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Svil supervillin [ Mus musculus (house mouse) ]

Gene ID: 225115, updated on 28-May-2016
Official Symbol
Svilprovided by MGI
Official Full Name
supervillinprovided by MGI
Primary source
MGI:MGI:2147319
See related
Ensembl:ENSMUSG00000024236 Vega:OTTMUSG00000033148
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
AU024053; B430302E16Rik
Orthologs
Location:
18; 18 A1
Exon count:
44
Annotation release Status Assembly Chr Location
105 current GRCm38.p3 (GCF_000001635.23) 18 NC_000084.6 (4920236..5119293)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 18 NC_000084.5 (5046587..5119291)

Chromosome 18 - NC_000084.6Genomic Context describing neighboring genes Neighboring gene predicted gene 10556 Neighboring gene predicted gene, 34269 Neighboring gene predicted gene, 41659 Neighboring gene predicted gene, 34326 Neighboring gene predicted gene, 34541 Neighboring gene predicted gene, 26682 Neighboring gene predicted gene, 38715

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (1) 
  • Androgen Receptor Signaling Pathway, organism-specific biosystem (from WikiPathways)
    Androgen Receptor Signaling Pathway, organism-specific biosystemThe androgen receptor is a member of the nuclear receptor family of ligand activated transcription factors. These receptors bind to steroid hormones, thyroid hormone, retinoids and vitamin D among ot...
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
actin binding IEA
Inferred from Electronic Annotation
more info
 
actin filament binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
cytoskeleton organization IEA
Inferred from Electronic Annotation
more info
 
skeletal muscle tissue development ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
actin cytoskeleton ISO
Inferred from Sequence Orthology
more info
 
cell junction IEA
Inferred from Electronic Annotation
more info
 
cell projection IEA
Inferred from Electronic Annotation
more info
 
costamere ISO
Inferred from Sequence Orthology
more info
 
cytoplasm ISO
Inferred from Sequence Orthology
more info
 
cytoskeleton IEA
Inferred from Electronic Annotation
more info
 
focal adhesion ISO
Inferred from Sequence Orthology
more info
 
membrane IEA
Inferred from Electronic Annotation
more info
 
nucleus ISO
Inferred from Sequence Orthology
more info
 
plasma membrane ISO
Inferred from Sequence Orthology
more info
 
Preferred Names
supervillin
Names
archvillin
p205/p250
supervillin muscle-specific isoform

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_153153.3NP_694793.1  supervillin

    See identical proteins and their annotated locations for NP_694793.1

    Status: VALIDATED

    Source sequence(s)
    AC115928, AF317422, AK161114, BC099602
    Consensus CDS
    CCDS37720.1
    UniProtKB/Swiss-Prot
    Q8K4L3
    UniProtKB/TrEMBL
    Q3TTX5
    Related
    ENSMUSP00000025079, ENSMUST00000025079
    Conserved Domains (7) summary
    pfam08934
    Location:222262
    Rb_C; Rb C-terminal domain
    cd11280
    Location:15191619
    gelsolin_like; Tandemly repeated domains found in gelsolin, severin, villin, and related proteins
    cd11288
    Location:18351940
    gelsolin_S5_like; Gelsolin sub-domain 5-like domain found in gelsolin, severin, villin, and related proteins
    cd11289
    Location:13981494
    gelsolin_S2_like; Gelsolin sub-domain 2-like domain found in gelsolin, severin, villin, and related proteins
    cd11293
    Location:17021815
    gelsolin_S4_like; Gelsolin sub-domain 4-like domain found in gelsolin, severin, villin, and related proteins
    pfam02209
    Location:21352170
    VHP; Villin headpiece domain
    cl15697
    Location:19572079
    ADF_gelsolin; Actin depolymerization factor/cofilin- and gelsolin-like domains

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 105 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p3 C57BL/6J

Genomic

  1. NC_000084.6 Reference GRCm38.p3 C57BL/6J

    Range
    4920236..5119293
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011246887.1XP_011245189.1  

  2. XM_011246886.1XP_011245188.1  

  3. XM_006525789.1XP_006525852.1  

    See identical proteins and their annotated locations for XP_006525852.1

    Conserved Domains (6) summary
    smart00153
    Location:21522187
    VHP; Villin headpiece domain
    cd11280
    Location:15361636
    gelsolin_like; Tandemly repeated domains found in gelsolin, severin, villin, and related proteins
    cd11288
    Location:18521957
    gelsolin_S5_like; Gelsolin sub-domain 5-like domain found in gelsolin, severin, villin, and related proteins
    cd11289
    Location:14151511
    gelsolin_S2_like; Gelsolin sub-domain 2-like domain found in gelsolin, severin, villin, and related proteins
    cd11293
    Location:17191832
    gelsolin_S4_like; Gelsolin sub-domain 4-like domain found in gelsolin, severin, villin, and related proteins
    cl15697
    Location:19742096
    ADF_gelsolin; Actin depolymerization factor/cofilin- and gelsolin-like domains
  4. XM_011246877.1XP_011245179.1  

    Conserved Domains (6) summary
    smart00153
    Location:21362171
    VHP; Villin headpiece domain
    cd11280
    Location:15201620
    gelsolin_like; Tandemly repeated domains found in gelsolin, severin, villin, and related proteins
    cd11288
    Location:18361941
    gelsolin_S5_like; Gelsolin sub-domain 5-like domain found in gelsolin, severin, villin, and related proteins
    cd11289
    Location:13991495
    gelsolin_S2_like; Gelsolin sub-domain 2-like domain found in gelsolin, severin, villin, and related proteins
    cd11293
    Location:17031816
    gelsolin_S4_like; Gelsolin sub-domain 4-like domain found in gelsolin, severin, villin, and related proteins
    cl15697
    Location:19582080
    ADF_gelsolin; Actin depolymerization factor/cofilin- and gelsolin-like domains
  5. XM_011246876.1XP_011245178.1  

    Conserved Domains (7) summary
    pfam08934
    Location:222262
    Rb_C; Rb C-terminal domain
    cd11280
    Location:15351635
    gelsolin_like; Tandemly repeated domains found in gelsolin, severin, villin, and related proteins
    cd11288
    Location:18511956
    gelsolin_S5_like; Gelsolin sub-domain 5-like domain found in gelsolin, severin, villin, and related proteins
    cd11289
    Location:14141510
    gelsolin_S2_like; Gelsolin sub-domain 2-like domain found in gelsolin, severin, villin, and related proteins
    cd11293
    Location:17181831
    gelsolin_S4_like; Gelsolin sub-domain 4-like domain found in gelsolin, severin, villin, and related proteins
    pfam02209
    Location:21512186
    VHP; Villin headpiece domain
    cl15697
    Location:19732095
    ADF_gelsolin; Actin depolymerization factor/cofilin- and gelsolin-like domains
  6. XM_011246878.1XP_011245180.1  

    See identical proteins and their annotated locations for XP_011245180.1

    UniProtKB/Swiss-Prot
    Q8K4L3
    Related
    ENSMUSP00000115078, OTTMUSP00000044479, ENSMUST00000126977, OTTMUST00000082891
    Conserved Domains (7) summary
    pfam08934
    Location:222262
    Rb_C; Rb C-terminal domain
    cd11280
    Location:15191619
    gelsolin_like; Tandemly repeated domains found in gelsolin, severin, villin, and related proteins
    cd11288
    Location:18351940
    gelsolin_S5_like; Gelsolin sub-domain 5-like domain found in gelsolin, severin, villin, and related proteins
    cd11289
    Location:13981494
    gelsolin_S2_like; Gelsolin sub-domain 2-like domain found in gelsolin, severin, villin, and related proteins
    cd11293
    Location:17021815
    gelsolin_S4_like; Gelsolin sub-domain 4-like domain found in gelsolin, severin, villin, and related proteins
    pfam02209
    Location:21352170
    VHP; Villin headpiece domain
    cl15697
    Location:19572079
    ADF_gelsolin; Actin depolymerization factor/cofilin- and gelsolin-like domains
  7. XM_006525792.1XP_006525855.1  

    See identical proteins and their annotated locations for XP_006525855.1

    Conserved Domains (6) summary
    smart00153
    Location:21522187
    VHP; Villin headpiece domain
    cd11280
    Location:15361636
    gelsolin_like; Tandemly repeated domains found in gelsolin, severin, villin, and related proteins
    cd11288
    Location:18521957
    gelsolin_S5_like; Gelsolin sub-domain 5-like domain found in gelsolin, severin, villin, and related proteins
    cd11289
    Location:14151511
    gelsolin_S2_like; Gelsolin sub-domain 2-like domain found in gelsolin, severin, villin, and related proteins
    cd11293
    Location:17191832
    gelsolin_S4_like; Gelsolin sub-domain 4-like domain found in gelsolin, severin, villin, and related proteins
    cl15697
    Location:19742096
    ADF_gelsolin; Actin depolymerization factor/cofilin- and gelsolin-like domains
  8. XM_006525791.1XP_006525854.1  

    See identical proteins and their annotated locations for XP_006525854.1

    Conserved Domains (6) summary
    smart00153
    Location:21522187
    VHP; Villin headpiece domain
    cd11280
    Location:15361636
    gelsolin_like; Tandemly repeated domains found in gelsolin, severin, villin, and related proteins
    cd11288
    Location:18521957
    gelsolin_S5_like; Gelsolin sub-domain 5-like domain found in gelsolin, severin, villin, and related proteins
    cd11289
    Location:14151511
    gelsolin_S2_like; Gelsolin sub-domain 2-like domain found in gelsolin, severin, villin, and related proteins
    cd11293
    Location:17191832
    gelsolin_S4_like; Gelsolin sub-domain 4-like domain found in gelsolin, severin, villin, and related proteins
    cl15697
    Location:19742096
    ADF_gelsolin; Actin depolymerization factor/cofilin- and gelsolin-like domains
  9. XM_011246879.1XP_011245181.1  

    Conserved Domains (6) summary
    smart00153
    Location:21202155
    VHP; Villin headpiece domain
    cd11280
    Location:15041604
    gelsolin_like; Tandemly repeated domains found in gelsolin, severin, villin, and related proteins
    cd11288
    Location:18201925
    gelsolin_S5_like; Gelsolin sub-domain 5-like domain found in gelsolin, severin, villin, and related proteins
    cd11289
    Location:13831475
    gelsolin_S2_like; Gelsolin sub-domain 2-like domain found in gelsolin, severin, villin, and related proteins
    cd11293
    Location:16871800
    gelsolin_S4_like; Gelsolin sub-domain 4-like domain found in gelsolin, severin, villin, and related proteins
    cl15697
    Location:19422064
    ADF_gelsolin; Actin depolymerization factor/cofilin- and gelsolin-like domains
  10. XM_011246881.1XP_011245183.1  

    Conserved Domains (6) summary
    smart00153
    Location:20972132
    VHP; Villin headpiece domain
    cd11280
    Location:14811581
    gelsolin_like; Tandemly repeated domains found in gelsolin, severin, villin, and related proteins
    cd11288
    Location:17971902
    gelsolin_S5_like; Gelsolin sub-domain 5-like domain found in gelsolin, severin, villin, and related proteins
    cd11289
    Location:13601456
    gelsolin_S2_like; Gelsolin sub-domain 2-like domain found in gelsolin, severin, villin, and related proteins
    cd11293
    Location:16641777
    gelsolin_S4_like; Gelsolin sub-domain 4-like domain found in gelsolin, severin, villin, and related proteins
    cl15697
    Location:19192041
    ADF_gelsolin; Actin depolymerization factor/cofilin- and gelsolin-like domains
  11. XM_011246880.1XP_011245182.1  

    Conserved Domains (7) summary
    pfam08934
    Location:222262
    Rb_C; Rb C-terminal domain
    cd11280
    Location:14871587
    gelsolin_like; Tandemly repeated domains found in gelsolin, severin, villin, and related proteins
    cd11288
    Location:18031908
    gelsolin_S5_like; Gelsolin sub-domain 5-like domain found in gelsolin, severin, villin, and related proteins
    cd11289
    Location:13661458
    gelsolin_S2_like; Gelsolin sub-domain 2-like domain found in gelsolin, severin, villin, and related proteins
    cd11293
    Location:16701783
    gelsolin_S4_like; Gelsolin sub-domain 4-like domain found in gelsolin, severin, villin, and related proteins
    pfam02209
    Location:21032138
    VHP; Villin headpiece domain
    cl15697
    Location:19252047
    ADF_gelsolin; Actin depolymerization factor/cofilin- and gelsolin-like domains
  12. XM_011246882.1XP_011245184.1  

    Conserved Domains (7) summary
    pfam08934
    Location:222307
    Rb_C; Rb C-terminal domain
    cd11280
    Location:12181318
    gelsolin_like; Tandemly repeated domains found in gelsolin, severin, villin, and related proteins
    cd11288
    Location:15341639
    gelsolin_S5_like; Gelsolin sub-domain 5-like domain found in gelsolin, severin, villin, and related proteins
    cd11289
    Location:10971189
    gelsolin_S2_like; Gelsolin sub-domain 2-like domain found in gelsolin, severin, villin, and related proteins
    cd11293
    Location:14011514
    gelsolin_S4_like; Gelsolin sub-domain 4-like domain found in gelsolin, severin, villin, and related proteins
    pfam02209
    Location:18341869
    VHP; Villin headpiece domain
    cl15697
    Location:16561778
    ADF_gelsolin; Actin depolymerization factor/cofilin- and gelsolin-like domains
  13. XM_011246883.1XP_011245185.1  

    Conserved Domains (6) summary
    cd11280
    Location:11911291
    gelsolin_like; Tandemly repeated domains found in gelsolin, severin, villin, and related proteins
    cd11288
    Location:15071612
    gelsolin_S5_like; Gelsolin sub-domain 5-like domain found in gelsolin, severin, villin, and related proteins
    cd11289
    Location:10701166
    gelsolin_S2_like; Gelsolin sub-domain 2-like domain found in gelsolin, severin, villin, and related proteins
    cd11293
    Location:13741487
    gelsolin_S4_like; Gelsolin sub-domain 4-like domain found in gelsolin, severin, villin, and related proteins
    pfam02209
    Location:18071842
    VHP; Villin headpiece domain
    cl15697
    Location:16291751
    ADF_gelsolin; Actin depolymerization factor/cofilin- and gelsolin-like domains
  14. XM_006525800.2XP_006525863.1  

    See identical proteins and their annotated locations for XP_006525863.1

    Conserved Domains (6) summary
    smart00153
    Location:17791814
    VHP; Villin headpiece domain
    cd11280
    Location:11631263
    gelsolin_like; Tandemly repeated domains found in gelsolin, severin, villin, and related proteins
    cd11288
    Location:14791584
    gelsolin_S5_like; Gelsolin sub-domain 5-like domain found in gelsolin, severin, villin, and related proteins
    cd11289
    Location:10421138
    gelsolin_S2_like; Gelsolin sub-domain 2-like domain found in gelsolin, severin, villin, and related proteins
    cd11293
    Location:13461459
    gelsolin_S4_like; Gelsolin sub-domain 4-like domain found in gelsolin, severin, villin, and related proteins
    cl15697
    Location:16011723
    ADF_gelsolin; Actin depolymerization factor/cofilin- and gelsolin-like domains
  15. XM_006525801.2XP_006525864.1  

    See identical proteins and their annotated locations for XP_006525864.1

    Conserved Domains (6) summary
    smart00153
    Location:17791814
    VHP; Villin headpiece domain
    cd11280
    Location:11631263
    gelsolin_like; Tandemly repeated domains found in gelsolin, severin, villin, and related proteins
    cd11288
    Location:14791584
    gelsolin_S5_like; Gelsolin sub-domain 5-like domain found in gelsolin, severin, villin, and related proteins
    cd11289
    Location:10421138
    gelsolin_S2_like; Gelsolin sub-domain 2-like domain found in gelsolin, severin, villin, and related proteins
    cd11293
    Location:13461459
    gelsolin_S4_like; Gelsolin sub-domain 4-like domain found in gelsolin, severin, villin, and related proteins
    cl15697
    Location:16011723
    ADF_gelsolin; Actin depolymerization factor/cofilin- and gelsolin-like domains
  16. XM_011246884.1XP_011245186.1  

    Conserved Domains (6) summary
    smart00153
    Location:17471782
    VHP; Villin headpiece domain
    cd11280
    Location:11311231
    gelsolin_like; Tandemly repeated domains found in gelsolin, severin, villin, and related proteins
    cd11288
    Location:14471552
    gelsolin_S5_like; Gelsolin sub-domain 5-like domain found in gelsolin, severin, villin, and related proteins
    cd11289
    Location:10101102
    gelsolin_S2_like; Gelsolin sub-domain 2-like domain found in gelsolin, severin, villin, and related proteins
    cd11293
    Location:13141427
    gelsolin_S4_like; Gelsolin sub-domain 4-like domain found in gelsolin, severin, villin, and related proteins
    cl15697
    Location:15691691
    ADF_gelsolin; Actin depolymerization factor/cofilin- and gelsolin-like domains
  17. XM_011246885.1XP_011245187.1  

    Related
    ENSMUSP00000119287, OTTMUSP00000044483, ENSMUST00000143254, OTTMUST00000082900
    Conserved Domains (6) summary
    smart00153
    Location:17311766
    VHP; Villin headpiece domain
    cd11280
    Location:11151215
    gelsolin_like; Tandemly repeated domains found in gelsolin, severin, villin, and related proteins
    cd11288
    Location:14311536
    gelsolin_S5_like; Gelsolin sub-domain 5-like domain found in gelsolin, severin, villin, and related proteins
    cd11289
    Location:9941086
    gelsolin_S2_like; Gelsolin sub-domain 2-like domain found in gelsolin, severin, villin, and related proteins
    cd11293
    Location:12981411
    gelsolin_S4_like; Gelsolin sub-domain 4-like domain found in gelsolin, severin, villin, and related proteins
    cl15697
    Location:15531675
    ADF_gelsolin; Actin depolymerization factor/cofilin- and gelsolin-like domains
  18. XM_006525790.1XP_006525853.1  

    See identical proteins and their annotated locations for XP_006525853.1

    Conserved Domains (6) summary
    smart00153
    Location:21522187
    VHP; Villin headpiece domain
    cd11280
    Location:15361636
    gelsolin_like; Tandemly repeated domains found in gelsolin, severin, villin, and related proteins
    cd11288
    Location:18521957
    gelsolin_S5_like; Gelsolin sub-domain 5-like domain found in gelsolin, severin, villin, and related proteins
    cd11289
    Location:14151511
    gelsolin_S2_like; Gelsolin sub-domain 2-like domain found in gelsolin, severin, villin, and related proteins
    cd11293
    Location:17191832
    gelsolin_S4_like; Gelsolin sub-domain 4-like domain found in gelsolin, severin, villin, and related proteins
    cl15697
    Location:19742096
    ADF_gelsolin; Actin depolymerization factor/cofilin- and gelsolin-like domains
  19. XM_006525793.2XP_006525856.1  

    See identical proteins and their annotated locations for XP_006525856.1

    Conserved Domains (6) summary
    smart00153
    Location:21522187
    VHP; Villin headpiece domain
    cd11280
    Location:15361636
    gelsolin_like; Tandemly repeated domains found in gelsolin, severin, villin, and related proteins
    cd11288
    Location:18521957
    gelsolin_S5_like; Gelsolin sub-domain 5-like domain found in gelsolin, severin, villin, and related proteins
    cd11289
    Location:14151511
    gelsolin_S2_like; Gelsolin sub-domain 2-like domain found in gelsolin, severin, villin, and related proteins
    cd11293
    Location:17191832
    gelsolin_S4_like; Gelsolin sub-domain 4-like domain found in gelsolin, severin, villin, and related proteins
    cl15697
    Location:19742096
    ADF_gelsolin; Actin depolymerization factor/cofilin- and gelsolin-like domains
  20. XM_006525794.2XP_006525857.1  

    See identical proteins and their annotated locations for XP_006525857.1

    Conserved Domains (6) summary
    smart00153
    Location:21522187
    VHP; Villin headpiece domain
    cd11280
    Location:15361636
    gelsolin_like; Tandemly repeated domains found in gelsolin, severin, villin, and related proteins
    cd11288
    Location:18521957
    gelsolin_S5_like; Gelsolin sub-domain 5-like domain found in gelsolin, severin, villin, and related proteins
    cd11289
    Location:14151511
    gelsolin_S2_like; Gelsolin sub-domain 2-like domain found in gelsolin, severin, villin, and related proteins
    cd11293
    Location:17191832
    gelsolin_S4_like; Gelsolin sub-domain 4-like domain found in gelsolin, severin, villin, and related proteins
    cl15697
    Location:19742096
    ADF_gelsolin; Actin depolymerization factor/cofilin- and gelsolin-like domains

Alternate Mm_Celera

Genomic

  1. AC_000040.1 Alternate Mm_Celera

    Range
    5092122..5164709
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_178046.3: Suppressed sequence

    Description
    NM_178046.3: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.