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SLITRK3 SLIT and NTRK like family member 3 [ Homo sapiens (human) ]

Gene ID: 22865, updated on 26-May-2016
Official Symbol
SLITRK3provided by HGNC
Official Full Name
SLIT and NTRK like family member 3provided by HGNC
Primary source
HGNC:HGNC:23501
See related
Ensembl:ENSG00000121871 HPRD:18064; MIM:609679; Vega:OTTHUMG00000158072
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
This gene encodes a member of the Slitrk family of structurally related transmembrane proteins that are involved in controlling neurite outgrowth. The encoded protein contains two leucine-rich repeat (LRR) domains and a C-terminal domain that is partially similar to Trk neurotrophin receptor protein. Enhanced expression of this gene was found in tissue from several different types of tumors. Alternative splicing results in multiple transcript variants, all encoding the same protein. [provided by RefSeq, Jan 2016]
Orthologs
Location:
3q26.1
Exon count:
4
Annotation release Status Assembly Chr Location
107 current GRCh38.p2 (GCF_000001405.28) 3 NC_000003.12 (165186720..165196681, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (164902010..164914469, complement)

Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105374192 Neighboring gene sucrase-isomaltase Neighboring gene uncharacterized LOC101928405 Neighboring gene long intergenic non-protein coding RNA 1322 Neighboring gene butyrylcholinesterase

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Products Interactant Other Gene Complex Source Pubs Description

Homology

Clone Names

  • KIAA0848, MGC138681

Gene Ontology Provided by GOA

Process Evidence Code Pubs
axonogenesis IBA
Inferred from Biological aspect of Ancestor
more info
 
positive regulation of synapse assembly IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
Preferred Names
SLIT and NTRK-like protein 3
Names
SLIT and NTRK-like family, member 3
slit and trk like gene 3

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001318810.1NP_001305739.1  SLIT and NTRK-like protein 3 precursor

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript. Variants 1 - 3 encode the same protein.
    Source sequence(s)
    AB020655, AC013458, AK290024, BC040491
    UniProtKB/Swiss-Prot
    O94933
    Conserved Domains (5) summary
    smart00082
    Location:562597
    LRRCT; Leucine rich repeat C-terminal domain
    cd00116
    Location:81209
    LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
    pfam12799
    Location:456497
    LRR_4; Leucine Rich repeats (2 copies)
    pfam13855
    Location:432492
    LRR_8; Leucine rich repeat
    sd00033
    Location:81102
    LRR_RI; leucine-rich repeat [structural motif]
  2. NM_001318811.1NP_001305740.1  SLIT and NTRK-like protein 3 precursor

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1 - 3 encode the same protein.
    Source sequence(s)
    AB020655, AC013458, BC040491, DA233757
    UniProtKB/Swiss-Prot
    O94933
    Conserved Domains (5) summary
    smart00082
    Location:562597
    LRRCT; Leucine rich repeat C-terminal domain
    cd00116
    Location:81209
    LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
    pfam12799
    Location:456497
    LRR_4; Leucine Rich repeats (2 copies)
    pfam13855
    Location:432492
    LRR_8; Leucine rich repeat
    sd00033
    Location:81102
    LRR_RI; leucine-rich repeat [structural motif]
  3. NM_014926.3NP_055741.2  SLIT and NTRK-like protein 3 precursor

    See identical proteins and their annotated locations for NP_055741.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 - 3 encode the same protein.
    Source sequence(s)
    AB020655, AC013458, BC040491, DA123399
    Consensus CDS
    CCDS3197.1
    UniProtKB/Swiss-Prot
    O94933
    Related
    ENSP00000241274, OTTHUMP00000212596, ENST00000241274, OTTHUMT00000350125
    Conserved Domains (5) summary
    smart00082
    Location:562597
    LRRCT; Leucine rich repeat C-terminal domain
    cd00116
    Location:81209
    LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
    pfam12799
    Location:456497
    LRR_4; Leucine Rich repeats (2 copies)
    pfam13855
    Location:432492
    LRR_8; Leucine rich repeat
    sd00033
    Location:81102
    LRR_RI; leucine-rich repeat [structural motif]

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 107 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p2 Primary Assembly

Genomic

  1. NC_000003.12 Reference GRCh38.p2 Primary Assembly

    Range
    165186720..165196681 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005247230.2XP_005247287.1  

    Related
    ENSP00000420091, OTTHUMP00000212597, ENST00000475390, OTTHUMT00000350126
    Conserved Domains (5) summary
    smart00082
    Location:562597
    LRRCT; Leucine rich repeat C-terminal domain
    cd00116
    Location:81209
    LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
    pfam12799
    Location:456497
    LRR_4; Leucine Rich repeats (2 copies)
    pfam13855
    Location:432492
    LRR_8; Leucine rich repeat
    sd00033
    Location:81102
    LRR_RI; leucine-rich repeat [structural motif]
  2. XM_011512550.1XP_011510852.1  

    See identical proteins and their annotated locations for XP_011510852.1

    UniProtKB/Swiss-Prot
    O94933
    Conserved Domains (5) summary
    smart00082
    Location:562597
    LRRCT; Leucine rich repeat C-terminal domain
    cd00116
    Location:81209
    LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
    pfam12799
    Location:456497
    LRR_4; Leucine Rich repeats (2 copies)
    pfam13855
    Location:432492
    LRR_8; Leucine rich repeat
    sd00033
    Location:81102
    LRR_RI; leucine-rich repeat [structural motif]

Alternate CHM1_1.1

Genomic

  1. NC_018914.2 Alternate CHM1_1.1

    Range
    164867392..164877350 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)