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FNDC3A fibronectin type III domain containing 3A [ Homo sapiens (human) ]

Gene ID: 22862, updated on 8-May-2016
Official Symbol
FNDC3Aprovided by HGNC
Official Full Name
fibronectin type III domain containing 3Aprovided by HGNC
Primary source
HGNC:HGNC:20296
See related
Ensembl:ENSG00000102531 HPRD:13548; MIM:615794; Vega:OTTHUMG00000016911
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
HUGO; FNDC3; bA203I16.1; bA203I16.5
Orthologs
Location:
13q14.2
Exon count:
30
Annotation release Status Assembly Chr Location
107 current GRCh38.p2 (GCF_000001405.28) 13 NC_000013.11 (48975912..49209779)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 13 NC_000013.10 (49550048..49783915)

Chromosome 13 - NC_000013.11Genomic Context describing neighboring genes Neighboring gene cysteinyl leukotriene receptor 2 Neighboring gene proteasome activator subunit 2 pseudogene 2 Neighboring gene RAD17 checkpoint clamp loader component pseudogene 2 Neighboring gene RNA, Ro-associated Y3 pseudogene 2 Neighboring gene uncharacterized LOC105370203 Neighboring gene cytochrome c oxidase subunit 7C pseudogene 1 Neighboring gene 2-oxoglutarate and iron dependent oxygenase domain containing 1 pseudogene 1 Neighboring gene motilin receptor

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Clone Names

  • FLJ31509, KIAA0970

Gene Ontology Provided by GOA

Function Evidence Code Pubs
poly(A) RNA binding IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
Sertoli cell development IEA
Inferred from Electronic Annotation
more info
 
fertilization IEA
Inferred from Electronic Annotation
more info
 
single organismal cell-cell adhesion IEA
Inferred from Electronic Annotation
more info
 
spermatid development IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
Golgi apparatus IDA
Inferred from Direct Assay
more info
PubMed 
Golgi membrane IEA
Inferred from Electronic Annotation
more info
 
acrosomal vesicle IEA
Inferred from Electronic Annotation
more info
 
cytosol IEA
Inferred from Electronic Annotation
more info
 
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
membrane IDA
Inferred from Direct Assay
more info
PubMed 
vesicle membrane IEA
Inferred from Electronic Annotation
more info
 
Preferred Names
fibronectin type-III domain-containing protein 3A
Names
human gene expressed in odontoblasts

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001079673.1NP_001073141.1  fibronectin type-III domain-containing protein 3A isoform 1

    See identical proteins and their annotated locations for NP_001073141.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (1). Variants 1 and 3 encode the same isoform.
    Source sequence(s)
    AJ749706, AL137000, BM973827
    Consensus CDS
    CCDS41886.1
    UniProtKB/Swiss-Prot
    Q9Y2H6
    UniProtKB/TrEMBL
    A0A024RDT9
    Related
    ENSP00000417257, OTTHUMP00000214998, ENST00000492622, OTTHUMT00000354845
    Conserved Domains (1) summary
    cd00063
    Location:371462
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
  2. NM_001278438.1NP_001265367.1  fibronectin type-III domain-containing protein 3A isoform 1

    See identical proteins and their annotated locations for NP_001265367.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR exon, compared to variant 1. Variants 1 and 3 encode the same isoform (1).
    Source sequence(s)
    BC060816, BC132812, BM973827, DB460317
    Consensus CDS
    CCDS41886.1
    UniProtKB/Swiss-Prot
    Q9Y2H6
    UniProtKB/TrEMBL
    A0A024RDT9
    Related
    ENSP00000441831, ENST00000541916
    Conserved Domains (1) summary
    cd00063
    Location:371462
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
  3. NM_014923.4NP_055738.3  fibronectin type-III domain-containing protein 3A isoform 2

    See identical proteins and their annotated locations for NP_055738.3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at an alternate start codon, compared to variant 1. The encoded isoform (2) has a distinct N-terminus and is shorter than isoform 1.
    Source sequence(s)
    AJ749707, AK302415, BC051029, BM973827
    Consensus CDS
    CCDS9413.2
    UniProtKB/Swiss-Prot
    Q9Y2H6
    UniProtKB/TrEMBL
    A0A024RDV5
    Related
    ENSP00000381362, OTTHUMP00000018404, ENST00000398316, OTTHUMT00000044900
    Conserved Domains (1) summary
    cd00063
    Location:315406
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

RNA

  1. NR_103528.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) has an alternate 5' exon and an alternate splice site in the 3' region, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most supported translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    BC051029, BM973827, DB460317
    Related
    ENST00000484074, OTTHUMT00000354846

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 107 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p2 Primary Assembly

Genomic

  1. NC_000013.11 Reference GRCh38.p2 Primary Assembly

    Range
    48975912..49209779
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006719777.2XP_006719840.1  

    Conserved Domains (1) summary
    cd00063
    Location:560636
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
  2. XM_011534998.1XP_011533300.1  

    Conserved Domains (1) summary
    cd00063
    Location:371462
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
  3. XM_011534997.1XP_011533299.1  

    See identical proteins and their annotated locations for XP_011533299.1

    UniProtKB/Swiss-Prot
    Q9Y2H6
    Conserved Domains (1) summary
    cd00063
    Location:307398
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

Alternate CHM1_1.1

Genomic

  1. NC_018924.2 Alternate CHM1_1.1

    Range
    49517625..49751465
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)