FIGF c-fos induced growth factor (vascular endothelial growth factor D) [Homo sapiens] - Gene

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Summary

Official Symbol: FIGFprovided by HGNC
Official Full Name: c-fos induced growth factor (vascular endothelial growth factor D)provided by HGNC
Primary source: HGNC:3708
See related: Ensembl:ENSG00000165197; HPRD:02102; MIM:300091; Vega:OTTHUMG00000021175
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: VEGFD; VEGF-D
Summary: The protein encoded by this gene is a member of the platelet-derived growth factor/vascular endothelial growth factor (PDGF/VEGF) family and is active in angiogenesis, lymphangiogenesis, and endothelial cell growth. This secreted protein undergoes a complex proteolytic maturation, generating multiple processed forms which bind and activate VEGFR-2 and VEGFR-3 receptors. This protein is structurally and functionally similar to vascular endothelial growth factor C. Read-through transcription has been observed between this locus and the upstream PIR (GeneID 8544) locus. [provided by RefSeq, Feb 2011]

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Genomic context

Location :: Xp22.31

Sequence :: Chromosome: X; NC_000023.10 (15363713..15402535, complement)

See FIGF in Epigenomics, MapViewer

Chromosome X - NC_000023.10 Genomic Context describing neighboring genes

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Genomic regions, transcripts, and products

Genomic Sequence

Go to nucleotideGraphics FASTA GenBank

Go to reference sequence details

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Bibliography

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Vascular endothelial growth factor D was expressed in 4 of 7 primary and 7 of 7 metastatic lesions. In culture, vascular endothelial growth factor D significantly increased the migration of sarcoma cells through lymphatic endothelial monolayers.
Title: Vascular endothelial growth factor-D is a key molecule that enhances lymphatic metastasis of soft tissue sarcomas.
VEGF-D is involved and plays an important role in gallbladder cancer (GBC), progression, suggesting that VEGF-D may be a potential molecular target in the treatment of GBC.
Title: Vascular endothelial growth factor-D promotes growth, lymphangiogenesis and lymphatic metastasis in gallbladder cancer.
Processing of VEGF-D is required for tumor angiogenesis, lymphangiogenesis, and recruitment of tumor-associated macrophages.
Title: Proteolytic processing of vascular endothelial growth factor-D is essential for its capacity to promote the growth and spread of cancer.
Serum VEGF-D level that was correlated with the presence of cervical lymph node metastases in papillary thyroid carcinoma.
Title: Serum vascular endothelial growth factor-D levels correlate with cervical lymph node metastases in papillary thyroid carcinoma.
Production of VEGF-D increases and is related to lymphangiogenesis in patients with acute Kawasaki disease. Low VEGF-D production appears to be associated with the development of coronary artery lesions.
Title: Increased production of vascular endothelial growth factor-d and lymphangiogenesis in acute Kawasaki disease.
our results suggest that high levels of both VEGF-C and VEGF-D proteins are associated with lymph node metastasis
Title: Vascular endothelial growth factor C and D expression correlates with lymph node metastasis and poor prognosis in patients with resected esophageal cancer.
Expression of the ligand VEGF-D is significantly correlated with distant metastatic disease but not with patient survival in patients with gastric adenocarcinoma.
Title: VEGF-D correlates with metastatic disease in gastric cancer patients undergoing surgery.
Vascular endothelial growth factor-D stimulates endothelial cell VEGF-A, stanniocalcin-1, and neuropilin-2 and has potent angiogenic effects.
Title: Vascular endothelial growth factor (VEGF)-D stimulates VEGF-A, stanniocalcin-1, and neuropilin-2 and has potent angiogenic effects.
the 936_C>T polymorphism appears to modify disease risks in BRCA1 carriers.
Title: The VEGF_936_C>T 3'UTR polymorphism reduces BRCA1-associated breast cancer risk in Polish women.
The expression of VEGF-C and -D in papillary thyroid carcinoma was significantly higher than those in follicular thyroid carcinoma and adenoma tissues.
Title: [Expression and significance of VEGF-C and VEGF-D in differentiated thyroid carcinoma].

Submit: New GeneRIF Correction See all (67)

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Phenotypes

Review eQTL and phenotype association data in this region using PheGenI

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Products	Interactant	Other Gene	Source	Pubs	Description
O43915	O43915	FIGF	HPRD	PubMed
O43915	P35916	FLT4	HPRD	PubMed
O43915	Q13797	ITGA9	HPRD	PubMed
O43915	P35968	KDR	HPRD	PubMed
BioGRID:108567	BioGRID:109992	KDR	BioGRID	PubMed	Reconstituted Complex

Function	Evidence Code	Pubs
chemoattractant activity	IDA Inferred from Direct Assay more info	PubMed
growth factor activity	IEA Inferred from Electronic Annotation more info
platelet-derived growth factor receptor binding	TAS Traceable Author Statement more info	PubMed
protein homodimerization activity	IEA Inferred from Electronic Annotation more info
vascular endothelial growth factor receptor 3 binding	IEA Inferred from Electronic Annotation more info
vascular endothelial growth factor receptor binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
angiogenesis	IEA Inferred from Electronic Annotation more info
blood coagulation	TAS Traceable Author Statement more info
cell differentiation	IEA Inferred from Electronic Annotation more info
induction of positive chemotaxis	IDA Inferred from Direct Assay more info	PubMed
multicellular organismal development	IEA Inferred from Electronic Annotation more info
platelet activation	TAS Traceable Author Statement more info
platelet degranulation	TAS Traceable Author Statement more info
positive chemotaxis	IDA Inferred from Direct Assay more info	PubMed
positive regulation of cell division	IEA Inferred from Electronic Annotation more info
positive regulation of cell proliferation	IEA Inferred from Electronic Annotation more info
positive regulation of interleukin-6 production	IEA Inferred from Electronic Annotation more info
positive regulation of mast cell chemotaxis	IDA Inferred from Direct Assay more info	PubMed
regulation of vascular endothelial growth factor receptor signaling pathway	IEA Inferred from Electronic Annotation more info
response to hypoxia	IEA Inferred from Electronic Annotation more info
response to interleukin-1	IEA Inferred from Electronic Annotation more info
vascular endothelial growth factor receptor signaling pathway	TAS Traceable Author Statement more info

Component	Evidence Code	Pubs
extracellular region	TAS Traceable Author Statement more info
extracellular space	IEA Inferred from Electronic Annotation more info
membrane	IEA Inferred from Electronic Annotation more info
platelet alpha granule lumen	TAS Traceable Author Statement more info

General protein information

Preferred Names: vascular endothelial growth factor D

Names: vascular endothelial growth factor D

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NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

NG_012509.1 RefSeqGene

Range

5043..43865

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_004469.4 → NP_004460.1 vascular endothelial growth factor D preproprotein

Status: REVIEWED

Source sequence(s)

BC027948, DA587496, Y12863

Consensus CDS

CCDS14166.1

UniProtKB/Swiss-Prot

O43915

Related

ENSP00000297904, OTTHUMP00000022960, ENST00000297904, OTTHUMT00000055859

Conserved Domains (1) summary

cd00135
Location:109 – 194
Blast Score: 238

PDGF; Platelet-derived and vascular endothelial growth factors (PDGF, VEGF) family domain; PDGF is a potent activator for cells of mesenchymal origin; PDGF-A and PDGF-B form AA and BB homodimers and an AB heterodimer; VEGF is a potent mitogen in embryonic and ...

RefSeqs of Annotated Genomes: Build 37.3

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh37.p5 Primary Assembly

Genomic

NC_000023.10 Reference GRCh37.p5 Primary Assembly

Range

15363713..15402535, complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Alternate HuRef

Genomic

AC_000155.1 Alternate HuRef

Range

13122815..13159253, complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

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Related Sequences

Nucleotide		Protein
Heading	Accession and Version	Protein
genomic	AC095351.5 (31082..69941)	None
genomic	CH471074.1	EAW98885.1
genomic	CQ858318.1	CAH23420.1
genomic	CS023802.1	CAI59113.1
genomic	CS037005.1	CAI63839.1
genomic	CS067232.1	CAI84579.1
genomic	CS148545.1	CAJ29849.1
genomic	CS172369.1	CAJ32892.1
genomic	CS172815.1	CAJ32904.1
genomic	CS367410.1	CAL32762.1
genomic	FB510795.1	CAV32972.1
genomic	HC040689.1	CBH30537.1
genomic	U69570.1 (18723..19321)	None
genomic	Y12864.1	CAA73371.1
genomic	Y12865.1 (10..220)	None
genomic	Y12866.1 (10..200)	None
genomic	Y12867.1 (10..158)	None
genomic	Y12868.1 (10..110)	None
genomic	Y12869.1 (10..205)	None
genomic	Y12870.1	None
mRNA	AJ000185.1	CAA03942.1
mRNA	AK223160.1	BAD96880.1
mRNA	AK313173.1	BAG35990.1
mRNA	BC027948.1	AAH27948.1
mRNA	D89630.1	BAA24264.1
mRNA	DA587496.1	None
mRNA	Y12863.1	CAA73370.1