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FKBP3 FK506 binding protein 3 [ Homo sapiens (human) ]

Gene ID: 2287, updated on 12-May-2016
Official Symbol
FKBP3provided by HGNC
Official Full Name
FK506 binding protein 3provided by HGNC
Primary source
HGNC:HGNC:3719
See related
Ensembl:ENSG00000100442 HPRD:01743; MIM:186947
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
FKBP-3; FKBP25; PPIase; FKBP-25
Summary
The protein encoded by this gene is a member of the immunophilin protein family, which play a role in immunoregulation and basic cellular processes involving protein folding and trafficking. This encoded protein is a cis-trans prolyl isomerase that binds the immunosuppressants FK506 and rapamycin, as well as histone deacetylases, the transcription factor YY1, casein kinase II, and nucleolin. It has a higher affinity for rapamycin than for FK506 and thus may be an important target molecule for immunosuppression by rapamycin. [provided by RefSeq, Sep 2008]
Orthologs
Location:
14q21.2
Exon count:
8
Annotation release Status Assembly Chr Location
107 current GRCh38.p2 (GCF_000001405.28) 14 NC_000014.9 (45115599..45134529, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 14 NC_000014.8 (45584802..45603732, complement)

Chromosome 14 - NC_000014.9Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105370474 Neighboring gene pre-mRNA processing factor 39 Neighboring gene small nucleolar RNA, C/D box 127 Neighboring gene Fanconi anemia complementation group M Neighboring gene MIS18 binding protein 1

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
FK506 binding TAS
Traceable Author Statement
more info
PubMed 
peptidyl-prolyl cis-trans isomerase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
poly(A) RNA binding IDA
Inferred from Direct Assay
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
receptor activity TAS
Traceable Author Statement
more info
PubMed 
Process Evidence Code Pubs
chaperone-mediated protein folding IBA
Inferred from Biological aspect of Ancestor
more info
 
protein peptidyl-prolyl isomerization IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
endoplasmic reticulum membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
nucleus IEA
Inferred from Electronic Annotation
more info
 
Preferred Names
peptidyl-prolyl cis-trans isomerase FKBP3
Names
25 kDa FK506-binding protein
25 kDa FKBP
FK506 binding protein 3, 25kDa
FK506-binding protein 25, T-cell
FK506-binding protein 3 (25kD)
PPIase FKBP3
immunophilin FKBP25
rapamycin binding protein
rapamycin-selective 25 kDa immunophilin
rotamase
NP_002004.1

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_002013.3NP_002004.1  peptidyl-prolyl cis-trans isomerase FKBP3

    See identical proteins and their annotated locations for NP_002004.1

    Status: REVIEWED

    Source sequence(s)
    BC020809, BI598048, CN315192
    Consensus CDS
    CCDS9683.1
    UniProtKB/Swiss-Prot
    Q00688
    Related
    ENSP00000379374, ENST00000396062
    Conserved Domains (1) summary
    pfam00254
    Location:121221
    FKBP_C; FKBP-type peptidyl-prolyl cis-trans isomerase

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 107 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p2 Primary Assembly

Genomic

  1. NC_000014.9 Reference GRCh38.p2 Primary Assembly

    Range
    45115599..45134529 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011536565.1XP_011534867.1  

    Conserved Domains (1) summary
    pfam00254
    Location:88188
    FKBP_C; FKBP-type peptidyl-prolyl cis-trans isomerase

Alternate CHM1_1.1

Genomic

  1. NC_018925.2 Alternate CHM1_1.1

    Range
    45522949..45541880 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)