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Pik3c3 phosphoinositide-3-kinase, class 3 [ Mus musculus (house mouse) ]

Gene ID: 225326, updated on 28-May-2016
Official Symbol
Pik3c3provided by MGI
Official Full Name
phosphoinositide-3-kinase, class 3provided by MGI
Primary source
MGI:MGI:2445019
See related
Ensembl:ENSMUSG00000033628 Vega:OTTMUSG00000021153
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Vps34; 5330434F23Rik
Orthologs
Location:
18; 18 B1
Exon count:
25
Annotation release Status Assembly Chr Location
105 current GRCm38.p3 (GCF_000001635.23) 18 NC_000084.6 (30272094..30348126)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 18 NC_000084.5 (30432550..30507774)

Chromosome 18 - NC_000084.6Genomic Context describing neighboring genes Neighboring gene predicted gene, 41680 Neighboring gene predicted gene, 34327 Neighboring gene predicted gene 7926 Neighboring gene predicted gene 7930

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
Products Interactant Other Gene Complex Source Pubs Description

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
1-phosphatidylinositol-3-kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
1-phosphatidylinositol-3-kinase activity ISO
Inferred from Sequence Orthology
more info
 
ATP binding IEA
Inferred from Electronic Annotation
more info
 
kinase activity IEA
Inferred from Electronic Annotation
more info
 
nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
phosphatidylinositol 3-kinase activity ISO
Inferred from Sequence Orthology
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein kinase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
transferase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
autophagosome assembly IMP
Inferred from Mutant Phenotype
more info
PubMed 
autophagosome assembly ISO
Inferred from Sequence Orthology
more info
 
autophagy IEA
Inferred from Electronic Annotation
more info
 
cell cycle IEA
Inferred from Electronic Annotation
more info
 
cell division IEA
Inferred from Electronic Annotation
more info
 
cellular response to glucose starvation IDA
Inferred from Direct Assay
more info
PubMed 
cellular response to starvation IMP
Inferred from Mutant Phenotype
more info
PubMed 
cytokinesis ISO
Inferred from Sequence Orthology
more info
 
early endosome to late endosome transport ISO
Inferred from Sequence Orthology
more info
 
endosome organization ISO
Inferred from Sequence Orthology
more info
 
macroautophagy IMP
Inferred from Mutant Phenotype
more info
PubMed 
phosphatidylinositol phosphorylation IEA
Inferred from Electronic Annotation
more info
 
phosphatidylinositol-3-phosphate biosynthetic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
phosphatidylinositol-mediated signaling ISO
Inferred from Sequence Orthology
more info
 
phosphorylation IEA
Inferred from Electronic Annotation
more info
 
protein localization to pre-autophagosomal structure IMP
Inferred from Mutant Phenotype
more info
PubMed 
protein phosphorylation IMP
Inferred from Mutant Phenotype
more info
PubMed 
protein processing ISO
Inferred from Sequence Orthology
more info
 
regulation of cytokinesis ISO
Inferred from Sequence Orthology
more info
 
regulation of protein secretion ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
cytoplasmic vesicle IEA
Inferred from Electronic Annotation
more info
 
endosome IEA
Inferred from Electronic Annotation
more info
 
late endosome ISO
Inferred from Sequence Orthology
more info
 
membrane ISO
Inferred from Sequence Orthology
more info
 
midbody ISO
Inferred from Sequence Orthology
more info
 
phagocytic vesicle IDA
Inferred from Direct Assay
more info
PubMed 
phosphatidylinositol 3-kinase complex, class III IDA
Inferred from Direct Assay
more info
PubMed 
Preferred Names
phosphatidylinositol 3-kinase catalytic subunit type 3
Names
PI3-kinase type 3
PI3K type 3
ptdIns-3-kinase type 3
NP_852079.2

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_181414.5NP_852079.2  phosphatidylinositol 3-kinase catalytic subunit type 3

    See identical proteins and their annotated locations for NP_852079.2

    Status: PROVISIONAL

    Source sequence(s)
    AC163399
    Consensus CDS
    CCDS37752.1
    UniProtKB/Swiss-Prot
    Q6PF93
    Related
    ENSMUSP00000111479, OTTMUSP00000023341, ENSMUST00000115812, OTTMUST00000050105
    Conserved Domains (3) summary
    cd08397
    Location:26186
    C2_PI3K_class_III; C2 domain present in class III phosphatidylinositol 3-kinases (PI3Ks)
    cd00870
    Location:283503
    PI3Ka_III; Phosphoinositide 3-kinase (PI3K) class III, accessory domain (PIK domain); PIK domain is conserved in all PI3 and PI4-kinases. Its role is unclear but it has been suggested to be involved in substrate presentation. In general, PI3Ks class III ...
    cd00896
    Location:539883
    PI3Kc_III; Catalytic domain of Class III Phosphoinositide 3-kinase

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 105 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p3 C57BL/6J

Genomic

  1. NC_000084.6 Reference GRCm38.p3 C57BL/6J

    Range
    30272094..30348126
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RNA

  1. XR_385985.2 RNA Sequence

Alternate Mm_Celera

Genomic

  1. AC_000040.1 Alternate Mm_Celera

    Range
    30744294..30819480
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)