Inferred from Direct Assay
more info
PubMed 
NOT ribosome biogenesis IDA
Inferred from Direct Assay
more info
PubMed 
translation TAS
Traceable Author Statement
more info
PubMed 
translational initiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
transmembrane transport TAS
Traceable Author Statement
more info
 
Component Evidence Code Pubs
cytoplasm IDA
Inferred from Direct Assay
more info
 
cytosol TAS
Traceable Author Statement
more info
 
membrane IDA
Inferred from Direct Assay
more info
PubMed 
nuclear envelope IDA
Inferred from Direct Assay
more info
PubMed 
nuclear envelope IEA
Inferred from Electronic Annotation
more info
 
nucleoplasm IDA
Inferred from Direct Assay
more info
PubMed 
nucleoplasm IEA
Inferred from Electronic Annotation
more info
 
polysomal ribosome IDA
Inferred from Direct Assay
more info
PubMed 
ribosome IEA
Inferred from Electronic Annotation
more info
 
Preferred Names
ATP-binding cassette sub-family F member 1
Names
ATP-binding cassette sub-family F member 1
ATP-binding cassette 50 (TNF-alpha stimulated)
TNF-alpha-stimulated ABC protein
TNFalpha-inducible ATP-binding protein

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001025091.1NP_001020262.1  ATP-binding cassette sub-family F member 1 isoform a

    See identical proteins and their annotated locations for NP_001020262.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (a).
    Source sequence(s)
    AF027302, BC034488, BI547952, BM556481, BU620927
    Consensus CDS
    CCDS34380.1
    UniProtKB/Swiss-Prot
    Q8NE71
    Related
    ENSP00000313603, OTTHUMP00000029111, ENST00000326195, OTTHUMT00000076137
    Conserved Domains (3) summary
    cd03221
    Location:304525
    ABCF_EF-3; ATP-binding cassette domain of elongation factor 3, subfamily F
    COG0488
    Location:302833
    Uup; ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]
    cl21455
    Location:697774
    ABC_ATPase; ATP-binding cassette transporter nucleotide-binding domain
  2. NM_001090.2NP_001081.1  ATP-binding cassette sub-family F member 1 isoform b

    See identical proteins and their annotated locations for NP_001081.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon, compared to variant 1. The resulting protein (isoform b) is shorter than isoform a.
    Source sequence(s)
    AF027302, BI547952, BM556481, BU620927
    Consensus CDS
    CCDS34381.1
    UniProtKB/TrEMBL
    Q2L6I2
    UniProtKB/Swiss-Prot
    Q8NE71
    Related
    ENSP00000365728, OTTHUMP00000029110, ENST00000376545, OTTHUMT00000076136
    Conserved Domains (3) summary
    cd03221
    Location:266487
    ABCF_EF-3; ATP-binding cassette domain of elongation factor 3, subfamily F
    COG0488
    Location:264795
    Uup; ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]
    cl21455
    Location:659736
    ABC_ATPase; ATP-binding cassette transporter nucleotide-binding domain

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 107

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p2 Primary Assembly

Genomic

  1. NC_000006.12 Reference GRCh38.p2 Primary Assembly

    Range
    30571393..30591532
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p2 ALT_REF_LOCI_2

Genomic

  1. NT_113891.3 Reference GRCh38.p2 ALT_REF_LOCI_2

    Range
    2051115..2071250
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p2 ALT_REF_LOCI_3

Genomic

  1. NT_167245.2 Reference GRCh38.p2 ALT_REF_LOCI_3

    Range
    1827220..1847359
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p2 ALT_REF_LOCI_4

Genomic

  1. NT_167246.2 Reference GRCh38.p2 ALT_REF_LOCI_4

    Range
    1881622..1901761
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p2 ALT_REF_LOCI_5

Genomic

  1. NT_167247.2 Reference GRCh38.p2 ALT_REF_LOCI_5

    Range
    1915439..1935578
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p2 ALT_REF_LOCI_6

Genomic

  1. NT_167248.2 Reference GRCh38.p2 ALT_REF_LOCI_6

    Range
    1826480..1846615
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p2 ALT_REF_LOCI_7

Genomic

  1. NT_167249.2 Reference GRCh38.p2 ALT_REF_LOCI_7

    Range
    1872150..1892288
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate CHM1_1.1

Genomic

  1. NC_018917.2 Alternate CHM1_1.1

    Range
    30541266..30561417
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)