MAPK15 mitogen-activated protein kinase 15 [Homo sapiens] - Gene

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Summary

Official Symbol: MAPK15provided by HGNC
Official Full Name: mitogen-activated protein kinase 15provided by HGNC
Primary source: HGNC:24667
See related: Ensembl:ENSG00000181085; HPRD:16867; Vega:OTTHUMG00000146450
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: ERK7; ERK8

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Genomic context

Location :: chromosome: 8

Sequence :: Chromosome: 8; NC_000008.10 (144798507..144804633)

See MAPK15 in Epigenomics, MapViewer

Chromosome 8 - NC_000008.10 Genomic Context describing neighboring genes

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Genomic regions, transcripts, and products

Genomic Sequence

Go to nucleotideGraphics FASTA GenBank

Go to reference sequence details

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Bibliography

GeneRIFs: Gene References Into Functions What's a GeneRIF?

a novel function for ERK8 as a bona fide ERRalpha corepressor, involved in control of its cellular localization by nuclear exclusion, and suggest a key role for this MAP kinase in the regulation of the biological activities of this nuclear receptor.
Title: Extracellular signal-regulated kinase 8 (ERK8) controls estrogen-related receptor α (ERRα) cellular localization and inhibits its transcriptional activity.
Data show that ERK8 prevents HDM2-mediated PCNA destruction by inhibiting the association of PCNA with HDM2, and implicate ERK8 in the regulation of genomic stability.
Title: A chromatin-bound kinase, ERK8, protects genomic integrity by inhibiting HDM2-mediated degradation of the DNA clamp PCNA.
Extracellular signal-regulated kinase 8-mediated c-Jun phosphorylation increases tumorigenesis of human colon cancer
Title: Extracellular signal-regulated kinase 8-mediated c-Jun phosphorylation increases tumorigenesis of human colon cancer.
Regulation of the activity and expression of DERK8 by DNA damage are reported.
Title: Regulation of the activity and expression of ERK8 by DNA damage.
The activity of ERK8 in transfected HEK-293 cells depends on the relative rates of ERK8 autophosphorylation and dephosphorylation by one or more members of the PPP family of protein serine/threonine phosphatases.
Title: Characterization of the reversible phosphorylation and activation of ERK8.
Erk8 has a role as a novel effector of RET/PTC3 and, therefore, RET biological functions
Title: Activation of the Erk8 mitogen-activated protein (MAP) kinase by RET/PTC3, a constitutively active form of the RET proto-oncogene.
human ERK8 has a role as a negative regulator of human GRalpha, acting through Hic-5
Title: ERK8 down-regulates transactivation of the glucocorticoid receptor through Hic-5.
ERK8, a new member of the mitogen-activated protein kinase family.
Title: ERK8, a new member of the mitogen-activated protein kinase family.

Submit: New GeneRIF Correction

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Phenotypes

Review eQTL and phenotype association data in this region using PheGenI

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HIV-1 protein interactions

Protein	Gene	Interaction	Pubs
Envelope surface glycoprotein gp120	env	HIV-1 gp120 binding to CD4 results in activation of the mitogen-activated protein kinase (MAPK) in CD4(+) lymphocytes prestimulated through their T-cell receptor (TCR)	PubMed

Go to the HIV-1, Human Protein Interaction Database

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Products	Interactant	Other Gene	Source	Pubs	Description
Q8TD08	O95833	CLIC3	HPRD	PubMed
Q8TD08	P41240	CSK	HPRD	PubMed
Q8TD08	Q8TD08	MAPK15	HPRD	PubMed
Q8TD08	P02686	MBP	HPRD	PubMed
Q8TD08	P04150	NR3C1	HPRD	PubMed
Q8TD08	P12931	SRC	HPRD	PubMed
Q8TD08	HIC5	TGFB1I1	HPRD	PubMed
BioGRID:128827	BioGRID:114489	CLIC3	BioGRID	PubMed	Affinity Capture-Western
BioGRID:128827	BioGRID:111142	PCNA	BioGRID	PubMed	Affinity Capture-Western

Function	Evidence Code	Pubs
ATP binding	IEA Inferred from Electronic Annotation more info
MAP kinase activity	IDA Inferred from Direct Assay more info	PubMed
SH3 domain binding	NAS Non-traceable Author Statement more info	PubMed
nucleotide binding	IEA Inferred from Electronic Annotation more info
protein serine/threonine kinase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
MAPK cascade	IDA Inferred from Direct Assay more info	PubMed
negative regulation of DNA replication	IEA Inferred from Electronic Annotation more info
positive regulation of protein catabolic process	IEA Inferred from Electronic Annotation more info
positive regulation of protein phosphorylation	IEA Inferred from Electronic Annotation more info
positive regulation of protein ubiquitination	IEA Inferred from Electronic Annotation more info
protein autophosphorylation	IDA Inferred from Direct Assay more info	PubMed
response to estradiol stimulus	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
extracellular region	NAS Non-traceable Author Statement more info	PubMed
intracellular	NAS Non-traceable Author Statement more info	PubMed
nucleus	IEA Inferred from Electronic Annotation more info

General protein information

Preferred Names: mitogen-activated protein kinase 15

Names: mitogen-activated protein kinase 15; ERK-7; ERK-8; MAPK 15; MAP kinase 15; extracellular regulated kinase 8 delta; extracellular signal regulated kinase 8; extracellular signal-regulated kinase 7; extracellular signal-regulated kinase 8

NP_620590.2

EC 2.7.11.24

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NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_139021.2 → NP_620590.2 mitogen-activated protein kinase 15

Status: VALIDATED

Source sequence(s)

AY065978, BP357805

Consensus CDS

CCDS6409.2

UniProtKB/Swiss-Prot

Q8TD08

Related

ENSP00000337691, OTTHUMP00000189334, ENST00000338033, OTTHUMT00000300348

Conserved Domains (3) summary

cd07852
Location:5 – 343
Blast Score: 1612

STKc_MAPK15; Catalytic domain of the Serine/Threonine Kinase, Mitogen-Activated Protein Kinase 15

PRK14954
Location:350 – 475
Blast Score: 91

PRK14954; DNA polymerase III subunits gamma and tau; Provisional

smart00220
Location:23 – 304
Blast Score: 734

S_TKc; Serine/Threonine protein kinases, catalytic domain

RefSeqs of Annotated Genomes: Build 37.3

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh37.p5 Primary Assembly

Genomic

NC_000008.10 Reference GRCh37.p5 Primary Assembly

Range

144798507..144804633

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh37.p5 PATCHES

Genomic

NW_003315923.1 Reference GRCh37.p5 PATCHES

Range

54982..61108

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Alternate HuRef

Genomic

AC_000140.1 Alternate HuRef

Range

140051333..140057442

Download

GenBank, FASTA, Sequence Viewer (Graphics)

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Related Sequences

Nucleotide		Protein
Heading	Accession and Version	Protein
genomic	AC105219.6 (106337..112455)	None
genomic	CH471162.2	EAW82203.1
		EAW82204.1
		EAW82205.1
mRNA	AY065978.1	AAL40897.1
mRNA	AY994058.1	AAY44299.1
mRNA	BC028034.1	AAH28034.1
mRNA	BP357805.1	None
other-genetic	DQ891473.2	ABM82399.1
other-genetic	DQ894661.2	ABM85587.1