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FGFR1 fibroblast growth factor receptor 1 [ Homo sapiens (human) ]

Gene ID: 2260, updated on 26-Jul-2015
Official Symbol
FGFR1provided by HGNC
Official Full Name
fibroblast growth factor receptor 1provided by HGNC
Primary source
HGNC:HGNC:3688
See related
Ensembl:ENSG00000077782; HPRD:00634; MIM:136350; Vega:OTTHUMG00000147366
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CEK; FLG; HH2; OGD; FLT2; KAL2; BFGFR; CD331; FGFBR; FLT-2; HBGFR; N-SAM; FGFR-1; HRTFDS; bFGF-R-1
Summary
The protein encoded by this gene is a member of the fibroblast growth factor receptor (FGFR) family, where amino acid sequence is highly conserved between members and throughout evolution. FGFR family members differ from one another in their ligand affinities and tissue distribution. A full-length representative protein consists of an extracellular region, composed of three immunoglobulin-like domains, a single hydrophobic membrane-spanning segment and a cytoplasmic tyrosine kinase domain. The extracellular portion of the protein interacts with fibroblast growth factors, setting in motion a cascade of downstream signals, ultimately influencing mitogenesis and differentiation. This particular family member binds both acidic and basic fibroblast growth factors and is involved in limb induction. Mutations in this gene have been associated with Pfeiffer syndrome, Jackson-Weiss syndrome, Antley-Bixler syndrome, osteoglophonic dysplasia, and autosomal dominant Kallmann syndrome 2. Chromosomal aberrations involving this gene are associated with stem cell myeloproliferative disorder and stem cell leukemia lymphoma syndrome. Alternatively spliced variants which encode different protein isoforms have been described; however, not all variants have been fully characterized. [provided by RefSeq, Jul 2008]
Orthologs
See FGFR1 in Epigenomics, MapViewer
Location:
8p11.23-p11.22
Exon count:
24
Annotation release Status Assembly Chr Location
107 current GRCh38.p2 (GCF_000001405.28) 8 NC_000008.11 (38411138..38468834, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 8 NC_000008.10 (38268656..38326352, complement)

Chromosome 8 - NC_000008.11Genomic Context describing neighboring genes Neighboring gene DDHD domain containing 2 Neighboring gene Wolf-Hirschhorn syndrome candidate 1-like 1 Neighboring gene uncharacterized LOC102723716 Neighboring gene leucine zipper-EF-hand containing transmembrane protein 2 Neighboring gene ribosomal protein S20 pseudogene 22 Neighboring gene chromosome 8 open reading frame 86 Neighboring gene uncharacterized LOC105379383

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Copy number response

Description
Copy number response
Triplosensitivity

No evidence available (Last evaluated (2012-03-22)

ClinGen Genome Curation Page
Haploinsufficency

Sufficient evidence for dosage pathogenicity (Last evaluated (2012-03-22)

ClinGen Genome Curation PagePubMed
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  • SOS-mediated signalling, organism-specific biosystem (from REACTOME)
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    Signal transduction by L1, organism-specific biosystemBesides adhesive roles in cell cell interaction, L1 functions as a signal transducing receptor providing neurons with cues from their environment for axonal growth and guidance. L1 associates with be...
  • Signaling Pathways in Glioblastoma, organism-specific biosystem (from WikiPathways)
    Signaling Pathways in Glioblastoma, organism-specific biosystemThe most frequently altered genes in glioblastoma. This pathway originally accompanied the 2008 Nature publication on the comprehensive genomic characterization of human glioblastoma genes and core p...
  • Signaling by EGFR, organism-specific biosystem (from REACTOME)
    Signaling by EGFR, organism-specific biosystemThe epidermal growth factor receptor (EGFR) is one member of the ERBB family of transmembrane glycoprotein tyrosine receptor kinases (RTK). Binding of EGFR to its ligands induces conformational chang...
  • Signaling by ERBB2, organism-specific biosystem (from REACTOME)
    Signaling by ERBB2, organism-specific biosystemERBB2, also known as HER2 or NEU, is a receptor tyrosine kinase (RTK) belonging to the EGFR family. ERBB2 possesses an extracellular domain that does not bind any known ligand, contrary to other EGFR...
  • Signaling by ERBB4, organism-specific biosystem (from REACTOME)
    Signaling by ERBB4, organism-specific biosystemERBB4, also known as HER4, belongs to the ERBB family of receptors, which also includes ERBB1 (EGFR i.e. HER1), ERBB2 (HER2 i.e. NEU) and ERBB3 (HER3). Similar to EGFR, ERBB4 has an extracellular lig...
  • Signaling by FGFR, organism-specific biosystem (from REACTOME)
    Signaling by FGFR, organism-specific biosystemThe 22 members of the fibroblast growth factor (FGF) family of growth factors mediate their cellular responses by binding to and activating the different isoforms encoded by the four receptor tyrosin...
  • Signaling by FGFR in disease, organism-specific biosystem (from REACTOME)
    Signaling by FGFR in disease, organism-specific biosystemA number of skeletal and developmental diseases have been shown to arise as a result of mutations in the FGFR1, 2 and 3 genes. These include dwarfism syndromes (achondroplasia, hypochondroplasia and...
  • Signaling by FGFR1, organism-specific biosystem (from REACTOME)
    Signaling by FGFR1, organism-specific biosystemThe 22 members of the fibroblast growth factor (FGF) family of growth factors mediate their cellular responses by binding to and activating the different isoforms encoded by the four receptor tyrosin...
  • Signaling by FGFR1 amplification mutants, organism-specific biosystem (from REACTOME)
    Signaling by FGFR1 amplification mutants, organism-specific biosystemAmplification or activation of FGFR1 has been reported in lung cancer (Weiss, 2001; Marek, 2009; Dutt, 2011), breast cancer (Reis-Filho, 2006; Turner, 2010), oral squamous carcinoma (Freier, 2007), ...
  • Signaling by FGFR1 in disease, organism-specific biosystem (from REACTOME)
    Signaling by FGFR1 in disease, organism-specific biosystemThe FGFR1 gene has been shown to be subject to activating mutations, chromosomal rearrangements and gene amplification leading to a variety of proliferative and developmental disorders depending on w...
  • Signaling by FGFR2, organism-specific biosystem (from REACTOME)
    Signaling by FGFR2, organism-specific biosystemThe 22 members of the fibroblast growth factor (FGF) family of growth factors mediate their cellular responses by binding to and activating the different isoforms encoded by the four receptor tyrosin...
  • Signaling by FGFR3, organism-specific biosystem (from REACTOME)
    Signaling by FGFR3, organism-specific biosystemThe 22 members of the fibroblast growth factor (FGF) family of growth factors mediate their cellular responses by binding to and activating the different isoforms encoded by the four receptor tyrosin...
  • Signaling by FGFR4, organism-specific biosystem (from REACTOME)
    Signaling by FGFR4, organism-specific biosystemThe 22 members of the fibroblast growth factor (FGF) family of growth factors mediate their cellular responses by binding to and activating the different isoforms encoded by the four receptor tyrosin...
  • Signaling by GPCR, organism-specific biosystem (from REACTOME)
    Signaling by GPCR, organism-specific biosystemG protein-coupled receptors (GPCRs; 7TM receptors; seven transmembrane domain receptors; heptahelical receptors; G protein-linked receptors [GPLR]) are the largest family of transmembrane receptors i...
  • Signaling by Insulin receptor, organism-specific biosystem (from REACTOME)
    Signaling by Insulin receptor, organism-specific biosystemInsulin binding to its receptor results in receptor autophosphorylation on tyrosine residues and the tyrosine phosphorylation of insulin receptor substrates (e.g. IRS and Shc) by the insulin receptor...
  • Signaling by Interleukins, organism-specific biosystem (from REACTOME)
    Signaling by Interleukins, organism-specific biosystemInterleukins are low molecular weight proteins that bind to cell surface receptors and act in an autocrine and/or paracrine fashion. They were first identified as factors produced by leukocytes but a...
  • Signaling by Leptin, organism-specific biosystem (from REACTOME)
    Signaling by Leptin, organism-specific biosystemLeptin (LEP, OB, OBS), a circulating adipokine, and its receptor LEPR (DB, OBR) control food intake and energy balance and are implicated in obesity-related diseases (recently reviewed in Amitani et ...
  • Signaling by PDGF, organism-specific biosystem (from REACTOME)
    Signaling by PDGF, organism-specific biosystemPlatelet-derived Growth Factor (PDGF) is a potent stimulator of growth and motility of connective tissue cells such as fibroblasts and smooth muscle cells as well as other cells such as capillary end...
  • Signaling by SCF-KIT, organism-specific biosystem (from REACTOME)
    Signaling by SCF-KIT, organism-specific biosystemStem cell factor (SCF) is a growth factor with membrane bound and soluble forms. It is expressed by fibroblasts and endothelial cells throughout the body, promoting proliferation, migration, survival...
  • Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R), organism-specific biosystem (from REACTOME)
    Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R), organism-specific biosystemBinding of IGF1 (IGF-I) or IGF2 (IGF-II) to the extracellular alpha peptides of the type 1 insulin-like growth factor receptor (IGF1R) triggers the activation of two major signaling pathways: the SOS...
  • Signaling by VEGF, organism-specific biosystem (from REACTOME)
    Signaling by VEGF, organism-specific biosystemIn normal development vascular endothelial growth factors (VEGFs) are crucial regulators of vascular development during embryogenesis (vasculogenesis) and blood-vessel formation in the adult (angioge...
  • Signaling by activated point mutants of FGFR1, organism-specific biosystem (from REACTOME)
    Signaling by activated point mutants of FGFR1, organism-specific biosystemUnlike FGFR2 and FGFR3, FGFR1 appears not to be a frequent target of activating point mutations (reviewed in Wesche, 2011; Turner and Grose, 2010). Germline point mutations at residue P252 have been...
  • Signaling by the B Cell Receptor (BCR), organism-specific biosystem (from REACTOME)
    Signaling by the B Cell Receptor (BCR), organism-specific biosystemMature B cells express IgM and IgD immunoglobulins which are complexed at the plasma membrane with Ig-alpha (CD79A, MB-1) and Ig-beta (CD79B, B29) to form the B cell receptor (BCR) (Fu et al. 1974, F...
  • Signaling pathways regulating pluripotency of stem cells, organism-specific biosystem (from KEGG)
    Signaling pathways regulating pluripotency of stem cells, organism-specific biosystemPluripotent stem cells (PSCs) are basic cells with an indefinite self-renewal capacity and the potential to generate all the cell types of the three germinal layers. The types of PSCs known to date i...
  • Signaling pathways regulating pluripotency of stem cells, conserved biosystem (from KEGG)
    Signaling pathways regulating pluripotency of stem cells, conserved biosystemPluripotent stem cells (PSCs) are basic cells with an indefinite self-renewal capacity and the potential to generate all the cell types of the three germinal layers. The types of PSCs known to date i...
  • Signalling by NGF, organism-specific biosystem (from REACTOME)
    Signalling by NGF, organism-specific biosystemNeurotrophins (NGF, BDNF, NT-3, NT-4/5) play pivotal roles in survival, differentiation, and plasticity of neurons in the peripheral and central nervous system. They are produced, and secreted in mi...
  • Signalling to ERKs, organism-specific biosystem (from REACTOME)
    Signalling to ERKs, organism-specific biosystemNeurotrophins utilize multiple pathways to activate ERKs (ERK1 and ERK2), a subgroup of the large MAP kinase (MAPK) family, from the plasma membrane. The major signalling pathways to ERKs are via RAS...
  • Signalling to RAS, organism-specific biosystem (from REACTOME)
    Signalling to RAS, organism-specific biosystemSignalling through Shc adaptor proteins appears to be identical for both NGF and EGF. It leads to a fast, but transient, MAPK/ERK activation, which is insufficient to explain the prolonged activation...
  • Signalling to p38 via RIT and RIN, organism-specific biosystem (from REACTOME)
    Signalling to p38 via RIT and RIN, organism-specific biosystemRIT and RIN are two small guanine nucleotide binding proteins that share more than 50% sequence identity with RAS, including highly conserved core effector domains. Unlike RAS, the C termini of RIT a...
  • Syndecan-4-mediated signaling events, organism-specific biosystem (from Pathway Interaction Database)
    Syndecan-4-mediated signaling events, organism-specific biosystem
    Syndecan-4-mediated signaling events
  • VEGFA-VEGFR2 Pathway, organism-specific biosystem (from REACTOME)
    VEGFA-VEGFR2 Pathway, organism-specific biosystemAngiogenesis is the formation of new blood vessels from preexisting vasculature. One of the most important proangiogenic factors is vascular endothelial growth factor (VEGF). VEGF exerts its biologic...
  • VEGFR2 mediated cell proliferation, organism-specific biosystem (from REACTOME)
    VEGFR2 mediated cell proliferation, organism-specific biosystemVEGFR2 stimulates ERK not via GRB2-SOS-RAS, but via pY1175-dependent phosphorylation of PLC gamma and subsequent activation of PKCs. PKC plays an important mediatory role in the proliferative Ras/Raf...
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Clone Names

  • FLJ99988

Gene Ontology Provided by GOA

Function Evidence Code Pubs
ATP binding IEA
Inferred from Electronic Annotation
more info
 
cell adhesion molecule binding IEA
Inferred from Electronic Annotation
more info
 
fibroblast growth factor binding IDA
Inferred from Direct Assay
more info
PubMed 
fibroblast growth factor-activated receptor activity IDA
Inferred from Direct Assay
more info
PubMed 
fibroblast growth factor-activated receptor activity TAS
Traceable Author Statement
more info
PubMed 
glycoprotein binding IEA
Inferred from Electronic Annotation
more info
 
heparin binding IDA
Inferred from Direct Assay
more info
PubMed 
identical protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein complex binding IEA
Inferred from Electronic Annotation
more info
 
protein homodimerization activity IPI
Inferred from Physical Interaction
more info
PubMed 
protein tyrosine kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
Fc-epsilon receptor signaling pathway TAS
Traceable Author Statement
more info
 
MAPK cascade TAS
Traceable Author Statement
more info
PubMed 
angiogenesis IEA
Inferred from Electronic Annotation
more info
 
auditory receptor cell development IEA
Inferred from Electronic Annotation
more info
 
axon guidance TAS
Traceable Author Statement
more info
 
branching involved in salivary gland morphogenesis IEA
Inferred from Electronic Annotation
more info
 
cell maturation IEA
Inferred from Electronic Annotation
more info
 
cell migration TAS
Traceable Author Statement
more info
PubMed 
chondrocyte differentiation IEA
Inferred from Electronic Annotation
more info
 
chordate embryonic development TAS
Traceable Author Statement
more info
PubMed 
embryonic limb morphogenesis IEA
Inferred from Electronic Annotation
more info
 
epidermal growth factor receptor signaling pathway TAS
Traceable Author Statement
more info
 
fibroblast growth factor receptor signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
fibroblast growth factor receptor signaling pathway IGI
Inferred from Genetic Interaction
more info
PubMed 
fibroblast growth factor receptor signaling pathway IPI
Inferred from Physical Interaction
more info
PubMed 
fibroblast growth factor receptor signaling pathway TAS
Traceable Author Statement
more info
 
fibroblast growth factor receptor signaling pathway involved in orbitofrontal cortex development IEA
Inferred from Electronic Annotation
more info
 
in utero embryonic development IEA
Inferred from Electronic Annotation
more info
 
innate immune response TAS
Traceable Author Statement
more info
 
inner ear morphogenesis IEA
Inferred from Electronic Annotation
more info
 
insulin receptor signaling pathway TAS
Traceable Author Statement
more info
 
lung-associated mesenchyme development IEA
Inferred from Electronic Annotation
more info
 
mesenchymal cell differentiation IEA
Inferred from Electronic Annotation
more info
 
midbrain development IEA
Inferred from Electronic Annotation
more info
 
middle ear morphogenesis IEA
Inferred from Electronic Annotation
more info
 
motogenic signaling involved in postnatal olfactory bulb interneuron migration IEA
Inferred from Electronic Annotation
more info
 
negative regulation of osteoblast differentiation IEA
Inferred from Electronic Annotation
more info
 
negative regulation of transcription from RNA polymerase II promoter IEA
Inferred from Electronic Annotation
more info
 
neuron migration TAS
Traceable Author Statement
more info
PubMed 
neurotrophin TRK receptor signaling pathway TAS
Traceable Author Statement
more info
 
organ induction IEA
Inferred from Electronic Annotation
more info
 
outer ear morphogenesis IEA
Inferred from Electronic Annotation
more info
 
paraxial mesoderm development IEA
Inferred from Electronic Annotation
more info
 
peptidyl-tyrosine phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
phosphatidylinositol-mediated signaling TAS
Traceable Author Statement
more info
PubMed 
positive regulation of MAP kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of MAPK cascade IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of MAPKKK cascade by fibroblast growth factor receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
positive regulation of cardiac muscle cell proliferation IEA
Inferred from Electronic Annotation
more info
 
positive regulation of cell cycle IEA
Inferred from Electronic Annotation
more info
 
positive regulation of cell proliferation IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of cell proliferation IGI
Inferred from Genetic Interaction
more info
PubMed 
positive regulation of cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of mesenchymal cell proliferation IEA
Inferred from Electronic Annotation
more info
 
positive regulation of neuron differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of neuron projection development IEA
Inferred from Electronic Annotation
more info
 
positive regulation of phosphatidylinositol 3-kinase signaling TAS
Traceable Author Statement
more info
PubMed 
positive regulation of phospholipase C activity IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of phospholipase activity TAS
Traceable Author Statement
more info
PubMed 
protein autophosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
protein phosphorylation NAS
Non-traceable Author Statement
more info
PubMed 
regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling IEA
Inferred from Electronic Annotation
more info
 
regulation of cell differentiation TAS
Traceable Author Statement
more info
PubMed 
regulation of extrinsic apoptotic signaling pathway in absence of ligand IEA
Inferred from Electronic Annotation
more info
 
regulation of lateral mesodermal cell fate specification IEA
Inferred from Electronic Annotation
more info
 
regulation of sensory perception of pain IEA
Inferred from Electronic Annotation
more info
 
sensory perception of sound IEA
Inferred from Electronic Annotation
more info
 
skeletal system development TAS
Traceable Author Statement
more info
PubMed 
skeletal system morphogenesis TAS
Traceable Author Statement
more info
PubMed 
stem cell maintenance IEA
Inferred from Electronic Annotation
more info
 
transcription, DNA-templated IEA
Inferred from Electronic Annotation
more info
 
ureteric bud development IEA
Inferred from Electronic Annotation
more info
 
ventricular zone neuroblast division IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
cytoplasmic membrane-bounded vesicle IEA
Inferred from Electronic Annotation
more info
 
cytosol IEA
Inferred from Electronic Annotation
more info
 
extracellular region NAS
Non-traceable Author Statement
more info
PubMed 
integral component of membrane NAS
Non-traceable Author Statement
more info
PubMed 
integral component of plasma membrane TAS
Traceable Author Statement
more info
PubMed 
nucleus IEA
Inferred from Electronic Annotation
more info
 
plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
plasma membrane TAS
Traceable Author Statement
more info
 
receptor complex IDA
Inferred from Direct Assay
more info
PubMed 
Preferred Names
fibroblast growth factor receptor 1
Names
FGFR1/PLAG1 fusion
FMS-like tyrosine kinase 2
basic fibroblast growth factor receptor 1
fms-related tyrosine kinase 2
heparin-binding growth factor receptor
hydroxyaryl-protein kinase
proto-oncogene c-Fgr
NP_001167534.1
NP_001167535.1
NP_001167536.1
NP_001167537.1
NP_001167538.1
NP_056934.2
NP_075593.1
NP_075594.1
NP_075598.2

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_007729.1 RefSeqGene

    Range
    5001..62697
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001174063.1NP_001167534.1  fibroblast growth factor receptor 1 isoform 10 precursor

    See identical proteins and their annotated locations for NP_001167534.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (10) uses an alternate in-frame splice site in the central coding region, compared to variant 1. The resulting isoform (10) lacks a 2-aa segment, compared to isoform 1.
    Source sequence(s)
    BC015035, FJ809917
    Consensus CDS
    CCDS55222.1
    UniProtKB/Swiss-Prot
    P11362
    Related
    ENSP00000432972, OTTHUMP00000190875, ENST00000532791, OTTHUMT00000304011
    Conserved Domains (8) summary
    cd04973
    Location:40118
    Ig1_FGFR; First immunoglobulin (Ig)-like domain of fibroblast growth factor receptor (FGFR)
    cd04974
    Location:270359
    Ig3_FGFR; Third immunoglobulin (Ig)-like domain of fibroblast growth factor receptor (FGFR)
    cd05857
    Location:163247
    Ig2_FGFR; Second immunoglobulin (Ig)-like domain of fibroblast growth factor (FGF) receptor
    smart00408
    Location:47108
    IGc2; Immunoglobulin C-2 Type
    smart00410
    Location:262358
    IG_like; Immunoglobulin like
    pfam07679
    Location:160247
    I-set; Immunoglobulin I-set domain
    pfam07714
    Location:476752
    Pkinase_Tyr; Protein tyrosine kinase
    cd05098
    Location:462763
    PTKc_FGFR1; Catalytic domain of the Protein Tyrosine Kinase, Fibroblast Growth Factor Receptor 1
  2. NM_001174064.1NP_001167535.1  fibroblast growth factor receptor 1 isoform 11 precursor

    See identical proteins and their annotated locations for NP_001167535.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (11) includes an alternate exon, uses an alternate translation start site, and uses an alternate in-frame splice site in the central coding region, compared to variant 1. The resulting isoform (11) has a shorter and distinct N-terminus and lacks a 2-aa segment, compared to isoform 1.
    Source sequence(s)
    AB208919, FJ809917
    Consensus CDS
    CCDS55221.1
    UniProtKB/Swiss-Prot
    P11362
    Conserved Domains (8) summary
    cd04973
    Location:32110
    Ig1_FGFR; First immunoglobulin (Ig)-like domain of fibroblast growth factor receptor (FGFR)
    cd04974
    Location:262351
    Ig3_FGFR; Third immunoglobulin (Ig)-like domain of fibroblast growth factor receptor (FGFR)
    cd05857
    Location:155239
    Ig2_FGFR; Second immunoglobulin (Ig)-like domain of fibroblast growth factor (FGF) receptor
    smart00408
    Location:39100
    IGc2; Immunoglobulin C-2 Type
    smart00410
    Location:254350
    IG_like; Immunoglobulin like
    pfam07679
    Location:152239
    I-set; Immunoglobulin I-set domain
    pfam07714
    Location:468744
    Pkinase_Tyr; Protein tyrosine kinase
    cd05098
    Location:454755
    PTKc_FGFR1; Catalytic domain of the Protein Tyrosine Kinase, Fibroblast Growth Factor Receptor 1
  3. NM_001174065.1NP_001167536.1  fibroblast growth factor receptor 1 isoform 2 precursor

    See identical proteins and their annotated locations for NP_001167536.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (12) represents use of an alternate promoter and 5' UTR and uses an alternate in-frame splice site in the central coding region, compared to variant 1. The resulting isoform (2), also known as isoform A, III, and the 3-Ig domain form, lacks a 2-aa segment, compared to isoform 1. Both variants 2 and 12 encode the same isoform.z
    Source sequence(s)
    AK291754, AK292470, FJ809917
    Consensus CDS
    CCDS43732.1
    UniProtKB/Swiss-Prot
    P11362
    Conserved Domains (8) summary
    cd04973
    Location:40118
    Ig1_FGFR; First immunoglobulin (Ig)-like domain of fibroblast growth factor receptor (FGFR)
    cd04974
    Location:268357
    Ig3_FGFR; Third immunoglobulin (Ig)-like domain of fibroblast growth factor receptor (FGFR)
    cd05857
    Location:161245
    Ig2_FGFR; Second immunoglobulin (Ig)-like domain of fibroblast growth factor (FGF) receptor
    smart00408
    Location:47108
    IGc2; Immunoglobulin C-2 Type
    smart00410
    Location:260356
    IG_like; Immunoglobulin like
    pfam07679
    Location:158245
    I-set; Immunoglobulin I-set domain
    pfam07714
    Location:476752
    Pkinase_Tyr; Protein tyrosine kinase
    cd05098
    Location:462763
    PTKc_FGFR1; Catalytic domain of the Protein Tyrosine Kinase, Fibroblast Growth Factor Receptor 1
  4. NM_001174066.1NP_001167537.1  fibroblast growth factor receptor 1 isoform 3 precursor

    See identical proteins and their annotated locations for NP_001167537.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (12) represents use of an alternate promoter and 5' UTR and lacks an alternate in-frame exon in the 5' coding region, compared to variant 1. The resulting isoform (3), also known as isoform Beta A1, II, H2, and the 2-Ig Domain+2 AA insert form, lacks the first Ig domain, compared to isoform 1. Both variants 3 and 13 encode the same isoform.
    Source sequence(s)
    AK292470, FJ809917
    Consensus CDS
    CCDS43730.1
    UniProtKB/Swiss-Prot
    P11362
    Conserved Domains (6) summary
    cd04974
    Location:181270
    Ig3_FGFR; Third immunoglobulin (Ig)-like domain of fibroblast growth factor receptor (FGFR)
    cd05857
    Location:74158
    Ig2_FGFR; Second immunoglobulin (Ig)-like domain of fibroblast growth factor (FGF) receptor
    smart00410
    Location:173269
    IG_like; Immunoglobulin like
    pfam07679
    Location:71158
    I-set; Immunoglobulin I-set domain
    pfam07714
    Location:389665
    Pkinase_Tyr; Protein tyrosine kinase
    cd05098
    Location:375676
    PTKc_FGFR1; Catalytic domain of the Protein Tyrosine Kinase, Fibroblast Growth Factor Receptor 1
  5. NM_001174067.1NP_001167538.1  fibroblast growth factor receptor 1 isoform 14 precursor

    Status: REVIEWED

    Description
    Transcript Variant: This variant (14) represents use of an alternate promoter and 5' UTR, includes an alternate exon, uses an alternate translation start site, and uses an alternate in-frame splice site, compared to variant 1. The resulting isoform (14) lacks two internal segments, compared to isoform 1.
    Source sequence(s)
    AC087623, AK292470, AK309947, FJ809917
    Consensus CDS
    CCDS55223.1
    UniProtKB/Swiss-Prot
    P11362
    Related
    ENSP00000393312, ENST00000425967
    Conserved Domains (8) summary
    cd04973
    Location:73151
    Ig1_FGFR; First immunoglobulin (Ig)-like domain of fibroblast growth factor receptor (FGFR)
    cd04974
    Location:301390
    Ig3_FGFR; Third immunoglobulin (Ig)-like domain of fibroblast growth factor receptor (FGFR)
    cd05857
    Location:194278
    Ig2_FGFR; Second immunoglobulin (Ig)-like domain of fibroblast growth factor (FGF) receptor
    smart00408
    Location:80141
    IGc2; Immunoglobulin C-2 Type
    smart00410
    Location:293389
    IG_like; Immunoglobulin like
    pfam07679
    Location:191278
    I-set; Immunoglobulin I-set domain
    pfam07714
    Location:509785
    Pkinase_Tyr; Protein tyrosine kinase
    cd05098
    Location:495796
    PTKc_FGFR1; Catalytic domain of the Protein Tyrosine Kinase, Fibroblast Growth Factor Receptor 1
  6. NM_015850.3NP_056934.2  fibroblast growth factor receptor 1 isoform 2 precursor

    See identical proteins and their annotated locations for NP_056934.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 5' coding region, compared to variant 1. The resulting isoform (2), also known as isoform A, III, and the 3-Ig domain form, lacks a 2-aa segment, compared to isoform 1. Both variants 2 and 12 encode the same isoform.
    Source sequence(s)
    AC087623, AK130555, AK222718, AW206093, BC018128, BQ774633, CX757985
    Consensus CDS
    CCDS43732.1
    UniProtKB/Swiss-Prot
    P11362
    Related
    ENSP00000380280, OTTHUMP00000190874, ENST00000397091, OTTHUMT00000304010
    Conserved Domains (8) summary
    cd04973
    Location:40118
    Ig1_FGFR; First immunoglobulin (Ig)-like domain of fibroblast growth factor receptor (FGFR)
    cd04974
    Location:268357
    Ig3_FGFR; Third immunoglobulin (Ig)-like domain of fibroblast growth factor receptor (FGFR)
    cd05857
    Location:161245
    Ig2_FGFR; Second immunoglobulin (Ig)-like domain of fibroblast growth factor (FGF) receptor
    smart00408
    Location:47108
    IGc2; Immunoglobulin C-2 Type
    smart00410
    Location:260356
    IG_like; Immunoglobulin like
    pfam07679
    Location:158245
    I-set; Immunoglobulin I-set domain
    pfam07714
    Location:476752
    Pkinase_Tyr; Protein tyrosine kinase
    cd05098
    Location:462763
    PTKc_FGFR1; Catalytic domain of the Protein Tyrosine Kinase, Fibroblast Growth Factor Receptor 1
  7. NM_023105.2NP_075593.1  fibroblast growth factor receptor 1 isoform 3 precursor

    See identical proteins and their annotated locations for NP_075593.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) lacks an alternate in-frame exon, compared to variant 1. The resulting isoform (3), also known as isoform Beta A1, II, H2, and the 2-Ig Domain+2 AA insert form, lacks the first Ig domain, compared to isoform 1. Both variants 3 and 13 encode the same isoform.
    Source sequence(s)
    AC087623, AK130555, AW206093, BC018128, BQ774633, CX756209, CX757985, M34185
    Consensus CDS
    CCDS43730.1
    UniProtKB/Swiss-Prot
    P11362
    Conserved Domains (6) summary
    cd04974
    Location:181270
    Ig3_FGFR; Third immunoglobulin (Ig)-like domain of fibroblast growth factor receptor (FGFR)
    cd05857
    Location:74158
    Ig2_FGFR; Second immunoglobulin (Ig)-like domain of fibroblast growth factor (FGF) receptor
    smart00410
    Location:173269
    IG_like; Immunoglobulin like
    pfam07679
    Location:71158
    I-set; Immunoglobulin I-set domain
    pfam07714
    Location:389665
    Pkinase_Tyr; Protein tyrosine kinase
    cd05098
    Location:375676
    PTKc_FGFR1; Catalytic domain of the Protein Tyrosine Kinase, Fibroblast Growth Factor Receptor 1
  8. NM_023106.2NP_075594.1  fibroblast growth factor receptor 1 isoform 4 precursor

    See identical proteins and their annotated locations for NP_075594.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) lacks an alternate in-frame exon and uses a different in-frame splice junction compared to variant 1. This variant encodes isoform 4, also known as isoform I, H3, and the 2-Ig Domain form, which is 91 aa shorter than isoform 1.
    Source sequence(s)
    AC087623, AK130555, AW206093, BC091494, BQ774633, CX757985, M37722
    Consensus CDS
    CCDS43731.1
    UniProtKB/Swiss-Prot
    P11362
    Conserved Domains (6) summary
    cd04974
    Location:179268
    Ig3_FGFR; Third immunoglobulin (Ig)-like domain of fibroblast growth factor receptor (FGFR)
    cd05857
    Location:72156
    Ig2_FGFR; Second immunoglobulin (Ig)-like domain of fibroblast growth factor (FGF) receptor
    smart00410
    Location:171267
    IG_like; Immunoglobulin like
    pfam07679
    Location:69156
    I-set; Immunoglobulin I-set domain
    pfam07714
    Location:387663
    Pkinase_Tyr; Protein tyrosine kinase
    cd05098
    Location:373674
    PTKc_FGFR1; Catalytic domain of the Protein Tyrosine Kinase, Fibroblast Growth Factor Receptor 1
  9. NM_023110.2NP_075598.2  fibroblast growth factor receptor 1 isoform 1 precursor

    See identical proteins and their annotated locations for NP_075598.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1), also known as isoform Alpha A1, IV and the 3-Ig domain+2 AA insert form.
    Source sequence(s)
    AC087623, AK130555, AW206093, BC018128, BQ774633, CX757985, X66945
    Consensus CDS
    CCDS6107.2
    UniProtKB/Swiss-Prot
    P11362
    Related
    ENSP00000400162, ENST00000447712
    Conserved Domains (8) summary
    cd04973
    Location:40118
    Ig1_FGFR; First immunoglobulin (Ig)-like domain of fibroblast growth factor receptor (FGFR)
    cd04974
    Location:270359
    Ig3_FGFR; Third immunoglobulin (Ig)-like domain of fibroblast growth factor receptor (FGFR)
    cd05857
    Location:163247
    Ig2_FGFR; Second immunoglobulin (Ig)-like domain of fibroblast growth factor (FGF) receptor
    smart00408
    Location:47108
    IGc2; Immunoglobulin C-2 Type
    smart00410
    Location:262358
    IG_like; Immunoglobulin like
    pfam07679
    Location:160247
    I-set; Immunoglobulin I-set domain
    pfam07714
    Location:478754
    Pkinase_Tyr; Protein tyrosine kinase
    cd05098
    Location:464765
    PTKc_FGFR1; Catalytic domain of the Protein Tyrosine Kinase, Fibroblast Growth Factor Receptor 1

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 107

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p2 Primary Assembly

Genomic

  1. NC_000008.11 Reference GRCh38.p2 Primary Assembly

    Range
    38411138..38468834
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006716313.2XP_006716376.1  

    See identical proteins and their annotated locations for XP_006716376.1

    Conserved Domains (6) summary
    cd04974
    Location:179268
    Ig3_FGFR; Third immunoglobulin (Ig)-like domain of fibroblast growth factor receptor (FGFR)
    cd05857
    Location:72156
    Ig2_FGFR; Second immunoglobulin (Ig)-like domain of fibroblast growth factor (FGF) receptor
    smart00410
    Location:171267
    IG_like; Immunoglobulin like
    pfam07679
    Location:69156
    I-set; Immunoglobulin I-set domain
    pfam07714
    Location:387663
    Pkinase_Tyr; Protein tyrosine kinase
    cd05098
    Location:373673
    PTKc_FGFR1; Catalytic domain of the Protein Tyrosine Kinase, Fibroblast Growth Factor Receptor 1
  2. XM_006716310.2XP_006716373.1  

    See identical proteins and their annotated locations for XP_006716373.1

    Conserved Domains (6) summary
    cd04974
    Location:181270
    Ig3_FGFR; Third immunoglobulin (Ig)-like domain of fibroblast growth factor receptor (FGFR)
    cd05857
    Location:74158
    Ig2_FGFR; Second immunoglobulin (Ig)-like domain of fibroblast growth factor (FGF) receptor
    smart00410
    Location:173269
    IG_like; Immunoglobulin like
    pfam07679
    Location:71158
    I-set; Immunoglobulin I-set domain
    pfam07714
    Location:389665
    Pkinase_Tyr; Protein tyrosine kinase
    cd05098
    Location:375675
    PTKc_FGFR1; Catalytic domain of the Protein Tyrosine Kinase, Fibroblast Growth Factor Receptor 1
  3. XM_006716306.2XP_006716369.1  

    See identical proteins and their annotated locations for XP_006716369.1

    Conserved Domains (8) summary
    cd04973
    Location:40118
    Ig1_FGFR; First immunoglobulin (Ig)-like domain of fibroblast growth factor receptor (FGFR)
    cd04974
    Location:268357
    Ig3_FGFR; Third immunoglobulin (Ig)-like domain of fibroblast growth factor receptor (FGFR)
    cd05857
    Location:161245
    Ig2_FGFR; Second immunoglobulin (Ig)-like domain of fibroblast growth factor (FGF) receptor
    smart00408
    Location:47108
    IGc2; Immunoglobulin C-2 Type
    smart00410
    Location:260356
    IG_like; Immunoglobulin like
    pfam07679
    Location:158245
    I-set; Immunoglobulin I-set domain
    pfam07714
    Location:476752
    Pkinase_Tyr; Protein tyrosine kinase
    cd05098
    Location:462762
    PTKc_FGFR1; Catalytic domain of the Protein Tyrosine Kinase, Fibroblast Growth Factor Receptor 1
  4. XM_006716303.2XP_006716366.1  

    See identical proteins and their annotated locations for XP_006716366.1

    Conserved Domains (8) summary
    cd04973
    Location:40118
    Ig1_FGFR; First immunoglobulin (Ig)-like domain of fibroblast growth factor receptor (FGFR)
    cd04974
    Location:270359
    Ig3_FGFR; Third immunoglobulin (Ig)-like domain of fibroblast growth factor receptor (FGFR)
    cd05857
    Location:163247
    Ig2_FGFR; Second immunoglobulin (Ig)-like domain of fibroblast growth factor (FGF) receptor
    smart00408
    Location:47108
    IGc2; Immunoglobulin C-2 Type
    smart00410
    Location:262358
    IG_like; Immunoglobulin like
    pfam07679
    Location:160247
    I-set; Immunoglobulin I-set domain
    pfam07714
    Location:478754
    Pkinase_Tyr; Protein tyrosine kinase
    cd05098
    Location:464764
    PTKc_FGFR1; Catalytic domain of the Protein Tyrosine Kinase, Fibroblast Growth Factor Receptor 1
  5. XM_006716307.1XP_006716370.1  

    See identical proteins and their annotated locations for XP_006716370.1

    Conserved Domains (8) summary
    cd04973
    Location:40118
    Ig1_FGFR; First immunoglobulin (Ig)-like domain of fibroblast growth factor receptor (FGFR)
    cd04974
    Location:268357
    Ig3_FGFR; Third immunoglobulin (Ig)-like domain of fibroblast growth factor receptor (FGFR)
    cd05857
    Location:161245
    Ig2_FGFR; Second immunoglobulin (Ig)-like domain of fibroblast growth factor (FGF) receptor
    smart00408
    Location:47108
    IGc2; Immunoglobulin C-2 Type
    smart00410
    Location:260356
    IG_like; Immunoglobulin like
    pfam07679
    Location:158245
    I-set; Immunoglobulin I-set domain
    pfam07714
    Location:476752
    Pkinase_Tyr; Protein tyrosine kinase
    cd05098
    Location:462762
    PTKc_FGFR1; Catalytic domain of the Protein Tyrosine Kinase, Fibroblast Growth Factor Receptor 1
  6. XM_006716304.1XP_006716367.1  

    See identical proteins and their annotated locations for XP_006716367.1

    Conserved Domains (8) summary
    cd04973
    Location:40118
    Ig1_FGFR; First immunoglobulin (Ig)-like domain of fibroblast growth factor receptor (FGFR)
    cd04974
    Location:270359
    Ig3_FGFR; Third immunoglobulin (Ig)-like domain of fibroblast growth factor receptor (FGFR)
    cd05857
    Location:163247
    Ig2_FGFR; Second immunoglobulin (Ig)-like domain of fibroblast growth factor (FGF) receptor
    smart00408
    Location:47108
    IGc2; Immunoglobulin C-2 Type
    smart00410
    Location:262358
    IG_like; Immunoglobulin like
    pfam07679
    Location:160247
    I-set; Immunoglobulin I-set domain
    pfam07714
    Location:478754
    Pkinase_Tyr; Protein tyrosine kinase
    cd05098
    Location:464764
    PTKc_FGFR1; Catalytic domain of the Protein Tyrosine Kinase, Fibroblast Growth Factor Receptor 1
  7. XM_006716314.1XP_006716377.1  

    See identical proteins and their annotated locations for XP_006716377.1

    Conserved Domains (6) summary
    cd04974
    Location:179268
    Ig3_FGFR; Third immunoglobulin (Ig)-like domain of fibroblast growth factor receptor (FGFR)
    cd05857
    Location:72156
    Ig2_FGFR; Second immunoglobulin (Ig)-like domain of fibroblast growth factor (FGF) receptor
    smart00410
    Location:171267
    IG_like; Immunoglobulin like
    pfam07679
    Location:69156
    I-set; Immunoglobulin I-set domain
    pfam07714
    Location:387663
    Pkinase_Tyr; Protein tyrosine kinase
    cd05098
    Location:373673
    PTKc_FGFR1; Catalytic domain of the Protein Tyrosine Kinase, Fibroblast Growth Factor Receptor 1
  8. XM_006716311.1XP_006716374.1  

    See identical proteins and their annotated locations for XP_006716374.1

    Conserved Domains (6) summary
    cd04974
    Location:181270
    Ig3_FGFR; Third immunoglobulin (Ig)-like domain of fibroblast growth factor receptor (FGFR)
    cd05857
    Location:74158
    Ig2_FGFR; Second immunoglobulin (Ig)-like domain of fibroblast growth factor (FGF) receptor
    smart00410
    Location:173269
    IG_like; Immunoglobulin like
    pfam07679
    Location:71158
    I-set; Immunoglobulin I-set domain
    pfam07714
    Location:389665
    Pkinase_Tyr; Protein tyrosine kinase
    cd05098
    Location:375675
    PTKc_FGFR1; Catalytic domain of the Protein Tyrosine Kinase, Fibroblast Growth Factor Receptor 1
  9. XM_006716305.2XP_006716368.1  

    See identical proteins and their annotated locations for XP_006716368.1

    Conserved Domains (8) summary
    cd04973
    Location:40118
    Ig1_FGFR; First immunoglobulin (Ig)-like domain of fibroblast growth factor receptor (FGFR)
    cd04974
    Location:270359
    Ig3_FGFR; Third immunoglobulin (Ig)-like domain of fibroblast growth factor receptor (FGFR)
    cd05857
    Location:163247
    Ig2_FGFR; Second immunoglobulin (Ig)-like domain of fibroblast growth factor (FGF) receptor
    smart00408
    Location:47108
    IGc2; Immunoglobulin C-2 Type
    smart00410
    Location:262358
    IG_like; Immunoglobulin like
    pfam07679
    Location:160247
    I-set; Immunoglobulin I-set domain
    pfam07714
    Location:478754
    Pkinase_Tyr; Protein tyrosine kinase
    cd05098
    Location:464764
    PTKc_FGFR1; Catalytic domain of the Protein Tyrosine Kinase, Fibroblast Growth Factor Receptor 1
  10. XM_011544444.1XP_011542746.1  

    Conserved Domains (8) summary
    cd04973
    Location:73151
    Ig1_FGFR; First immunoglobulin (Ig)-like domain of fibroblast growth factor receptor (FGFR)
    cd04974
    Location:301390
    Ig3_FGFR; Third immunoglobulin (Ig)-like domain of fibroblast growth factor receptor (FGFR)
    cd05857
    Location:194278
    Ig2_FGFR; Second immunoglobulin (Ig)-like domain of fibroblast growth factor (FGF) receptor
    smart00408
    Location:80141
    IGc2; Immunoglobulin C-2 Type
    smart00410
    Location:293389
    IG_like; Immunoglobulin like
    pfam07679
    Location:191278
    I-set; Immunoglobulin I-set domain
    pfam07714
    Location:509785
    Pkinase_Tyr; Protein tyrosine kinase
    cd05098
    Location:495795
    PTKc_FGFR1; Catalytic domain of the Protein Tyrosine Kinase, Fibroblast Growth Factor Receptor 1
  11. XM_011544445.1XP_011542747.1  

    Conserved Domains (8) summary
    cd04973
    Location:73151
    Ig1_FGFR; First immunoglobulin (Ig)-like domain of fibroblast growth factor receptor (FGFR)
    cd04974
    Location:303392
    Ig3_FGFR; Third immunoglobulin (Ig)-like domain of fibroblast growth factor receptor (FGFR)
    cd05857
    Location:196280
    Ig2_FGFR; Second immunoglobulin (Ig)-like domain of fibroblast growth factor (FGF) receptor
    smart00408
    Location:80141
    IGc2; Immunoglobulin C-2 Type
    smart00410
    Location:295391
    IG_like; Immunoglobulin like
    pfam07679
    Location:193280
    I-set; Immunoglobulin I-set domain
    pfam07714
    Location:509785
    Pkinase_Tyr; Protein tyrosine kinase
    cd05098
    Location:495795
    PTKc_FGFR1; Catalytic domain of the Protein Tyrosine Kinase, Fibroblast Growth Factor Receptor 1
  12. XM_011544443.1XP_011542745.1  

    Conserved Domains (8) summary
    cd04973
    Location:73151
    Ig1_FGFR; First immunoglobulin (Ig)-like domain of fibroblast growth factor receptor (FGFR)
    cd04974
    Location:303392
    Ig3_FGFR; Third immunoglobulin (Ig)-like domain of fibroblast growth factor receptor (FGFR)
    cd05857
    Location:196280
    Ig2_FGFR; Second immunoglobulin (Ig)-like domain of fibroblast growth factor (FGF) receptor
    smart00408
    Location:80141
    IGc2; Immunoglobulin C-2 Type
    smart00410
    Location:295391
    IG_like; Immunoglobulin like
    pfam07679
    Location:193280
    I-set; Immunoglobulin I-set domain
    pfam07714
    Location:511787
    Pkinase_Tyr; Protein tyrosine kinase
    cd05098
    Location:497797
    PTKc_FGFR1; Catalytic domain of the Protein Tyrosine Kinase, Fibroblast Growth Factor Receptor 1
  13. XM_011544449.1XP_011542751.1  

    Conserved Domains (6) summary
    cd04974
    Location:212301
    Ig3_FGFR; Third immunoglobulin (Ig)-like domain of fibroblast growth factor receptor (FGFR)
    cd05857
    Location:105189
    Ig2_FGFR; Second immunoglobulin (Ig)-like domain of fibroblast growth factor (FGF) receptor
    smart00410
    Location:204300
    IG_like; Immunoglobulin like
    pfam07679
    Location:102189
    I-set; Immunoglobulin I-set domain
    pfam07714
    Location:420696
    Pkinase_Tyr; Protein tyrosine kinase
    cd05098
    Location:406706
    PTKc_FGFR1; Catalytic domain of the Protein Tyrosine Kinase, Fibroblast Growth Factor Receptor 1
  14. XM_011544448.1XP_011542750.1  

    Conserved Domains (6) summary
    cd04974
    Location:214303
    Ig3_FGFR; Third immunoglobulin (Ig)-like domain of fibroblast growth factor receptor (FGFR)
    cd05857
    Location:107191
    Ig2_FGFR; Second immunoglobulin (Ig)-like domain of fibroblast growth factor (FGF) receptor
    smart00410
    Location:206302
    IG_like; Immunoglobulin like
    pfam07679
    Location:104191
    I-set; Immunoglobulin I-set domain
    pfam07714
    Location:422698
    Pkinase_Tyr; Protein tyrosine kinase
    cd05098
    Location:408708
    PTKc_FGFR1; Catalytic domain of the Protein Tyrosine Kinase, Fibroblast Growth Factor Receptor 1
  15. XM_006716312.1XP_006716375.1  

    See identical proteins and their annotated locations for XP_006716375.1

    Conserved Domains (6) summary
    cd04974
    Location:181270
    Ig3_FGFR; Third immunoglobulin (Ig)-like domain of fibroblast growth factor receptor (FGFR)
    cd05857
    Location:74158
    Ig2_FGFR; Second immunoglobulin (Ig)-like domain of fibroblast growth factor (FGF) receptor
    smart00410
    Location:173269
    IG_like; Immunoglobulin like
    pfam07679
    Location:71158
    I-set; Immunoglobulin I-set domain
    pfam07714
    Location:389665
    Pkinase_Tyr; Protein tyrosine kinase
    cd05098
    Location:375675
    PTKc_FGFR1; Catalytic domain of the Protein Tyrosine Kinase, Fibroblast Growth Factor Receptor 1
  16. XM_011544451.1XP_011542753.1  

    Conserved Domains (6) summary
    cd04974
    Location:173262
    Ig3_FGFR; Third immunoglobulin (Ig)-like domain of fibroblast growth factor receptor (FGFR)
    cd05857
    Location:66150
    Ig2_FGFR; Second immunoglobulin (Ig)-like domain of fibroblast growth factor (FGF) receptor
    smart00410
    Location:165261
    IG_like; Immunoglobulin like
    pfam07679
    Location:63150
    I-set; Immunoglobulin I-set domain
    pfam07714
    Location:381657
    Pkinase_Tyr; Protein tyrosine kinase
    cd05098
    Location:367667
    PTKc_FGFR1; Catalytic domain of the Protein Tyrosine Kinase, Fibroblast Growth Factor Receptor 1
  17. XM_006716309.2XP_006716372.1  

    Conserved Domains (8) summary
    cd04973
    Location:32110
    Ig1_FGFR; First immunoglobulin (Ig)-like domain of fibroblast growth factor receptor (FGFR)
    cd04974
    Location:262351
    Ig3_FGFR; Third immunoglobulin (Ig)-like domain of fibroblast growth factor receptor (FGFR)
    cd05857
    Location:155239
    Ig2_FGFR; Second immunoglobulin (Ig)-like domain of fibroblast growth factor (FGF) receptor
    smart00408
    Location:39100
    IGc2; Immunoglobulin C-2 Type
    smart00410
    Location:254350
    IG_like; Immunoglobulin like
    pfam07679
    Location:152239
    I-set; Immunoglobulin I-set domain
    pfam07714
    Location:470746
    Pkinase_Tyr; Protein tyrosine kinase
    cd05098
    Location:456756
    PTKc_FGFR1; Catalytic domain of the Protein Tyrosine Kinase, Fibroblast Growth Factor Receptor 1
  18. XM_011544447.1XP_011542749.1  

    Conserved Domains (8) summary
    cd04973
    Location:73151
    Ig1_FGFR; First immunoglobulin (Ig)-like domain of fibroblast growth factor receptor (FGFR)
    cd04974
    Location:303392
    Ig3_FGFR; Third immunoglobulin (Ig)-like domain of fibroblast growth factor receptor (FGFR)
    cd05857
    Location:196280
    Ig2_FGFR; Second immunoglobulin (Ig)-like domain of fibroblast growth factor (FGF) receptor
    smart00408
    Location:80141
    IGc2; Immunoglobulin C-2 Type
    smart00410
    Location:295391
    IG_like; Immunoglobulin like
    pfam07679
    Location:193280
    I-set; Immunoglobulin I-set domain
    pfam07714
    Location:509785
    Pkinase_Tyr; Protein tyrosine kinase
    cd05098
    Location:495796
    PTKc_FGFR1; Catalytic domain of the Protein Tyrosine Kinase, Fibroblast Growth Factor Receptor 1
  19. XM_011544446.1XP_011542748.1  

    Related
    ENSP00000380302, OTTHUMP00000190881, ENST00000397113, OTTHUMT00000304021
    Conserved Domains (8) summary
    cd04973
    Location:73151
    Ig1_FGFR; First immunoglobulin (Ig)-like domain of fibroblast growth factor receptor (FGFR)
    cd04974
    Location:303392
    Ig3_FGFR; Third immunoglobulin (Ig)-like domain of fibroblast growth factor receptor (FGFR)
    cd05857
    Location:196280
    Ig2_FGFR; Second immunoglobulin (Ig)-like domain of fibroblast growth factor (FGF) receptor
    smart00408
    Location:80141
    IGc2; Immunoglobulin C-2 Type
    smart00410
    Location:295391
    IG_like; Immunoglobulin like
    pfam07679
    Location:193280
    I-set; Immunoglobulin I-set domain
    pfam07714
    Location:511787
    Pkinase_Tyr; Protein tyrosine kinase
    cd05098
    Location:497798
    PTKc_FGFR1; Catalytic domain of the Protein Tyrosine Kinase, Fibroblast Growth Factor Receptor 1
  20. XM_011544450.1XP_011542752.1  

    Related
    ENSP00000327229, OTTHUMP00000190879, ENST00000326324, OTTHUMT00000304017
    Conserved Domains (6) summary
    cd04974
    Location:212301
    Ig3_FGFR; Third immunoglobulin (Ig)-like domain of fibroblast growth factor receptor (FGFR)
    cd05857
    Location:105189
    Ig2_FGFR; Second immunoglobulin (Ig)-like domain of fibroblast growth factor (FGF) receptor
    smart00410
    Location:204300
    IG_like; Immunoglobulin like
    pfam07679
    Location:102189
    I-set; Immunoglobulin I-set domain
    pfam07714
    Location:420696
    Pkinase_Tyr; Protein tyrosine kinase
    cd05098
    Location:406707
    PTKc_FGFR1; Catalytic domain of the Protein Tyrosine Kinase, Fibroblast Growth Factor Receptor 1
  21. XM_011544452.1XP_011542754.1  

    Conserved Domains (6) summary
    cd04973
    Location:73151
    Ig1_FGFR; First immunoglobulin (Ig)-like domain of fibroblast growth factor receptor (FGFR)
    cd04974
    Location:301387
    Ig3_FGFR; Third immunoglobulin (Ig)-like domain of fibroblast growth factor receptor (FGFR)
    cd05857
    Location:194278
    Ig2_FGFR; Second immunoglobulin (Ig)-like domain of fibroblast growth factor (FGF) receptor
    smart00408
    Location:80141
    IGc2; Immunoglobulin C-2 Type
    smart00410
    Location:293387
    IG_like; Immunoglobulin like
    pfam07679
    Location:191278
    I-set; Immunoglobulin I-set domain

Alternate CHM1_1.1

Genomic

  1. NC_018919.2 Alternate CHM1_1.1

    Range
    38470562..38528261
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_023107.2: Suppressed sequence

    Description
    NM_023107.2: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.
  2. NM_023108.2: Suppressed sequence

    Description
    NM_023108.2: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.
  3. NM_023109.1: Suppressed sequence

    Description
    NM_023109.1: This RefSeq was permanently suppressed because it is a nonsense-mediated mRNA decay (NMD) candidate.
  4. NM_023111.2: Suppressed sequence

    Description
    NM_023111.2: This RefSeq was permanently suppressed because it represents a poorly supported variant with non-consensus splice sites.
  5. NM_032191.1: Suppressed sequence

    Description
    NM_032191.1: This RefSeq was permanently suppressed because it contains the wrong CDS.