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    FGFR4 fibroblast growth factor receptor 4 [ Homo sapiens ]

    Gene ID: 2264, updated on 11-May-2012
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    Summary

    Official Symbol
    FGFR4provided by HGNC
    Official Full Name
    fibroblast growth factor receptor 4provided by HGNC
    Primary source
    HGNC:3691
    See related
    Ensembl:ENSG00000160867; HPRD:00625; MIM:134935; Vega:OTTHUMG00000151523
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    TKF; JTK2; CD334; MGC20292
    Summary
    The protein encoded by this gene is a member of the fibroblast growth factor receptor family, where amino acid sequence is highly conserved between members and throughout evolution. FGFR family members differ from one another in their ligand affinities and tissue distribution. A full-length representative protein would consist of an extracellular region, composed of three immunoglobulin-like domains, a single hydrophobic membrane-spanning segment and a cytoplasmic tyrosine kinase domain. The extracellular portion of the protein interacts with fibroblast growth factors, setting in motion a cascade of downstream signals, ultimately influencing mitogenesis and differentiation. The genomic organization of this gene, compared to members 1-3, encompasses 18 exons rather than 19 or 20. Although alternative splicing has been observed, there is no evidence that the C-terminal half of the IgIII domain of this protein varies between three alternate forms, as indicated for members 1-3. This particular family member preferentially binds acidic fibroblast growth factor and, although its specific function is unknown, it is overexpressed in gynecological tumor samples, suggesting a role in breast and ovarian tumorigenesis. [provided by RefSeq, Jul 2008]
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    Genomic context

    Location :
    5q35.1-qter
    Sequence :
    Chromosome: 5; NC_000005.9 (176513921..176525127)
    See FGFR4 in Epigenomics, MapViewer

    Chromosome 5 - NC_000005.9Genomic Context describing neighboring genes Neighboring gene ubiquitin interaction motif containing 1 Neighboring gene zinc finger protein 346 Neighboring gene nuclear receptor binding SET domain protein 1 Neighboring gene protein arginine methyltransferase 1 pseudogene Neighboring gene ribosomal protein L21 pseudogene 60

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    Genomic regions, transcripts, and products

    Go to nucleotideGraphics FASTA GenBank

    Go to reference sequence details
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    Bibliography

    Related articles in PubMed

    1. The FGFR4-G388R polymorphism promotes mitochondrial STAT3 serine phosphorylation to facilitate pituitary growth hormone cell tumorigenesis. Tateno T, et al. PLoS Genet, 2011 Dec. PMID 22174695.
    2. PAX3-FOXO1 and FGFR4 in alveolar rhabdomyosarcoma. Marshall AD, et al. Mol Carcinog, 2011 Aug 31. PMID 21882254.
    3. Sulfated glycosaminoglycans are required for specific and sensitive fibroblast growth factor (FGF) 19 signaling via FGF receptor 4 and betaKlotho. Nakamura M, et al. J Biol Chem, 2011 Jul 29. PMID 21653700.
    4. HFE, MTHFR, and FGFR4 genes polymorphisms and breast cancer in Brazilian women. Batschauer AP, et al. Mol Cell Biochem, 2011 Nov. PMID 21625954.
    5. Association between fibroblast growth factor receptor-4 gene polymorphism and risk of prostate cancer: a meta-analysis. Liwei L, et al. Urol Int, 2011. PMID 21625079.

    See all (128) citations in PubMed

    GeneRIFs: Gene References Into Functions What's a GeneRIF?

    1. Our findings establish a new role for the FGFR4-G388R polymorphism in pituitary oncogenesis, providing a rationale for targeting Src and STAT3 in the personalized treatment of associated disorders.
      Title: The FGFR4-G388R polymorphism promotes mitochondrial STAT3 serine phosphorylation to facilitate pituitary growth hormone cell tumorigenesis.
    2. Our data suggests that the polymorphisms FGFR4, MTHFR, and HFE(G388A, C677T, and H63D) are not useful in breast cancer diagnosis, but they may be significant additional prognostic markers related to breast cancer survival.
      Title: HFE, MTHFR, and FGFR4 genes polymorphisms and breast cancer in Brazilian women.
    3. Gly-388Arg polymorphism of FGFR-4 most likely contributes to susceptibility to prostate cancer, especially in men of European descent
      Title: Association between fibroblast growth factor receptor-4 gene polymorphism and risk of prostate cancer: a meta-analysis.
    4. knockdown of FGFR-4 Arg388 in PCa cells decreases proliferation and invasion in vitro and primary tumor growth and metastasis in vivo.
      Title: FGFR-4 Arg³⁸⁸ enhances prostate cancer progression via extracellular signal-related kinase and serum response factor signaling.
    5. Sulfated glycosaminoglycans are required for specific and sensitive fibroblast growth factor (FGF) 19 signaling via FGF receptor 4 and betaKlotho.
      Title: Sulfated glycosaminoglycans are required for specific and sensitive fibroblast growth factor (FGF) 19 signaling via FGF receptor 4 and betaKlotho.
    6. FGFR4 Gly388Arg polymorphism is associated with cancer.
      Title: Meta and pooled analyses of FGFR4 Gly388Arg polymorphism as a cancer prognostic factor.
    7. these results demonstrate that FGFR4-ECD can block FGFR4 signaling and prevent hepatic steatosis, highlighting the potential value of inhibition of FGFR4 signaling as a method for therapeutic intervention against NAFLD
      Title: Soluble FGFR4 extracellular domain inhibits FGF19-induced activation of FGFR4 signaling and prevents nonalcoholic fatty liver disease.
    8. FGFR4 negatively regulates NF-kappaB signaling
      Title: The receptor tyrosine kinase FGFR4 negatively regulates NF-kappaB signaling.
    9. FGFR4 Gly388Arg polymorphism could be a marker for prostate cancer development and progression.
      Title: FGFR4 Gly388Arg polymorphism contributes to prostate cancer development and progression: a meta-analysis of 2618 cases and 2305 controls.
    10. FGFR4 expression is markedly increased in high-grade PanIN and PDAC compared with that in normal and low-grade PanIN, and that FGFR4 stimulation by FGF19 of PDAC cells contributes to tumor suppression by increasing cell adhesion to extracellular matrix.
      Title: Overexpression of fibroblast growth factor receptor 4 in high-grade pancreatic intraepithelial neoplasia and pancreatic ductal adenocarcinoma.
    Submit: New GeneRIF Correction See all (66)
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    Phenotypes

    Review eQTL and phenotype association data in this region using PheGenI

    Cancer progression/metastasis

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    Interactions

    Products Interactant Other Gene Complex Source Pubs Description
    P22455 P19022 CDH2    HPRD  PubMed  
    P22455 P54764 EPHA4    HPRD  PubMed  
    P22455 P05230 FGF1    HPRD  PubMed  
    P22455 O60258 FGF17    HPRD  PubMed  
    P22455 O76093 FGF18    HPRD  PubMed  
    P22455 O95750 FGF19    HPRD  PubMed  
    P22455 P09038 FGF2    HPRD  PubMed  
    P22455 P11487 FGF3    HPRD  PubMed  
    P22455 P08620 FGF4    HPRD  PubMed  
    P22455 P12034 FGF5    HPRD  PubMed  
    P22455 P10767 FGF6    HPRD  PubMed  
    P22455 P21781 FGF7    HPRD  PubMed  
    P22455 P55075 FGF8    HPRD  PubMed  
    P22455 P31371 FGF9    HPRD  PubMed  
    P22455 P22455 FGFR4    HPRD  PubMed  
    P22455 P19174 PLCG1    HPRD  PubMed  
    P22455 P42224 STAT1    HPRD  PubMed  
    P22455 P40763 STAT3    HPRD  PubMed  
    BioGRID:108555 BioGRID:108537 FGF1    BioGRID  PubMed Reconstituted Complex 
    BioGRID:108555 BioGRID:115290 FGF19    BioGRID  PubMed Reconstituted Complex 
    BioGRID:108555 BioGRID:113164 UBC    BioGRID  PubMed Affinity Capture-Western 
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    General gene information

    Markers

    Genotypes

    Homology

    Pathways from BioSystems

    • Downstream signaling of activated FGFR, organism-specific biosystem (from REACTOME)
      Downstream signaling of activated FGFR, organism-specific biosystemSignaling via FGFRs is mediated via direct recruitment of signaling proteins that bind to tyrosine auto-phosphorylation sites on the activated receptor and via closely linked docking proteins that be...
    • Endocytosis, organism-specific biosystem (from KEGG)
      Endocytosis, organism-specific biosystemEndocytosis is a mechanism for cells to remove ligands, nutrients, and plasma membrane (PM) proteins, and lipids from the cell surface, bringing them into the cell interior. Transmembrane proteins en...
    • Endocytosis, conserved biosystem (from KEGG)
      Endocytosis, conserved biosystemEndocytosis is a mechanism for cells to remove ligands, nutrients, and plasma membrane (PM) proteins, and lipids from the cell surface, bringing them into the cell interior. Transmembrane proteins en...
    • FGF signaling pathway, organism-specific biosystem (from Pathway Interaction Database)
      FGF signaling pathway, organism-specific biosystem
      FGF signaling pathway
    • FGFR ligand binding and activation, organism-specific biosystem (from REACTOME)
      FGFR ligand binding and activation, organism-specific biosystemThe FGFs are a family of 22 secreted glycoproteins that are sequestered in the extracellular matrix (ECM) through their interaction with heparin and heparin sulphate proteoglycans (HSPGs). Release o...
    • FGFR4 ligand binding and activation, organism-specific biosystem (from REACTOME)
      FGFR4 ligand binding and activation, organism-specific biosystemFGFR4 is expressed mainly in mature skeletal muscle, and disruption of FGFR4 signaling interrupts limb muscle formation in vertebrates.
    • FRS2-mediated cascade, organism-specific biosystem (from REACTOME)
      FRS2-mediated cascade, organism-specific biosystemThe FRS family of scaffolding adaptor proteins has two members, FRS2alpha and FRS2beta (also known as FRS3 or SNT-2). Activation of FGFR tyrosine kinase allows FRS2 proteins to become phosphorylated...
    • IRS-mediated signalling, organism-specific biosystem (from REACTOME)
      IRS-mediated signalling, organism-specific biosystemRelease of phospho-IRS from the insulin receptor triggers a cascade of signalling events via PI3K, SOS, RAF and the MAP kinases.
    • IRS-related events, organism-specific biosystem (from REACTOME)
      IRS-related events, organism-specific biosystemIRS is one of the mediators of insulin signalling events. It is activated by phosphorylation and triggers a cascade of events involving PI3K, SOS, RAF and the MAP kinases. The proteins mentioned unde...
    • Insulin receptor signalling cascade, organism-specific biosystem (from REACTOME)
      Insulin receptor signalling cascade, organism-specific biosystemAutophosphorylation of the insulin receptor triggers a series of signalling events, mediated by SHC or IRS, and resulting in activation of the Ras/RAF and MAP kinase cascades. A second effect of the ...
    • Klotho-mediated ligand binding, organism-specific biosystem (from REACTOME)
      Klotho-mediated ligand binding, organism-specific biosystemThe endocrine FGFs (19, 21 and 23) have lower affinity for heparin and HSPG compared to their paracrine or autocrine coutnerparts. Binding of these ligands to their receptors is generally aided by t...
    • MAPK signaling pathway, organism-specific biosystem (from KEGG)
      MAPK signaling pathway, organism-specific biosystemThe mitogen-activated protein kinase (MAPK) cascade is a highly conserved module that is involved in various cellular functions, including cell proliferation, differentiation and migration. Mammals e...
    • MAPK signaling pathway, conserved biosystem (from KEGG)
      MAPK signaling pathway, conserved biosystemThe mitogen-activated protein kinase (MAPK) cascade is a highly conserved module that is involved in various cellular functions, including cell proliferation, differentiation and migration. Mammals e...
    • Negative regulation of FGFR signaling, organism-specific biosystem (from REACTOME)
      Negative regulation of FGFR signaling, organism-specific biosystemOnce activated, the FGFR signaling pathway is regulated by numerous negative feedback mechanisms. These include downregulation of receptors through CBL-mediated ubiquitination and endocytosis, ERK-m...
    • PI-3K cascade, organism-specific biosystem (from REACTOME)
      PI-3K cascade, organism-specific biosystemThe ability of growth factors to protect from apoptosis is primarily due to the activation of the AKT survival pathway. P-I-3-kinase dependent activation of PDK leads to the activation of AKT which i...
    • PI3K Cascade, organism-specific biosystem (from REACTOME)
      PI3K Cascade, organism-specific biosystem
      PI3K Cascade
    • Phospholipase C-mediated cascade, organism-specific biosystem (from REACTOME)
      Phospholipase C-mediated cascade, organism-specific biosystemPhospholipase C-gamma (PLC-gamma) is a substrate of the fibroblast growth factor receptor (FGFR) and other receptors with tyrosine kinase activity. It is known that the src homology region 2 (SH2 dom...
    • Regulation of Actin Cytoskeleton, organism-specific biosystem (from WikiPathways)
      Regulation of Actin Cytoskeleton, organism-specific biosystem
      Regulation of Actin Cytoskeleton
    • Regulation of actin cytoskeleton, organism-specific biosystem (from KEGG)
      Regulation of actin cytoskeleton, organism-specific biosystem
      Regulation of actin cytoskeleton
    • Regulation of actin cytoskeleton, conserved biosystem (from KEGG)
      Regulation of actin cytoskeleton, conserved biosystem
      Regulation of actin cytoskeleton
    • SHC-mediated cascade, organism-specific biosystem (from REACTOME)
      SHC-mediated cascade, organism-specific biosystemThe exact role of SHC1 in FGFR signaling remains unclear. Numerous studies have shown that the p46 and p52 isoforms of SHC1 are phosphorylated in response to FGF stimulation, but direct interaction...
    • Signal Transduction, organism-specific biosystem (from REACTOME)
      Signal Transduction, organism-specific biosystemSignal transduction is a process in which extracellular signals elicit changes in cell state and activity. Transmembrane receptors sense changes in the cellular environment by binding ligands, such a...
    • Signaling by FGFR, organism-specific biosystem (from REACTOME)
      Signaling by FGFR, organism-specific biosystemThe 22 members of the fibroblast growth factor (FGF) family of growth factors mediate their cellular responses by binding to and activating the different isoforms encoded by the four receptor tyrosin...
    • Signaling by Insulin receptor, organism-specific biosystem (from REACTOME)
      Signaling by Insulin receptor, organism-specific biosystemInsulin binding to its receptor results in receptor autophosphorylation on tyrosine residues and the tyrosine phosphorylation of insulin receptor substrates (e.g. IRS and Shc) by the insulin receptor...
    • betaKlotho-mediated ligand binding, organism-specific biosystem (from REACTOME)
      betaKlotho-mediated ligand binding, organism-specific biosystemFGF21 and FGF19 require betaKlotho for efficient signaling through FGFR1c and FGFR3c. betaKlotho does not interact with 'b' receptor isoforms, and only weakly with FGFR2c. In addition, FGF19, but n...

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    fibroblast growth factor 1 binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    fibroblast growth factor 2 binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    fibroblast growth factor binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    fibroblast growth factor-activated receptor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    fibroblast growth factor-activated receptor activity IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    heparin binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    protein tyrosine kinase activity TAS
    Traceable Author Statement
    more info
    		  
    receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    cell migration IMP
    Inferred from Mutant Phenotype
    more info
    		  
    fibroblast growth factor receptor signaling pathway IDA
    Inferred from Direct Assay
    more info
    		  
    fibroblast growth factor receptor signaling pathway IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    fibroblast growth factor receptor signaling pathway IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    fibroblast growth factor receptor signaling pathway TAS
    Traceable Author Statement
    more info
    		  
    glucose homeostasis ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    insulin receptor signaling pathway TAS
    Traceable Author Statement
    more info
    		  
    peptidyl-tyrosine phosphorylation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    phosphate ion homeostasis ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    positive regulation of DNA biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		  
    positive regulation of ERK1 and ERK2 cascade IMP
    Inferred from Mutant Phenotype
    more info
    		  
    positive regulation of cell proliferation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    positive regulation of cell proliferation IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    positive regulation of metalloenzyme activity IMP
    Inferred from Mutant Phenotype
    more info
    		  
    positive regulation of proteolysis IMP
    Inferred from Mutant Phenotype
    more info
    		  
    protein autophosphorylation IDA
    Inferred from Direct Assay
    more info
    		  
    regulation of bile acid biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    regulation of cholesterol homeostasis ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    regulation of extracellular matrix disassembly IMP
    Inferred from Mutant Phenotype
    more info
    		  
    regulation of lipid metabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    colocalizes_with cell-cell junction IDA
    Inferred from Direct Assay
    more info
    		  
    cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    endoplasmic reticulum IDA
    Inferred from Direct Assay
    more info
    		  
    endosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    extracellular region IEA
    Inferred from Electronic Annotation
    more info
    		  
    integral to plasma membrane IDA
    Inferred from Direct Assay
    more info
    		  
    NOT nucleolus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    plasma membrane TAS
    Traceable Author Statement
    more info
    		  
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    General protein information

    Preferred Names
    fibroblast growth factor receptor 4
    Names
    fibroblast growth factor receptor 4
    FGFR-4
    tyrosylprotein kinase
    protein-tyrosine kinase
    hydroxyaryl-protein kinase
    tyrosine kinase related to fibroblast growth factor receptor
    NP_002002.3
    NP_075252.2
    NP_998812.1
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    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_012067.1 RefSeqGene

      Range
      5001..16207
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_002011.3 → NP_002002.3  fibroblast growth factor receptor 4 isoform 1 precursor

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) utilizes alternatively spliced exon 9, generating isoform (1) that contains a transmembrane domain, suggesting a membrane bound receptor.
      Source sequence(s)
      BC011847, L03840
      Consensus CDS
      CCDS4410.1
      UniProtKB/TrEMBL
      G3JVM2
      UniProtKB/Swiss-Prot
      P22455
      Related
      ENSP00000424960, OTTHUMP00000223541, ENST00000502906, OTTHUMT00000372595
      Conserved Domains (5) summary
      cd05099
      Location:454 – 764
      Blast Score: 1652
      PTKc_FGFR4; Catalytic domain of the Protein Tyrosine Kinase, Fibroblast Growth Factor Receptor 4
      cd05858
      Location:264 – 351
      Blast Score: 410
      Ig3_FGFR-2; Third immunoglobulin (Ig)-like domain of fibroblast growth factor receptor 2 (FGFR2)
      pfam07679
      Location:256 – 350
      Blast Score: 150
      I-set; Immunoglobulin I-set domain
      pfam07714
      Location:467 – 743
      Blast Score: 1047
      Pkinase_Tyr; Protein tyrosine kinase
      cl11960
      Location:157 – 241
      Blast Score: 401
      Ig; Immunoglobulin domain

    2. NM_022963.2 → NP_075252.2  fibroblast growth factor receptor 4 isoform 2 precursor

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) is missing alternatively spliced exon 9, incorporating intron 9 in its place. The intron 9 does not cause a frame-shift, but encodes 40 fewer amino acids than exon 9. This shorter isoform (2) is missing the transmembrane region, suggesting a soluble rather than membrane-bound receptor.
      Source sequence(s)
      AF202063, AF359246, BC011847, BF307233, L03840
      Consensus CDS
      CCDS4411.1
      UniProtKB/Swiss-Prot
      P22455
      UniProtKB/TrEMBL
      Q96KE5
      Related
      ENSP00000377254, OTTHUMP00000161430, ENST00000393637, OTTHUMT00000253411
      Conserved Domains (5) summary
      cd05099
      Location:414 – 724
      Blast Score: 1657
      PTKc_FGFR4; Catalytic domain of the Protein Tyrosine Kinase, Fibroblast Growth Factor Receptor 4
      cd05858
      Location:264 – 351
      Blast Score: 409
      Ig3_FGFR-2; Third immunoglobulin (Ig)-like domain of fibroblast growth factor receptor 2 (FGFR2)
      pfam07679
      Location:256 – 350
      Blast Score: 150
      I-set; Immunoglobulin I-set domain
      pfam07714
      Location:427 – 703
      Blast Score: 1047
      Pkinase_Tyr; Protein tyrosine kinase
      cl11960
      Location:157 – 241
      Blast Score: 402
      Ig; Immunoglobulin domain

    3. NM_213647.1 → NP_998812.1  fibroblast growth factor receptor 4 isoform 1 precursor

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) uses an alternative splice site for the first exon compared to variant 1. Both variants encode the same isoform (1).
      Source sequence(s)
      BC011847
      Consensus CDS
      CCDS4410.1
      UniProtKB/TrEMBL
      G3JVM2
      UniProtKB/Swiss-Prot
      P22455
      Related
      ENSP00000292408, OTTHUMP00000161429, ENST00000292408, OTTHUMT00000253410
      Conserved Domains (5) summary
      cd05099
      Location:454 – 764
      Blast Score: 1652
      PTKc_FGFR4; Catalytic domain of the Protein Tyrosine Kinase, Fibroblast Growth Factor Receptor 4
      cd05858
      Location:264 – 351
      Blast Score: 410
      Ig3_FGFR-2; Third immunoglobulin (Ig)-like domain of fibroblast growth factor receptor 2 (FGFR2)
      pfam07679
      Location:256 – 350
      Blast Score: 150
      I-set; Immunoglobulin I-set domain
      pfam07714
      Location:467 – 743
      Blast Score: 1047
      Pkinase_Tyr; Protein tyrosine kinase
      cl11960
      Location:157 – 241
      Blast Score: 401
      Ig; Immunoglobulin domain

    RefSeqs of Annotated Genomes: Build 37.3

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh37.p5 Primary Assembly

    Genomic

    1. NC_000005.9 Reference GRCh37.p5 Primary Assembly

      Range
      176513921..176525127
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate HuRef

    Genomic

    1. AC_000137.1 Alternate HuRef

      Range
      171435609..171446679
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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    Related Sequences

    Nucleotide Protein
    Heading Accession and Version
    genomic AC027314.5 (84296..95502) None
    genomic AF487555.1 AAM13666.1
    genomic CH471195.1 EAW85034.1
      EAW85035.1
      EAW85036.1
      EAW85037.1
    genomic EF571596.1 ABQ01235.1
    genomic X68559.1 CAB75718.1
    genomic Y13901.1 CAA74200.1
    mRNA AF202063.1 AAF27432.1
    mRNA AF359241.1 AAK43714.1
    mRNA AF359246.1 AAK51435.1
    mRNA AK225280.1 None
    mRNA AK225909.1 None
    mRNA AK301169.1 BAG62757.1
    mRNA BC011847.2 AAH11847.1
    mRNA BF307233.1 None
    mRNA EU826602.1 ACF47638.1
    mRNA EU826603.1 ACF47639.1
    mRNA JN007471.1 AEO19712.1
    mRNA JN007472.1 AEO19713.1
    mRNA JN007473.1 AEO19714.1
    mRNA JN007474.1 AEO19715.1
    mRNA JN007475.1 AEO19716.1
    mRNA JN007476.1 AEO19717.1
    mRNA JN007477.1 AEO19718.1
    mRNA JN007478.1 AEO19719.1
    mRNA JN007479.1 AEO19720.1
    mRNA JN007480.1 AEO19721.1
    mRNA JN007481.1 AEO19722.1
    mRNA JN007482.1 AEO19723.1
    mRNA L03840.1 AAB59389.1
    mRNA M59373.1 AAA63208.1
    mRNA X57205.1 CAA40490.1
    mRNA AB209631.1 BAD92868.1
    other-genetic DQ893458.2 ABM84384.1
    other-genetic DQ896348.2 ABM87347.1
    Protein Accession Links
    GenPept Link UniProtKB Link
    AAB25788.1 GenPept
    P22455.2 GenPept UniProtKB/Swiss-Prot:P22455
    Q59F30 GenPept UniProtKB/TrEMBL:Q59F30
    Q6LBK2 GenPept UniProtKB/TrEMBL:Q6LBK2
    Q96KE5 GenPept UniProtKB/TrEMBL:Q96KE5
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    Additional Links

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Medical
    Molecular Biology Databases
    Research Materials
    Tools
    Miscellaneous

      Supplemental Content

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