Format

Send to:

Choose Destination

MORC2 MORC family CW-type zinc finger 2 [ Homo sapiens (human) ]

Gene ID: 22880, updated on 29-May-2016
Official Symbol
MORC2provided by HGNC
Official Full Name
MORC family CW-type zinc finger 2provided by HGNC
Primary source
HGNC:HGNC:23573
See related
Ensembl:ENSG00000133422 HPRD:11699; MIM:616661; Vega:OTTHUMG00000151193
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ZCW3; CMT2Z; ZCWCC1
Summary
This gene encodes a member of the Microrchidia (MORC) protein superfamily. The encoded protein is known to regulate the condensation of heterochromatin in response to DNA damage and play a role in repressing transcription. The protein has been found to regulate the activity of ATP citrate lyase via specific interaction with this enzyme in the cytosol of lipogenic breast cancer cells. The protein also plays a role in lipogenesis and adipocyte differentiation. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Feb 2016]
Orthologs
Location:
22q12.2
Exon count:
27
Annotation release Status Assembly Chr Location
107 current GRCh38.p2 (GCF_000001405.28) 22 NC_000022.11 (30925138..30968497, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 22 NC_000022.10 (31322598..31364483, complement)

Chromosome 22 - NC_000022.11Genomic Context describing neighboring genes Neighboring gene oxysterol binding protein 2 Neighboring gene uncharacterized LOC105372994 Neighboring gene uncharacterized LOC105372993 Neighboring gene uncharacterized LOC105372992 Neighboring gene eukaryotic translation initiation factor 4H pseudogene 2 Neighboring gene MORC2 antisense RNA 1 Neighboring gene taurine up-regulated 1 (non-protein coding) Neighboring gene smoothelin

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
zinc ion binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
fatty acid metabolic process IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
cytoplasm IDA
Inferred from Direct Assay
more info
 
cytosol IEA
Inferred from Electronic Annotation
more info
 
nucleus IDA
Inferred from Direct Assay
more info
 
Preferred Names
MORC family CW-type zinc finger protein 2
Names
zinc finger CW-type coiled-coil domain protein 1

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_046752.1 RefSeqGene

    Range
    5211..48368
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001303256.2NP_001290185.1  MORC family CW-type zinc finger protein 2 isoform 1

    See identical proteins and their annotated locations for NP_001290185.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AC004542, BC019257, BM683680, CD653611, DR000665
    Consensus CDS
    CCDS77668.1
    UniProtKB/Swiss-Prot
    Q9Y6X9
    Related
    ENSP00000380763, OTTHUMP00000199346, ENST00000397641, OTTHUMT00000321710
    Conserved Domains (3) summary
    cd00075
    Location:32106
    HATPase_c; Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins
    pfam03938
    Location:9471030
    OmpH; Outer membrane protein (OmpH-like)
    pfam07496
    Location:494541
    zf-CW; CW-type Zinc Finger
  2. NM_001303257.2NP_001290186.1  MORC family CW-type zinc finger protein 2 isoform 2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) uses an alternate, in-frame splice junction in the 3' coding region, compared to variant 1. This difference results in a shorter isoform (2) compared to variant 1.
    Source sequence(s)
    AC004542, BC019257, BM683680, BU733868, CD653611, DR000665
    UniProtKB/Swiss-Prot
    Q9Y6X9
    Conserved Domains (2) summary
    cd00075
    Location:32106
    HATPase_c; Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins
    pfam07496
    Location:494541
    zf-CW; CW-type Zinc Finger
  3. NM_014941.3NP_055756.1  MORC family CW-type zinc finger protein 2 isoform 3

    See identical proteins and their annotated locations for NP_055756.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) has an additional exon which results in the use of an in-frame downstream start codon, compared to variant 1. This difference results in an isoform (3) with a shorter N-terminus, compared to isoform 1.
    Source sequence(s)
    AB020659, AC004542, BC019257, BM683680, CD653611
    Consensus CDS
    CCDS33636.1
    UniProtKB/Swiss-Prot
    Q9Y6X9
    Related
    ENSP00000215862, OTTHUMP00000199347, ENST00000215862, OTTHUMT00000321711
    Conserved Domains (3) summary
    pfam03938
    Location:885968
    OmpH; Outer membrane protein (OmpH-like)
    pfam07496
    Location:432479
    zf-CW; CW-type Zinc Finger
    pfam13589
    Location:2107
    HATPase_c_3; Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 107 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p2 Primary Assembly

Genomic

  1. NC_000022.11 Reference GRCh38.p2 Primary Assembly

    Range
    30925138..30968497 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011530005.1XP_011528307.1  

    Conserved Domains (2) summary
    cd00075
    Location:32114
    HATPase_c; Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins
    pfam07496
    Location:502549
    zf-CW; CW-type Zinc Finger
  2. XM_011530004.1XP_011528306.1  

    Conserved Domains (3) summary
    cd00075
    Location:32111
    HATPase_c; Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins
    pfam03938
    Location:9521035
    OmpH; Outer membrane protein (OmpH-like)
    pfam07496
    Location:499546
    zf-CW; CW-type Zinc Finger
  3. XM_011530003.1XP_011528305.1  

    Conserved Domains (3) summary
    cd00075
    Location:32114
    HATPase_c; Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins
    pfam03938
    Location:9551038
    OmpH; Outer membrane protein (OmpH-like)
    pfam07496
    Location:502549
    zf-CW; CW-type Zinc Finger
  4. XM_011530006.1XP_011528308.1  

    Conserved Domains (3) summary
    pfam03938
    Location:902985
    OmpH; Outer membrane protein (OmpH-like)
    pfam07496
    Location:449496
    zf-CW; CW-type Zinc Finger
    pfam13589
    Location:11124
    HATPase_c_3; Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase

Alternate CHM1_1.1

Genomic

  1. NC_018933.2 Alternate CHM1_1.1

    Range
    31282431..31324307 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)