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MSRB2 methionine sulfoxide reductase B2 [ Homo sapiens (human) ]

Gene ID: 22921, updated on 12-May-2016
Official Symbol
MSRB2provided by HGNC
Official Full Name
methionine sulfoxide reductase B2provided by HGNC
Primary source
HGNC:HGNC:17061
See related
Ensembl:ENSG00000148450 HPRD:17606; MIM:613782; Vega:OTTHUMG00000017812
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CBS1; MSRB; PILB; CBS-1; CGI-131
Orthologs
Location:
10p12
Exon count:
6
Annotation release Status Assembly Chr Location
107 current GRCh38.p2 (GCF_000001405.28) 10 NC_000010.11 (23095498..23122013)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (23384427..23410942)

Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene armadillo repeat containing 3 Neighboring gene uncharacterized LOC105376452 Neighboring gene RNA, 5S ribosomal pseudogene 304 Neighboring gene tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein zeta pseudogene 3 Neighboring gene pancreas specific transcription factor, 1a

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

NHGRI GWAS Catalog

Description
Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population.
NHGRI GWA Catalog
  • Metabolism of proteins, organism-specific biosystem (from REACTOME)
    Metabolism of proteins, organism-specific biosystemProtein metabolism comprises the pathways of translation, post-translational modification and protein folding.
  • Protein repair, organism-specific biosystem (from REACTOME)
    Protein repair, organism-specific biosystemReactive oxygen species (ROS) such as H2O2, superoxide anions and hydroxyl radicals interact with molecules in the cell causing damage that impairs cellular functions. Although cells have mechanisms ...
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Clone Names

  • MGC26104

Gene Ontology Provided by GOA

Function Evidence Code Pubs
actin binding ISS
Inferred from Sequence or Structural Similarity
more info
 
peptide-methionine (R)-S-oxide reductase activity ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
peptide-methionine (R)-S-oxide reductase activity TAS
Traceable Author Statement
more info
 
transcription factor activity, sequence-specific DNA binding TAS
Traceable Author Statement
more info
PubMed 
zinc ion binding ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
Process Evidence Code Pubs
actin filament polymerization ISS
Inferred from Sequence or Structural Similarity
more info
 
oxidation-reduction process IEA
Inferred from Electronic Annotation
more info
 
protein repair ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
protein repair TAS
Traceable Author Statement
more info
 
regulation of transcription, DNA-templated IEA
Inferred from Electronic Annotation
more info
 
response to oxidative stress IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
cytosol TAS
Traceable Author Statement
more info
 
mitochondrion ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
Preferred Names
methionine-R-sulfoxide reductase B2, mitochondrial
Names
pilin-like transcription factor
NP_036360.3

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_012228.3NP_036360.3  methionine-R-sulfoxide reductase B2, mitochondrial precursor

    See identical proteins and their annotated locations for NP_036360.3

    Status: VALIDATED

    Source sequence(s)
    AF151889, AL139281, BC117471
    Consensus CDS
    CCDS41495.1
    UniProtKB/Swiss-Prot
    Q9Y3D2
    Related
    ENSP00000365693, OTTHUMP00000019305, ENST00000376510, OTTHUMT00000047205
    Conserved Domains (1) summary
    PRK00222
    Location:51181
    PRK00222; methionine sulfoxide reductase B; Provisional

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 107 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p2 Primary Assembly

Genomic

  1. NC_000010.11 Reference GRCh38.p2 Primary Assembly

    Range
    23095498..23122013
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011519426.1XP_011517728.1  

    Conserved Domains (1) summary
    cl15841
    Location:51100
    SelR; SelR domain

Alternate CHM1_1.1

Genomic

  1. NC_018921.2 Alternate CHM1_1.1

    Range
    23384967..23411480
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)