Mib1 mindbomb homolog 1 (Drosophila) [Mus musculus] - Gene

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Summary

Official Symbol: Mib1provided by MGI
Official Full Name: mindbomb homolog 1 (Drosophila)provided by MGI
Primary source: MGI:2443157
See related: Ensembl:ENSMUSG00000024294; Vega:OTTMUSG00000028579
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Mib; DIP-1; mKIAA1323; E430019M12Rik; MGC18948

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Genomic context

Location :: 18 A1; 18

Sequence :: Chromosome: 18; NC_000084.6 (10725625..10812217)

See Mib1 in Epigenomics, MapViewer

Chromosome 18 - NC_000084.6 Genomic Context describing neighboring genes

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Genomic regions, transcripts, and products

Genomic Sequence

Go to nucleotideGraphics FASTA GenBank

Go to reference sequence details

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Bibliography

GeneRIFs: Gene References Into Functions What's a GeneRIF?

show that exogenously expressed Mib1 could partially rescue the phenotypes associated with miR-137 overexpression.
Title: MicroRNA miR-137 regulates neuronal maturation by targeting ubiquitin ligase mind bomb-1.
Myeloproliferative disease development in the Mib1 CKO mice is due to defective Notch activation in the nonhematopoietic cells.
Title: Defective Notch activation in microenvironment leads to myeloproliferative disease.
Mib1 is the essential E3 ligase in T and marginal zone B cell development, through the regulation of Notch ligands in the thymic and splenic microenvironments.
Title: Mind bomb 1 in the lymphopoietic niches is essential for T and marginal zone B cell development.
data provide the first evidence that Mib1 is essential for Jagged as well as Deltalike ligand-mediated Notch signaling in mammalian development, while Neur1, Neur2, and Mib2 are dispensable
Title: An obligatory role of mind bomb-1 in notch signaling of mammalian development.
These results suggest that Mib1 is important for intraembryonic hematopoiesis not only in the aortic endothelium but also in the subaortic patches.
Title: Mind bomb-1 is essential for intraembryonic hematopoiesis in the aortic endothelium and the subaortic patches.
A targeted mutation of Mib1 in mice results in embryonic lethality;MIB1 activity is required for S3 cleavage of the Notch1 receptor.
Title: Mind bomb1 is a ubiquitin ligase essential for mouse embryonic development and Notch signaling.
mice lacking Mib1 die prior to embryonic day 11.5, with pan-Notch defects in somitogenesis, neurogenesis, vasculogenesis and cardiogenesis.
Title: Mind bomb 1 is essential for generating functional Notch ligands to activate Notch.
Neuralized-2 regulates a Notch ligand in cooperation with Mind bomb-1
Title: Neuralized-2 regulates a Notch ligand in cooperation with Mind bomb-1.

Submit: New GeneRIF Correction

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (Floxed/Frt) (2) 1 citation
Targeted (knock-out) (2) 1 citation

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Products	Interactant	Other Gene	Source	Pubs	Description
BioGRID:230365	BioGRID:114364	CFLAR	BioGRID	PubMed	Affinity Capture-Western
BioGRID:230365	BioGRID:113164	UBC	BioGRID	PubMed	Affinity Capture-Western
BioGRID:230365	BioGRID:1078915	dll1	BioGRID	PubMed	Affinity Capture-Western

Function	Evidence Code	Pubs
ligase activity	IEA Inferred from Electronic Annotation more info
metal ion binding	IEA Inferred from Electronic Annotation more info
protein binding	IPI Inferred from Physical Interaction more info	PubMed
ubiquitin-protein ligase activity	IEA Inferred from Electronic Annotation more info
zinc ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
Notch signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
blood vessel development	IMP Inferred from Mutant Phenotype more info	PubMed
heart development	IMP Inferred from Mutant Phenotype more info	PubMed
heart looping	IMP Inferred from Mutant Phenotype more info	PubMed
in utero embryonic development	IMP Inferred from Mutant Phenotype more info	PubMed
negative regulation of neuron differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
neural tube formation	IMP Inferred from Mutant Phenotype more info	PubMed
positive regulation of endocytosis	IDA Inferred from Direct Assay more info	PubMed
protein ubiquitination	IEA Inferred from Electronic Annotation more info
somitogenesis	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
centrosome	ISO Inferred from Sequence Orthology more info
cytoplasm	IEA Inferred from Electronic Annotation more info
cytoplasmic vesicle	IDA Inferred from Direct Assay more info	PubMed
intracellular membrane-bounded organelle	ISO Inferred from Sequence Orthology more info
membrane	IEA Inferred from Electronic Annotation more info
nuclear membrane	ISO Inferred from Sequence Orthology more info
plasma membrane	ISO Inferred from Sequence Orthology more info
postsynaptic density	ISO Inferred from Sequence Orthology more info

General protein information

Preferred Names: E3 ubiquitin-protein ligase MIB1

Names: E3 ubiquitin-protein ligase MIB1; mind bomb-1; skeletrophin; mind bomb homolog 1; DAPK-interacting protein 1; DAPK-interacting protein-1

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NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_144860.2 → NP_659109.2 E3 ubiquitin-protein ligase MIB1

Status: PROVISIONAL

Source sequence(s)

AY245539

Consensus CDS

CCDS29058.1

UniProtKB/Swiss-Prot

Q80SY4

Related

ENSMUSP00000054428, OTTMUSP00000036148, ENSMUST00000052838, OTTMUST00000070815

Conserved Domains (9) summary

cd00204
Location:524 – 652
Blast Score: 307

ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...

cd02339
Location:83 – 127
Blast Score: 226

ZZ_Mind_bomb; Zinc finger, ZZ type. Zinc finger present in Drosophila Mind bomb (D-mib) and related proteins. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. Mind bomb is an E3 ubiqitin ligase that has ...

COG1627
Location:301 – 453
Blast Score: 93

COG1627; Uncharacterized protein conserved in archaea [Function unknown]

pfam06701
Location:15 – 74
Blast Score: 254

MIB_HERC2; Mib_herc2

PHA03095
Location:668 – 778
Blast Score: 101

PHA03095; ankyrin-like protein; Provisional

pfam12796
Location:600 – 696
Blast Score: 214

Ank_2; Ankyrin repeats (3 copies)

pfam13857
Location:450 – 504
Blast Score: 98

Ank_5; Ankyrin repeats (many copies)

pfam13923
Location:959 – 997
Blast Score: 112

zf-C3HC4_2; Zinc finger, C3HC4 type (RING finger)

cl15348
Location:864 – 907
Blast Score: 146

RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...

RefSeqs of Annotated Genomes: Build 38.1

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38 C57BL/6J

Genomic

NC_000084.6 Reference GRCm38 C57BL/6J

Range

10725625..10812217

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Alternate Mm_Celera

Genomic

AC_000040.1 Alternate Mm_Celera

Range

10755617..10842201

Download

GenBank, FASTA, Sequence Viewer (Graphics)

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Related Sequences

Nucleotide		Protein	Strain
Heading	Accession and Version	Protein	Strain
genomic	AC105947.11 (130019..207138)	None
genomic	AC140316.3 (128586..138058)	None
genomic	CH466592.2	EDL22989.1	mixed
mRNA	AK047045.1	None	C57BL/6J
mRNA	AK048082.1	None	C57BL/6J
mRNA	AK053011.1	None	C57BL/6J
mRNA	AK053035.1	BAC35245.1	C57BL/6J
mRNA	AK079855.1	None	C57BL/6J
mRNA	AK080083.1	None	C57BL/6J
mRNA	AK080847.1	BAC38042.1	C57BL/6J
mRNA	AK081370.1	None	C57BL/6J
mRNA	AK088539.1	None	NOD
mRNA	AK129331.1	BAC98141.1
mRNA	AK139338.1	BAE23964.1	C57BL/6J
mRNA	AK153523.1	None	C57BL/6J
mRNA	AK161848.1	BAE36604.1	C57BL/6J
mRNA	AY147848.1	AAN18022.1
mRNA	AY149907.1	AAN75492.1	C3H
mRNA	AY245539.1	AAO91933.1
mRNA	AY974091.1	AAX84653.1	C57BL/6
mRNA	BC011287.1	AAH11287.1	FVB/N
mRNA	BC069870.1	AAH69870.1
mRNA	BC083072.1	AAH83072.1
mRNA	BC131662.1	AAI31663.1

Protein Accession	Links
Protein Accession	GenPept Link	UniProtKB Link
Q3TSS1	GenPept	UniProtKB/TrEMBL:Q3TSS1
Q3UTL6	GenPept	UniProtKB/TrEMBL:Q3UTL6
Q80SY4.1	GenPept	UniProtKB/Swiss-Prot:Q80SY4