FKBP3 FK506 binding protein 3, 25kDa [Homo sapiens] - Gene

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Summary

Official Symbol: FKBP3provided by HGNC
Official Full Name: FK506 binding protein 3, 25kDaprovided by HGNC
Primary source: HGNC:3719
See related: Ensembl:ENSG00000100442; HPRD:01743; MIM:186947; Vega:OTTHUMG00000140267
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: FKBP-3; FKBP25; PPIase; FKBP-25
Summary: The protein encoded by this gene is a member of the immunophilin protein family, which play a role in immunoregulation and basic cellular processes involving protein folding and trafficking. This encoded protein is a cis-trans prolyl isomerase that binds the immunosuppressants FK506 and rapamycin, as well as histone deacetylases, the transcription factor YY1, casein kinase II, and nucleolin. It has a higher affinity for rapamycin than for FK506 and thus may be an important target molecule for immunosuppression by rapamycin. [provided by RefSeq, Sep 2008]

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Genomic context

Location :: 14q21.2

Sequence :: Chromosome: 14; NC_000014.8 (45584802..45603732, complement)

See FKBP3 in Epigenomics, MapViewer

Chromosome 14 - NC_000014.8 Genomic Context describing neighboring genes

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Genomic regions, transcripts, and products

Genomic Sequence

Go to nucleotideGraphics FASTA GenBank

Go to reference sequence details

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Bibliography

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Observational study of gene-disease association. (HuGE Navigator)
Title: Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.
Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
Title: Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study.
FKBP3, a novel regulator of the p53 pathway, induces the degradation of MDM2 and activation of p53.
Title: FKBP25, a novel regulator of the p53 pathway, induces the degradation of MDM2 and activation of p53.

Submit: New GeneRIF Correction

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Phenotypes

Review eQTL and phenotype association data in this region using PheGenI

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Products	Interactant	Other Gene	Source	Pubs	Description
Q00688	P68400	CSNK2A1	HPRD	PubMed
Q00688	P19784	CSNK2A2	HPRD	PubMed
Q00688	P67870	CSNK2B	HPRD	PubMed
Q00688	Q13547	HDAC1	HPRD	PubMed
Q00688	Q92769	HDAC2	HPRD	PubMed
Q00688	P25490	YY1	HPRD	PubMed
BioGRID:108577	BioGRID:107252	CALM1	BioGRID	PubMed	Reconstituted Complex
BioGRID:108577	BioGRID:109315	HDAC1	BioGRID	PubMed	Affinity Capture-Western
BioGRID:108577	BioGRID:109316	HDAC2	BioGRID	PubMed	Affinity Capture-Western
BioGRID:108577	BioGRID:110358	MDM2	BioGRID	PubMed	Affinity Capture-Western; Reconstituted Complex
BioGRID:108577	BioGRID:114652	MTA2	BioGRID	PubMed	Reconstituted Complex
BioGRID:108577	BioGRID:110811	NEDD4	BioGRID	PubMed	Reconstituted Complex
BioGRID:108577	BioGRID:116915	NEDD4L	BioGRID	PubMed	Biochemical Activity; Reconstituted Complex
BioGRID:108577	BioGRID:247522	Nedd4	BioGRID	PubMed	Biochemical Activity; Reconstituted Complex
BioGRID:108577	BioGRID:113010	TP53	BioGRID	PubMed	Affinity Capture-Western
BioGRID:108577	BioGRID:113164	UBC	BioGRID	PubMed	Affinity Capture-MS
BioGRID:108577	BioGRID:113360	YY1	BioGRID	PubMed	Affinity Capture-Western; Reconstituted Complex

Function	Evidence Code	Pubs
FK506 binding	IBA Inferred from Biological aspect of Ancestor more info
isomerase activity	IEA Inferred from Electronic Annotation more info
peptidyl-prolyl cis-trans isomerase activity	IBA Inferred from Biological aspect of Ancestor more info
receptor activity	TAS Traceable Author Statement more info	PubMed

Process	Evidence Code	Pubs
peptidyl-proline modification	IBA Inferred from Biological aspect of Ancestor more info
protein folding	IEA Inferred from Electronic Annotation more info
protein peptidyl-prolyl isomerization	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
membrane	IBA Inferred from Biological aspect of Ancestor more info
nucleus	IBA Inferred from Biological aspect of Ancestor more info

General protein information

Preferred Names: peptidyl-prolyl cis-trans isomerase FKBP3

Names: peptidyl-prolyl cis-trans isomerase FKBP3; rotamase; 25 kDa FKBP; PPIase FKBP3; immunophilin FKBP25; rapamycin binding protein; 25 kDa FK506-binding protein; FK506-binding protein 3 (25kD); FK506-binding protein 25, T-cell; rapamycin-selective 25 kDa immunophilin

NP_002004.1

EC 5.2.1.8

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NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_002013.3 → NP_002004.1 peptidyl-prolyl cis-trans isomerase FKBP3

Status: REVIEWED

Source sequence(s)

BC020809, BI598048, CN315192

Consensus CDS

CCDS9683.1

UniProtKB/Swiss-Prot

Q00688

Related

ENSP00000379374, ENST00000396062

Conserved Domains (1) summary

cl11587
Location:121 – 221
Blast Score: 310

FKBP_C; FKBP-type peptidyl-prolyl cis-trans isomerase

RefSeqs of Annotated Genomes: Build 37.3

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh37.p5 Primary Assembly

Genomic

NC_000014.8 Reference GRCh37.p5 Primary Assembly

Range

45584802..45603732, complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Alternate HuRef

Genomic

AC_000146.1 Alternate HuRef

Range

25695534..25714603, complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

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Related Sequences

Nucleotide		Protein
Heading	Accession and Version	Protein
genomic	AL121809.6 (125005..144418)	None
genomic	CH471078.2	EAW65785.1
genomic	Z58738.1	None
mRNA	AK222993.1	BAD96713.1
mRNA	AK311915.1	BAG34856.1
mRNA	BC016288.1	AAH16288.1
mRNA	BC020809.1	AAH20809.1
mRNA	BI598048.1	None
mRNA	BT006904.1	AAP35550.1
mRNA	CN315192.1	None
mRNA	M96256.1	AAA58471.1
other-genetic	DQ890734.2	ABM81660.1
other-genetic	DQ891132.2	ABM82058.1
other-genetic	DQ893906.2	ABM84832.1
other-genetic	DQ894311.2	ABM85237.1