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    HMGXB3 HMG box domain containing 3 [ Homo sapiens ]

    Gene ID: 22993, updated on 11-May-2012
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    Summary

    Official Symbol
    HMGXB3provided by HGNC
    Official Full Name
    HMG box domain containing 3provided by HGNC
    Primary source
    HGNC:28982
    See related
    Ensembl:ENSG00000113716; Vega:OTTHUMG00000163493
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    SMF; HMGX3; KIAA0194
    Summary
    This gene is one of the non-canonical high mobility group (HMG) genes. The encoded protein contains an HMG-box domain found in DNA binding proteins such as transcription factors and chromosomal proteins. [provided by RefSeq, Aug 2011]
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    Genomic context

    Location :
    5q32
    Sequence :
    Chromosome: 5; NC_000005.9 (149380169..149432706)
    See HMGXB3 in Epigenomics, MapViewer

    Chromosome 5 - NC_000005.9Genomic Context describing neighboring genes Neighboring gene phosphodiesterase 6A, cGMP-specific, rod, alpha Neighboring gene solute carrier family 26 (sulfate transporter), member 2 Neighboring gene tigger transposable element derived 6 Neighboring gene ribosomal protein S20 pseudogene 4 Neighboring gene colony stimulating factor 1 receptor Neighboring gene ribosomal protein L7 pseudogene Neighboring gene platelet-derived growth factor receptor, beta polypeptide

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    Genomic regions, transcripts, and products

    Go to nucleotideGraphics FASTA GenBank

    Go to reference sequence details
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    Bibliography

    Related articles in PubMed

    1. Systematic and quantitative assessment of the ubiquitin-modified proteome. Kim W, et al. Mol Cell, 2011 Oct 21. PMID 21906983.
    2. A directed protein interaction network for investigating intracellular signal transduction. Vinayagam A, et al. Sci Signal, 2011 Sep 6. PMID 21900206.
    3. Common genetic variation and the control of HIV-1 in humans. Fellay J, et al. PLoS Genet, 2009 Dec. PMID 20041166.
    4. Toward a confocal subcellular atlas of the human proteome. Barbe L, et al. Mol Cell Proteomics, 2008 Mar. PMID 18029348.
    5. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. Kimura K, et al. Genome Res, 2006 Jan. PMID 16344560.

    See all (11) citations in PubMed

    See citations in PubMed for homologs of this gene provided by HomoloGene

    GeneRIFs: Gene References Into Functions What's a GeneRIF?

    Submit: New GeneRIF Correction
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    Phenotypes

    Review eQTL and phenotype association data in this region using PheGenI

    Common genetic variation and the control of HIV-1 in humans.

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    Interactions

    Products Interactant Other Gene Complex Source Pubs Description
    BioGRID:116640 BioGRID:106807 ANXA7    BioGRID  PubMed Two-hybrid 
    BioGRID:116640 BioGRID:107454 CDK4    BioGRID  PubMed Two-hybrid 
    BioGRID:116640 BioGRID:107460 CDKN1A    BioGRID  PubMed Two-hybrid 
    BioGRID:116640 BioGRID:111223 PFDN1    BioGRID  PubMed Two-hybrid 
    BioGRID:116640 BioGRID:112490 SMN1    BioGRID  PubMed Two-hybrid 
    BioGRID:116640 BioGRID:112938 TK1    BioGRID  PubMed Two-hybrid 
    BioGRID:116640 BioGRID:113164 UBC    BioGRID  PubMed Affinity Capture-MS 
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    General gene information

    Markers

    Genotypes

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    kinase activity NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    Process Evidence Code Pubs
    biological_process ND
    No biological Data available
    more info
    		  
    phosphorylation NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    cellular_component ND
    No biological Data available
    more info
    		  
    nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
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    General protein information

    Preferred Names
    HMG domain-containing protein 3
    Names
    HMG domain-containing protein 3
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    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_021389.1 RefSeqGene

      Range
      5001..57538
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_014983.2 → NP_055798.2  HMG domain-containing protein 3

      Status: VALIDATED

      Source sequence(s)
      BC035434, BC051025, BC092520, BM974831, DA324742
      Consensus CDS
      CCDS54935.1
      UniProtKB/Swiss-Prot
      Q12766
      UniProtKB/TrEMBL
      Q562E5
      Related
      ENSP00000421917, OTTHUMP00000224091, ENST00000502717, OTTHUMT00000373771
      Conserved Domains (1) summary
      cd00084
      Location:45 – 100
      Blast Score: 153
      HMG-box; High Mobility Group (HMG)-box is found in a variety of eukaryotic chromosomal proteins and transcription factors. HMGs bind to the minor groove of DNA and have been classified by DNA binding preferences. Two phylogenically distinct groups of Class I ...

    RefSeqs of Annotated Genomes: Build 37.3

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh37.p5 Primary Assembly

    Genomic

    1. NC_000005.9 Reference GRCh37.p5 Primary Assembly

      Range
      149380169..149432706
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate HuRef

    Genomic

    1. AC_000137.1 Alternate HuRef

      Range
      144528135..144580656
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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    Related Sequences

    Nucleotide Protein
    Heading Accession and Version
    genomic AC011382.4 (5156..6541) None
    genomic AC011406.5 None
    genomic U63963.1 AAB51697.1
    mRNA BC005880.2 AAH05880.2
    mRNA BC035219.1 None
    mRNA BC035434.1 None
    mRNA BC051025.1 AAH51025.1
    mRNA BC063691.1 AAH63691.1
    mRNA BC092520.1 AAH92520.1
    mRNA BM974831.1 None
    mRNA D83778.1 BAA12107.1
    mRNA DA324742.1 None
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q12766.2 GenPept UniProtKB/Swiss-Prot:Q12766
    Q562E5 GenPept UniProtKB/TrEMBL:Q562E5
    Q6P442 GenPept UniProtKB/TrEMBL:Q6P442
    Q9BRX4 GenPept UniProtKB/TrEMBL:Q9BRX4
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    Additional Links

    Additional Links

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Molecular Biology Databases
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