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MAPK15 mitogen-activated protein kinase 15 [ Homo sapiens (human) ]

Gene ID: 225689, updated on 26-May-2016
Official Symbol
MAPK15provided by HGNC
Official Full Name
mitogen-activated protein kinase 15provided by HGNC
Primary source
HGNC:HGNC:24667
See related
Ensembl:ENSG00000181085 HPRD:16867; Vega:OTTHUMG00000146450
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ERK7; ERK8
Orthologs
Location:
chromosome: 8
Exon count:
15
Annotation release Status Assembly Chr Location
107 current GRCh38.p2 (GCF_000001405.28) 8 NC_000008.11 (143716302..143722463)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 8 NC_000008.10 (144798507..144804633)

Chromosome 8 - NC_000008.11Genomic Context describing neighboring genes Neighboring gene breast cancer estrogen-induced apoptosis 2 Neighboring gene uncharacterized LOC101928160 Neighboring gene coiled-coil domain containing 166 Neighboring gene family with sequence similarity 83 member H Neighboring gene FAM83H antisense RNA 1 (head to head) Neighboring gene microRNA 4664

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

NHGRI GWAS Catalog

Description
Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population.
NHGRI GWA Catalog

Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp120 env HIV-1 gp120 binding to CD4 results in activation of the mitogen-activated protein kinase (MAPK) in CD4(+) lymphocytes prestimulated through their T-cell receptor (TCR) PubMed

Go to the HIV-1, Human Interaction Database

Products Interactant Other Gene Complex Source Pubs Description

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
ATP binding IEA
Inferred from Electronic Annotation
more info
 
MAP kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
SH3 domain binding NAS
Non-traceable Author Statement
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Component Evidence Code Pubs
extracellular region NAS
Non-traceable Author Statement
more info
PubMed 
intracellular NAS
Non-traceable Author Statement
more info
PubMed 
nucleus IEA
Inferred from Electronic Annotation
more info
 
Preferred Names
mitogen-activated protein kinase 15
Names
ERK-7
ERK-8
MAP kinase 15
MAPK 15
extracellular regulated kinase 8 delta
extracellular signal regulated kinase 8
extracellular signal-regulated kinase 7
extracellular signal-regulated kinase 8
NP_620590.2

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_139021.2NP_620590.2  mitogen-activated protein kinase 15

    See identical proteins and their annotated locations for NP_620590.2

    Status: VALIDATED

    Source sequence(s)
    AY065978, BP357805
    Consensus CDS
    CCDS6409.2
    UniProtKB/Swiss-Prot
    Q8TD08
    Related
    ENSP00000337691, OTTHUMP00000189334, ENST00000338033, OTTHUMT00000300348
    Conserved Domains (2) summary
    smart00220
    Location:13304
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd07852
    Location:5343
    STKc_MAPK15-like; Catalytic domain of the Serine/Threonine Kinase, Mitogen-Activated Protein Kinase 15 and similar MAPKs

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 107 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p2 Primary Assembly

Genomic

  1. NC_000008.11 Reference GRCh38.p2 Primary Assembly

    Range
    143716302..143722463
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011516926.1XP_011515228.1  

    See identical proteins and their annotated locations for XP_011515228.1

    Conserved Domains (2) summary
    smart00220
    Location:13323
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd07852
    Location:5362
    STKc_MAPK15-like; Catalytic domain of the Serine/Threonine Kinase, Mitogen-Activated Protein Kinase 15 and similar MAPKs
  2. XM_011516925.1XP_011515227.1  

    See identical proteins and their annotated locations for XP_011515227.1

    Conserved Domains (2) summary
    smart00220
    Location:25325
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd07852
    Location:25364
    STKc_MAPK15-like; Catalytic domain of the Serine/Threonine Kinase, Mitogen-Activated Protein Kinase 15 and similar MAPKs
  3. XM_011516927.1XP_011515229.1  

    See identical proteins and their annotated locations for XP_011515229.1

    Conserved Domains (2) summary
    smart00220
    Location:25306
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd07852
    Location:25345
    STKc_MAPK15-like; Catalytic domain of the Serine/Threonine Kinase, Mitogen-Activated Protein Kinase 15 and similar MAPKs
  4. XM_011516928.1XP_011515230.1  

    See identical proteins and their annotated locations for XP_011515230.1

    Conserved Domains (2) summary
    smart00220
    Location:25325
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd07852
    Location:25327
    STKc_MAPK15-like; Catalytic domain of the Serine/Threonine Kinase, Mitogen-Activated Protein Kinase 15 and similar MAPKs

Reference GRCh38.p2 ALT_REF_LOCI_1

Genomic

  1. NT_187571.1 Reference GRCh38.p2 ALT_REF_LOCI_1

    Range
    193349..199510
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011546525.1XP_011544827.1  

    See identical proteins and their annotated locations for XP_011544827.1

    Conserved Domains (2) summary
    smart00220
    Location:13323
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd07852
    Location:5362
    STKc_MAPK15-like; Catalytic domain of the Serine/Threonine Kinase, Mitogen-Activated Protein Kinase 15 and similar MAPKs
  2. XM_011546524.1XP_011544826.1  

    See identical proteins and their annotated locations for XP_011544826.1

    Conserved Domains (2) summary
    smart00220
    Location:25325
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd07852
    Location:25364
    STKc_MAPK15-like; Catalytic domain of the Serine/Threonine Kinase, Mitogen-Activated Protein Kinase 15 and similar MAPKs
  3. XM_011546526.1XP_011544828.1  

    See identical proteins and their annotated locations for XP_011544828.1

    Conserved Domains (2) summary
    smart00220
    Location:25306
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd07852
    Location:25345
    STKc_MAPK15-like; Catalytic domain of the Serine/Threonine Kinase, Mitogen-Activated Protein Kinase 15 and similar MAPKs
  4. XM_011546527.1XP_011544829.1  

    See identical proteins and their annotated locations for XP_011544829.1

    Conserved Domains (2) summary
    smart00220
    Location:25325
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd07852
    Location:25327
    STKc_MAPK15-like; Catalytic domain of the Serine/Threonine Kinase, Mitogen-Activated Protein Kinase 15 and similar MAPKs

Alternate CHM1_1.1

Genomic

  1. NC_018919.2 Alternate CHM1_1.1

    Range
    144838551..144844676
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)