NID2 nidogen 2 (osteonidogen) [Homo sapiens] - Gene

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Summary

Official Symbol: NID2provided by HGNC
Official Full Name: nidogen 2 (osteonidogen)provided by HGNC
Primary source: HGNC:13389
See related: Ensembl:ENSG00000087303; HPRD:05654; MIM:605399; Vega:OTTHUMG00000140298
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: NID-2
Summary: This gene encodes a member of the nidogen family of basement membrane proteins. This protein is a cell-adhesion protein that binds collagens I and IV and laminin and may be involved in maintaining the structure of the basement membrane.[provided by RefSeq, Jun 2010]

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Genomic context

Location :: 14q22.1

Sequence :: Chromosome: 14; NC_000014.8 (52471520..52535946, complement)

See NID2 in Epigenomics, MapViewer

Chromosome 14 - NC_000014.8 Genomic Context describing neighboring genes

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Genomic regions, transcripts, and products

Genomic Sequence

Go to nucleotideGraphics FASTA GenBank

Go to reference sequence details

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Bibliography

GeneRIFs: Gene References Into Functions What's a GeneRIF?

NID2 promoter hypermethylation is associated with oral cavity squamous cell carcinoma.
Title: NID2 and HOXA9 promoter hypermethylation as biomarkers for prevention and early detection in oral cavity squamous cell carcinoma tissues and saliva.
Nidogen-2 is a new biomarker for ovarian cancer which correlates closely with CA125.
Title: Nidogen-2: a new serum biomarker for ovarian cancer.
nidogen-2 is equivalent to nidogen-1 in skin-organotypic coculture, and both can promote the development of a functional basement membrane zone
Title: Lack of nidogen-1 and -2 prevents basement membrane assembly in skin-organotypic coculture.
short arm region of laminin-5 gamma2 chain: structure, mechanism of processing and binding to heparin, nidogen-1, fibulin-1 and fibulin-2
Title: Short arm region of laminin-5 gamma2 chain: structure, mechanism of processing and binding to heparin and proteins.
found to be ubiquitous component of basement membrane zones underneath developing epithelia of most of the major organ systems; may participate in cell biological functions during human development
Title: Nidogen-1 and nidogen-2 are found in basement membranes during human embryonic development.
Nidogen-2 compensation hypothesis to explain limited phenotype observed following elimination of nidogen-1 gene.
Title: Evidence of nidogen-2 compensation for nidogen-1 deficiency in transgenic mice.
CpG islands of both NID1 and NID2 genes are aberrantly methylated in human cancer samples and cancer cell lines.
Title: Nidogen 1 and 2 gene promoters are aberrantly methylated in human gastrointestinal cancer.

Submit: New GeneRIF Correction

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Phenotypes

Review eQTL and phenotype association data in this region using PheGenI

Framingham Heart Study genome-wide association: results for pulmonary function measures.

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Products	Interactant	Other Gene	Source	Pubs	Description
NP_031387.2	NP_000492.1	ELN	BIND	PubMed	Tropoelastin interacts with Nidogen-2.
Q14112	Collagen, type XIII, alpha 1	COL13A1	HPRD	PubMed
Q14112	P15502	ELN	HPRD	PubMed
Q14112	P98160	HSPG2	HPRD	PubMed
Q14112	P11047	LAMC1	HPRD	PubMed
Q14112	P12757	SKIL	HPRD	PubMed
BioGRID:116476	BioGRID:107674	COL1A1	BioGRID	PubMed	Reconstituted Complex
BioGRID:116476	BioGRID:107679	COL4A1	BioGRID	PubMed	Reconstituted Complex
BioGRID:116476	BioGRID:108321	ELN	BioGRID	PubMed	Reconstituted Complex
BioGRID:116476	BioGRID:109571	HSPG2	BioGRID	PubMed	Reconstituted Complex
BioGRID:116476	BioGRID:110109	LAMC1	BioGRID	PubMed	Reconstituted Complex
BioGRID:116476	BioGRID:110357	MDK	BioGRID	PubMed	Affinity Capture-MS
BioGRID:116476	BioGRID:111540	PRELP	BioGRID	PubMed	Reconstituted Complex

Function	Evidence Code	Pubs
calcium ion binding	IEA Inferred from Electronic Annotation more info
collagen binding	TAS Traceable Author Statement more info	PubMed
protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
cell adhesion	IEA Inferred from Electronic Annotation more info
cell-matrix adhesion	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
basement membrane	IEA Inferred from Electronic Annotation more info
colocalizes_with extracellular matrix	IDA Inferred from Direct Assay more info
extracellular region	IEA Inferred from Electronic Annotation more info

General protein information

Preferred Names: nidogen-2

Names: nidogen-2; osteonidogen

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NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_007361.3 → NP_031387.3 nidogen-2 precursor

Status: REVIEWED

Source sequence(s)

AJ223500, AL118557, BM719690, CA413165

Consensus CDS

CCDS9706.1

UniProtKB/Swiss-Prot

Q14112

Related

ENSP00000216286, OTTHUMP00000178985, ENST00000216286, OTTHUMT00000276888

Conserved Domains (6) summary

cd00054
Location:892 – 925
Blast Score: 122

EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...

cd00191
Location:1019 – 1084
Blast Score: 204

TY; Thyroglobulin type I repeats.; The N-terminal region of human thyroglobulin contains 11 type-1 repeats TY repeats are proposed to be inhibitors of cysteine proteases

cd00255
Location:527 – 751
Blast Score: 738

nidG2; Nidogen, G2 domain; Nidogen is an important component of the basement membrane, an extracellular sheet-like matrix. Nidogen is a multifunctional protein that interacts with many other basement membrane proteins, like collagen, perlecan, lamin, and has a ...

cl02648
Location:108 – 273
Blast Score: 437

NIDO; Nidogen-like

cl09941
Location:852 – 890
Blast Score: 110

EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...

cl10508
Location:1221 – 1265
Blast Score: 157

Ldl_recept_b; Low-density lipoprotein receptor repeat class B

RefSeqs of Annotated Genomes: Build 37.3

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh37.p5 Primary Assembly

Genomic

NC_000014.8 Reference GRCh37.p5 Primary Assembly

Range

52471520..52535946, complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Alternate HuRef

Genomic

AC_000146.1 Alternate HuRef

Range

32632190..32696681, complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

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Related Sequences

Nucleotide		Protein
Heading	Accession and Version	Protein
genomic	AB009799.2	BAA24112.1
genomic	AL118557.5 (25780..76522)	None
genomic	AL358333.4 (2001..15684)	None
genomic	CH471078.2	EAW65658.1
mRNA	AJ223500.1	CAA11418.1
mRNA	AK291652.1	BAF84341.1
mRNA	AK298542.1	BAG60740.1
mRNA	AK300462.1	BAG62181.1
mRNA	AL701794.1	None
mRNA	AU119925.1	None
mRNA	BC035608.1	AAH35608.1
mRNA	BM719690.1	None
mRNA	BX648241.1	CAI56714.1
mRNA	CA413165.1	None
mRNA	D86425.1	BAA13087.1

Protein Accession	Links
Protein Accession	GenePept Link	UniProtKB Link
Q14112.3	GenPept	UniProtKB/Swiss-Prot:Q14112
Q5CZI2	GenPept	UniProtKB/TrEMBL:Q5CZI2
Q8IV28	GenPept	UniProtKB/TrEMBL:Q8IV28