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Rbbp8 retinoblastoma binding protein 8 [ Mus musculus (house mouse) ]

Gene ID: 225182, updated on 21-May-2016
Official Symbol
Rbbp8provided by MGI
Official Full Name
retinoblastoma binding protein 8provided by MGI
Primary source
MGI:MGI:2442995
See related
Ensembl:ENSMUSG00000041238
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
RIM; CtIP; SAE2; RBBP-8; 9930104E21Rik
Orthologs
Location:
18; 18 A1
Exon count:
20
Annotation release Status Assembly Chr Location
105 current GRCm38.p3 (GCF_000001635.23) 18 NC_000084.6 (11633276..11743207)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 18 NC_000084.5 (11816351..11901716)

Chromosome 18 - NC_000084.6Genomic Context describing neighboring genes Neighboring gene predicted gene, 35918 Neighboring gene predicted gene 7581 Neighboring gene ring finger and WD repeat domain 2 pseudogene Neighboring gene predicted gene, 41665

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
DNA binding IEA
Inferred from Electronic Annotation
more info
 
RNA polymerase II repressing transcription factor binding ISO
Inferred from Sequence Orthology
more info
 
RNA polymerase II transcription corepressor activity ISO
Inferred from Sequence Orthology
more info
 
T/G mismatch-specific endonuclease activity IEA
Inferred from Electronic Annotation
more info
 
damaged DNA binding ISO
Inferred from Sequence Orthology
more info
 
endonuclease activity IEA
Inferred from Electronic Annotation
more info
 
hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
nuclease activity IEA
Inferred from Electronic Annotation
more info
 
phosphoric ester hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
retroviral 3' processing activity IEA
Inferred from Electronic Annotation
more info
 
single-stranded DNA endodeoxyribonuclease activity ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
DNA damage checkpoint IEA
Inferred from Electronic Annotation
more info
 
DNA double-strand break processing involved in repair via single-strand annealing ISO
Inferred from Sequence Orthology
more info
 
DNA repair IEA
Inferred from Electronic Annotation
more info
 
G1/S transition of mitotic cell cycle IMP
Inferred from Mutant Phenotype
more info
PubMed 
G2 DNA damage checkpoint ISO
Inferred from Sequence Orthology
more info
 
blastocyst hatching IMP
Inferred from Mutant Phenotype
more info
PubMed 
cell cycle IEA
Inferred from Electronic Annotation
more info
 
cell division IEA
Inferred from Electronic Annotation
more info
 
cellular response to DNA damage stimulus IEA
Inferred from Electronic Annotation
more info
 
double-strand break repair via homologous recombination ISO
Inferred from Sequence Orthology
more info
 
meiotic cell cycle IEA
Inferred from Electronic Annotation
more info
 
mitotic nuclear division IEA
Inferred from Electronic Annotation
more info
 
nucleotide-excision repair ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
chromosome IEA
Inferred from Electronic Annotation
more info
 
nucleolus ISO
Inferred from Sequence Orthology
more info
 
nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
nucleus IEA
Inferred from Electronic Annotation
more info
 
transcriptional repressor complex ISO
Inferred from Sequence Orthology
more info
 
Preferred Names
DNA endonuclease RBBP8
Names
ctBP-interacting protein
retinoblastoma-binding protein 8
sporulation in the absence of SPO11 protein 2 homolog

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001081223.2NP_001074692.1  DNA endonuclease RBBP8

    See identical proteins and their annotated locations for NP_001074692.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript. Variants 1 and 2 encode the same protein.
    Source sequence(s)
    AC090479, AC115894, AK037049
    Consensus CDS
    CCDS37738.1
    UniProtKB/Swiss-Prot
    Q80YR6
    Related
    ENSMUSP00000046255, ENSMUST00000047322
    Conserved Domains (2) summary
    pfam08573
    Location:791854
    SAE2; DNA repair protein endonuclease SAE2/CtIP C-terminus
    pfam10482
    Location:20139
    CtIP_N; tumor-suppressor protein CtIP N-terminal domain
  2. NM_001252495.1NP_001239424.1  DNA endonuclease RBBP8

    See identical proteins and their annotated locations for NP_001239424.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 encode the same protein.
    Source sequence(s)
    AC090479, AC115894
    Consensus CDS
    CCDS37738.1
    UniProtKB/Swiss-Prot
    Q80YR6
    Related
    ENSMUSP00000111527, ENSMUST00000115861
    Conserved Domains (2) summary
    pfam08573
    Location:791854
    SAE2; DNA repair protein endonuclease SAE2/CtIP C-terminus
    pfam10482
    Location:20139
    CtIP_N; tumor-suppressor protein CtIP N-terminal domain

RNA

  1. NR_045526.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks an internal exon compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AC090479, AC115894, AK163908, CD352622, CX567593
  2. NR_045527.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) has multiple differences compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AC090479, AC115894, AK041384

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 105 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p3 C57BL/6J

Genomic

  1. NC_000084.6 Reference GRCm38.p3 C57BL/6J

    Range
    11633276..11743207
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006525812.2XP_006525875.1  

    See identical proteins and their annotated locations for XP_006525875.1

    UniProtKB/Swiss-Prot
    Q80YR6
    Conserved Domains (2) summary
    pfam08573
    Location:791854
    SAE2; DNA repair protein endonuclease SAE2/CtIP C-terminus
    pfam10482
    Location:20139
    CtIP_N; tumor-suppressor protein CtIP N-terminal domain

Alternate Mm_Celera

Genomic

  1. AC_000040.1 Alternate Mm_Celera

    Range
    11932050..11982146
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate Mm_Celera

Genomic

  1. NW_001035533.1 Alternate Mm_Celera

    Range
    5251..8845 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_175458.2: Suppressed sequence

    Description
    NM_175458.2: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.