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EPN2 epsin 2 [ Homo sapiens (human) ]

Gene ID: 22905, updated on 8-May-2016
Official Symbol
EPN2provided by HGNC
Official Full Name
epsin 2provided by HGNC
Primary source
HGNC:HGNC:18639
See related
Ensembl:ENSG00000072134 HPRD:06271; MIM:607263; Vega:OTTHUMG00000187034
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
EHB21
Summary
This gene encodes a protein which interacts with clathrin and adaptor-related protein complex 2, alpha 1 subunit. The protein is found in a brain-derived clathrin-coated vesicle fraction and localizes to the peri-Golgi region and the cell periphery. The protein is thought to be involved in clathrin-mediated endocytosis. Alternate splicing of this gene results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]
Orthologs
Location:
17p11.2
Exon count:
11
Annotation release Status Assembly Chr Location
107 current GRCh38.p2 (GCF_000001405.28) 17 NC_000017.11 (19237377..19336715)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (19140690..19240028)

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene kynureninase pseudogene 3 Neighboring gene uncharacterized protein ENSP00000382042 Neighboring gene EPN2 intronic transcript 1 Neighboring gene EPN2 antisense RNA 1 Neighboring gene B9 domain containing 1 Neighboring gene microRNA 1180 Neighboring gene uncharacterized LOC105371573

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Protein interactions

Protein Gene Interaction Pubs
Rev rev HIV-1 Rev interacting protein, epsin 2 (EPN2), is identified by the in-vitro binding experiments involving cytosolic or nuclear extracts from HeLa cells. The interaction of Rev with EPN2 is increased by RRE PubMed

Go to the HIV-1, Human Interaction Database

  • Endocytosis, organism-specific biosystem (from KEGG)
    Endocytosis, organism-specific biosystemEndocytosis is a mechanism for cells to remove ligands, nutrients, and plasma membrane (PM) proteins, and lipids from the cell surface, bringing them into the cell interior. Transmembrane proteins en...
  • Endocytosis, conserved biosystem (from KEGG)
    Endocytosis, conserved biosystemEndocytosis is a mechanism for cells to remove ligands, nutrients, and plasma membrane (PM) proteins, and lipids from the cell surface, bringing them into the cell interior. Transmembrane proteins en...
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Clone Names

  • KIAA1065

Gene Ontology Provided by GOA

Function Evidence Code Pubs
lipid binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
endocytosis IEA
Inferred from Electronic Annotation
more info
 
regulation of endocytosis IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
Golgi apparatus IDA
Inferred from Direct Assay
more info
 
clathrin coat of endocytic vesicle IEA
Inferred from Electronic Annotation
more info
 
intracellular membrane-bounded organelle IDA
Inferred from Direct Assay
more info
 
nucleoplasm IDA
Inferred from Direct Assay
more info
 
Preferred Names
epsin-2
Names
EPS-15-interacting protein 2
Eps15 binding protein

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001102664.1NP_001096134.1  epsin-2 isoform c

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR and coding region compared to variant 2. The resulting isoform (c) is shorter at the N-terminus compared to isoform b.
    Source sequence(s)
    AC124066, AK092366, DA220261, DC316524
    Consensus CDS
    CCDS42277.1
    UniProtKB/Swiss-Prot
    O95208
    Related
    ENSP00000378980, OTTHUMP00000065810, ENST00000395618, OTTHUMT00000132285
    Conserved Domains (1) summary
    PHA03247
    Location:44349
    PHA03247; large tegument protein UL36; Provisional
  2. NM_014964.4NP_055779.2  epsin-2 isoform b

    See identical proteins and their annotated locations for NP_055779.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) represents the longest transcript and encodes the longest isoform (b).
    Source sequence(s)
    AB028988, AC124066, AK092366, DC316524
    Consensus CDS
    CCDS11203.1
    UniProtKB/Swiss-Prot
    O95208
    Related
    ENSP00000320543, OTTHUMP00000065808, ENST00000314728, OTTHUMT00000132283
    Conserved Domains (1) summary
    cd03571
    Location:19141
    ENTH_epsin; ENTH domain, Epsin family; The epsin (Eps15 interactor) N-terminal homology (ENTH) domain is an evolutionarily conserved protein module found primarily in proteins that participate in clathrin-mediated endocytosis. A set of proteins previously designated ...
  3. NM_148921.3NP_683723.2  epsin-2 isoform a

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) lacks an alternate in-frame exon compared to variant 2. The resulting isoform (a) has the same N- and C-termini but is shorter compared to isoform b.
    Source sequence(s)
    AC124066, AK092366, BC093972, DC316524
    Consensus CDS
    CCDS11204.1
    UniProtKB/Swiss-Prot
    O95208
    Related
    ENSP00000261495, ENST00000347697
    Conserved Domains (1) summary
    cd03571
    Location:19141
    ENTH_epsin; ENTH domain, Epsin family; The epsin (Eps15 interactor) N-terminal homology (ENTH) domain is an evolutionarily conserved protein module found primarily in proteins that participate in clathrin-mediated endocytosis. A set of proteins previously designated ...

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 107 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p2 Primary Assembly

Genomic

  1. NC_000017.11 Reference GRCh38.p2 Primary Assembly

    Range
    19237377..19336715
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate CHM1_1.1

Genomic

  1. NC_018928.2 Alternate CHM1_1.1

    Range
    19149312..19248777
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)