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ADGRL1 adhesion G protein-coupled receptor L1 [ Homo sapiens (human) ]

Gene ID: 22859, updated on 26-May-2016
Official Symbol
ADGRL1provided by HGNC
Official Full Name
adhesion G protein-coupled receptor L1provided by HGNC
Primary source
HGNC:HGNC:20973
See related
Ensembl:ENSG00000072071 HPRD:14305; MIM:616416; Vega:OTTHUMG00000182138
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CL1; LEC2; CIRL1; LPHN1
Summary
This gene encodes a member of the latrophilin subfamily of G-protein coupled receptors (GPCR). Latrophilins may function in both cell adhesion and signal transduction. In experiments with non-human species, endogenous proteolytic cleavage within a cysteine-rich GPS (G-protein-coupled-receptor proteolysis site) domain resulted in two subunits (a large extracellular N-terminal cell adhesion subunit and a subunit with substantial similarity to the secretin/calcitonin family of GPCRs) being non-covalently bound at the cell membrane. Latrophilin-1 has been shown to recruit the neurotoxin from black widow spider venom, alpha-latrotoxin, to the synapse plasma membrane. Alternative splicing results in multiple variants encoding distinct isoforms.[provided by RefSeq, Oct 2008]
Orthologs
Location:
19p13.2
Exon count:
27
Annotation release Status Assembly Chr Location
107 current GRCh38.p2 (GCF_000001405.28) 19 NC_000019.10 (14147737..14206248, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (14258549..14316997, complement)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene protein kinase cAMP-activated catalytic subunit alpha Neighboring gene uncharacterized LOC105372286 Neighboring gene uncharacterized LOC100507373 Neighboring gene anti-silencing function 1B histone chaperone Neighboring gene uncharacterized LOC105372287 Neighboring gene uncharacterized LOC105372288

  • GPCRs, Class B Secretin-like, organism-specific biosystem (from WikiPathways)
    GPCRs, Class B Secretin-like, organism-specific biosystemThis pathway was created using the GPCRDB (Horn et al., 1998), http://www.cmbi.kun.nl/7tm/. The groupings are based on the GPCR phylogenetic tree available from the GPCRDB and the training sets used ...
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
G-protein coupled receptor activity IEA
Inferred from Electronic Annotation
more info
 
carbohydrate binding IEA
Inferred from Electronic Annotation
more info
 
cell adhesion molecule binding ISS
Inferred from Sequence or Structural Similarity
more info
 
latrotoxin receptor activity ISS
Inferred from Sequence or Structural Similarity
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
G-protein coupled receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
calcium-mediated signaling using intracellular calcium source ISS
Inferred from Sequence or Structural Similarity
more info
 
cell surface receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of synapse assembly IEA
Inferred from Electronic Annotation
more info
 
positive regulation of synapse maturation ISS
Inferred from Sequence or Structural Similarity
more info
 
synaptic vesicle exocytosis IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
axon ISS
Inferred from Sequence or Structural Similarity
more info
 
cell junction IEA
Inferred from Electronic Annotation
more info
 
cytosol IEA
Inferred from Electronic Annotation
more info
 
growth cone ISS
Inferred from Sequence or Structural Similarity
more info
 
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
neuron projection ISS
Inferred from Sequence or Structural Similarity
more info
 
plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
 
presynaptic membrane ISS
Inferred from Sequence or Structural Similarity
more info
 
synapse ISS
Inferred from Sequence or Structural Similarity
more info
 
Preferred Names
adhesion G protein-coupled receptor L1
Names
CIRL-1
calcium-independent alpha-latrotoxin receptor 1
latrophilin 1
latrophilin-1
lectomedin-2

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001008701.2NP_001008701.1  adhesion G protein-coupled receptor L1 isoform 1 precursor

    See identical proteins and their annotated locations for NP_001008701.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AB020628, AF307079, BC002974, BC072445
    Consensus CDS
    CCDS32928.1
    UniProtKB/Swiss-Prot
    O94910
    Related
    ENSP00000340688, OTTHUMP00000268519, ENST00000340736, OTTHUMT00000459696
    Conserved Domains (7) summary
    smart00303
    Location:798850
    GPS; G-protein-coupled receptor proteolytic site domain
    smart00008
    Location:476539
    HormR; Domain present in hormone receptors
    pfam00002
    Location:8581093
    7tm_2; 7 transmembrane receptor (Secretin family)
    pfam02140
    Location:48128
    Gal_Lectin; Galactose binding lectin domain
    pfam02191
    Location:143398
    OLF; Olfactomedin-like domain
    pfam02354
    Location:11131474
    Latrophilin; Latrophilin Cytoplasmic C-terminal region
    pfam12003
    Location:541775
    DUF3497; Domain of unknown function (DUF3497)
  2. NM_014921.4NP_055736.2  adhesion G protein-coupled receptor L1 isoform 2 precursor

    See identical proteins and their annotated locations for NP_055736.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon, compared to variant 1, resulting in a shorter protein (isoform 2) compared to isoform 1.
    Source sequence(s)
    AB020628, AF307079, BC002974, BC072445
    Consensus CDS
    CCDS12307.1
    UniProtKB/Swiss-Prot
    O94910
    Related
    ENSP00000355328, OTTHUMP00000268520, ENST00000361434, OTTHUMT00000459697
    Conserved Domains (7) summary
    smart00303
    Location:793845
    GPS; G-protein-coupled receptor proteolytic site domain
    smart00008
    Location:471534
    HormR; Domain present in hormone receptors
    pfam00002
    Location:8531088
    7tm_2; 7 transmembrane receptor (Secretin family)
    pfam02140
    Location:48128
    Gal_Lectin; Galactose binding lectin domain
    pfam02191
    Location:138393
    OLF; Olfactomedin-like domain
    pfam02354
    Location:11081469
    Latrophilin; Latrophilin Cytoplasmic C-terminal region
    pfam12003
    Location:536770
    DUF3497; Domain of unknown function (DUF3497)

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 107 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p2 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p2 Primary Assembly

    Range
    14147737..14206248 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005259818.2XP_005259875.1  

    See identical proteins and their annotated locations for XP_005259875.1

    Conserved Domains (7) summary
    smart00303
    Location:793845
    GPS; G-protein-coupled receptor proteolytic site domain
    smart00008
    Location:471534
    HormR; Domain present in hormone receptors
    pfam00002
    Location:8531088
    7tm_2; 7 transmembrane receptor (Secretin family)
    pfam02140
    Location:48128
    Gal_Lectin; Galactose binding lectin domain
    pfam02191
    Location:138393
    OLF; Olfactomedin-like domain
    pfam02354
    Location:11081493
    Latrophilin; Latrophilin Cytoplasmic C-terminal region
    pfam12003
    Location:536770
    DUF3497; Domain of unknown function (DUF3497)
  2. XM_011527798.1XP_011526100.1  

    See identical proteins and their annotated locations for XP_011526100.1

    Conserved Domains (7) summary
    smart00303
    Location:800852
    GPS; G-protein-coupled receptor proteolytic site domain
    smart00008
    Location:478541
    HormR; Domain present in hormone receptors
    pfam00002
    Location:8601095
    7tm_2; 7 transmembrane receptor (Secretin family)
    pfam02140
    Location:48128
    Gal_Lectin; Galactose binding lectin domain
    pfam02191
    Location:138393
    OLF; Olfactomedin-like domain
    pfam02354
    Location:11151500
    Latrophilin; Latrophilin Cytoplasmic C-terminal region
    pfam12003
    Location:543777
    DUF3497; Domain of unknown function (DUF3497)
  3. XM_005259819.2XP_005259876.1  

    See identical proteins and their annotated locations for XP_005259876.1

    Conserved Domains (7) summary
    smart00303
    Location:798850
    GPS; G-protein-coupled receptor proteolytic site domain
    smart00008
    Location:476539
    HormR; Domain present in hormone receptors
    pfam00002
    Location:8581093
    7tm_2; 7 transmembrane receptor (Secretin family)
    pfam02140
    Location:48128
    Gal_Lectin; Galactose binding lectin domain
    pfam02191
    Location:143398
    OLF; Olfactomedin-like domain
    pfam02354
    Location:11131498
    Latrophilin; Latrophilin Cytoplasmic C-terminal region
    pfam12003
    Location:541775
    DUF3497; Domain of unknown function (DUF3497)
  4. XM_011527800.1XP_011526102.1  

    Conserved Domains (7) summary
    smart00303
    Location:805857
    GPS; G-protein-coupled receptor proteolytic site domain
    smart00008
    Location:483546
    HormR; Domain present in hormone receptors
    pfam00002
    Location:8651100
    7tm_2; 7 transmembrane receptor (Secretin family)
    pfam02140
    Location:48128
    Gal_Lectin; Galactose binding lectin domain
    pfam02191
    Location:143398
    OLF; Olfactomedin-like domain
    pfam02354
    Location:11201475
    Latrophilin; Latrophilin Cytoplasmic C-terminal region
    pfam12003
    Location:548782
    DUF3497; Domain of unknown function (DUF3497)
  5. XM_011527799.1XP_011526101.1  

    See identical proteins and their annotated locations for XP_011526101.1

    Conserved Domains (7) summary
    smart00303
    Location:805857
    GPS; G-protein-coupled receptor proteolytic site domain
    smart00008
    Location:483546
    HormR; Domain present in hormone receptors
    pfam00002
    Location:8651100
    7tm_2; 7 transmembrane receptor (Secretin family)
    pfam02140
    Location:48128
    Gal_Lectin; Galactose binding lectin domain
    pfam02191
    Location:143398
    OLF; Olfactomedin-like domain
    pfam02354
    Location:11201481
    Latrophilin; Latrophilin Cytoplasmic C-terminal region
    pfam12003
    Location:548782
    DUF3497; Domain of unknown function (DUF3497)
  6. XM_011527796.1XP_011526098.1  

    See identical proteins and their annotated locations for XP_011526098.1

    Conserved Domains (7) summary
    smart00303
    Location:805857
    GPS; G-protein-coupled receptor proteolytic site domain
    smart00008
    Location:483546
    HormR; Domain present in hormone receptors
    pfam00002
    Location:8651100
    7tm_2; 7 transmembrane receptor (Secretin family)
    pfam02140
    Location:48128
    Gal_Lectin; Galactose binding lectin domain
    pfam02191
    Location:143398
    OLF; Olfactomedin-like domain
    pfam02354
    Location:11201505
    Latrophilin; Latrophilin Cytoplasmic C-terminal region
    pfam12003
    Location:548782
    DUF3497; Domain of unknown function (DUF3497)
  7. XM_011527797.1XP_011526099.1  

    See identical proteins and their annotated locations for XP_011526099.1

    Conserved Domains (7) summary
    smart00303
    Location:805857
    GPS; G-protein-coupled receptor proteolytic site domain
    smart00008
    Location:483546
    HormR; Domain present in hormone receptors
    pfam00002
    Location:8651100
    7tm_2; 7 transmembrane receptor (Secretin family)
    pfam02140
    Location:48128
    Gal_Lectin; Galactose binding lectin domain
    pfam02191
    Location:143398
    OLF; Olfactomedin-like domain
    pfam02354
    Location:11201505
    Latrophilin; Latrophilin Cytoplasmic C-terminal region
    pfam12003
    Location:548782
    DUF3497; Domain of unknown function (DUF3497)
  8. XM_011527801.1XP_011526103.1  

    Conserved Domains (6) summary
    smart00303
    Location:725777
    GPS; G-protein-coupled receptor proteolytic site domain
    smart00008
    Location:403466
    HormR; Domain present in hormone receptors
    pfam00002
    Location:7851020
    7tm_2; 7 transmembrane receptor (Secretin family)
    pfam02191
    Location:63318
    OLF; Olfactomedin-like domain
    pfam02354
    Location:10401425
    Latrophilin; Latrophilin Cytoplasmic C-terminal region
    pfam12003
    Location:468702
    DUF3497; Domain of unknown function (DUF3497)
  9. XM_011527802.1XP_011526104.1  

    Conserved Domains (5) summary
    smart00303
    Location:805857
    GPS; G-protein-coupled receptor proteolytic site domain
    smart00008
    Location:483546
    HormR; Domain present in hormone receptors
    pfam02140
    Location:48128
    Gal_Lectin; Galactose binding lectin domain
    pfam02191
    Location:143398
    OLF; Olfactomedin-like domain
    pfam12003
    Location:548782
    DUF3497; Domain of unknown function (DUF3497)

Alternate CHM1_1.1

Genomic

  1. NC_018930.2 Alternate CHM1_1.1

    Range
    14258980..14317433 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)