Lamc1 laminin, gamma 1 [Mus musculus (house mouse)] - Gene

Summary

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Official Symbol: Lamc1provided by MGI
Official Full Name: laminin, gamma 1provided by MGI
Primary source: MGI:99914
See related: Ensembl:ENSMUSG00000026478; Vega:OTTMUSG00000030992
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Lamb2

Genomic context

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Location :: 1 G3; 1 65.3 cM

Sequence :: Chromosome: 1; NC_000067.6 (153218922..153332786, complement)

See Lamc1 in Epigenomics, MapViewer

Chromosome 1 - NC_000067.6 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence

Go to nucleotideGraphics FASTA GenBank

Go to reference sequence details

Bibliography

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GeneRIFs: Gene References Into Functions What's a GeneRIF?

Laminins integrate scaffold-forming and cell-adhesion activities to assemble an endoneurial basement membrane.
Title: Schwann cell myelination requires integration of laminin activities.
STI1 and Ln-gamma1 promote robust axonogenesis in wild-type neurons, whereas no effect is observed in neurons from PrPC-null mice.
Title: Laminin-γ1 chain and stress inducible protein 1 synergistically mediate PrPC-dependent axonal growth via Ca2+ mobilization in dorsal root ganglia neurons.
requirement of gamma1 laminins for assembly of the renal collecting duct system basement membrane, in which immobilized ligands act as solid-phase agonists to promote branching morphogenesis, growth and water transport functions
Title: Renal collecting system growth and function depend upon embryonic γ1 laminin expression.
Data show that expression of either mGluR1 or mGluR5 in HEK293 cells reconstituted the signaling pathways mediated by PrP(C)-Ln gamma1 peptide interaction.
Title: Metabotropic glutamate receptors transduce signals for neurite outgrowth after binding of the prion protein to laminin γ1 chain.
Laminin beta(1) and gamma(1) N-terminal domains share the galactose-binding domain-like fold.
Title: Computational modeling of laminin N-terminal domains using sparse distance constraints from disulfide bonds and chemical cross-linking.
Basement membrane deposition of nidogen 1 but not nidogen 2 requires the nidogen binding module of the laminin gamma1 chain.
Title: Basement membrane deposition of nidogen 1 but not nidogen 2 requires the nidogen binding module of the laminin gamma1 chain.
laminin-111 (alpha(1), beta(1), gamma(1)), which is expressed during embryonic development but absent in normal or dystrophic skeletal muscle, increased alpha(7)-integrin expression in mouse and DMD patient myoblasts
Title: Laminin-111 protein therapy prevents muscle disease in the mdx mouse model for Duchenne muscular dystrophy.
The role of the laminin gamma1 chain for cardiac muscle differentiation and function using cardiomyocytes derived from embryonic stem cells deficient in the LAMC1 gene, was investigated.
Title: Lack of laminin gamma1 in embryonic stem cell-derived cardiomyocytes causes inhomogeneous electrical spreading despite intact differentiation and function.
Laminins are required for Schwann cell to form a bipolar shape as well as for process extension.
Title: Laminin is required for Schwann cell morphogenesis.
laminin regulates neurite growth and neuronal migration via integrin signaling through the AKT/GSK-3beta pathway
Title: Cortical deficiency of laminin gamma1 impairs the AKT/GSK-3beta signaling pathway and leads to defects in neurite outgrowth and neuronal migration.

Submit: New GeneRIF Correction See all (15)

Alleles

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Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (Floxed/Frt) (1) 1 citation
Targeted (knock-out) (1) 1 citation
Targeted (Reporter) (1) 1 citation
Gene trapped (1) 1 citation

Interactions

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Products	Interactant	Other Gene	Source	Pubs	Description
BioGRID:230522	BioGRID:201096	Lama1	BioGRID	PubMed	Affinity Capture-Western
BioGRID:230522	BioGRID:208320	Ntn4	BioGRID	PubMed	Reconstituted Complex
BioGRID:230522	BioGRID:202313	Pou5f1	BioGRID	PubMed	Affinity Capture-MS

Pathways from BioSystems

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Alpha6-Beta4 Integrin Signaling Pathway, organism-specific biosystem (from WikiPathways)
Alpha6-Beta4 Integrin Signaling Pathway, organism-specific biosystemIntegrins are cell surface heterodimeric protein complex consisting of one alpha and one beta chain. Integrins act as cell adhesion molecules as well as participate in cellular signaling. The ligands...
Amoebiasis, organism-specific biosystem (from KEGG)
Amoebiasis, organism-specific biosystemEntamoeba histolytica, an extracellular protozoan parasite is a human pathogen that invades the intestinal epithelium. Infection occurs on ingestion of contaminated water and food. The pathogenesis o...
Amoebiasis, conserved biosystem (from KEGG)
Amoebiasis, conserved biosystemEntamoeba histolytica, an extracellular protozoan parasite is a human pathogen that invades the intestinal epithelium. Infection occurs on ingestion of contaminated water and food. The pathogenesis o...
Axon guidance, organism-specific biosystem (from REACTOME)
Axon guidance, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Developmental Biology, organism-specific biosystem (from REACTOME)
Developmental Biology, organism-specific biosystemcomputationally inferred pathway (not manually curated)
ECM-receptor interaction, organism-specific biosystem (from KEGG)
ECM-receptor interaction, organism-specific biosystemThe extracellular matrix (ECM) consists of a complex mixture of structural and functional macromolecules and serves an important role in tissue and organ morphogenesis and in the maintenance of cell ...
ECM-receptor interaction, conserved biosystem (from KEGG)
ECM-receptor interaction, conserved biosystemThe extracellular matrix (ECM) consists of a complex mixture of structural and functional macromolecules and serves an important role in tissue and organ morphogenesis and in the maintenance of cell ...
Focal Adhesion, organism-specific biosystem (from WikiPathways)
Focal Adhesion, organism-specific biosystemCell-matrix adhesions play essential roles in important biological processes including cell motility, cell proliferation, cell differentiation, regulation of gene expression and cell survival. At the...
Focal adhesion, organism-specific biosystem (from KEGG)
Focal adhesion, organism-specific biosystemCell-matrix adhesions play essential roles in important biological processes including cell motility, cell proliferation, cell differentiation, regulation of gene expression and cell survival. At the...
Focal adhesion, conserved biosystem (from KEGG)
Focal adhesion, conserved biosystemCell-matrix adhesions play essential roles in important biological processes including cell motility, cell proliferation, cell differentiation, regulation of gene expression and cell survival. At the...
Inflammatory Response Pathway, organism-specific biosystem (from WikiPathways)
Inflammatory Response Pathway, organism-specific biosystem
Inflammatory Response Pathway
Integrin cell surface interactions, organism-specific biosystem (from REACTOME)
Integrin cell surface interactions, organism-specific biosystemcomputationally inferred pathway (not manually curated)
L1CAM interactions, organism-specific biosystem (from REACTOME)
L1CAM interactions, organism-specific biosystemcomputationally inferred pathway (not manually curated)
PI3K-Akt signaling pathway, organism-specific biosystem (from KEGG)
PI3K-Akt signaling pathway, organism-specific biosystemThe phosphatidylinositol 3' -kinase(PI3K)-Akt signaling pathway is activated by many types of cellular stimuli or toxic insults and regulates fundamental cellular functions such as transcription, tra...
PI3K-Akt signaling pathway, conserved biosystem (from KEGG)
PI3K-Akt signaling pathway, conserved biosystemThe phosphatidylinositol 3' -kinase(PI3K)-Akt signaling pathway is activated by many types of cellular stimuli or toxic insults and regulates fundamental cellular functions such as transcription, tra...
Pathways in cancer, organism-specific biosystem (from KEGG)
Pathways in cancer, organism-specific biosystem
Pathways in cancer
PodNet: protein-protein interactions in the podocyte, organism-specific biosystem (from WikiPathways)
PodNet: protein-protein interactions in the podocyte, organism-specific biosystemPodNet is a manually curated network of protein-protein interactions occurring in the podocyte.
Prion diseases, organism-specific biosystem (from KEGG)
Prion diseases, organism-specific biosystemPrion diseases, also termed transmissible spongiform encephalopathies (TSEs), are a group of fatal neurodegenerative diseases that affect humans and a number of other animal species. The etiology of ...
Prion diseases, conserved biosystem (from KEGG)
Prion diseases, conserved biosystemPrion diseases, also termed transmissible spongiform encephalopathies (TSEs), are a group of fatal neurodegenerative diseases that affect humans and a number of other animal species. The etiology of ...
Signal Transduction, organism-specific biosystem (from REACTOME)
Signal Transduction, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Small cell lung cancer, organism-specific biosystem (from KEGG)
Small cell lung cancer, organism-specific biosystemLung cancer is a leading cause of cancer death among men and women in industrialized countries. Small cell lung carcinoma (SCLC) is a highly aggressive neoplasm, which accounts for approximately 25% ...
Small cell lung cancer, conserved biosystem (from KEGG)
Small cell lung cancer, conserved biosystemLung cancer is a leading cause of cancer death among men and women in industrialized countries. Small cell lung carcinoma (SCLC) is a highly aggressive neoplasm, which accounts for approximately 25% ...
Toxoplasmosis, organism-specific biosystem (from KEGG)
Toxoplasmosis, organism-specific biosystemToxoplasma gondii is an obligate intracellular parasite that is prevalent worldwide. The tachyzoite form acquired by oral ingestion downmodulates proinflammatory signaling pathways via various mechan...
Toxoplasmosis, conserved biosystem (from KEGG)
Toxoplasmosis, conserved biosystemToxoplasma gondii is an obligate intracellular parasite that is prevalent worldwide. The tachyzoite form acquired by oral ingestion downmodulates proinflammatory signaling pathways via various mechan...
XPodNet - protein-protein interactions in the podocyte expanded by STRING, organism-specific biosystem (from WikiPathways)
XPodNet - protein-protein interactions in the podocyte expanded by STRING, organism-specific biosystemXPodNet is a larger version of PodNet. Interactions from STRING database have been added to PodNet to build XPodNet. Hence, not all interactions found in XPodNet do necessarily have to be curated.

General gene information

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Markers

D1Mit43 (e-PCR), detects polymorphism
- UniSTS:128798

J02930 (e-PCR)
- UniSTS:178479

Lamc1 (e-PCR), detects polymorphism
- UniSTS:256621

Lamc1 (e-PCR), detects polymorphism
- UniSTS:507014

Homology

Homologs of the Lamc1 gene: The Lamc1 gene is conserved in human, chimpanzee, Rhesus monkey, dog, cow, rat, chicken, zebrafish, fruit fly, mosquito, and C.elegans.
Map Viewer (Human, Rat)
OrthoDB: The Hierarchical Catalog of Eukaryotic Orthologs

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
extracellular matrix structural constituent	ISO Inferred from Sequence Orthology more info
glycosphingolipid binding	IDA Inferred from Direct Assay more info	PubMed
protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
cell adhesion	ISO Inferred from Sequence Orthology more info
cell migration	ISO Inferred from Sequence Orthology more info
extracellular matrix disassembly	ISO Inferred from Sequence Orthology more info
hemidesmosome assembly	ISO Inferred from Sequence Orthology more info
neuron projection development	IDA Inferred from Direct Assay more info	PubMed
protein complex assembly	ISO Inferred from Sequence Orthology more info
substrate adhesion-dependent cell spreading	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
basal lamina	IDA Inferred from Direct Assay more info	PubMed
basement membrane	IDA Inferred from Direct Assay more info	PubMed
colocalizes_with basement membrane	IDA Inferred from Direct Assay more info	PubMed
basement membrane	ISO Inferred from Sequence Orthology more info
extracellular matrix	ISO Inferred from Sequence Orthology more info
extracellular region	IEA Inferred from Electronic Annotation more info
extracellular vesicular exosome	ISO Inferred from Sequence Orthology more info
laminin-1 complex	ISO Inferred from Sequence Orthology more info
laminin-10 complex	IPI Inferred from Physical Interaction more info	PubMed
proteinaceous extracellular matrix	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: laminin subunit gamma-1

Names: laminin subunit gamma-1; S-LAM gamma; laminin B2 chain; S-laminin subunit gamma; laminin-1 subunit gamma; laminin-2 subunit gamma; laminin-3 subunit gamma; laminin-4 subunit gamma; laminin-6 subunit gamma; laminin-7 subunit gamma; laminin-8 subunit gamma; laminin-9 subunit gamma; laminin-10 subunit gamma; laminin-11 subunit gamma

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_010683.2 → NP_034813.2 laminin subunit gamma-1 precursor

Status: VALIDATED

Source sequence(s)

AC117550, AC159966

Consensus CDS

CCDS15370.1

UniProtKB/TrEMBL

F8VQJ3

Related

ENSMUSP00000027752, OTTMUSP00000040460, ENSMUST00000027752, OTTMUST00000076764

Conserved Domains (7) summary

cd00055
Location:932 – 979
Blast Score: 144

EGF_Lam; Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in ...

cd00176
Location:1047 – 1252
Blast Score: 112

SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

pfam00052
Location:556 – 686
Blast Score: 488

Laminin_B; Laminin B (Domain IV)

smart00180
Location:933 – 978
Blast Score: 167

EGF_Lam; Laminin-type epidermal growth factor-like domai

smart00283
Location:1089 – 1300
Blast Score: 149

MA; Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer).

pfam00053
Location:443 – 490
Blast Score: 163

Laminin_EGF; Laminin EGF-like (Domains III and V)

pfam00055
Location:48 – 282
Blast Score: 884

Laminin_N; Laminin N-terminal (Domain VI)

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 103

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p1 C57BL/6J

Genomic

NC_000067.6 Reference GRCm38.p1 C57BL/6J

Range

153218922..153332786, complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Alternate Mm_Celera

Genomic

AC_000023.1 Alternate Mm_Celera

Range

155640123..155755639, complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Nucleotide		Protein	Strain
Heading	Accession and Version	Protein	Strain
genomic	AAHY01000096.1	None
genomic	AAHY01000097.1	None
genomic	AAHY01000098.1 (3458..34452)	None
genomic	AC117550.8 (73976..141559)	None
genomic	AC159966.5 (161861..208142)	None
genomic	CH466520.2	EDL39441.1	mixed
		EDL39442.1	mixed
genomic	J03749.1	AAA39409.1
mRNA	AK141201.1	BAE24583.1	C57BL/6J
mRNA	AK144233.1	BAE25787.1
mRNA	AK148199.1	BAE28410.1	C57BL/6J
mRNA	AK162773.1	BAE37055.1	C57BL/6J
mRNA	BC032194.1	None	FVB/N
mRNA	BC056497.1	AAH56497.1	C57BL/6
mRNA	J02930.1	AAA39408.1
mRNA	J03484.1	AAA39405.1
mRNA	X05211.1	CAA28838.1
other-genetic	BC165945.1	AAI65945.1