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Xpa xeroderma pigmentosum, complementation group A [ Mus musculus (house mouse) ]

Gene ID: 22590, updated on 28-May-2016
Official Symbol
Xpaprovided by MGI
Official Full Name
xeroderma pigmentosum, complementation group Aprovided by MGI
Primary source
MGI:MGI:99135
See related
Ensembl:ENSMUSG00000028329 Vega:OTTMUSG00000006889
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Xpac; AI573865
Orthologs
Location:
4 24.49 cM; 4 C2
Exon count:
7
Annotation release Status Assembly Chr Location
105 current GRCm38.p3 (GCF_000001635.23) 4 NC_000070.6 (46174746..46196349, complement)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 4 NC_000070.5 (46188094..46209183, complement)

Chromosome 4 - NC_000070.6Genomic Context describing neighboring genes Neighboring gene tropomodulin 1 Neighboring gene thiosulfate sulfurtransferase (rhodanese)-like domain containing 2 Neighboring gene nuclear cap binding protein subunit 1 Neighboring gene predicted gene, 31617 Neighboring gene predicted gene 12444

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
DNA binding IEA
Inferred from Electronic Annotation
more info
 
damaged DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
 
damaged DNA binding ISO
Inferred from Sequence Orthology
more info
 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
protein domain specific binding ISO
Inferred from Sequence Orthology
more info
 
protein homodimerization activity ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
DNA repair IMP
Inferred from Mutant Phenotype
more info
PubMed 
UV-damage excision repair IBA
Inferred from Biological aspect of Ancestor
more info
 
base-excision repair IBA
Inferred from Biological aspect of Ancestor
more info
 
cellular response to DNA damage stimulus IEA
Inferred from Electronic Annotation
more info
 
intrinsic apoptotic signaling pathway in response to DNA damage IMP
Inferred from Mutant Phenotype
more info
PubMed 
multicellular organism growth IGI
Inferred from Genetic Interaction
more info
PubMed 
nucleotide-excision repair IMP
Inferred from Mutant Phenotype
more info
PubMed 
nucleotide-excision repair involved in interstrand cross-link repair IBA
Inferred from Biological aspect of Ancestor
more info
 
nucleotide-excision repair, DNA damage recognition IBA
Inferred from Biological aspect of Ancestor
more info
 
nucleotide-excision repair, DNA incision IBA
Inferred from Biological aspect of Ancestor
more info
 
nucleotide-excision repair, DNA incision ISO
Inferred from Sequence Orthology
more info
 
response to UV IMP
Inferred from Mutant Phenotype
more info
PubMed 
response to oxidative stress IMP
Inferred from Mutant Phenotype
more info
PubMed 
response to toxic substance IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
colocalizes_with DNA replication factor A complex ISO
Inferred from Sequence Orthology
more info
 
Golgi apparatus ISO
Inferred from Sequence Orthology
more info
 
cytoplasm ISO
Inferred from Sequence Orthology
more info
 
intercellular bridge ISO
Inferred from Sequence Orthology
more info
 
nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
nucleotide-excision repair factor 1 complex IBA
Inferred from Biological aspect of Ancestor
more info
 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 
nucleus ISO
Inferred from Sequence Orthology
more info
 
Preferred Names
DNA repair protein complementing XP-A cells homolog
Names
xeroderma pigmentosum group A-complementing protein homolog

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_011728.2NP_035858.2  DNA repair protein complementing XP-A cells homolog

    See identical proteins and their annotated locations for NP_035858.2

    Status: VALIDATED

    Source sequence(s)
    AI172779, AI838722, BP771655, CB058423
    Consensus CDS
    CCDS18146.1
    UniProtKB/Swiss-Prot
    Q64267
    Related
    ENSMUSP00000030013, OTTMUSP00000007309, ENSMUST00000030013, OTTMUST00000015906
    Conserved Domains (3) summary
    pfam05181
    Location:133185
    XPA_C; XPA protein C-terminus
    pfam01286
    Location:99132
    XPA_N; XPA protein N-terminal
    TIGR00598
    Location:104272
    rad14; DNA repair protein

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 105 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p3 C57BL/6J

Genomic

  1. NC_000070.6 Reference GRCm38.p3 C57BL/6J

    Range
    46174746..46196349 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RNA

  1. XR_881061.1 RNA Sequence

  2. XR_390317.2 RNA Sequence

Alternate Mm_Celera

Genomic

  1. AC_000026.1 Alternate Mm_Celera

    Range
    46197357..46218441 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)