Taf4a TAF4A RNA polymerase II, TATA box binding protein (TBP)-associated factor [Mus musculus (house mouse)] - Gene

Summary

Go to the top of the page Help

Official Symbol: Taf4aprovided by MGI
Official Full Name: TAF4A RNA polymerase II, TATA box binding protein (TBP)-associated factorprovided by MGI
Primary source: MGI:2152346
Locus tag: RP23-23G3.2
See related: Ensembl:ENSMUSG00000039117
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: 135kDa; Taf2c1; AI450312; TAFII130; TAFII135

Genomic context

Go to the top of the page Help

Location :: 2 H4; 2

Sequence :: Chromosome: 2; NC_000068.7 (179912146..179976646, complement)

See Taf4a in Epigenomics, MapViewer

Chromosome 2 - NC_000068.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

Go to the top of the page Help

Genomic Sequence

Go to nucleotideGraphics FASTA GenBank

Go to reference sequence details

Bibliography

Go to the top of the page Help

GeneRIFs: Gene References Into Functions What's a GeneRIF?

A role for TAF4 as a cofactor in the cellular response to trans retinoic acid.
Title: Retinoic acid induces TGFbeta-dependent autocrine fibroblast growth.
TAF4 is an important regulator of keratinocyte proliferation and has cell-autonomous and non-cell-autonomous tumour suppressor activity.
Title: The TFIID subunit TAF4 regulates keratinocyte proliferation and has cell-autonomous and non-cell-autonomous tumour suppressor activity in mouse epidermis.

Submit: New GeneRIF Correction

Alleles

Go to the top of the page Help

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (Floxed/Frt) (1) 1 citation
Targeted (knock-out) (1) 1 citation

Interactions

Go to the top of the page Help

Products	Interactant	Other Gene	Complex	Source	Pubs	Description
BioGRID:230801	BioGRID:204938	Esrrb		BioGRID	PubMed	Affinity Capture-MS

Pathways from BioSystems

Go to the top of the page Help

Basal transcription factors, organism-specific biosystem (from KEGG)
Basal transcription factors, organism-specific biosystem
Basal transcription factors
Basal transcription factors, conserved biosystem (from KEGG)
Basal transcription factors, conserved biosystem
Basal transcription factors
Gene Expression, organism-specific biosystem (from REACTOME)
Gene Expression, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Herpes simplex infection, organism-specific biosystem (from KEGG)
Herpes simplex infection, organism-specific biosystemHerpes simplex virus (HSV) infections are very common worldwide, with the prevalence of HSV-1 reaching up to 80%-90%. Primary infection with HSV takes place in the mucosa, followed by the establishme...
Herpes simplex infection, conserved biosystem (from KEGG)
Herpes simplex infection, conserved biosystemHerpes simplex virus (HSV) infections are very common worldwide, with the prevalence of HSV-1 reaching up to 80%-90%. Primary infection with HSV takes place in the mucosa, followed by the establishme...
Huntington's disease, organism-specific biosystem (from KEGG)
Huntington's disease, organism-specific biosystemHuntington disease (HD) is an autosomal-dominant neurodegenerative disorder that primarily affects medium spiny striatal neurons (MSN). The symptoms are choreiform, involuntary movements, personality...
Huntington's disease, conserved biosystem (from KEGG)
Huntington's disease, conserved biosystemHuntington disease (HD) is an autosomal-dominant neurodegenerative disorder that primarily affects medium spiny striatal neurons (MSN). The symptoms are choreiform, involuntary movements, personality...
RNA Polymerase II Pre-transcription Events, organism-specific biosystem (from REACTOME)
RNA Polymerase II Pre-transcription Events, organism-specific biosystemcomputationally inferred pathway (not manually curated)
RNA Polymerase II Promoter Escape, organism-specific biosystem (from REACTOME)
RNA Polymerase II Promoter Escape, organism-specific biosystemcomputationally inferred pathway (not manually curated)
RNA Polymerase II Transcription, organism-specific biosystem (from REACTOME)
RNA Polymerase II Transcription, organism-specific biosystemcomputationally inferred pathway (not manually curated)
RNA Polymerase II Transcription Initiation, organism-specific biosystem (from REACTOME)
RNA Polymerase II Transcription Initiation, organism-specific biosystemcomputationally inferred pathway (not manually curated)
RNA Polymerase II Transcription Initiation And Promoter Clearance, organism-specific biosystem (from REACTOME)
RNA Polymerase II Transcription Initiation And Promoter Clearance, organism-specific biosystemcomputationally inferred pathway (not manually curated)
RNA Polymerase II Transcription Pre-Initiation And Promoter Opening, organism-specific biosystem (from REACTOME)
RNA Polymerase II Transcription Pre-Initiation And Promoter Opening, organism-specific biosystemcomputationally inferred pathway (not manually curated)

General gene information

Go to the top of the page Help

Markers

AI450312 (e-PCR)
- UniSTS:165235

UniSTS:234624 (e-PCR)
- UniSTS:234624

Homology

Homologs of the Taf4a gene: The Taf4a gene is conserved in human, chimpanzee, dog, cow, chicken, and zebrafish.
Map Viewer (Human)
OrthoDB: The Hierarchical Catalog of Eukaryotic Orthologs

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
DNA binding	IDA Inferred from Direct Assay more info	PubMed
DNA binding	ISO Inferred from Sequence Orthology more info
protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
DNA-dependent transcription, initiation	ISO Inferred from Sequence Orthology more info
ovarian follicle development	IMP Inferred from Mutant Phenotype more info	PubMed
positive regulation of transcription, DNA-dependent	ISO Inferred from Sequence Orthology more info
regulation of transcription from RNA polymerase II promoter	IDA Inferred from Direct Assay more info	PubMed
regulation of transcription from RNA polymerase II promoter	TAS Traceable Author Statement more info	PubMed
transcription from RNA polymerase II promoter	TAS Traceable Author Statement more info	PubMed
transcription initiation from RNA polymerase II promoter	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
MLL1 complex	ISO Inferred from Sequence Orthology more info
cytoplasm	ISO Inferred from Sequence Orthology more info
nucleus	IDA Inferred from Direct Assay more info	PubMed
nucleus	ISO Inferred from Sequence Orthology more info
transcription factor TFIID complex	ISO Inferred from Sequence Orthology more info	PubMed
transcription factor TFTC complex	ISO Inferred from Sequence Orthology more info

General protein information

Go to the top of the page Help

Preferred Names: transcription initiation factor TFIID subunit 4

Names: transcription initiation factor TFIID subunit 4; TATA box binding protein (TBP)-associated factor, RNA polymerase II, C1, 130kd

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001081092.1 → NP_001074561.1 transcription initiation factor TFIID subunit 4

Status: PROVISIONAL

Source sequence(s)

AL663067

Consensus CDS

CCDS38373.1

UniProtKB/TrEMBL

E9QAP7

Related

ENSMUSP00000038610, ENSMUST00000041618

Conserved Domains (2) summary

cd08045
Location:786 – 1038
Blast Score: 649

TAF4; TATA Binding Protein (TBP) Associated Factor 4 (TAF4) is one of several TAFs that bind TBP and is involved in forming Transcription Factor IID (TFIID) complex

pfam07531
Location:548 – 633
Blast Score: 328

TAFH; NHR1 homology to TAF

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 103

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p1 C57BL/6J

Genomic

NC_000068.7 Reference GRCm38.p1 C57BL/6J

Range

179912146..179976646, complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Alternate Mm_Celera

Genomic

AC_000024.1 Alternate Mm_Celera

Range

183996374..184059855, complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Nucleotide		Protein	Strain
Heading	Accession and Version	Protein	Strain
genomic	AAHY01013389.1 (4700..8316)	None
genomic	AAHY01013390.1	None
genomic	AAHY01013391.1	None
genomic	AAHY01013392.1	None
genomic	AL663067.14 (33019..97520)	None
mRNA	AK136225.1	None	C57BL/6J
mRNA	AK136234.1	BAE22888.1	C57BL/6J
mRNA	AY038601.1	AAK94779.1	BALB/c
mRNA	BC026493.1	None
other-genetic	BC169204.1	None