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Xbp1 X-box binding protein 1 [ Mus musculus (house mouse) ]

Gene ID: 22433, updated on 29-May-2016
Official Symbol
Xbp1provided by MGI
Official Full Name
X-box binding protein 1provided by MGI
Primary source
MGI:MGI:98970
See related
Ensembl:ENSMUSG00000020484 Vega:OTTMUSG00000006338
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
TREB5; XBP-1; TREB-5; D11Ertd39e
Orthologs
Location:
11 A1; 11 3.61 cM
Exon count:
6
Annotation release Status Assembly Chr Location
105 current GRCm38.p3 (GCF_000001635.23) 11 NC_000077.6 (5520641..5525993)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 11 NC_000077.5 (5420970..5425875)

Chromosome 11 - NC_000077.6Genomic Context describing neighboring genes Neighboring gene polymerase (RNA) II (DNA directed) polypeptide D pseudogene Neighboring gene predicted gene 11963 Neighboring gene coiled-coil domain containing 117 Neighboring gene predicted gene 3186

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

  • HTLV-I infection, organism-specific biosystem (from KEGG)
    HTLV-I infection, organism-specific biosystemHuman T-lymphotropic virus type 1 (HTLV-1) is a pathogenic retrovirus that is associated with adult T-cell leukemia/lymphoma (ATL). It is also strongly implicated in non-neoplastic chronic inflammato...
  • HTLV-I infection, conserved biosystem (from KEGG)
    HTLV-I infection, conserved biosystemHuman T-lymphotropic virus type 1 (HTLV-1) is a pathogenic retrovirus that is associated with adult T-cell leukemia/lymphoma (ATL). It is also strongly implicated in non-neoplastic chronic inflammato...
  • Insulin Signaling, organism-specific biosystem (from WikiPathways)
    Insulin Signaling, organism-specific biosystem
    Insulin Signaling
  • Non-alcoholic fatty liver disease (NAFLD), organism-specific biosystem (from KEGG)
    Non-alcoholic fatty liver disease (NAFLD), organism-specific biosystemNon-alcoholic fatty liver disease (NAFLD) represents a spectrum ranging from simple steatosis to more severe steatohepatitis with hepatic inflammation and fibrosis, known as nonalcoholic steatohepati...
  • Non-alcoholic fatty liver disease (NAFLD), conserved biosystem (from KEGG)
    Non-alcoholic fatty liver disease (NAFLD), conserved biosystemNon-alcoholic fatty liver disease (NAFLD) represents a spectrum ranging from simple steatosis to more severe steatohepatitis with hepatic inflammation and fibrosis, known as nonalcoholic steatohepati...
  • Protein processing in endoplasmic reticulum, organism-specific biosystem (from KEGG)
    Protein processing in endoplasmic reticulum, organism-specific biosystemThe endoplasmic reticulum (ER) is a subcellular organelle where proteins are folded with the help of lumenal chaperones. Newly synthesized peptides enter the ER via the sec61 pore and are glycosylate...
  • Protein processing in endoplasmic reticulum, conserved biosystem (from KEGG)
    Protein processing in endoplasmic reticulum, conserved biosystemThe endoplasmic reticulum (ER) is a subcellular organelle where proteins are folded with the help of lumenal chaperones. Newly synthesized peptides enter the ER via the sec61 pore and are glycosylate...
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
DNA binding IEA
Inferred from Electronic Annotation
more info
 
RNA polymerase II regulatory region sequence-specific DNA binding ISO
Inferred from Sequence Orthology
more info
 
RNA polymerase II transcription factor activity, sequence-specific DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
RNA polymerase II transcription factor binding IPI
Inferred from Physical Interaction
more info
PubMed 
chromatin DNA binding ISO
Inferred from Sequence Orthology
more info
 
core promoter binding IDA
Inferred from Direct Assay
more info
PubMed 
enhancer sequence-specific DNA binding ISO
Inferred from Sequence Orthology
more info
 
histone deacetylase binding IPI
Inferred from Physical Interaction
more info
PubMed 
phosphatidylinositol 3-kinase regulatory subunit binding IPI
Inferred from Physical Interaction
more info
PubMed 
protease binding ISO
Inferred from Sequence Orthology
more info
 
protein heterodimerization activity ISO
Inferred from Sequence Orthology
more info
 
protein kinase binding ISO
Inferred from Sequence Orthology
more info
 
sequence-specific DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
sequence-specific DNA binding ISO
Inferred from Sequence Orthology
more info
 
transcription factor activity, sequence-specific DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
transcription factor activity, sequence-specific DNA binding ISO
Inferred from Sequence Orthology
more info
 
transcription regulatory region DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
transcription regulatory region DNA binding ISO
Inferred from Sequence Orthology
more info
 
ubiquitin protein ligase binding ISO
Inferred from Sequence Orthology
more info
 
ubiquitin-like protein ligase binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
adipose tissue development IMP
Inferred from Mutant Phenotype
more info
PubMed 
angiogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
apoptotic process IEA
Inferred from Electronic Annotation
more info
 
autophagy IEA
Inferred from Electronic Annotation
more info
 
cell differentiation IEA
Inferred from Electronic Annotation
more info
 
cell growth ISO
Inferred from Sequence Orthology
more info
 
cellular response to amino acid stimulus IDA
Inferred from Direct Assay
more info
PubMed 
cellular response to fluid shear stress ISO
Inferred from Sequence Orthology
more info
 
cellular response to fructose stimulus IDA
Inferred from Direct Assay
more info
PubMed 
cellular response to glucose starvation IDA
Inferred from Direct Assay
more info
PubMed 
cellular response to glucose stimulus IDA
Inferred from Direct Assay
more info
PubMed 
cellular response to insulin stimulus IDA
Inferred from Direct Assay
more info
PubMed 
cellular response to interleukin-4 IDA
Inferred from Direct Assay
more info
PubMed 
cellular response to laminar fluid shear stress ISO
Inferred from Sequence Orthology
more info
 
cellular response to lipopolysaccharide IDA
Inferred from Direct Assay
more info
PubMed 
cellular response to lipopolysaccharide ISO
Inferred from Sequence Orthology
more info
 
cellular response to nutrient IDA
Inferred from Direct Assay
more info
PubMed 
cellular response to oxidative stress ISO
Inferred from Sequence Orthology
more info
 
cellular response to peptide hormone stimulus IDA
Inferred from Direct Assay
more info
PubMed 
cellular response to vascular endothelial growth factor stimulus ISO
Inferred from Sequence Orthology
more info
 
cellular triglyceride homeostasis IMP
Inferred from Mutant Phenotype
more info
PubMed 
cholesterol homeostasis IMP
Inferred from Mutant Phenotype
more info
PubMed 
endoplasmic reticulum unfolded protein response IDA
Inferred from Direct Assay
more info
PubMed 
endoplasmic reticulum unfolded protein response ISO
Inferred from Sequence Orthology
more info
 
endothelial cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
endothelial cell proliferation ISO
Inferred from Sequence Orthology
more info
 
epithelial cell maturation IMP
Inferred from Mutant Phenotype
more info
PubMed 
epithelial cell maturation involved in salivary gland development IMP
Inferred from Mutant Phenotype
more info
PubMed 
exocrine pancreas development IMP
Inferred from Mutant Phenotype
more info
PubMed 
fatty acid homeostasis IMP
Inferred from Mutant Phenotype
more info
PubMed 
glucose homeostasis IDA
Inferred from Direct Assay
more info
PubMed 
intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress IMP
Inferred from Mutant Phenotype
more info
PubMed 
lipid metabolic process IEA
Inferred from Electronic Annotation
more info
 
liver development IMP
Inferred from Mutant Phenotype
more info
PubMed 
multicellular organism development IEA
Inferred from Electronic Annotation
more info
 
muscle organ development IEA
Inferred from Electronic Annotation
more info
 
negative regulation of apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway ISO
Inferred from Sequence Orthology
more info
 
negative regulation of endoplasmic reticulum unfolded protein response ISO
Inferred from Sequence Orthology
more info
 
negative regulation of myotube differentiation IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of transcription from RNA polymerase II promoter ISO
Inferred from Sequence Orthology
more info
 
neuron development IDA
Inferred from Direct Assay
more info
PubMed 
phosphatidylinositol 3-kinase signaling ISO
Inferred from Sequence Orthology
more info
 
positive regulation of B cell differentiation ISO
Inferred from Sequence Orthology
more info
 
positive regulation of MHC class II biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
positive regulation of T cell differentiation ISO
Inferred from Sequence Orthology
more info
 
positive regulation of TOR signaling ISO
Inferred from Sequence Orthology
more info
 
positive regulation of autophagy ISO
Inferred from Sequence Orthology
more info
 
positive regulation of endoplasmic reticulum unfolded protein response ISO
Inferred from Sequence Orthology
more info
 
positive regulation of endothelial cell apoptotic process ISO
Inferred from Sequence Orthology
more info
 
positive regulation of fat cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of hepatocyte proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of histone methylation ISO
Inferred from Sequence Orthology
more info
 
positive regulation of immunoglobulin production ISO
Inferred from Sequence Orthology
more info
 
positive regulation of immunoglobulin secretion IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of interleukin-6 secretion IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of lactation IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of plasma cell differentiation ISO
Inferred from Sequence Orthology
more info
 
positive regulation of proteasomal protein catabolic process IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of protein acetylation ISO
Inferred from Sequence Orthology
more info
 
positive regulation of protein phosphorylation ISO
Inferred from Sequence Orthology
more info
 
positive regulation of transcription factor import into nucleus ISO
Inferred from Sequence Orthology
more info
 
positive regulation of transcription from RNA polymerase II promoter IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of transcription from RNA polymerase II promoter IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of transcription from RNA polymerase II promoter ISO
Inferred from Sequence Orthology
more info
 
positive regulation of transcription from RNA polymerase II promoter involved in unfolded protein response IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of transcription from RNA polymerase II promoter involved in unfolded protein response IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of transcription from RNA polymerase II promoter involved in unfolded protein response ISO
Inferred from Sequence Orthology
more info
 
protein destabilization IMP
Inferred from Mutant Phenotype
more info
PubMed 
protein destabilization ISO
Inferred from Sequence Orthology
more info
 
protein transport IEA
Inferred from Electronic Annotation
more info
 
regulation of autophagy IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of protein stability ISO
Inferred from Sequence Orthology
more info
 
regulation of transcription from RNA polymerase II promoter IDA
Inferred from Direct Assay
more info
PubMed 
regulation of transcription, DNA-templated IEA
Inferred from Electronic Annotation
more info
 
response to drug ISO
Inferred from Sequence Orthology
more info
 
response to electrical stimulus ISO
Inferred from Sequence Orthology
more info
 
response to endoplasmic reticulum stress IDA
Inferred from Direct Assay
more info
PubMed 
response to endoplasmic reticulum stress ISO
Inferred from Sequence Orthology
more info
 
response to insulin-like growth factor stimulus IDA
Inferred from Direct Assay
more info
PubMed 
response to unfolded protein IEA
Inferred from Electronic Annotation
more info
 
serotonin secretion, neurotransmission ISO
Inferred from Sequence Orthology
more info
 
sterol homeostasis IMP
Inferred from Mutant Phenotype
more info
PubMed 
transcription from RNA polymerase II promoter IDA
Inferred from Direct Assay
more info
PubMed 
transcription from RNA polymerase II promoter ISO
Inferred from Sequence Orthology
more info
 
transcription, DNA-templated IEA
Inferred from Electronic Annotation
more info
 
transport IEA
Inferred from Electronic Annotation
more info
 
ubiquitin-dependent protein catabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
vascular endothelial growth factor receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
cytoplasm ISO
Inferred from Sequence Orthology
more info
 
cytosol ISO
Inferred from Sequence Orthology
more info
 
endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
 
integral component of endoplasmic reticulum membrane ISO
Inferred from Sequence Orthology
more info
 
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
membrane IEA
Inferred from Electronic Annotation
more info
 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 
nucleus ISO
Inferred from Sequence Orthology
more info
 
Preferred Names
X-box-binding protein 1
Names
tax-responsive element-binding protein 5 homolog

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001271730.1NP_001258659.1  X-box-binding protein 1 isoform XBP1(S)

    See identical proteins and their annotated locations for NP_001258659.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks a 26 nt segment in the CDS compared to variant 1, that causes a frameshift. The resulting isoform, XBP1(S), has the same N-terminus, but a longer and distinct C-terminus compared to isoform XBP1(U). Isoform XBP1(S) functions as a transcription factor.
    Source sequence(s)
    AL662876, BF453945, BG800705
    UniProtKB/Swiss-Prot
    O35426
    Conserved Domains (1) summary
    cd14691
    Location:63119
    bZIP_XBP1; Basic leucine zipper (bZIP) domain of X-box binding protein 1 (XBP1) and similar proteins: a DNA-binding and dimerization domain
  2. NM_013842.3NP_038870.2  X-box-binding protein 1 isoform XBP1(U)

    See identical proteins and their annotated locations for NP_038870.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript but encodes the shorter isoform, XBP1(U).
    Source sequence(s)
    AK007724, AL662876, BF453945
    Consensus CDS
    CCDS24400.1
    UniProtKB/Swiss-Prot
    O35426
    Related
    ENSMUSP00000054852, OTTMUSP00000006681, ENSMUST00000063084, OTTMUST00000014402
    Conserved Domains (1) summary
    cd14691
    Location:63119
    bZIP_XBP1; Basic leucine zipper (bZIP) domain of X-box binding protein 1 (XBP1) and similar proteins: a DNA-binding and dimerization domain

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 105 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p3 C57BL/6J

Genomic

  1. NC_000077.6 Reference GRCm38.p3 C57BL/6J

    Range
    5520641..5525993
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate Mm_Celera

Genomic

  1. AC_000033.1 Alternate Mm_Celera

    Range
    6013628..6018986
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)