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FGFR2 fibroblast growth factor receptor 2 [ Homo sapiens (human) ]

Gene ID: 2263, updated on 26-Nov-2014
Official Symbol
FGFR2provided by HGNC
Official Full Name
fibroblast growth factor receptor 2provided by HGNC
Primary source
HGNC:HGNC:3689
See related
Ensembl:ENSG00000066468; HPRD:01492; MIM:176943; Vega:OTTHUMG00000019175
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
BEK; JWS; BBDS; CEK3; CFD1; ECT1; KGFR; TK14; TK25; BFR-1; CD332; K-SAM
Summary
The protein encoded by this gene is a member of the fibroblast growth factor receptor family, where amino acid sequence is highly conserved between members and throughout evolution. FGFR family members differ from one another in their ligand affinities and tissue distribution. A full-length representative protein consists of an extracellular region, composed of three immunoglobulin-like domains, a single hydrophobic membrane-spanning segment and a cytoplasmic tyrosine kinase domain. The extracellular portion of the protein interacts with fibroblast growth factors, setting in motion a cascade of downstream signals, ultimately influencing mitogenesis and differentiation. This particular family member is a high-affinity receptor for acidic, basic and/or keratinocyte growth factor, depending on the isoform. Mutations in this gene are associated with Crouzon syndrome, Pfeiffer syndrome, Craniosynostosis, Apert syndrome, Jackson-Weiss syndrome, Beare-Stevenson cutis gyrata syndrome, Saethre-Chotzen syndrome, and syndromic craniosynostosis. Multiple alternatively spliced transcript variants encoding different isoforms have been noted for this gene. [provided by RefSeq, Jan 2009]
See FGFR2 in Epigenomics, MapViewer
Location:
10q26
Exon count:
21
Annotation release Status Assembly Chr Location
106 current GRCh38 (GCF_000001405.26) 10 NC_000010.11 (121478330..121598458, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (123237844..123357972, complement)

Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene ribosomal protein L19 pseudogene 16 Neighboring gene long intergenic non-protein coding RNA 1153 Neighboring gene ribosomal protein S15a pseudogene 5 Neighboring gene arginyltransferase 1

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Associated conditions

Description Tests
Acrocephalosyndactyly type I Compare labs
Antley-Bixler syndrome without genital anomalies or disordered steroidogenesis Compare labs
Bent bone dysplasia syndrome
MedGen: C3281247 OMIM: 614592 GeneReviews: Not available
Compare labs
Crouzon syndrome Compare labs
Cutis Gyrata syndrome of Beare and Stevenson Compare labs
Isolated coronal synostosis Compare labs
Jackson-Weiss syndrome Compare labs
Levy-Hollister syndrome
MedGen: C0265269 OMIM: 149730 GeneReviews: Not available
Compare labs
Neoplasm of stomach
MedGen: C0038356 OMIM: 613659 GeneReviews: Not available
Compare labs
Pfeiffer syndrome Compare labs
Saethre-Chotzen syndrome
MedGen: C0175699 OMIM: 101400 GeneReviews: Saethre-Chotzen Syndrome
Compare labs
Scaphocephaly, maxillary retrusion, and mental retardation
MedGen: C1865070 OMIM: 609579 GeneReviews: Not available
Compare labs

NHGRI GWAS Catalog

Description
A combined analysis of genome-wide association studies in breast cancer.
NHGRI GWA Catalog
A genome-wide association study identifies a genetic variant in the SIAH2 locus associated with hormonal receptor-positive breast cancer in Japanese.
NHGRI GWA Catalog
A genome-wide association study identifies alleles in FGFR2 associated with risk of sporadic postmenopausal breast cancer.
NHGRI GWA Catalog
A genome-wide association study of early-onset breast cancer identifies PFKM as a novel breast cancer gene and supports a common genetic spectrum for breast cancer at any age.
NHGRI GWA Catalog
A meta-analysis of genome-wide association studies for adiponectin levels in East Asians identifies a novel locus near WDR11-FGFR2.
NHGRI GWA Catalog
A multistage genome-wide association study in breast cancer identifies two new risk alleles at 1p11.2 and 14q24.1 (RAD51L1).
NHGRI GWA Catalog
Common genetic variants and modification of penetrance of BRCA2-associated breast cancer.
NHGRI GWA Catalog
Genetic correction of PSA values using sequence variants associated with PSA levels.
NHGRI GWA Catalog
Genetic variants associated with breast cancer risk for Ashkenazi Jewish women with strong family histories but no identifiable BRCA1/2 mutation.
NHGRI GWA Catalog
Genome-wide association analyses identify 18 new loci associated with serum urate concentrations.
NHGRI GWA Catalog
Genome-wide association study identifies five new breast cancer susceptibility loci.
NHGRI GWA Catalog
Genome-wide association study identifies novel breast cancer susceptibility loci.
NHGRI GWA Catalog
Genome-wide association study of breast cancer in the Japanese population.
NHGRI GWA Catalog
Large-scale genotyping identifies 41 new loci associated with breast cancer risk.
NHGRI GWA Catalog
Novel breast cancer susceptibility locus at 9q31.2: results of a genome-wide association study.
NHGRI GWA Catalog
  • Activated point mutants of FGFR2, organism-specific biosystem (from REACTOME)
    Activated point mutants of FGFR2, organism-specific biosystemAutosomal dominant mutations in FGFR2 are associated with the development of a range of skeletal disorders including Beare-Stevensen cutis gyrata syndrome, Pfeiffer syndrome, Jackson-Weiss syndrome, ...
  • Adaptive Immune System, organism-specific biosystem (from REACTOME)
    Adaptive Immune System, organism-specific biosystemAdaptive immunity refers to antigen-specific immune response efficiently involved in clearing the pathogens. The adaptive immune system is comprised of B and T lymphocytes that express receptors with...
  • Angiogenesis, organism-specific biosystem (from WikiPathways)
    Angiogenesis, organism-specific biosystemThis pathway is a concise and simplified version of the basic proteins involved in angiogenesis. The proces is regulated by hyopoxia, which results in the transcription of eg. VEGF1, FGF2, PDGFbeta, ...
  • Constitutive PI3K/AKT Signaling in Cancer, organism-specific biosystem (from REACTOME)
    Constitutive PI3K/AKT Signaling in Cancer, organism-specific biosystemClass IA PI3K is a heterodimer of a p85 regulatory subunit (encoded by PIK3R1, PIK3R2 or PIK3R3) and a p110 catalytic subunit (encoded by PIK3CA, PIK3CB or PIK3CD). In the absence of activating signa...
  • DAP12 interactions, organism-specific biosystem (from REACTOME)
    DAP12 interactions, organism-specific biosystemDNAX activation protein of 12kDa (DAP12) is an immunoreceptor tyrosine-based activation motif (ITAM)-bearing adapter molecule that transduces activating signals in natural killer (NK) and myeloid cel...
  • DAP12 signaling, organism-specific biosystem (from REACTOME)
    DAP12 signaling, organism-specific biosystemIn response to receptor ligation, the tyrosine residues in DAP12's immunoreceptor tyrosine-based activation motif (ITAM) are phosphorylated by Src family kinases. These phosphotyrosines form the dock...
  • Disease, organism-specific biosystem (from REACTOME)
    Disease, organism-specific biosystemBiological processes are captured in Reactome by identifying the molecules (DNA, RNA, protein, small molecules) involved in them and describing the details of their interactions. From this molecular ...
  • Downstream signal transduction, organism-specific biosystem (from REACTOME)
    Downstream signal transduction, organism-specific biosystemThe role of autophosphorylation sites on PDGF receptors are to provide docking sites for downstream signal transduction molecules which contain SH2 domains. The SH2 domain is a conserved motif of aro...
  • Downstream signaling events of B Cell Receptor (BCR), organism-specific biosystem (from REACTOME)
    Downstream signaling events of B Cell Receptor (BCR), organism-specific biosystemSecond messengers (calcium, diacylglycerol, inositol 1,4,5-trisphosphate, and phosphatidyinositol 3,4,5-trisphosphate) trigger signaling pathways: NF-kappaB is activated via protein kinase C beta, RA...
  • Downstream signaling of activated FGFR, organism-specific biosystem (from REACTOME)
    Downstream signaling of activated FGFR, organism-specific biosystemSignaling via FGFRs is mediated via direct recruitment of signaling proteins that bind to tyrosine auto-phosphorylation sites on the activated receptor and via closely linked docking proteins that be...
  • Endocytosis, organism-specific biosystem (from KEGG)
    Endocytosis, organism-specific biosystemEndocytosis is a mechanism for cells to remove ligands, nutrients, and plasma membrane (PM) proteins, and lipids from the cell surface, bringing them into the cell interior. Transmembrane proteins en...
  • Endocytosis, conserved biosystem (from KEGG)
    Endocytosis, conserved biosystemEndocytosis is a mechanism for cells to remove ligands, nutrients, and plasma membrane (PM) proteins, and lipids from the cell surface, bringing them into the cell interior. Transmembrane proteins en...
  • FGF signaling pathway, organism-specific biosystem (from Pathway Interaction Database)
    FGF signaling pathway, organism-specific biosystem
    FGF signaling pathway
  • FGFR ligand binding and activation, organism-specific biosystem (from REACTOME)
    FGFR ligand binding and activation, organism-specific biosystemThe FGFs are a family of 22 secreted glycoproteins that are sequestered in the extracellular matrix (ECM) through their interaction with heparin and heparin sulphate proteoglycans (HSPGs). Release o...
  • FGFR2 ligand binding and activation, organism-specific biosystem (from REACTOME)
    FGFR2 ligand binding and activation, organism-specific biosystemDominant mutations in the fibroblast growth factor receptor 2 (FGFR2) gene have been identified as causes of four phenotypically distinct craniosynostosis syndromes, including Crouzon, Jackson- Weiss...
  • FGFR2b ligand binding and activation, organism-specific biosystem (from REACTOME)
    FGFR2b ligand binding and activation, organism-specific biosystemThis pathway depicts the binding of an experimentally-verified range of ligands to FGFR2b. While binding affinities may vary considerably within this set, the ligands listed have been established to ...
  • FGFR2c ligand binding and activation, organism-specific biosystem (from REACTOME)
    FGFR2c ligand binding and activation, organism-specific biosystemThis pathway depicts the binding of an experimentally-verified range of ligands to FGFR2c. While binding affinities may vary considerably within this set, the ligands listed have been established to ...
  • FRS2-mediated cascade, organism-specific biosystem (from REACTOME)
    FRS2-mediated cascade, organism-specific biosystemThe FRS family of scaffolding adaptor proteins has two members, FRS2alpha and FRS2beta (also known as FRS3 or SNT-2). Activation of FGFR tyrosine kinase allows FRS2 proteins to become phosphorylated...
  • Fc epsilon receptor (FCERI) signaling, organism-specific biosystem (from REACTOME)
    Fc epsilon receptor (FCERI) signaling, organism-specific biosystemMast cells (MC) are distributed in tissues throughout the human body and have long been recognized as key cells of type I hypersensitivity reactions. They also play important roles in inflammatory an...
  • GAB1 signalosome, organism-specific biosystem (from REACTOME)
    GAB1 signalosome, organism-specific biosystemGAB1 is recruited to the activated EGFR indirectly, through GRB2. GAB1 acts as an adaptor protein that enables formation of an active PIK3, through recruitment of PIK3 regulatory subunit PIK3R1 (also...
  • IGF1R signaling cascade, organism-specific biosystem (from REACTOME)
    IGF1R signaling cascade, organism-specific biosystemAfter autophosphorylation the type 1 insulin-like growth factor receptor (IGF1R) binds and phosphorylates scaffold proteins, IRS1/2/4 and SHC1, which in turn bind effectors possessing enzymatic activ...
  • IRS-mediated signalling, organism-specific biosystem (from REACTOME)
    IRS-mediated signalling, organism-specific biosystemRelease of phospho-IRS from the insulin receptor triggers a cascade of signalling events via PI3K, SOS, RAF and the MAP kinases.
  • IRS-related events, organism-specific biosystem (from REACTOME)
    IRS-related events, organism-specific biosystemIRS is one of the mediators of insulin signalling events. It is activated by phosphorylation and triggers a cascade of events involving PI3K, SOS, RAF and the MAP kinases. The proteins mentioned unde...
  • IRS-related events triggered by IGF1R, organism-specific biosystem (from REACTOME)
    IRS-related events triggered by IGF1R, organism-specific biosystemThe phosphorylated type 1 insulin-like growth factor receptor phosphorylates IR1, IRS2, IRS4 and possibly other IRS/DOK family members (reviewed in Pavelic et al. 2007, Chitnis et al. 2008, Maki et a...
  • Immune System, organism-specific biosystem (from REACTOME)
    Immune System, organism-specific biosystemHumans are exposed to millions of potential pathogens daily, through contact, ingestion, and inhalation. Our ability to avoid infection depends on the adaptive immune system and during the first crit...
  • Innate Immune System, organism-specific biosystem (from REACTOME)
    Innate Immune System, organism-specific biosystemInnate immunity encompases the nonspecific part of immunity tha are part of an individual's natural biologic makeup
  • Insulin receptor signalling cascade, organism-specific biosystem (from REACTOME)
    Insulin receptor signalling cascade, organism-specific biosystemAutophosphorylation of the insulin receptor triggers a series of signalling events, mediated by SHC or IRS, and resulting in activation of the Ras/RAF and MAP kinase cascades. A second effect of the ...
  • MAPK signaling pathway, organism-specific biosystem (from KEGG)
    MAPK signaling pathway, organism-specific biosystemThe mitogen-activated protein kinase (MAPK) cascade is a highly conserved module that is involved in various cellular functions, including cell proliferation, differentiation and migration. Mammals e...
  • MAPK signaling pathway, conserved biosystem (from KEGG)
    MAPK signaling pathway, conserved biosystemThe mitogen-activated protein kinase (MAPK) cascade is a highly conserved module that is involved in various cellular functions, including cell proliferation, differentiation and migration. Mammals e...
  • MicroRNAs in cardiomyocyte hypertrophy, organism-specific biosystem (from WikiPathways)
    MicroRNAs in cardiomyocyte hypertrophy, organism-specific biosystemThis pathway shows the role of microRNAs in the process of cardiac hypertrophy. MicroRNA targets were predicted by the TargetScan algorithm, and the predicted interactions are shown in red dashed lin...
  • NGF signalling via TRKA from the plasma membrane, organism-specific biosystem (from REACTOME)
    NGF signalling via TRKA from the plasma membrane, organism-specific biosystemTrk receptors signal from the plasma membrane and from intracellular membranes, particularly from early endosomes. Signalling from the plasma membrane is fast but transient; signalling from endosomes...
  • Negative regulation of FGFR signaling, organism-specific biosystem (from REACTOME)
    Negative regulation of FGFR signaling, organism-specific biosystemOnce activated, the FGFR signaling pathway is regulated by numerous negative feedback mechanisms. These include downregulation of receptors through CBL-mediated ubiquitination and endocytosis, ERK-m...
  • Neural Crest Differentiation, organism-specific biosystem (from WikiPathways)
    Neural Crest Differentiation, organism-specific biosystemGene regulatory network model of cranial neural crest cell (CNCC) development, adaped from PMID: 19575671. Most interactions in the model are proposed to regulate transcription of core factors involv...
  • PI-3K cascade, organism-specific biosystem (from REACTOME)
    PI-3K cascade, organism-specific biosystemThe ability of growth factors to protect from apoptosis is primarily due to the activation of the AKT survival pathway. P-I-3-kinase dependent activation of PDK leads to the activation of AKT which i...
  • PI3K Cascade, organism-specific biosystem (from REACTOME)
    PI3K Cascade, organism-specific biosystem
    PI3K Cascade
  • PI3K events in ERBB2 signaling, organism-specific biosystem (from REACTOME)
    PI3K events in ERBB2 signaling, organism-specific biosystemERBB2:ERBB3 and ERBB2:ERBB4cyt1 heterodimers activate PI3K signaling by direct binding of PI3K regulatory subunit p85 (Yang et al. 2007, Cohen et al. 1996, Kaushansky et al. 2008) to phosphorylated t...
  • PI3K events in ERBB4 signaling, organism-specific biosystem (from REACTOME)
    PI3K events in ERBB4 signaling, organism-specific biosystemThe CYT1 isoforms of ERBB4 possess a C-tail tyrosine residue that, upon trans-autophosphorylation, serves as a docking site for the p85 alpha subunit of PI3K - PIK3R1 (Kaushansky et al. 2008, Cohen e...
  • PI3K-Akt signaling pathway, organism-specific biosystem (from KEGG)
    PI3K-Akt signaling pathway, organism-specific biosystemThe phosphatidylinositol 3' -kinase(PI3K)-Akt signaling pathway is activated by many types of cellular stimuli or toxic insults and regulates fundamental cellular functions such as transcription, tra...
  • PI3K-Akt signaling pathway, conserved biosystem (from KEGG)
    PI3K-Akt signaling pathway, conserved biosystemThe phosphatidylinositol 3' -kinase(PI3K)-Akt signaling pathway is activated by many types of cellular stimuli or toxic insults and regulates fundamental cellular functions such as transcription, tra...
  • PI3K/AKT Signaling in Cancer, organism-specific biosystem (from REACTOME)
    PI3K/AKT Signaling in Cancer, organism-specific biosystemThis pathway describes how normal signaling by PI3K/AKT, presented in the contained module 'PIP3 Activates AKT Signaling' and recently reviewed by Manning and Cantley in 2007, is perturbed in cancer,...
  • PI3K/AKT activation, organism-specific biosystem (from REACTOME)
    PI3K/AKT activation, organism-specific biosystemPI3K/AKT signalling is a major regulator of neuron survival. It blocks cell death by both impinging on the cytoplasmic cell death machinery and by regulating the expression of genes involved in cell...
  • PIP3 activates AKT signaling, organism-specific biosystem (from REACTOME)
    PIP3 activates AKT signaling, organism-specific biosystemSignaling by AKT is one of the key outcomes of receptor tyrosine kinase (RTK) activation. AKT is activated by the cellular second messenger PIP3, a phospholipid that is generated by PI3K. In ustimula...
  • Pathways in cancer, organism-specific biosystem (from KEGG)
    Pathways in cancer, organism-specific biosystem
    Pathways in cancer
  • Phospholipase C-mediated cascade, organism-specific biosystem (from REACTOME)
    Phospholipase C-mediated cascade, organism-specific biosystemPhospholipase C-gamma (PLC-gamma) is a substrate of the fibroblast growth factor receptor (FGFR) and other receptors with tyrosine kinase activity. It is known that the src homology region 2 (SH2 dom...
  • Prostate cancer, organism-specific biosystem (from KEGG)
    Prostate cancer, organism-specific biosystemProstate cancer constitutes a major health problem in Western countries. It is the most frequently diagnosed cancer among men and the second leading cause of male cancer deaths. The identification of...
  • Prostate cancer, conserved biosystem (from KEGG)
    Prostate cancer, conserved biosystemProstate cancer constitutes a major health problem in Western countries. It is the most frequently diagnosed cancer among men and the second leading cause of male cancer deaths. The identification of...
  • Rap1 signaling pathway, organism-specific biosystem (from KEGG)
    Rap1 signaling pathway, organism-specific biosystemRap1 is a small GTPase that controls diverse processes, such as cell adhesion, cell-cell junction formation and cell polarity. Like all G proteins, Rap1 cycles between an inactive GDP-bound and an ac...
  • Rap1 signaling pathway, conserved biosystem (from KEGG)
    Rap1 signaling pathway, conserved biosystemRap1 is a small GTPase that controls diverse processes, such as cell adhesion, cell-cell junction formation and cell polarity. Like all G proteins, Rap1 cycles between an inactive GDP-bound and an ac...
  • Ras signaling pathway, organism-specific biosystem (from KEGG)
    Ras signaling pathway, organism-specific biosystemThe Ras proteins are GTPases that function as molecular switches for signaling pathways regulating cell proliferation, survival, growth, migration, differentiation or cytoskeletal dynamism. Ras prote...
  • Regulation of Actin Cytoskeleton, organism-specific biosystem (from WikiPathways)
    Regulation of Actin Cytoskeleton, organism-specific biosystemhttp://www.genome.jp/kegg/pathway/hsa/hsa04810.html
  • Regulation of actin cytoskeleton, organism-specific biosystem (from KEGG)
    Regulation of actin cytoskeleton, organism-specific biosystem
    Regulation of actin cytoskeleton
  • Regulation of actin cytoskeleton, conserved biosystem (from KEGG)
    Regulation of actin cytoskeleton, conserved biosystem
    Regulation of actin cytoskeleton
  • Role of LAT2/NTAL/LAB on calcium mobilization, organism-specific biosystem (from REACTOME)
    Role of LAT2/NTAL/LAB on calcium mobilization, organism-specific biosystemThe lipid raft resident adaptor molecules LAT1 and Non-T cell activation linker (NTAL), also known as linker for activation of B cells (LAB)/LAT2 are known participants in the regulation of mast cell...
  • SHC-mediated cascade, organism-specific biosystem (from REACTOME)
    SHC-mediated cascade, organism-specific biosystemThe exact role of SHC1 in FGFR signaling remains unclear. Numerous studies have shown that the p46 and p52 isoforms of SHC1 are phosphorylated in response to FGF stimulation, but direct interaction...
  • Signal Transduction, organism-specific biosystem (from REACTOME)
    Signal Transduction, organism-specific biosystemSignal transduction is a process in which extracellular signals elicit changes in cell state and activity. Transmembrane receptors sense changes in the cellular environment by binding ligands, such a...
  • Signaling Pathways in Glioblastoma, organism-specific biosystem (from WikiPathways)
    Signaling Pathways in Glioblastoma, organism-specific biosystemThe most frequently altered genes in glioblastoma. This pathway originally accompanied the 2008 Nature publication on the comprehensive genomic characterization of human glioblastoma genes and core p...
  • Signaling by EGFR, organism-specific biosystem (from REACTOME)
    Signaling by EGFR, organism-specific biosystemThe epidermal growth factor receptor (EGFR) is one member of the ERBB family of transmembrane glycoprotein tyrosine receptor kinases (RTK). Binding of EGFR to its ligands induces conformational chang...
  • Signaling by EGFR in Cancer, organism-specific biosystem (from REACTOME)
    Signaling by EGFR in Cancer, organism-specific biosystemThe pathway "Signaling by EGFR in Cancer" shows "Signaling by constitutively active EGFR" in parallel with "Signaling by EGFR". This allows users to compare signaling by constitutively active EGFR ca...
  • Signaling by ERBB2, organism-specific biosystem (from REACTOME)
    Signaling by ERBB2, organism-specific biosystemERBB2, also known as HER2 or NEU, is a receptor tyrosine kinase (RTK) belonging to the EGFR family. ERBB2 possesses an extracellular domain that does not bind any known ligand, contrary to other EGFR...
  • Signaling by ERBB4, organism-specific biosystem (from REACTOME)
    Signaling by ERBB4, organism-specific biosystemERBB4, also known as HER4, belongs to the ERBB family of receptors, which also includes ERBB1 (EGFR i.e. HER1), ERBB2 (HER2 i.e. NEU) and ERBB3 (HER3). Similar to EGFR, ERBB4 has an extracellular lig...
  • Signaling by FGFR, organism-specific biosystem (from REACTOME)
    Signaling by FGFR, organism-specific biosystemThe 22 members of the fibroblast growth factor (FGF) family of growth factors mediate their cellular responses by binding to and activating the different isoforms encoded by the four receptor tyrosin...
  • Signaling by FGFR in disease, organism-specific biosystem (from REACTOME)
    Signaling by FGFR in disease, organism-specific biosystemThe pathway 'Signaling by FGFR in disease' shows 'Signaling by FGFR mutants' in parallel with the wild-type pathway 'Signaling by FGFR', allowing users to compare disease and normal events. FGFR mut...
  • Signaling by FGFR mutants, organism-specific biosystem (from REACTOME)
    Signaling by FGFR mutants, organism-specific biosystemA number of skeletal and developmental diseases have been shown to arise as a result of mutations in the FGFR1, 2 and 3 genes. These include dwarfism syndromes (achondroplasia, hypochondroplasia and...
  • Signaling by FGFR2 amplification mutants, organism-specific biosystem (from REACTOME)
    Signaling by FGFR2 amplification mutants, organism-specific biosystemFGFR2 amplifications have been identified in 10% of gastric cancers, where they are associated with poor prognosis diffuse cancers (Hattori, 1996; Ueda, 1999; Shin, 2000; Kunii, 2008) , and in ~1% of...
  • Signaling by FGFR2 mutants, organism-specific biosystem (from REACTOME)
    Signaling by FGFR2 mutants, organism-specific biosystemThe FGFR2 gene has been shown to be subject to activating mutations and gene amplification leading to a variety of proliferative and developmental disorders depending on whether these events occur in...
  • Signaling by Insulin receptor, organism-specific biosystem (from REACTOME)
    Signaling by Insulin receptor, organism-specific biosystemInsulin binding to its receptor results in receptor autophosphorylation on tyrosine residues and the tyrosine phosphorylation of insulin receptor substrates (e.g. IRS and Shc) by the insulin receptor...
  • Signaling by PDGF, organism-specific biosystem (from REACTOME)
    Signaling by PDGF, organism-specific biosystemPlatelet-derived Growth Factor (PDGF) is a potent stimulator of growth and motility of connective tissue cells such as fibroblasts and smooth muscle cells as well as other cells such as capillary end...
  • Signaling by SCF-KIT, organism-specific biosystem (from REACTOME)
    Signaling by SCF-KIT, organism-specific biosystemStem cell factor (SCF) is a growth factor with membrane bound and soluble forms. It is expressed by fibroblasts and endothelial cells throughout the body, promoting proliferation, migration, survival...
  • Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R), organism-specific biosystem (from REACTOME)
    Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R), organism-specific biosystemBinding of IGF1 (IGF-I) or IGF2 (IGF-II) to the extracellular alpha peptides of the type 1 insulin-like growth factor receptor (IGF1R) triggers the activation of two major signaling pathways: the SOS...
  • Signaling by the B Cell Receptor (BCR), organism-specific biosystem (from REACTOME)
    Signaling by the B Cell Receptor (BCR), organism-specific biosystemMature B cells express IgM and IgD immunoglobulins which are complexed at the plasma membrane with Ig-alpha (CD79A, MB-1) and Ig-beta (CD79B, B29) to form the B cell receptor (BCR) (Fu et al. 1974, F...
  • Signaling pathways regulating pluripotency of stem cells, organism-specific biosystem (from KEGG)
    Signaling pathways regulating pluripotency of stem cells, organism-specific biosystemPluripotent stem cells (PSCs) are basic cells with an indefinite self-renewal capacity and the potential to generate all the cell types of the three germinal layers. The types of PSCs known to date i...
  • Signaling pathways regulating pluripotency of stem cells, conserved biosystem (from KEGG)
    Signaling pathways regulating pluripotency of stem cells, conserved biosystemPluripotent stem cells (PSCs) are basic cells with an indefinite self-renewal capacity and the potential to generate all the cell types of the three germinal layers. The types of PSCs known to date i...
  • Signalling by NGF, organism-specific biosystem (from REACTOME)
    Signalling by NGF, organism-specific biosystemNeurotrophins (NGF, BDNF, NT-3, NT-4/5) play pivotal roles in survival, differentiation, and plasticity of neurons in the peripheral and central nervous system. They are produced, and secreted in mi...
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Clone Names

  • FLJ98662

Gene Ontology Provided by GOA

Function Evidence Code Pubs
ATP binding IEA
Inferred from Electronic Annotation
more info
 
fibroblast growth factor binding IDA
Inferred from Direct Assay
more info
PubMed 
fibroblast growth factor binding IPI
Inferred from Physical Interaction
more info
PubMed 
fibroblast growth factor-activated receptor activity IDA
Inferred from Direct Assay
more info
PubMed 
fibroblast growth factor-activated receptor activity IGI
Inferred from Genetic Interaction
more info
PubMed 
fibroblast growth factor-activated receptor activity NAS
Non-traceable Author Statement
more info
PubMed 
heparin binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein homodimerization activity IPI
Inferred from Physical Interaction
more info
PubMed 
protein tyrosine kinase activity NAS
Non-traceable Author Statement
more info
PubMed 
Process Evidence Code Pubs
Fc-epsilon receptor signaling pathway TAS
Traceable Author Statement
more info
 
angiogenesis ISS
Inferred from Sequence or Structural Similarity
more info
 
apoptotic process IEA
Inferred from Electronic Annotation
more info
 
axonogenesis ISS
Inferred from Sequence or Structural Similarity
more info
 
bone development ISS
Inferred from Sequence or Structural Similarity
more info
 
bone mineralization ISS
Inferred from Sequence or Structural Similarity
more info
 
bone morphogenesis ISS
Inferred from Sequence or Structural Similarity
more info
 
branch elongation involved in salivary gland morphogenesis ISS
Inferred from Sequence or Structural Similarity
more info
 
branching involved in labyrinthine layer morphogenesis ISS
Inferred from Sequence or Structural Similarity
more info
 
branching involved in prostate gland morphogenesis ISS
Inferred from Sequence or Structural Similarity
more info
 
branching involved in salivary gland morphogenesis ISS
Inferred from Sequence or Structural Similarity
more info
 
branching morphogenesis of a nerve ISS
Inferred from Sequence or Structural Similarity
more info
 
bud elongation involved in lung branching ISS
Inferred from Sequence or Structural Similarity
more info
 
cell fate commitment ISS
Inferred from Sequence or Structural Similarity
more info
 
cell-cell signaling ISS
Inferred from Sequence or Structural Similarity
more info
 
coronal suture morphogenesis IEA
Inferred from Electronic Annotation
more info
 
digestive tract development ISS
Inferred from Sequence or Structural Similarity
more info
 
embryonic cranial skeleton morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
embryonic digestive tract morphogenesis ISS
Inferred from Sequence or Structural Similarity
more info
 
embryonic organ development ISS
Inferred from Sequence or Structural Similarity
more info
 
embryonic organ morphogenesis ISS
Inferred from Sequence or Structural Similarity
more info
 
embryonic pattern specification ISS
Inferred from Sequence or Structural Similarity
more info
 
endodermal digestive tract morphogenesis IEA
Inferred from Electronic Annotation
more info
 
epidermal growth factor receptor signaling pathway TAS
Traceable Author Statement
more info
 
epidermis morphogenesis ISS
Inferred from Sequence or Structural Similarity
more info
 
epithelial cell differentiation ISS
Inferred from Sequence or Structural Similarity
more info
 
epithelial cell proliferation involved in salivary gland morphogenesis ISS
Inferred from Sequence or Structural Similarity
more info
 
epithelial to mesenchymal transition IEA
Inferred from Electronic Annotation
more info
 
fibroblast growth factor receptor signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
fibroblast growth factor receptor signaling pathway IGI
Inferred from Genetic Interaction
more info
PubMed 
fibroblast growth factor receptor signaling pathway IPI
Inferred from Physical Interaction
more info
PubMed 
fibroblast growth factor receptor signaling pathway TAS
Traceable Author Statement
more info
 
fibroblast growth factor receptor signaling pathway involved in hemopoiesis ISS
Inferred from Sequence or Structural Similarity
more info
 
fibroblast growth factor receptor signaling pathway involved in mammary gland specification ISS
Inferred from Sequence or Structural Similarity
more info
 
fibroblast growth factor receptor signaling pathway involved in negative regulation of apoptotic process in bone marrow ISS
Inferred from Sequence or Structural Similarity
more info
 
fibroblast growth factor receptor signaling pathway involved in orbitofrontal cortex development ISS
Inferred from Sequence or Structural Similarity
more info
 
fibroblast growth factor receptor signaling pathway involved in positive regulation of cell proliferation in bone marrow ISS
Inferred from Sequence or Structural Similarity
more info
 
gland morphogenesis ISS
Inferred from Sequence or Structural Similarity
more info
 
hair follicle morphogenesis ISS
Inferred from Sequence or Structural Similarity
more info
 
in utero embryonic development ISS
Inferred from Sequence or Structural Similarity
more info
 
innate immune response TAS
Traceable Author Statement
more info
 
inner ear morphogenesis ISS
Inferred from Sequence or Structural Similarity
more info
 
insulin receptor signaling pathway TAS
Traceable Author Statement
more info
 
lacrimal gland development ISS
Inferred from Sequence or Structural Similarity
more info
 
lateral sprouting from an epithelium ISS
Inferred from Sequence or Structural Similarity
more info
 
lens fiber cell development IEA
Inferred from Electronic Annotation
more info
 
limb bud formation ISS
Inferred from Sequence or Structural Similarity
more info
 
lung alveolus development ISS
Inferred from Sequence or Structural Similarity
more info
 
lung development ISS
Inferred from Sequence or Structural Similarity
more info
 
lung lobe morphogenesis ISS
Inferred from Sequence or Structural Similarity
more info
 
lung-associated mesenchyme development ISS
Inferred from Sequence or Structural Similarity
more info
 
mammary gland bud formation ISS
Inferred from Sequence or Structural Similarity
more info
 
membranous septum morphogenesis ISS
Inferred from Sequence or Structural Similarity
more info
 
mesenchymal cell differentiation ISS
Inferred from Sequence or Structural Similarity
more info
 
mesenchymal cell differentiation involved in lung development ISS
Inferred from Sequence or Structural Similarity
more info
 
mesenchymal cell proliferation involved in lung development ISS
Inferred from Sequence or Structural Similarity
more info
 
mesodermal cell differentiation IEA
Inferred from Electronic Annotation
more info
 
midbrain development ISS
Inferred from Sequence or Structural Similarity
more info
 
morphogenesis of embryonic epithelium ISS
Inferred from Sequence or Structural Similarity
more info
 
multicellular organism growth ISS
Inferred from Sequence or Structural Similarity
more info
 
negative regulation of epithelial cell proliferation IEA
Inferred from Electronic Annotation
more info
 
negative regulation of mitosis IEA
Inferred from Electronic Annotation
more info
 
negative regulation of transcription from RNA polymerase II promoter ISS
Inferred from Sequence or Structural Similarity
more info
 
neuromuscular junction development IEA
Inferred from Electronic Annotation
more info
 
neurotrophin TRK receptor signaling pathway TAS
Traceable Author Statement
more info
 
odontogenesis ISS
Inferred from Sequence or Structural Similarity
more info
 
orbitofrontal cortex development ISS
Inferred from Sequence or Structural Similarity
more info
 
organ growth ISS
Inferred from Sequence or Structural Similarity
more info
 
organ morphogenesis ISS
Inferred from Sequence or Structural Similarity
more info
 
otic vesicle formation ISS
Inferred from Sequence or Structural Similarity
more info
 
outflow tract septum morphogenesis ISS
Inferred from Sequence or Structural Similarity
more info
 
peptidyl-tyrosine phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
phosphatidylinositol-mediated signaling TAS
Traceable Author Statement
more info
 
positive regulation of ERK1 and ERK2 cascade ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of MAPK cascade IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of Wnt signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of canonical Wnt signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of cardiac muscle cell proliferation ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of cell cycle ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of cell division ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of cell proliferation IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of cell proliferation IGI
Inferred from Genetic Interaction
more info
PubMed 
positive regulation of cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of epithelial cell proliferation ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of epithelial cell proliferation involved in lung morphogenesis ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of mesenchymal cell proliferation ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of phospholipase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of smooth muscle cell proliferation IEA
Inferred from Electronic Annotation
more info
 
positive regulation of transcription from RNA polymerase II promoter ISS
Inferred from Sequence or Structural Similarity
more info
 
post-embryonic development ISS
Inferred from Sequence or Structural Similarity
more info
 
prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis ISS
Inferred from Sequence or Structural Similarity
more info
 
prostate epithelial cord elongation ISS
Inferred from Sequence or Structural Similarity
more info
 
prostate gland morphogenesis ISS
Inferred from Sequence or Structural Similarity
more info
 
protein autophosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
pyramidal neuron development ISS
Inferred from Sequence or Structural Similarity
more info
 
regulation of ERK1 and ERK2 cascade ISS
Inferred from Sequence or Structural Similarity
more info
 
regulation of branching involved in prostate gland morphogenesis ISS
Inferred from Sequence or Structural Similarity
more info
 
regulation of cell fate commitment ISS
Inferred from Sequence or Structural Similarity
more info
 
regulation of fibroblast growth factor receptor signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
 
regulation of morphogenesis of a branching structure ISS
Inferred from Sequence or Structural Similarity
more info
 
regulation of multicellular organism growth ISS
Inferred from Sequence or Structural Similarity
more info
 
regulation of osteoblast differentiation TAS
Traceable Author Statement
more info
PubMed 
regulation of osteoblast proliferation TAS
Traceable Author Statement
more info
PubMed 
regulation of smooth muscle cell differentiation ISS
Inferred from Sequence or Structural Similarity
more info
 
regulation of smoothened signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
 
reproductive structure development ISS
Inferred from Sequence or Structural Similarity
more info
 
skeletal system morphogenesis TAS
Traceable Author Statement
more info
PubMed 
squamous basal epithelial stem cell differentiation involved in prostate gland acinus development ISS
Inferred from Sequence or Structural Similarity
more info
 
synaptic vesicle transport IEA
Inferred from Electronic Annotation
more info
 
ureteric bud development ISS
Inferred from Sequence or Structural Similarity
more info
 
ventricular cardiac muscle tissue morphogenesis ISS
Inferred from Sequence or Structural Similarity
more info
 
ventricular zone neuroblast division ISS
Inferred from Sequence or Structural Similarity
more info
 
Component Evidence Code Pubs
Golgi apparatus IEA
Inferred from Electronic Annotation
more info
 
cell cortex IDA
Inferred from Direct Assay
more info
PubMed 
cell surface IDA
Inferred from Direct Assay
more info
PubMed 
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
cytoplasmic membrane-bounded vesicle IEA
Inferred from Electronic Annotation
more info
 
excitatory synapse ISS
Inferred from Sequence or Structural Similarity
more info
 
colocalizes_with extracellular matrix IDA
Inferred from Direct Assay
more info
PubMed 
extracellular region IEA
Inferred from Electronic Annotation
more info
 
integral component of membrane NAS
Non-traceable Author Statement
more info
PubMed 
integral component of plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
intracellular membrane-bounded organelle IDA
Inferred from Direct Assay
more info
 
membrane NAS
Non-traceable Author Statement
more info
PubMed 
NOT nucleolus IDA
Inferred from Direct Assay
more info
 
nucleus IDA
Inferred from Direct Assay
more info
 
plasma membrane TAS
Traceable Author Statement
more info
 
Preferred Names
fibroblast growth factor receptor 2
Names
fibroblast growth factor receptor 2
FGFR-2
FGF receptor
soluble FGFR4 variant 4
bacteria-expressed kinase
hydroxyaryl-protein kinase
FGFR2-AHCYL1 fusion kinase protein
keratinocyte growth factor receptor
BEK fibroblast growth factor receptor
protein tyrosine kinase, receptor like 14
NP_000132.3
NP_001138385.1
NP_001138386.1
NP_001138387.1
NP_001138388.1
NP_001138389.1
NP_001138390.1
NP_001138391.1
NP_075259.4
NP_075418.1

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_012449.1 

    Range
    5001..125129
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_000141.4NP_000132.3  fibroblast growth factor receptor 2 isoform 1 precursor

    See proteins identical to NP_000132.3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes isoform 1, also referred to as isoform BEK and K-sam.
    Source sequence(s)
    BC037338, BC039243, CB305736, CN345547, CX873387, M87770
    Consensus CDS
    CCDS31298.1
    UniProtKB/Swiss-Prot
    P21802
    Related
    ENSP00000351276, OTTHUMP00000020621, ENST00000358487, OTTHUMT00000050715
    Conserved Domains (7) summary
    cd04973
    Location:47124
    Ig1_FGFR; First immunoglobulin (Ig)-like domain of fibroblast growth factor receptor (FGFR)
    cd05857
    Location:164248
    Ig2_FGFR; Second immunoglobulin (Ig)-like domain of fibroblast growth factor (FGF) receptor
    cd05858
    Location:271360
    Ig3_FGFR-2; Third immunoglobulin (Ig)-like domain of fibroblast growth factor receptor 2 (FGFR2)
    smart00408
    Location:173238
    IGc2; Immunoglobulin C-2 Type
    smart00410
    Location:263359
    IG_like; Immunoglobulin like
    pfam07714
    Location:481757
    Pkinase_Tyr; Protein tyrosine kinase
    cl09925
    Location:468801
    PKc_like; Protein Kinases, catalytic domain
  2. NM_001144913.1NP_001138385.1  fibroblast growth factor receptor 2 isoform 3 precursor

    See proteins identical to NP_001138385.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) uses an alternate internal in-frame coding exon (as in variant 2), and an alternate 3' terminal exon, compared to transcript variant 1. This results in an isoform (3) with a different, 1 aa longer protein segment in the mid-region, and a novel shorter C-terminus, compared to isoform 1.
    Source sequence(s)
    AC009988, AK026508, M97193, U11814, X56191
    Consensus CDS
    CCDS44489.1
    UniProtKB/Swiss-Prot
    P21802
    Related
    ENSP00000358052, OTTHUMP00000020626, ENST00000369056, OTTHUMT00000050720
    Conserved Domains (7) summary
    cd05101
    Location:466768
    PTKc_FGFR2; Catalytic domain of the Protein Tyrosine Kinase, Fibroblast Growth Factor Receptor 2
    cd04973
    Location:47124
    Ig1_FGFR; First immunoglobulin (Ig)-like domain of fibroblast growth factor receptor (FGFR)
    cd04974
    Location:271358
    Ig3_FGFR; Third immunoglobulin (Ig)-like domain of fibroblast growth factor receptor (FGFR)
    cd05857
    Location:164248
    Ig2_FGFR; Second immunoglobulin (Ig)-like domain of fibroblast growth factor (FGF) receptor
    smart00408
    Location:173238
    IGc2; Immunoglobulin C-2 Type
    smart00410
    Location:263357
    IG_like; Immunoglobulin like
    pfam07714
    Location:482758
    Pkinase_Tyr; Protein tyrosine kinase
  3. NM_001144914.1NP_001138386.1  fibroblast growth factor receptor 2 isoform 4 precursor

    See proteins identical to NP_001138386.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) is missing two consecutive in-frame coding exons compared to transcript variant 1. This results in a shorter isoform (4) lacking an internal protein segment compared to isoform 1.
    Source sequence(s)
    AB084153, BC037338, CB305736, M97193, U11814
    Consensus CDS
    CCDS44486.1
    UniProtKB/Swiss-Prot
    P21802
    Related
    ENSP00000358057, ENST00000369061
    Conserved Domains (5) summary
    cd04973
    Location:47124
    Ig1_FGFR; First immunoglobulin (Ig)-like domain of fibroblast growth factor receptor (FGFR)
    cd05857
    Location:164248
    Ig2_FGFR; Second immunoglobulin (Ig)-like domain of fibroblast growth factor (FGF) receptor
    smart00408
    Location:173238
    IGc2; Immunoglobulin C-2 Type
    pfam07714
    Location:369645
    Pkinase_Tyr; Protein tyrosine kinase
    cl09925
    Location:356689
    PKc_like; Protein Kinases, catalytic domain
  4. NM_001144915.1NP_001138387.1  fibroblast growth factor receptor 2 isoform 5 precursor

    See proteins identical to NP_001138387.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) uses an alternate 5' terminal non-coding exon, and is missing an internal in-frame coding exon, compared to transcript variant 1. This results in a shorter isoform (5) lacking an internal protein segment compared to isoform 1.
    Source sequence(s)
    AK294026, BC037338, CB305736, M87770
    Consensus CDS
    CCDS53584.1
    UniProtKB/Swiss-Prot
    P21802
    Related
    ENSP00000350166, ENST00000357555
    Conserved Domains (6) summary
    cd05101
    Location:376679
    PTKc_FGFR2; Catalytic domain of the Protein Tyrosine Kinase, Fibroblast Growth Factor Receptor 2
    cd05857
    Location:75159
    Ig2_FGFR; Second immunoglobulin (Ig)-like domain of fibroblast growth factor (FGF) receptor
    cd05858
    Location:182271
    Ig3_FGFR-2; Third immunoglobulin (Ig)-like domain of fibroblast growth factor receptor 2 (FGFR2)
    smart00408
    Location:84149
    IGc2; Immunoglobulin C-2 Type
    smart00410
    Location:174270
    IG_like; Immunoglobulin like
    pfam07714
    Location:392668
    Pkinase_Tyr; Protein tyrosine kinase
  5. NM_001144916.1NP_001138388.1  fibroblast growth factor receptor 2 isoform 6 precursor

    See proteins identical to NP_001138388.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (6) uses an alternate 5' terminal exon, and is missing two consecutive in-frame coding exons, compared to transcript variant 1. This results in a shorter isoform (6) lacking an internal protein segment compared to isoform 1.
    Source sequence(s)
    AK308621, BC037338, CB305736, M97193
    UniProtKB/Swiss-Prot
    P21802
    Conserved Domains (6) summary
    cd05857
    Location:49133
    Ig2_FGFR; Second immunoglobulin (Ig)-like domain of fibroblast growth factor (FGF) receptor
    cd05858
    Location:156245
    Ig3_FGFR-2; Third immunoglobulin (Ig)-like domain of fibroblast growth factor receptor 2 (FGFR2)
    smart00408
    Location:58123
    IGc2; Immunoglobulin C-2 Type
    smart00410
    Location:148244
    IG_like; Immunoglobulin like
    pfam07714
    Location:366642
    Pkinase_Tyr; Protein tyrosine kinase
    cl09925
    Location:353686
    PKc_like; Protein Kinases, catalytic domain
  6. NM_001144917.1NP_001138389.1  fibroblast growth factor receptor 2 isoform 7 precursor

    See proteins identical to NP_001138389.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (7) is missing two consecutive in-frame coding exons compared to transcript variant 1. This results in a shorter isoform (7) lacking an internal protein segment compared to isoform 1.
    Source sequence(s)
    BC037338, BC039243, CB305736, CN345547, M87771, U11814
    Consensus CDS
    CCDS44487.1
    UniProtKB/Swiss-Prot
    P21802
    Conserved Domains (6) summary
    cd04973
    Location:47124
    Ig1_FGFR; First immunoglobulin (Ig)-like domain of fibroblast growth factor receptor (FGFR)
    cd05857
    Location:164248
    Ig2_FGFR; Second immunoglobulin (Ig)-like domain of fibroblast growth factor (FGF) receptor
    smart00408
    Location:173238
    IGc2; Immunoglobulin C-2 Type
    pfam07714
    Location:365641
    Pkinase_Tyr; Protein tyrosine kinase
    cl09925
    Location:352685
    PKc_like; Protein Kinases, catalytic domain
    cl11960
    Location:271363
    Ig; Immunoglobulin domain
  7. NM_001144918.1NP_001138390.1  fibroblast growth factor receptor 2 isoform 8 precursor

    See proteins identical to NP_001138390.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (8) is missing two consecutive in-frame coding exons, and uses an alternate in-frame donor splice site at another coding exon, compared to transcript variant 1. This results in a shorter isoform (8) lacking an internal protein segment and additional 2 aa, compared to isoform 1.
    Source sequence(s)
    BC037338, BC039243, CB305736, CN345547, U11814
    Consensus CDS
    CCDS44485.1
    UniProtKB/Swiss-Prot
    P21802
    Related
    ENSP00000348559, OTTHUMP00000020631, ENST00000356226, OTTHUMT00000050726
    Conserved Domains (6) summary
    cd05857
    Location:49133
    Ig2_FGFR; Second immunoglobulin (Ig)-like domain of fibroblast growth factor (FGF) receptor
    cd05858
    Location:156245
    Ig3_FGFR-2; Third immunoglobulin (Ig)-like domain of fibroblast growth factor receptor 2 (FGFR2)
    smart00408
    Location:58123
    IGc2; Immunoglobulin C-2 Type
    smart00410
    Location:148244
    IG_like; Immunoglobulin like
    pfam07714
    Location:364640
    Pkinase_Tyr; Protein tyrosine kinase
    cl09925
    Location:351684
    PKc_like; Protein Kinases, catalytic domain
  8. NM_001144919.1NP_001138391.1  fibroblast growth factor receptor 2 isoform 9 precursor

    See proteins identical to NP_001138391.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (9) is missing an in-frame coding exon, uses an alternate internal in-frame coding exon (as in variant 2) and an alternate 3' terminal exon, compared to transcript variant 1. This results in a shorter isoform (9), which differs in two internal segments, and has a novel C-terminus compared to isoform 1.
    Source sequence(s)
    AC009988, AK026508, BC039243, CN345547, U11814
    Consensus CDS
    CCDS44488.1
    UniProtKB/Swiss-Prot
    P21802
    Related
    ENSP00000353262, OTTHUMP00000020624, ENST00000360144, OTTHUMT00000050718
    Conserved Domains (6) summary
    cd05101
    Location:377679
    PTKc_FGFR2; Catalytic domain of the Protein Tyrosine Kinase, Fibroblast Growth Factor Receptor 2
    cd04974
    Location:182269
    Ig3_FGFR; Third immunoglobulin (Ig)-like domain of fibroblast growth factor receptor (FGFR)
    cd05857
    Location:75159
    Ig2_FGFR; Second immunoglobulin (Ig)-like domain of fibroblast growth factor (FGF) receptor
    smart00408
    Location:84149
    IGc2; Immunoglobulin C-2 Type
    smart00410
    Location:174268
    IG_like; Immunoglobulin like
    pfam07714
    Location:393669
    Pkinase_Tyr; Protein tyrosine kinase
  9. NM_022970.3NP_075259.4  fibroblast growth factor receptor 2 isoform 2 precursor

    See proteins identical to NP_075259.4

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) uses an alternate internal in-frame coding exon compared to transcript variant 1, resulting in an isoform (2, also known as isoform K-sam-IIH1, IIIb, and BFR-1) with a different, 1 aa longer protein segment in the mid-region compared to isoform 1.
    Source sequence(s)
    BC037338, BC039243, CB305736, CN345547, M55614, M80634
    Consensus CDS
    CCDS7620.2
    UniProtKB/Swiss-Prot
    P21802
    Conserved Domains (7) summary
    cd04973
    Location:47124
    Ig1_FGFR; First immunoglobulin (Ig)-like domain of fibroblast growth factor receptor (FGFR)
    cd04974
    Location:271358
    Ig3_FGFR; Third immunoglobulin (Ig)-like domain of fibroblast growth factor receptor (FGFR)
    cd05857
    Location:164248
    Ig2_FGFR; Second immunoglobulin (Ig)-like domain of fibroblast growth factor (FGF) receptor
    smart00408
    Location:173238
    IGc2; Immunoglobulin C-2 Type
    smart00410
    Location:263357
    IG_like; Immunoglobulin like
    pfam07714
    Location:482758
    Pkinase_Tyr; Protein tyrosine kinase
    cl09925
    Location:469802
    PKc_like; Protein Kinases, catalytic domain
  10. NM_023029.2NP_075418.1  fibroblast growth factor receptor 2 isoform 11 precursor

    See proteins identical to NP_075418.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (11) lacks an in-frame coding exon in the 5' region, compared to variant 1. This results in a shorter isoform (11) lacking an internal protein segment compared to isoform 1.
    Source sequence(s)
    AC009988, AK308621, BC039243, CB305736, EF057068
    Consensus CDS
    CCDS73210.1
    UniProtKB/TrEMBL
    D2CGD1
    UniProtKB/Swiss-Prot
    P21802
    Related
    ENSP00000484154, ENST00000613048
    Conserved Domains (6) summary
    cd05857
    Location:75159
    Ig2_FGFR; Second immunoglobulin (Ig)-like domain of fibroblast growth factor (FGF) receptor
    cd05858
    Location:182271
    Ig3_FGFR-2; Third immunoglobulin (Ig)-like domain of fibroblast growth factor receptor 2 (FGFR2)
    smart00408
    Location:84149
    IGc2; Immunoglobulin C-2 Type
    smart00410
    Location:174270
    IG_like; Immunoglobulin like
    pfam07714
    Location:392668
    Pkinase_Tyr; Protein tyrosine kinase
    cl09925
    Location:379712
    PKc_like; Protein Kinases, catalytic domain

RNA

  1. NR_073009.1 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (14) lacks two consecutive exons in the 5' region and has an additional exon in the center region, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most supported translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AB030073, AC009988, BC039243, BC096749, CB305736, M87771, U11814, X52832

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 106

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38 Primary Assembly

Genomic

  1. NC_000010.11 

    Range
    121478330..121598458
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006717709.1XP_006717772.1  

    See proteins identical to XP_006717772.1

    UniProtKB/TrEMBL
    D3DRD5
    Related
    ENSP00000358056, OTTHUMP00000020625, ENST00000369060, OTTHUMT00000050719
    Conserved Domains (7) summary
    cd04973
    Location:66143
    Ig1_FGFR; First immunoglobulin (Ig)-like domain of fibroblast growth factor receptor (FGFR)
    cd05857
    Location:183267
    Ig2_FGFR; Second immunoglobulin (Ig)-like domain of fibroblast growth factor (FGF) receptor
    cd05858
    Location:290379
    Ig3_FGFR-2; Third immunoglobulin (Ig)-like domain of fibroblast growth factor receptor 2 (FGFR2)
    smart00408
    Location:192257
    IGc2; Immunoglobulin C-2 Type
    smart00410
    Location:282378
    IG_like; Immunoglobulin like
    pfam07714
    Location:498774
    Pkinase_Tyr; Protein tyrosine kinase
    cl09925
    Location:485818
    PKc_like; Protein Kinases, catalytic domain
  2. XM_006717708.1XP_006717771.1  

    Conserved Domains (7) summary
    cd04973
    Location:66143
    Ig1_FGFR; First immunoglobulin (Ig)-like domain of fibroblast growth factor receptor (FGFR)
    cd04974
    Location:290377
    Ig3_FGFR; Third immunoglobulin (Ig)-like domain of fibroblast growth factor receptor (FGFR)
    cd05857
    Location:183267
    Ig2_FGFR; Second immunoglobulin (Ig)-like domain of fibroblast growth factor (FGF) receptor
    smart00408
    Location:192257
    IGc2; Immunoglobulin C-2 Type
    smart00410
    Location:282376
    IG_like; Immunoglobulin like
    pfam07714
    Location:499775
    Pkinase_Tyr; Protein tyrosine kinase
    cl09925
    Location:486819
    PKc_like; Protein Kinases, catalytic domain
  3. XM_006717712.1XP_006717775.1  

    Conserved Domains (6) summary
    cd04974
    Location:175262
    Ig3_FGFR; Third immunoglobulin (Ig)-like domain of fibroblast growth factor receptor (FGFR)
    cd05857
    Location:68152
    Ig2_FGFR; Second immunoglobulin (Ig)-like domain of fibroblast growth factor (FGF) receptor
    smart00408
    Location:77142
    IGc2; Immunoglobulin C-2 Type
    smart00410
    Location:167261
    IG_like; Immunoglobulin like
    pfam07714
    Location:386662
    Pkinase_Tyr; Protein tyrosine kinase
    cl09925
    Location:373706
    PKc_like; Protein Kinases, catalytic domain
  4. XM_006717711.1XP_006717774.1  

    Conserved Domains (6) summary
    cd04974
    Location:201288
    Ig3_FGFR; Third immunoglobulin (Ig)-like domain of fibroblast growth factor receptor (FGFR)
    cd05857
    Location:94178
    Ig2_FGFR; Second immunoglobulin (Ig)-like domain of fibroblast growth factor (FGF) receptor
    smart00408
    Location:103168
    IGc2; Immunoglobulin C-2 Type
    smart00410
    Location:193287
    IG_like; Immunoglobulin like
    pfam07714
    Location:412688
    Pkinase_Tyr; Protein tyrosine kinase
    cl09925
    Location:399732
    PKc_like; Protein Kinases, catalytic domain
  5. XM_006717713.1XP_006717776.1  

    Related
    ENSP00000337665, OTTHUMP00000020623, ENST00000336553, OTTHUMT00000050717
    Conserved Domains (7) summary
    cd04973
    Location:66143
    Ig1_FGFR; First immunoglobulin (Ig)-like domain of fibroblast growth factor receptor (FGFR)
    cd05857
    Location:183267
    Ig2_FGFR; Second immunoglobulin (Ig)-like domain of fibroblast growth factor (FGF) receptor
    cd05858
    Location:290379
    Ig3_FGFR-2; Third immunoglobulin (Ig)-like domain of fibroblast growth factor receptor 2 (FGFR2)
    smart00408
    Location:192257
    IGc2; Immunoglobulin C-2 Type
    smart00410
    Location:282378
    IG_like; Immunoglobulin like
    pfam07714
    Location:500776
    Pkinase_Tyr; Protein tyrosine kinase
    cl09925
    Location:487800
    PKc_like; Protein Kinases, catalytic domain
  6. XM_006717710.1XP_006717773.1  

    Related
    ENSP00000358054, OTTHUMP00000020630, ENST00000369058, OTTHUMT00000050725
    Conserved Domains (7) summary
    cd04973
    Location:66143
    Ig1_FGFR; First immunoglobulin (Ig)-like domain of fibroblast growth factor receptor (FGFR)
    cd04974
    Location:290377
    Ig3_FGFR; Third immunoglobulin (Ig)-like domain of fibroblast growth factor receptor (FGFR)
    cd05857
    Location:183267
    Ig2_FGFR; Second immunoglobulin (Ig)-like domain of fibroblast growth factor (FGF) receptor
    smart00408
    Location:192257
    IGc2; Immunoglobulin C-2 Type
    smart00410
    Location:282376
    IG_like; Immunoglobulin like
    pfam07714
    Location:501777
    Pkinase_Tyr; Protein tyrosine kinase
    cl09925
    Location:488801
    PKc_like; Protein Kinases, catalytic domain

Alternate CHM1_1.1

Genomic

  1. NC_018921.2 

    Range
    123522903..123642701
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate HuRef

Genomic

  1. AC_000142.1 

    Range
    116868799..116988666
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_022971.1: Suppressed sequence

    Description
    NM_022971.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.
  2. NM_022972.1: Suppressed sequence

    Description
    NM_022972.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.
  3. NM_022973.1: Suppressed sequence

    Description
    NM_022973.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.
  4. NM_022974.1: Suppressed sequence

    Description
    NM_022974.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.
  5. NM_022975.2: Suppressed sequence

    Description
    NM_022975.2: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.
  6. NM_022976.1: Suppressed sequence

    Description
    NM_022976.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.
  7. NM_023028.1: Suppressed sequence

    Description
    NM_023028.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.
  8. NM_023030.1: Suppressed sequence

    Description
    NM_023030.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.