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FGFR2 fibroblast growth factor receptor 2 [ Homo sapiens (human) ]

Gene ID: 2263, updated on 23-Aug-2015
Official Symbol
FGFR2provided by HGNC
Official Full Name
fibroblast growth factor receptor 2provided by HGNC
Primary source
HGNC:HGNC:3689
See related
Ensembl:ENSG00000066468; HPRD:01492; MIM:176943; Vega:OTTHUMG00000019175
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
BEK; JWS; BBDS; CEK3; CFD1; ECT1; KGFR; TK14; TK25; BFR-1; CD332; K-SAM
Summary
The protein encoded by this gene is a member of the fibroblast growth factor receptor family, where amino acid sequence is highly conserved between members and throughout evolution. FGFR family members differ from one another in their ligand affinities and tissue distribution. A full-length representative protein consists of an extracellular region, composed of three immunoglobulin-like domains, a single hydrophobic membrane-spanning segment and a cytoplasmic tyrosine kinase domain. The extracellular portion of the protein interacts with fibroblast growth factors, setting in motion a cascade of downstream signals, ultimately influencing mitogenesis and differentiation. This particular family member is a high-affinity receptor for acidic, basic and/or keratinocyte growth factor, depending on the isoform. Mutations in this gene are associated with Crouzon syndrome, Pfeiffer syndrome, Craniosynostosis, Apert syndrome, Jackson-Weiss syndrome, Beare-Stevenson cutis gyrata syndrome, Saethre-Chotzen syndrome, and syndromic craniosynostosis. Multiple alternatively spliced transcript variants encoding different isoforms have been noted for this gene. [provided by RefSeq, Jan 2009]
Orthologs
See FGFR2 in Epigenomics, MapViewer
Location:
10q26
Exon count:
23
Annotation release Status Assembly Chr Location
107 current GRCh38.p2 (GCF_000001405.28) 10 NC_000010.11 (121478330..121598656, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (123237844..123357972, complement)

Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene long intergenic non-protein coding RNA 1153 Neighboring gene uncharacterized LOC105378523 Neighboring gene ribosomal protein S15a pseudogene 5 Neighboring gene arginyltransferase 1 Neighboring gene ATE1 antisense RNA 1

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Associated conditions

Description Tests
Acrocephalosyndactyly type I Compare labs
Antley-Bixler syndrome without genital anomalies or disordered steroidogenesis Compare labs
Bent bone dysplasia syndrome
MedGen: C3281247 OMIM: 614592 GeneReviews: Not available
Compare labs
Crouzon syndrome Compare labs
Cutis Gyrata syndrome of Beare and Stevenson Compare labs
Isolated coronal synostosis Compare labs
Jackson-Weiss syndrome Compare labs
Levy-Hollister syndrome
MedGen: C0265269 OMIM: 149730 GeneReviews: Not available
Compare labs
Neoplasm of stomach
MedGen: C0038356 OMIM: 613659 GeneReviews: Not available
Compare labs
Pfeiffer syndrome Compare labs
Saethre-Chotzen syndrome
MedGen: C0175699 OMIM: 101400 GeneReviews: Saethre-Chotzen Syndrome
Compare labs
Scaphocephaly, maxillary retrusion, and mental retardation
MedGen: C1865070 OMIM: 609579 GeneReviews: Not available
Compare labs

NHGRI GWAS Catalog

Description
A combined analysis of genome-wide association studies in breast cancer.
NHGRI GWA Catalog
A genome-wide association study identifies a genetic variant in the SIAH2 locus associated with hormonal receptor-positive breast cancer in Japanese.
NHGRI GWA Catalog
A genome-wide association study identifies alleles in FGFR2 associated with risk of sporadic postmenopausal breast cancer.
NHGRI GWA Catalog
A genome-wide association study of early-onset breast cancer identifies PFKM as a novel breast cancer gene and supports a common genetic spectrum for breast cancer at any age.
NHGRI GWA Catalog
A meta-analysis of genome-wide association studies for adiponectin levels in East Asians identifies a novel locus near WDR11-FGFR2.
NHGRI GWA Catalog
A multistage genome-wide association study in breast cancer identifies two new risk alleles at 1p11.2 and 14q24.1 (RAD51L1).
NHGRI GWA Catalog
Common genetic variants and modification of penetrance of BRCA2-associated breast cancer.
NHGRI GWA Catalog
Genetic correction of PSA values using sequence variants associated with PSA levels.
NHGRI GWA Catalog
Genetic variants associated with breast cancer risk for Ashkenazi Jewish women with strong family histories but no identifiable BRCA1/2 mutation.
NHGRI GWA Catalog
Genome-wide association analyses identify 18 new loci associated with serum urate concentrations.
NHGRI GWA Catalog
Genome-wide association study identifies five new breast cancer susceptibility loci.
NHGRI GWA Catalog
Genome-wide association study identifies novel breast cancer susceptibility loci.
NHGRI GWA Catalog
Genome-wide association study of breast cancer in the Japanese population.
NHGRI GWA Catalog
Large-scale genotyping identifies 41 new loci associated with breast cancer risk.
NHGRI GWA Catalog
Novel breast cancer susceptibility locus at 9q31.2: results of a genome-wide association study.
NHGRI GWA Catalog
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    SHC1 events in ERBB4 signaling, organism-specific biosystemAll splicing isoforms of ERBB4 possess two tyrosine residues in the C-tail that serve as docking sites for SHC1 (Kaushansky et al. 2008, Pinkas-Kramarski et al. 1996, Cohen et al. 1996). Once bound t...
  • SOS-mediated signalling, organism-specific biosystem (from REACTOME)
    SOS-mediated signalling, organism-specific biosystemSOS is recruited to the plasma membrane and mediates activation of Ras.
  • Signal Transduction, organism-specific biosystem (from REACTOME)
    Signal Transduction, organism-specific biosystemSignal transduction is a process in which extracellular signals elicit changes in cell state and activity. Transmembrane receptors sense changes in the cellular environment by binding ligands, such a...
  • Signaling Pathways in Glioblastoma, organism-specific biosystem (from WikiPathways)
    Signaling Pathways in Glioblastoma, organism-specific biosystemThe most frequently altered genes in glioblastoma. This pathway originally accompanied the 2008 Nature publication on the comprehensive genomic characterization of human glioblastoma genes and core p...
  • Signaling by EGFR, organism-specific biosystem (from REACTOME)
    Signaling by EGFR, organism-specific biosystemThe epidermal growth factor receptor (EGFR) is one member of the ERBB family of transmembrane glycoprotein tyrosine receptor kinases (RTK). Binding of EGFR to its ligands induces conformational chang...
  • Signaling by ERBB2, organism-specific biosystem (from REACTOME)
    Signaling by ERBB2, organism-specific biosystemERBB2, also known as HER2 or NEU, is a receptor tyrosine kinase (RTK) belonging to the EGFR family. ERBB2 possesses an extracellular domain that does not bind any known ligand, contrary to other EGFR...
  • Signaling by ERBB4, organism-specific biosystem (from REACTOME)
    Signaling by ERBB4, organism-specific biosystemERBB4, also known as HER4, belongs to the ERBB family of receptors, which also includes ERBB1 (EGFR i.e. HER1), ERBB2 (HER2 i.e. NEU) and ERBB3 (HER3). Similar to EGFR, ERBB4 has an extracellular lig...
  • Signaling by FGFR, organism-specific biosystem (from REACTOME)
    Signaling by FGFR, organism-specific biosystemThe 22 members of the fibroblast growth factor (FGF) family of growth factors mediate their cellular responses by binding to and activating the different isoforms encoded by the four receptor tyrosin...
  • Signaling by FGFR in disease, organism-specific biosystem (from REACTOME)
    Signaling by FGFR in disease, organism-specific biosystemA number of skeletal and developmental diseases have been shown to arise as a result of mutations in the FGFR1, 2 and 3 genes. These include dwarfism syndromes (achondroplasia, hypochondroplasia and...
  • Signaling by FGFR1, organism-specific biosystem (from REACTOME)
    Signaling by FGFR1, organism-specific biosystemThe 22 members of the fibroblast growth factor (FGF) family of growth factors mediate their cellular responses by binding to and activating the different isoforms encoded by the four receptor tyrosin...
  • Signaling by FGFR2, organism-specific biosystem (from REACTOME)
    Signaling by FGFR2, organism-specific biosystemThe 22 members of the fibroblast growth factor (FGF) family of growth factors mediate their cellular responses by binding to and activating the different isoforms encoded by the four receptor tyrosin...
  • Signaling by FGFR2 amplification mutants, organism-specific biosystem (from REACTOME)
    Signaling by FGFR2 amplification mutants, organism-specific biosystemFGFR2 amplifications have been identified in 10% of gastric cancers, where they are associated with poor prognosis diffuse cancers (Hattori, 1996; Ueda, 1999; Shin, 2000; Kunii, 2008) , and in ~1% of...
  • Signaling by FGFR2 in disease, organism-specific biosystem (from REACTOME)
    Signaling by FGFR2 in disease, organism-specific biosystemThe FGFR2 gene has been shown to be subject to activating mutations and gene amplification leading to a variety of proliferative and developmental disorders depending on whether these events occur in...
  • Signaling by FGFR3, organism-specific biosystem (from REACTOME)
    Signaling by FGFR3, organism-specific biosystemThe 22 members of the fibroblast growth factor (FGF) family of growth factors mediate their cellular responses by binding to and activating the different isoforms encoded by the four receptor tyrosin...
  • Signaling by FGFR4, organism-specific biosystem (from REACTOME)
    Signaling by FGFR4, organism-specific biosystemThe 22 members of the fibroblast growth factor (FGF) family of growth factors mediate their cellular responses by binding to and activating the different isoforms encoded by the four receptor tyrosin...
  • Signaling by GPCR, organism-specific biosystem (from REACTOME)
    Signaling by GPCR, organism-specific biosystemG protein-coupled receptors (GPCRs; 7TM receptors; seven transmembrane domain receptors; heptahelical receptors; G protein-linked receptors [GPLR]) are the largest family of transmembrane receptors i...
  • Signaling by Insulin receptor, organism-specific biosystem (from REACTOME)
    Signaling by Insulin receptor, organism-specific biosystemInsulin binding to its receptor results in receptor autophosphorylation on tyrosine residues and the tyrosine phosphorylation of insulin receptor substrates (e.g. IRS and Shc) by the insulin receptor...
  • Signaling by Interleukins, organism-specific biosystem (from REACTOME)
    Signaling by Interleukins, organism-specific biosystemInterleukins are low molecular weight proteins that bind to cell surface receptors and act in an autocrine and/or paracrine fashion. They were first identified as factors produced by leukocytes but a...
  • Signaling by Leptin, organism-specific biosystem (from REACTOME)
    Signaling by Leptin, organism-specific biosystemLeptin (LEP, OB, OBS), a circulating adipokine, and its receptor LEPR (DB, OBR) control food intake and energy balance and are implicated in obesity-related diseases (recently reviewed in Amitani et ...
  • Signaling by PDGF, organism-specific biosystem (from REACTOME)
    Signaling by PDGF, organism-specific biosystemPlatelet-derived Growth Factor (PDGF) is a potent stimulator of growth and motility of connective tissue cells such as fibroblasts and smooth muscle cells as well as other cells such as capillary end...
  • Signaling by SCF-KIT, organism-specific biosystem (from REACTOME)
    Signaling by SCF-KIT, organism-specific biosystemStem cell factor (SCF) is a growth factor with membrane bound and soluble forms. It is expressed by fibroblasts and endothelial cells throughout the body, promoting proliferation, migration, survival...
  • Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R), organism-specific biosystem (from REACTOME)
    Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R), organism-specific biosystemBinding of IGF1 (IGF-I) or IGF2 (IGF-II) to the extracellular alpha peptides of the type 1 insulin-like growth factor receptor (IGF1R) triggers the activation of two major signaling pathways: the SOS...
  • Signaling by VEGF, organism-specific biosystem (from REACTOME)
    Signaling by VEGF, organism-specific biosystemIn normal development vascular endothelial growth factors (VEGFs) are crucial regulators of vascular development during embryogenesis (vasculogenesis) and blood-vessel formation in the adult (angioge...
  • Signaling by the B Cell Receptor (BCR), organism-specific biosystem (from REACTOME)
    Signaling by the B Cell Receptor (BCR), organism-specific biosystemMature B cells express IgM and IgD immunoglobulins which are complexed at the plasma membrane with Ig-alpha (CD79A, MB-1) and Ig-beta (CD79B, B29) to form the B cell receptor (BCR) (Fu et al. 1974, F...
  • Signaling pathways regulating pluripotency of stem cells, organism-specific biosystem (from KEGG)
    Signaling pathways regulating pluripotency of stem cells, organism-specific biosystemPluripotent stem cells (PSCs) are basic cells with an indefinite self-renewal capacity and the potential to generate all the cell types of the three germinal layers. The types of PSCs known to date i...
  • Signaling pathways regulating pluripotency of stem cells, conserved biosystem (from KEGG)
    Signaling pathways regulating pluripotency of stem cells, conserved biosystemPluripotent stem cells (PSCs) are basic cells with an indefinite self-renewal capacity and the potential to generate all the cell types of the three germinal layers. The types of PSCs known to date i...
  • Signalling by NGF, organism-specific biosystem (from REACTOME)
    Signalling by NGF, organism-specific biosystemNeurotrophins (NGF, BDNF, NT-3, NT-4/5) play pivotal roles in survival, differentiation, and plasticity of neurons in the peripheral and central nervous system. They are produced, and secreted in mi...
  • Signalling to ERKs, organism-specific biosystem (from REACTOME)
    Signalling to ERKs, organism-specific biosystemNeurotrophins utilize multiple pathways to activate ERKs (ERK1 and ERK2), a subgroup of the large MAP kinase (MAPK) family, from the plasma membrane. The major signalling pathways to ERKs are via RAS...
  • Signalling to RAS, organism-specific biosystem (from REACTOME)
    Signalling to RAS, organism-specific biosystemSignalling through Shc adaptor proteins appears to be identical for both NGF and EGF. It leads to a fast, but transient, MAPK/ERK activation, which is insufficient to explain the prolonged activation...
  • Signalling to p38 via RIT and RIN, organism-specific biosystem (from REACTOME)
    Signalling to p38 via RIT and RIN, organism-specific biosystemRIT and RIN are two small guanine nucleotide binding proteins that share more than 50% sequence identity with RAS, including highly conserved core effector domains. Unlike RAS, the C termini of RIT a...
  • VEGFA-VEGFR2 Pathway, organism-specific biosystem (from REACTOME)
    VEGFA-VEGFR2 Pathway, organism-specific biosystemAngiogenesis is the formation of new blood vessels from preexisting vasculature. One of the most important proangiogenic factors is vascular endothelial growth factor (VEGF). VEGF exerts its biologic...
  • VEGFR2 mediated cell proliferation, organism-specific biosystem (from REACTOME)
    VEGFR2 mediated cell proliferation, organism-specific biosystemVEGFR2 stimulates ERK not via GRB2-SOS-RAS, but via pY1175-dependent phosphorylation of PLC gamma and subsequent activation of PKCs. PKC plays an important mediatory role in the proliferative Ras/Raf...
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Clone Names

  • FLJ98662

Gene Ontology Provided by GOA

Function Evidence Code Pubs
ATP binding IEA
Inferred from Electronic Annotation
more info
 
fibroblast growth factor binding IDA
Inferred from Direct Assay
more info
PubMed 
fibroblast growth factor binding IPI
Inferred from Physical Interaction
more info
PubMed 
fibroblast growth factor-activated receptor activity IDA
Inferred from Direct Assay
more info
PubMed 
fibroblast growth factor-activated receptor activity IGI
Inferred from Genetic Interaction
more info
PubMed 
fibroblast growth factor-activated receptor activity NAS
Non-traceable Author Statement
more info
PubMed 
heparin binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein homodimerization activity IPI
Inferred from Physical Interaction
more info
PubMed 
protein tyrosine kinase activity NAS
Non-traceable Author Statement
more info
PubMed 
Process Evidence Code Pubs
Fc-epsilon receptor signaling pathway TAS
Traceable Author Statement
more info
 
angiogenesis ISS
Inferred from Sequence or Structural Similarity
more info
 
apoptotic process IEA
Inferred from Electronic Annotation
more info
 
axonogenesis ISS
Inferred from Sequence or Structural Similarity
more info
 
bone development ISS
Inferred from Sequence or Structural Similarity
more info
 
bone mineralization ISS
Inferred from Sequence or Structural Similarity
more info
 
bone morphogenesis ISS
Inferred from Sequence or Structural Similarity
more info
 
branch elongation involved in salivary gland morphogenesis ISS
Inferred from Sequence or Structural Similarity
more info
 
branching involved in labyrinthine layer morphogenesis ISS
Inferred from Sequence or Structural Similarity
more info
 
branching involved in prostate gland morphogenesis ISS
Inferred from Sequence or Structural Similarity
more info
 
branching involved in salivary gland morphogenesis ISS
Inferred from Sequence or Structural Similarity
more info
 
branching morphogenesis of a nerve ISS
Inferred from Sequence or Structural Similarity
more info
 
bud elongation involved in lung branching ISS
Inferred from Sequence or Structural Similarity
more info
 
cell fate commitment ISS
Inferred from Sequence or Structural Similarity
more info
 
cell-cell signaling ISS
Inferred from Sequence or Structural Similarity
more info
 
coronal suture morphogenesis IEA
Inferred from Electronic Annotation
more info
 
digestive tract development ISS
Inferred from Sequence or Structural Similarity
more info
 
embryonic cranial skeleton morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
embryonic digestive tract morphogenesis ISS
Inferred from Sequence or Structural Similarity
more info
 
embryonic organ development ISS
Inferred from Sequence or Structural Similarity
more info
 
embryonic organ morphogenesis ISS
Inferred from Sequence or Structural Similarity
more info
 
embryonic pattern specification ISS
Inferred from Sequence or Structural Similarity
more info
 
endodermal digestive tract morphogenesis IEA
Inferred from Electronic Annotation
more info
 
epidermal growth factor receptor signaling pathway TAS
Traceable Author Statement
more info
 
epidermis morphogenesis ISS
Inferred from Sequence or Structural Similarity
more info
 
epithelial cell differentiation ISS
Inferred from Sequence or Structural Similarity
more info
 
epithelial cell proliferation involved in salivary gland morphogenesis ISS
Inferred from Sequence or Structural Similarity
more info
 
epithelial to mesenchymal transition IEA
Inferred from Electronic Annotation
more info
 
fibroblast growth factor receptor signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
fibroblast growth factor receptor signaling pathway IGI
Inferred from Genetic Interaction
more info
PubMed 
fibroblast growth factor receptor signaling pathway IPI
Inferred from Physical Interaction
more info
PubMed 
fibroblast growth factor receptor signaling pathway TAS
Traceable Author Statement
more info
 
fibroblast growth factor receptor signaling pathway involved in hemopoiesis ISS
Inferred from Sequence or Structural Similarity
more info
 
fibroblast growth factor receptor signaling pathway involved in mammary gland specification ISS
Inferred from Sequence or Structural Similarity
more info
 
fibroblast growth factor receptor signaling pathway involved in negative regulation of apoptotic process in bone marrow ISS
Inferred from Sequence or Structural Similarity
more info
 
fibroblast growth factor receptor signaling pathway involved in orbitofrontal cortex development ISS
Inferred from Sequence or Structural Similarity
more info
 
fibroblast growth factor receptor signaling pathway involved in positive regulation of cell proliferation in bone marrow ISS
Inferred from Sequence or Structural Similarity
more info
 
gland morphogenesis ISS
Inferred from Sequence or Structural Similarity
more info
 
hair follicle morphogenesis ISS
Inferred from Sequence or Structural Similarity
more info
 
in utero embryonic development ISS
Inferred from Sequence or Structural Similarity
more info
 
innate immune response TAS
Traceable Author Statement
more info
 
inner ear morphogenesis ISS
Inferred from Sequence or Structural Similarity
more info
 
insulin receptor signaling pathway TAS
Traceable Author Statement
more info
 
lacrimal gland development ISS
Inferred from Sequence or Structural Similarity
more info
 
lateral sprouting from an epithelium ISS
Inferred from Sequence or Structural Similarity
more info
 
lens fiber cell development IEA
Inferred from Electronic Annotation
more info
 
limb bud formation ISS
Inferred from Sequence or Structural Similarity
more info
 
lung alveolus development ISS
Inferred from Sequence or Structural Similarity
more info
 
lung development ISS
Inferred from Sequence or Structural Similarity
more info
 
lung lobe morphogenesis ISS
Inferred from Sequence or Structural Similarity
more info
 
lung-associated mesenchyme development ISS
Inferred from Sequence or Structural Similarity
more info
 
mammary gland bud formation ISS
Inferred from Sequence or Structural Similarity
more info
 
membranous septum morphogenesis ISS
Inferred from Sequence or Structural Similarity
more info
 
mesenchymal cell differentiation ISS
Inferred from Sequence or Structural Similarity
more info
 
mesenchymal cell differentiation involved in lung development ISS
Inferred from Sequence or Structural Similarity
more info
 
mesenchymal cell proliferation involved in lung development ISS
Inferred from Sequence or Structural Similarity
more info
 
mesodermal cell differentiation IEA
Inferred from Electronic Annotation
more info
 
midbrain development ISS
Inferred from Sequence or Structural Similarity
more info
 
morphogenesis of embryonic epithelium ISS
Inferred from Sequence or Structural Similarity
more info
 
multicellular organism growth ISS
Inferred from Sequence or Structural Similarity
more info
 
negative regulation of epithelial cell proliferation IEA
Inferred from Electronic Annotation
more info
 
negative regulation of mitotic nuclear division IEA
Inferred from Electronic Annotation
more info
 
negative regulation of transcription from RNA polymerase II promoter ISS
Inferred from Sequence or Structural Similarity
more info
 
neuromuscular junction development IEA
Inferred from Electronic Annotation
more info
 
neurotrophin TRK receptor signaling pathway TAS
Traceable Author Statement
more info
 
odontogenesis ISS
Inferred from Sequence or Structural Similarity
more info
 
orbitofrontal cortex development ISS
Inferred from Sequence or Structural Similarity
more info
 
organ growth ISS
Inferred from Sequence or Structural Similarity
more info
 
organ morphogenesis ISS
Inferred from Sequence or Structural Similarity
more info
 
otic vesicle formation ISS
Inferred from Sequence or Structural Similarity
more info
 
outflow tract septum morphogenesis ISS
Inferred from Sequence or Structural Similarity
more info
 
peptidyl-tyrosine phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
phosphatidylinositol-mediated signaling TAS
Traceable Author Statement
more info
 
positive regulation of ERK1 and ERK2 cascade ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of MAPK cascade IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of Wnt signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of canonical Wnt signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of cardiac muscle cell proliferation ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of cell cycle ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of cell division ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of cell proliferation IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of cell proliferation IGI
Inferred from Genetic Interaction
more info
PubMed 
positive regulation of cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of epithelial cell proliferation ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of epithelial cell proliferation involved in lung morphogenesis ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of mesenchymal cell proliferation ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of phospholipase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of smooth muscle cell proliferation IEA
Inferred from Electronic Annotation
more info
 
positive regulation of transcription from RNA polymerase II promoter ISS
Inferred from Sequence or Structural Similarity
more info
 
post-embryonic development ISS
Inferred from Sequence or Structural Similarity
more info
 
prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis ISS
Inferred from Sequence or Structural Similarity
more info
 
prostate epithelial cord elongation ISS
Inferred from Sequence or Structural Similarity
more info
 
prostate gland morphogenesis ISS
Inferred from Sequence or Structural Similarity
more info
 
protein autophosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
pyramidal neuron development ISS
Inferred from Sequence or Structural Similarity
more info
 
regulation of ERK1 and ERK2 cascade ISS
Inferred from Sequence or Structural Similarity
more info
 
regulation of branching involved in prostate gland morphogenesis ISS
Inferred from Sequence or Structural Similarity
more info
 
regulation of cell fate commitment ISS
Inferred from Sequence or Structural Similarity
more info
 
regulation of fibroblast growth factor receptor signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
 
regulation of morphogenesis of a branching structure ISS
Inferred from Sequence or Structural Similarity
more info
 
regulation of multicellular organism growth ISS
Inferred from Sequence or Structural Similarity
more info
 
regulation of osteoblast differentiation TAS
Traceable Author Statement
more info
PubMed 
regulation of osteoblast proliferation TAS
Traceable Author Statement
more info
PubMed 
regulation of smooth muscle cell differentiation ISS
Inferred from Sequence or Structural Similarity
more info
 
regulation of smoothened signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
 
reproductive structure development ISS
Inferred from Sequence or Structural Similarity
more info
 
skeletal system morphogenesis TAS
Traceable Author Statement
more info
PubMed 
squamous basal epithelial stem cell differentiation involved in prostate gland acinus development ISS
Inferred from Sequence or Structural Similarity
more info
 
synaptic vesicle transport IEA
Inferred from Electronic Annotation
more info
 
ureteric bud development ISS
Inferred from Sequence or Structural Similarity
more info
 
ventricular cardiac muscle tissue morphogenesis ISS
Inferred from Sequence or Structural Similarity
more info
 
ventricular zone neuroblast division ISS
Inferred from Sequence or Structural Similarity
more info
 
Component Evidence Code Pubs
Golgi apparatus IEA
Inferred from Electronic Annotation
more info
 
cell cortex IDA
Inferred from Direct Assay
more info
PubMed 
cell surface IDA
Inferred from Direct Assay
more info
PubMed 
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
cytoplasmic membrane-bounded vesicle IEA
Inferred from Electronic Annotation
more info
 
excitatory synapse ISS
Inferred from Sequence or Structural Similarity
more info
 
colocalizes_with extracellular matrix IDA
Inferred from Direct Assay
more info
PubMed 
extracellular region IEA
Inferred from Electronic Annotation
more info
 
integral component of membrane NAS
Non-traceable Author Statement
more info
PubMed 
integral component of plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
intracellular membrane-bounded organelle IDA
Inferred from Direct Assay
more info
 
membrane NAS
Non-traceable Author Statement
more info
PubMed 
nucleoplasm IDA
Inferred from Direct Assay
more info
 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 
plasma membrane TAS
Traceable Author Statement
more info
 
Preferred Names
fibroblast growth factor receptor 2
Names
BEK fibroblast growth factor receptor
FGF receptor
FGFR2-AHCYL1 fusion kinase protein
bacteria-expressed kinase
fibroblast growth factor receptor 2 isoform IgIIIc isoform
hydroxyaryl-protein kinase
keratinocyte growth factor receptor
protein tyrosine kinase, receptor like 14
soluble FGFR4 variant 4
NP_000132.3
NP_001138385.1
NP_001138386.1
NP_001138387.1
NP_001138388.1
NP_001138389.1
NP_001138390.1
NP_001138391.1
NP_075259.4
NP_075418.1

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_012449.1 RefSeqGene

    Range
    5001..125129
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_000141.4NP_000132.3  fibroblast growth factor receptor 2 isoform 1 precursor

    See identical proteins and their annotated locations for NP_000132.3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes isoform 1, also referred to as isoform BEK and K-sam.
    Source sequence(s)
    BC037338, BC039243, CB305736, CN345547, CX873387, M87770
    Consensus CDS
    CCDS31298.1
    UniProtKB/Swiss-Prot
    P21802
    Related
    ENSP00000351276, OTTHUMP00000020621, ENST00000358487, OTTHUMT00000050715
    Conserved Domains (7) summary
    cd04973
    Location:47124
    Ig1_FGFR; First immunoglobulin (Ig)-like domain of fibroblast growth factor receptor (FGFR)
    cd05857
    Location:164248
    Ig2_FGFR; Second immunoglobulin (Ig)-like domain of fibroblast growth factor (FGF) receptor
    cd05858
    Location:271360
    Ig3_FGFR-2; Third immunoglobulin (Ig)-like domain of fibroblast growth factor receptor 2 (FGFR2)
    smart00408
    Location:173238
    IGc2; Immunoglobulin C-2 Type
    smart00410
    Location:263359
    IG_like; Immunoglobulin like
    pfam07714
    Location:481757
    Pkinase_Tyr; Protein tyrosine kinase
    cd05101
    Location:456768
    PTKc_FGFR2; Catalytic domain of the Protein Tyrosine Kinase, Fibroblast Growth Factor Receptor 2
  2. NM_001144913.1NP_001138385.1  fibroblast growth factor receptor 2 isoform 3 precursor

    See identical proteins and their annotated locations for NP_001138385.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) uses an alternate internal in-frame coding exon (as in variant 2), and an alternate 3' terminal exon, compared to transcript variant 1. This results in an isoform (3) with a different, 1 aa longer protein segment in the mid-region, and a novel shorter C-terminus, compared to isoform 1.
    Source sequence(s)
    AC009988, AK026508, M97193, U11814, X56191
    Consensus CDS
    CCDS44489.1
    UniProtKB/Swiss-Prot
    P21802
    Related
    ENSP00000358052, OTTHUMP00000020626, ENST00000369056, OTTHUMT00000050720
    Conserved Domains (7) summary
    cd04973
    Location:47124
    Ig1_FGFR; First immunoglobulin (Ig)-like domain of fibroblast growth factor receptor (FGFR)
    cd04974
    Location:271358
    Ig3_FGFR; Third immunoglobulin (Ig)-like domain of fibroblast growth factor receptor (FGFR)
    cd05857
    Location:164248
    Ig2_FGFR; Second immunoglobulin (Ig)-like domain of fibroblast growth factor (FGF) receptor
    smart00408
    Location:173238
    IGc2; Immunoglobulin C-2 Type
    smart00410
    Location:263357
    IG_like; Immunoglobulin like
    pfam07714
    Location:482758
    Pkinase_Tyr; Protein tyrosine kinase
    cd05101
    Location:457768
    PTKc_FGFR2; Catalytic domain of the Protein Tyrosine Kinase, Fibroblast Growth Factor Receptor 2
  3. NM_001144914.1NP_001138386.1  fibroblast growth factor receptor 2 isoform 4 precursor

    See identical proteins and their annotated locations for NP_001138386.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) is missing two consecutive in-frame coding exons compared to transcript variant 1. This results in a shorter isoform (4) lacking an internal protein segment compared to isoform 1.
    Source sequence(s)
    AB084153, BC037338, CB305736, M97193, U11814
    Consensus CDS
    CCDS44486.1
    UniProtKB/Swiss-Prot
    P21802
    Related
    ENSP00000358057, ENST00000369061
    Conserved Domains (5) summary
    cd04973
    Location:47124
    Ig1_FGFR; First immunoglobulin (Ig)-like domain of fibroblast growth factor receptor (FGFR)
    cd05857
    Location:164248
    Ig2_FGFR; Second immunoglobulin (Ig)-like domain of fibroblast growth factor (FGF) receptor
    smart00408
    Location:173238
    IGc2; Immunoglobulin C-2 Type
    pfam07714
    Location:369645
    Pkinase_Tyr; Protein tyrosine kinase
    cd05101
    Location:344656
    PTKc_FGFR2; Catalytic domain of the Protein Tyrosine Kinase, Fibroblast Growth Factor Receptor 2
  4. NM_001144915.1NP_001138387.1  fibroblast growth factor receptor 2 isoform 5 precursor

    See identical proteins and their annotated locations for NP_001138387.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) uses an alternate 5' terminal non-coding exon, and is missing an internal in-frame coding exon, compared to transcript variant 1. This results in a shorter isoform (5) lacking an internal protein segment compared to isoform 1.
    Source sequence(s)
    AK294026, BC037338, CB305736, M87770
    Consensus CDS
    CCDS53584.1
    UniProtKB/Swiss-Prot
    P21802
    Related
    ENSP00000350166, ENST00000357555
    Conserved Domains (6) summary
    cd05857
    Location:75159
    Ig2_FGFR; Second immunoglobulin (Ig)-like domain of fibroblast growth factor (FGF) receptor
    cd05858
    Location:182271
    Ig3_FGFR-2; Third immunoglobulin (Ig)-like domain of fibroblast growth factor receptor 2 (FGFR2)
    smart00408
    Location:84149
    IGc2; Immunoglobulin C-2 Type
    smart00410
    Location:174270
    IG_like; Immunoglobulin like
    pfam07714
    Location:392668
    Pkinase_Tyr; Protein tyrosine kinase
    cd05101
    Location:367679
    PTKc_FGFR2; Catalytic domain of the Protein Tyrosine Kinase, Fibroblast Growth Factor Receptor 2
  5. NM_001144916.1NP_001138388.1  fibroblast growth factor receptor 2 isoform 6 precursor

    See identical proteins and their annotated locations for NP_001138388.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (6) uses an alternate 5' terminal exon, and is missing two consecutive in-frame coding exons, compared to transcript variant 1. This results in a shorter isoform (6) lacking an internal protein segment compared to isoform 1.
    Source sequence(s)
    AK308621, BC037338, CB305736, M97193
    UniProtKB/Swiss-Prot
    P21802
    Conserved Domains (6) summary
    cd05857
    Location:49133
    Ig2_FGFR; Second immunoglobulin (Ig)-like domain of fibroblast growth factor (FGF) receptor
    cd05858
    Location:156245
    Ig3_FGFR-2; Third immunoglobulin (Ig)-like domain of fibroblast growth factor receptor 2 (FGFR2)
    smart00408
    Location:58123
    IGc2; Immunoglobulin C-2 Type
    smart00410
    Location:148244
    IG_like; Immunoglobulin like
    pfam07714
    Location:366642
    Pkinase_Tyr; Protein tyrosine kinase
    cd05101
    Location:341653
    PTKc_FGFR2; Catalytic domain of the Protein Tyrosine Kinase, Fibroblast Growth Factor Receptor 2
  6. NM_001144917.1NP_001138389.1  fibroblast growth factor receptor 2 isoform 7 precursor

    See identical proteins and their annotated locations for NP_001138389.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (7) is missing two consecutive in-frame coding exons compared to transcript variant 1. This results in a shorter isoform (7) lacking an internal protein segment compared to isoform 1.
    Source sequence(s)
    BC037338, BC039243, CB305736, CN345547, M87771, U11814
    Consensus CDS
    CCDS44487.1
    UniProtKB/Swiss-Prot
    P21802
    Conserved Domains (6) summary
    cd04973
    Location:47124
    Ig1_FGFR; First immunoglobulin (Ig)-like domain of fibroblast growth factor receptor (FGFR)
    cd05857
    Location:164248
    Ig2_FGFR; Second immunoglobulin (Ig)-like domain of fibroblast growth factor (FGF) receptor
    smart00408
    Location:173238
    IGc2; Immunoglobulin C-2 Type
    pfam07714
    Location:365641
    Pkinase_Tyr; Protein tyrosine kinase
    cd05101
    Location:340652
    PTKc_FGFR2; Catalytic domain of the Protein Tyrosine Kinase, Fibroblast Growth Factor Receptor 2
    cl11960
    Location:271363
    Ig; Immunoglobulin domain
  7. NM_001144918.1NP_001138390.1  fibroblast growth factor receptor 2 isoform 8 precursor

    See identical proteins and their annotated locations for NP_001138390.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (8) is missing two consecutive in-frame coding exons, and uses an alternate in-frame donor splice site at another coding exon, compared to transcript variant 1. This results in a shorter isoform (8) lacking an internal protein segment and additional 2 aa, compared to isoform 1.
    Source sequence(s)
    BC037338, BC039243, CB305736, CN345547, U11814
    Consensus CDS
    CCDS44485.1
    UniProtKB/Swiss-Prot
    P21802
    Related
    ENSP00000348559, OTTHUMP00000020631, ENST00000356226, OTTHUMT00000050726
    Conserved Domains (6) summary
    cd05857
    Location:49133
    Ig2_FGFR; Second immunoglobulin (Ig)-like domain of fibroblast growth factor (FGF) receptor
    cd05858
    Location:156245
    Ig3_FGFR-2; Third immunoglobulin (Ig)-like domain of fibroblast growth factor receptor 2 (FGFR2)
    smart00408
    Location:58123
    IGc2; Immunoglobulin C-2 Type
    smart00410
    Location:148244
    IG_like; Immunoglobulin like
    pfam07714
    Location:364640
    Pkinase_Tyr; Protein tyrosine kinase
    cd05101
    Location:339651
    PTKc_FGFR2; Catalytic domain of the Protein Tyrosine Kinase, Fibroblast Growth Factor Receptor 2
  8. NM_001144919.1NP_001138391.1  fibroblast growth factor receptor 2 isoform 9 precursor

    See identical proteins and their annotated locations for NP_001138391.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (9) is missing an in-frame coding exon, uses an alternate internal in-frame coding exon (as in variant 2) and an alternate 3' terminal exon, compared to transcript variant 1. This results in a shorter isoform (9), which differs in two internal segments, and has a novel C-terminus compared to isoform 1.
    Source sequence(s)
    AC009988, AK026508, BC039243, CN345547, U11814
    Consensus CDS
    CCDS44488.1
    UniProtKB/Swiss-Prot
    P21802
    Related
    ENSP00000353262, OTTHUMP00000020624, ENST00000360144, OTTHUMT00000050718
    Conserved Domains (6) summary
    cd04974
    Location:182269
    Ig3_FGFR; Third immunoglobulin (Ig)-like domain of fibroblast growth factor receptor (FGFR)
    cd05857
    Location:75159
    Ig2_FGFR; Second immunoglobulin (Ig)-like domain of fibroblast growth factor (FGF) receptor
    smart00408
    Location:84149
    IGc2; Immunoglobulin C-2 Type
    smart00410
    Location:174268
    IG_like; Immunoglobulin like
    pfam07714
    Location:393669
    Pkinase_Tyr; Protein tyrosine kinase
    cd05101
    Location:368679
    PTKc_FGFR2; Catalytic domain of the Protein Tyrosine Kinase, Fibroblast Growth Factor Receptor 2
  9. NM_022970.3NP_075259.4  fibroblast growth factor receptor 2 isoform 2 precursor

    See identical proteins and their annotated locations for NP_075259.4

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) uses an alternate internal in-frame coding exon compared to transcript variant 1, resulting in an isoform (2, also known as isoform K-sam-IIH1, IIIb, and BFR-1) with a different, 1 aa longer protein segment in the mid-region compared to isoform 1.
    Source sequence(s)
    BC037338, BC039243, CB305736, CN345547, M55614, M80634
    Consensus CDS
    CCDS7620.2
    UniProtKB/Swiss-Prot
    P21802
    Conserved Domains (7) summary
    cd04973
    Location:47124
    Ig1_FGFR; First immunoglobulin (Ig)-like domain of fibroblast growth factor receptor (FGFR)
    cd04974
    Location:271358
    Ig3_FGFR; Third immunoglobulin (Ig)-like domain of fibroblast growth factor receptor (FGFR)
    cd05857
    Location:164248
    Ig2_FGFR; Second immunoglobulin (Ig)-like domain of fibroblast growth factor (FGF) receptor
    smart00408
    Location:173238
    IGc2; Immunoglobulin C-2 Type
    smart00410
    Location:263357
    IG_like; Immunoglobulin like
    pfam07714
    Location:482758
    Pkinase_Tyr; Protein tyrosine kinase
    cd05101
    Location:457769
    PTKc_FGFR2; Catalytic domain of the Protein Tyrosine Kinase, Fibroblast Growth Factor Receptor 2
  10. NM_023029.2NP_075418.1  fibroblast growth factor receptor 2 isoform 11 precursor

    See identical proteins and their annotated locations for NP_075418.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (11) lacks an in-frame coding exon in the 5' region, compared to variant 1. This results in a shorter isoform (11) lacking an internal protein segment compared to isoform 1.
    Source sequence(s)
    AC009988, AK308621, BC039243, CB305736, EF057068
    Consensus CDS
    CCDS73210.1
    UniProtKB/TrEMBL
    D2CGD1
    UniProtKB/Swiss-Prot
    P21802
    Related
    ENSP00000484154, ENST00000613048
    Conserved Domains (6) summary
    cd05857
    Location:75159
    Ig2_FGFR; Second immunoglobulin (Ig)-like domain of fibroblast growth factor (FGF) receptor
    cd05858
    Location:182271
    Ig3_FGFR-2; Third immunoglobulin (Ig)-like domain of fibroblast growth factor receptor 2 (FGFR2)
    smart00408
    Location:84149
    IGc2; Immunoglobulin C-2 Type
    smart00410
    Location:174270
    IG_like; Immunoglobulin like
    pfam07714
    Location:392668
    Pkinase_Tyr; Protein tyrosine kinase
    cd05101
    Location:367679
    PTKc_FGFR2; Catalytic domain of the Protein Tyrosine Kinase, Fibroblast Growth Factor Receptor 2

RNA

  1. NR_073009.1 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (14) lacks two consecutive exons in the 5' region and has an additional exon in the center region, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most supported translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AB030073, AC009988, BC039243, BC096749, CB305736, M87771, U11814, X52832

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 107

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p2 Primary Assembly

Genomic

  1. NC_000010.11 Reference GRCh38.p2 Primary Assembly

    Range
    121478330..121598656
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006717709.2XP_006717772.1  

    See identical proteins and their annotated locations for XP_006717772.1

    UniProtKB/TrEMBL
    D3DRD5
    Conserved Domains (7) summary
    cd04973
    Location:66143
    Ig1_FGFR; First immunoglobulin (Ig)-like domain of fibroblast growth factor receptor (FGFR)
    cd05857
    Location:183267
    Ig2_FGFR; Second immunoglobulin (Ig)-like domain of fibroblast growth factor (FGF) receptor
    cd05858
    Location:290379
    Ig3_FGFR-2; Third immunoglobulin (Ig)-like domain of fibroblast growth factor receptor 2 (FGFR2)
    smart00408
    Location:192257
    IGc2; Immunoglobulin C-2 Type
    smart00410
    Location:282378
    IG_like; Immunoglobulin like
    pfam07714
    Location:498774
    Pkinase_Tyr; Protein tyrosine kinase
    cd05101
    Location:473785
    PTKc_FGFR2; Catalytic domain of the Protein Tyrosine Kinase, Fibroblast Growth Factor Receptor 2
  2. XM_006717708.2XP_006717771.1  

    Conserved Domains (7) summary
    cd04973
    Location:66143
    Ig1_FGFR; First immunoglobulin (Ig)-like domain of fibroblast growth factor receptor (FGFR)
    cd04974
    Location:290377
    Ig3_FGFR; Third immunoglobulin (Ig)-like domain of fibroblast growth factor receptor (FGFR)
    cd05857
    Location:183267
    Ig2_FGFR; Second immunoglobulin (Ig)-like domain of fibroblast growth factor (FGF) receptor
    smart00408
    Location:192257
    IGc2; Immunoglobulin C-2 Type
    smart00410
    Location:282376
    IG_like; Immunoglobulin like
    pfam07714
    Location:499775
    Pkinase_Tyr; Protein tyrosine kinase
    cd05101
    Location:474786
    PTKc_FGFR2; Catalytic domain of the Protein Tyrosine Kinase, Fibroblast Growth Factor Receptor 2
  3. XM_006717712.2XP_006717775.1  

    Conserved Domains (6) summary
    cd04974
    Location:175262
    Ig3_FGFR; Third immunoglobulin (Ig)-like domain of fibroblast growth factor receptor (FGFR)
    cd05857
    Location:68152
    Ig2_FGFR; Second immunoglobulin (Ig)-like domain of fibroblast growth factor (FGF) receptor
    smart00408
    Location:77142
    IGc2; Immunoglobulin C-2 Type
    smart00410
    Location:167261
    IG_like; Immunoglobulin like
    pfam07714
    Location:386662
    Pkinase_Tyr; Protein tyrosine kinase
    cd05101
    Location:361673
    PTKc_FGFR2; Catalytic domain of the Protein Tyrosine Kinase, Fibroblast Growth Factor Receptor 2
  4. XM_006717711.2XP_006717774.1  

    Conserved Domains (6) summary
    cd04974
    Location:201288
    Ig3_FGFR; Third immunoglobulin (Ig)-like domain of fibroblast growth factor receptor (FGFR)
    cd05857
    Location:94178
    Ig2_FGFR; Second immunoglobulin (Ig)-like domain of fibroblast growth factor (FGF) receptor
    smart00408
    Location:103168
    IGc2; Immunoglobulin C-2 Type
    smart00410
    Location:193287
    IG_like; Immunoglobulin like
    pfam07714
    Location:412688
    Pkinase_Tyr; Protein tyrosine kinase
    cd05101
    Location:387699
    PTKc_FGFR2; Catalytic domain of the Protein Tyrosine Kinase, Fibroblast Growth Factor Receptor 2
  5. XM_011539510.1XP_011537812.1  

    UniProtKB/TrEMBL
    S4R381
    Related
    ENSP00000474011, OTTHUMP00000272645, ENST00000478859, OTTHUMT00000050722
    Conserved Domains (4) summary
    cd05858
    Location:43132
    Ig3_FGFR-2; Third immunoglobulin (Ig)-like domain of fibroblast growth factor receptor 2 (FGFR2)
    smart00410
    Location:35131
    IG_like; Immunoglobulin like
    pfam07714
    Location:253529
    Pkinase_Tyr; Protein tyrosine kinase
    cd05101
    Location:228540
    PTKc_FGFR2; Catalytic domain of the Protein Tyrosine Kinase, Fibroblast Growth Factor Receptor 2
  6. XM_006717713.2XP_006717776.1  

    Conserved Domains (7) summary
    cd04973
    Location:66143
    Ig1_FGFR; First immunoglobulin (Ig)-like domain of fibroblast growth factor receptor (FGFR)
    cd05857
    Location:183267
    Ig2_FGFR; Second immunoglobulin (Ig)-like domain of fibroblast growth factor (FGF) receptor
    cd05858
    Location:290379
    Ig3_FGFR-2; Third immunoglobulin (Ig)-like domain of fibroblast growth factor receptor 2 (FGFR2)
    smart00408
    Location:192257
    IGc2; Immunoglobulin C-2 Type
    smart00410
    Location:282378
    IG_like; Immunoglobulin like
    pfam07714
    Location:500776
    Pkinase_Tyr; Protein tyrosine kinase
    cd05101
    Location:475787
    PTKc_FGFR2; Catalytic domain of the Protein Tyrosine Kinase, Fibroblast Growth Factor Receptor 2
  7. XM_006717710.2XP_006717773.1  

    Related
    ENSP00000410294, OTTHUMP00000020629, ENST00000457416, OTTHUMT00000050724
    Conserved Domains (7) summary
    cd04973
    Location:66143
    Ig1_FGFR; First immunoglobulin (Ig)-like domain of fibroblast growth factor receptor (FGFR)
    cd04974
    Location:290377
    Ig3_FGFR; Third immunoglobulin (Ig)-like domain of fibroblast growth factor receptor (FGFR)
    cd05857
    Location:183267
    Ig2_FGFR; Second immunoglobulin (Ig)-like domain of fibroblast growth factor (FGF) receptor
    smart00408
    Location:192257
    IGc2; Immunoglobulin C-2 Type
    smart00410
    Location:282376
    IG_like; Immunoglobulin like
    pfam07714
    Location:501777
    Pkinase_Tyr; Protein tyrosine kinase
    cd05101
    Location:476788
    PTKc_FGFR2; Catalytic domain of the Protein Tyrosine Kinase, Fibroblast Growth Factor Receptor 2

Alternate CHM1_1.1

Genomic

  1. NC_018921.2 Alternate CHM1_1.1

    Range
    123522903..123642701
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_022971.1: Suppressed sequence

    Description
    NM_022971.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.
  2. NM_022972.1: Suppressed sequence

    Description
    NM_022972.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.
  3. NM_022973.1: Suppressed sequence

    Description
    NM_022973.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.
  4. NM_022974.1: Suppressed sequence

    Description
    NM_022974.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.
  5. NM_022975.2: Suppressed sequence

    Description
    NM_022975.2: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.
  6. NM_022976.1: Suppressed sequence

    Description
    NM_022976.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.
  7. NM_023028.1: Suppressed sequence

    Description
    NM_023028.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.
  8. NM_023030.1: Suppressed sequence

    Description
    NM_023030.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.