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Wnt5a wingless-type MMTV integration site family, member 5A [ Mus musculus (house mouse) ]

Gene ID: 22418, updated on 17-May-2016
Official Symbol
Wnt5aprovided by MGI
Official Full Name
wingless-type MMTV integration site family, member 5Aprovided by MGI
Primary source
MGI:MGI:98958
See related
Ensembl:ENSMUSG00000021994 Vega:OTTMUSG00000021010
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Wnt-5a; 8030457G12Rik
Orthologs
Location:
14 A3; 14 16.8 cM
Exon count:
9
Annotation release Status Assembly Chr Location
105 current GRCm38.p3 (GCF_000001635.23) 14 NC_000080.6 (28505473..28527448)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 14 NC_000080.5 (29318659..29338620)

Chromosome 14 - NC_000080.6Genomic Context describing neighboring genes Neighboring gene ELKS/RAB6-interacting/CAST family member 2 Neighboring gene aconitase 2, mitochondrial pseudogene Neighboring gene predicted gene, 34996 Neighboring gene predicted gene, 35164 Neighboring gene ribosomal protein L5 pseudogene

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (3)  1 citation
  • Chemically induced (ENU) (1) 
  • Asymmetric localization of PCP proteins, organism-specific biosystem (from REACTOME)
    Asymmetric localization of PCP proteins, organism-specific biosystemcomputationally inferred pathway (not manually curated)
  • Axon guidance, organism-specific biosystem (from KEGG)
    Axon guidance, organism-specific biosystemAxon guidance represents a key stage in the formation of neuronal network. Axons are guided by a variety of guidance factors, such as netrins, ephrins, Slits, and semaphorins. These guidance cues are...
  • Axon guidance, conserved biosystem (from KEGG)
    Axon guidance, conserved biosystemAxon guidance represents a key stage in the formation of neuronal network. Axons are guided by a variety of guidance factors, such as netrins, ephrins, Slits, and semaphorins. These guidance cues are...
  • Basal cell carcinoma, organism-specific biosystem (from KEGG)
    Basal cell carcinoma, organism-specific biosystemCancer of the skin is the most common cancer in Caucasians and basal cell carcinomas (BCC) account for 90% of all skin cancers. The vast majority of BCC cases are sporadic, though there is a rare fam...
  • Basal cell carcinoma, conserved biosystem (from KEGG)
    Basal cell carcinoma, conserved biosystemCancer of the skin is the most common cancer in Caucasians and basal cell carcinomas (BCC) account for 90% of all skin cancers. The vast majority of BCC cases are sporadic, though there is a rare fam...
  • Beta-catenin independent WNT signaling, organism-specific biosystem (from REACTOME)
    Beta-catenin independent WNT signaling, organism-specific biosystemcomputationally inferred pathway (not manually curated)
  • Ca2+ pathway, organism-specific biosystem (from REACTOME)
    Ca2+ pathway, organism-specific biosystemcomputationally inferred pathway (not manually curated)
  • ESC Pluripotency Pathways, organism-specific biosystem (from WikiPathways)
    ESC Pluripotency Pathways, organism-specific biosystemThe cytokine LIF and its downstream effector STAT3 are essential for maintenance of pluripotency in mouse ES cells. The requirement for the transcription factor Oct3/4 for ES cell pluripotency is als...
  • HTLV-I infection, organism-specific biosystem (from KEGG)
    HTLV-I infection, organism-specific biosystemHuman T-lymphotropic virus type 1 (HTLV-1) is a pathogenic retrovirus that is associated with adult T-cell leukemia/lymphoma (ATL). It is also strongly implicated in non-neoplastic chronic inflammato...
  • HTLV-I infection, conserved biosystem (from KEGG)
    HTLV-I infection, conserved biosystemHuman T-lymphotropic virus type 1 (HTLV-1) is a pathogenic retrovirus that is associated with adult T-cell leukemia/lymphoma (ATL). It is also strongly implicated in non-neoplastic chronic inflammato...
  • Hedgehog signaling pathway, organism-specific biosystem (from KEGG)
    Hedgehog signaling pathway, organism-specific biosystemThe Hedgehog (Hh) family of secreted signaling proteins plays a crucial role in development of diverse animal phyla, from Drosophila to humans, regulating morphogenesis of a variety of tissues and or...
  • Hedgehog signaling pathway, conserved biosystem (from KEGG)
    Hedgehog signaling pathway, conserved biosystemThe Hedgehog (Hh) family of secreted signaling proteins plays a crucial role in development of diverse animal phyla, from Drosophila to humans, regulating morphogenesis of a variety of tissues and or...
  • Hippo signaling pathway, organism-specific biosystem (from KEGG)
    Hippo signaling pathway, organism-specific biosystemHippo signaling is an evolutionarily conserved signaling pathway that controls organ size from flies to humans. In humans and mice, the pathway consists of the MST1 and MST2 kinases, their cofactor S...
  • Hippo signaling pathway, conserved biosystem (from KEGG)
    Hippo signaling pathway, conserved biosystemHippo signaling is an evolutionarily conserved signaling pathway that controls organ size from flies to humans. In humans and mice, the pathway consists of the MST1 and MST2 kinases, their cofactor S...
  • Melanogenesis, organism-specific biosystem (from KEGG)
    Melanogenesis, organism-specific biosystemCutaneous melanin pigment plays a critical role in camouflage, mimicry, social communication, and protection against harmful effects of solar radiation. Melanogenesis is under complex regulatory cont...
  • Melanogenesis, conserved biosystem (from KEGG)
    Melanogenesis, conserved biosystemCutaneous melanin pigment plays a critical role in camouflage, mimicry, social communication, and protection against harmful effects of solar radiation. Melanogenesis is under complex regulatory cont...
  • MicroRNAs in cardiomyocyte hypertrophy, organism-specific biosystem (from WikiPathways)
    MicroRNAs in cardiomyocyte hypertrophy, organism-specific biosystemThis pathway shows the role of microRNAs in the process of cardiac hypertrophy. Converted from the humane pathway. MicroRNA targets were predicted by the TargetScan algorithm, and the predicted inter...
  • Negative regulation of TCF-dependent signaling by WNT ligand antagonists, organism-specific biosystem (from REACTOME)
    Negative regulation of TCF-dependent signaling by WNT ligand antagonists, organism-specific biosystemcomputationally inferred pathway (not manually curated)
  • PCP/CE pathway, organism-specific biosystem (from REACTOME)
    PCP/CE pathway, organism-specific biosystemcomputationally inferred pathway (not manually curated)
  • Pathways in cancer, organism-specific biosystem (from KEGG)
    Pathways in cancer, organism-specific biosystem
    Pathways in cancer
  • PluriNetWork, organism-specific biosystem (from WikiPathways)
    PluriNetWork, organism-specific biosystemThe aim of the PluriNetWork is to give an overview of specific mechanisms associated with pluripotency in mouse. Each node represents a gene and its corresponding protein product. As stated, we inten...
  • Proteoglycans in cancer, organism-specific biosystem (from KEGG)
    Proteoglycans in cancer, organism-specific biosystemMany proteoglycans (PGs) in the tumor microenvironment have been shown to be key macromolecules that contribute to biology of various types of cancer including proliferation, adhesion, angiogenesis a...
  • Proteoglycans in cancer, conserved biosystem (from KEGG)
    Proteoglycans in cancer, conserved biosystemMany proteoglycans (PGs) in the tumor microenvironment have been shown to be key macromolecules that contribute to biology of various types of cancer including proliferation, adhesion, angiogenesis a...
  • Signal Transduction, organism-specific biosystem (from REACTOME)
    Signal Transduction, organism-specific biosystemcomputationally inferred pathway (not manually curated)
  • Signaling by Wnt, organism-specific biosystem (from REACTOME)
    Signaling by Wnt, organism-specific biosystemcomputationally inferred pathway (not manually curated)
  • Signaling pathways regulating pluripotency of stem cells, organism-specific biosystem (from KEGG)
    Signaling pathways regulating pluripotency of stem cells, organism-specific biosystemPluripotent stem cells (PSCs) are basic cells with an indefinite self-renewal capacity and the potential to generate all the cell types of the three germinal layers. The types of PSCs known to date i...
  • Signaling pathways regulating pluripotency of stem cells, conserved biosystem (from KEGG)
    Signaling pathways regulating pluripotency of stem cells, conserved biosystemPluripotent stem cells (PSCs) are basic cells with an indefinite self-renewal capacity and the potential to generate all the cell types of the three germinal layers. The types of PSCs known to date i...
  • TCF dependent signaling in response to WNT, organism-specific biosystem (from REACTOME)
    TCF dependent signaling in response to WNT, organism-specific biosystemcomputationally inferred pathway (not manually curated)
  • WNT ligand biogenesis and trafficking, organism-specific biosystem (from REACTOME)
    WNT ligand biogenesis and trafficking, organism-specific biosystemcomputationally inferred pathway (not manually curated)
  • WNT5A-dependent internalization of FZD2, FZD5 and ROR2, organism-specific biosystem (from REACTOME)
    WNT5A-dependent internalization of FZD2, FZD5 and ROR2, organism-specific biosystemcomputationally inferred pathway (not manually curated)
  • WNT5A-dependent internalization of FZD4, organism-specific biosystem (from REACTOME)
    WNT5A-dependent internalization of FZD4, organism-specific biosystemcomputationally inferred pathway (not manually curated)
  • Wnt Signaling Pathway, organism-specific biosystem (from WikiPathways)
    Wnt Signaling Pathway, organism-specific biosystemWnt proteins are secreted morphogens that are required for basic developmental processes, such as cell-fate specification, progenitor-cell proliferation and the control of asymmetric cell division, i...
  • Wnt Signaling Pathway NetPath, organism-specific biosystem (from WikiPathways)
    Wnt Signaling Pathway NetPath, organism-specific biosystemWnt family of proteins are a large family of cysteine-rich secreted glycoproteins that regulate cell-cell interactions. They bind to members of the Frizzled family of 7 transmembrane receptors. Bindi...
  • Wnt Signaling Pathway and Pluripotency, organism-specific biosystem (from WikiPathways)
    Wnt Signaling Pathway and Pluripotency, organism-specific biosystemThis pathway was adapted from several resources and is designed to provide a theoretical frame-work for examining Wnt signaling and interacting components in the context of embryonic stem-cell pluri...
  • Wnt signaling, organism-specific biosystem (from KEGG)
    Wnt signaling, organism-specific biosystemFunctional set; Cellular processes; Cell signaling
  • Wnt signaling, conserved biosystem (from KEGG)
    Wnt signaling, conserved biosystemFunctional set; Cellular processes; Cell signaling
  • Wnt signaling pathway, organism-specific biosystem (from KEGG)
    Wnt signaling pathway, organism-specific biosystemWnt proteins are secreted morphogens that are required for basic developmental processes, such as cell-fate specification, progenitor-cell proliferation and the control of asymmetric cell division, i...
  • Wnt signaling pathway, conserved biosystem (from KEGG)
    Wnt signaling pathway, conserved biosystemWnt proteins are secreted morphogens that are required for basic developmental processes, such as cell-fate specification, progenitor-cell proliferation and the control of asymmetric cell division, i...
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
chemoattractant activity involved in axon guidance IDA
Inferred from Direct Assay
more info
PubMed 
cytokine activity IDA
Inferred from Direct Assay
more info
PubMed 
frizzled binding IPI
Inferred from Physical Interaction
more info
PubMed 
frizzled binding ISO
Inferred from Sequence Orthology
more info
 
frizzled-2 binding IDA
Inferred from Direct Assay
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein domain specific binding IPI
Inferred from Physical Interaction
more info
PubMed 
receptor binding IPI
Inferred from Physical Interaction
more info
PubMed 
receptor binding TAS
Traceable Author Statement
more info
PubMed 
receptor tyrosine kinase-like orphan receptor binding ISO
Inferred from Sequence Orthology
more info
 
transcription factor activity, sequence-specific DNA binding ISO
Inferred from Sequence Orthology
more info
 
transcription regulatory region DNA binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
JNK cascade IDA
Inferred from Direct Assay
more info
PubMed 
Wnt signaling pathway IGI
Inferred from Genetic Interaction
more info
PubMed 
Wnt signaling pathway ISO
Inferred from Sequence Orthology
more info
 
Wnt signaling pathway involved in midbrain dopaminergic neuron differentiation IDA
Inferred from Direct Assay
more info
PubMed 
Wnt signaling pathway, calcium modulating pathway IDA
Inferred from Direct Assay
more info
PubMed 
Wnt signaling pathway, calcium modulating pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
Wnt signaling pathway, calcium modulating pathway ISO
Inferred from Sequence Orthology
more info
 
Wnt signaling pathway, planar cell polarity pathway IDA
Inferred from Direct Assay
more info
PubMed 
Wnt signaling pathway, planar cell polarity pathway IGI
Inferred from Genetic Interaction
more info
PubMed 
Wnt signaling pathway, planar cell polarity pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
Wnt signaling pathway, planar cell polarity pathway ISO
Inferred from Sequence Orthology
more info
 
activation of GTPase activity IDA
Inferred from Direct Assay
more info
PubMed 
activation of JUN kinase activity ISO
Inferred from Sequence Orthology
more info
 
activation of MAPK activity ISO
Inferred from Sequence Orthology
more info
 
activation of protein kinase B activity ISO
Inferred from Sequence Orthology
more info
 
ameboidal-type cell migration IMP
Inferred from Mutant Phenotype
more info
PubMed 
anterior/posterior axis specification, embryo IDA
Inferred from Direct Assay
more info
PubMed 
anterior/posterior pattern specification IMP
Inferred from Mutant Phenotype
more info
PubMed 
axis elongation IMP
Inferred from Mutant Phenotype
more info
PubMed 
axon guidance IDA
Inferred from Direct Assay
more info
PubMed 
axonal fasciculation TAS
Traceable Author Statement
more info
PubMed 
axonogenesis IDA
Inferred from Direct Assay
more info
PubMed 
canonical Wnt signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
NOT canonical Wnt signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
canonical Wnt signaling pathway IGI
Inferred from Genetic Interaction
more info
PubMed 
canonical Wnt signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
cartilage development IEA
Inferred from Electronic Annotation
more info
 
cell differentiation IEA
Inferred from Electronic Annotation
more info
 
cell fate commitment IBA
Inferred from Biological aspect of Ancestor
more info
 
cell migration IGI
Inferred from Genetic Interaction
more info
PubMed 
cell migration IMP
Inferred from Mutant Phenotype
more info
PubMed 
cell-cell signaling TAS
Traceable Author Statement
more info
PubMed 
cellular protein localization IMP
Inferred from Mutant Phenotype
more info
PubMed 
cellular protein localization ISO
Inferred from Sequence Orthology
more info
 
cellular response to molecule of bacterial origin IDA
Inferred from Direct Assay
more info
PubMed 
cervix development IMP
Inferred from Mutant Phenotype
more info
PubMed 
chemoattraction of serotonergic neuron axon IDA
Inferred from Direct Assay
more info
PubMed 
chemorepulsion of dopaminergic neuron axon IDA
Inferred from Direct Assay
more info
PubMed 
cochlea morphogenesis IGI
Inferred from Genetic Interaction
more info
PubMed 
cochlea morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
convergent extension IMP
Inferred from Mutant Phenotype
more info
PubMed 
convergent extension involved in axis elongation IGI
Inferred from Genetic Interaction
more info
PubMed 
convergent extension involved in axis elongation IMP
Inferred from Mutant Phenotype
more info
PubMed 
convergent extension involved in organogenesis IGI
Inferred from Genetic Interaction
more info
PubMed 
determination of left/right symmetry IMP
Inferred from Mutant Phenotype
more info
PubMed 
development of primary male sexual characteristics IMP
Inferred from Mutant Phenotype
more info
PubMed 
digestive tract morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
dopaminergic neuron differentiation IDA
Inferred from Direct Assay
more info
PubMed 
dopaminergic neuron differentiation IGI
Inferred from Genetic Interaction
more info
PubMed 
dopaminergic neuron differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
embryo development IMP
Inferred from Mutant Phenotype
more info
PubMed 
embryonic digit morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
embryonic limb morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
embryonic skeletal system development ISO
Inferred from Sequence Orthology
more info
 
epithelial cell proliferation involved in mammary gland duct elongation IDA
Inferred from Direct Assay
more info
PubMed 
establishment of epithelial cell apical/basal polarity IGI
Inferred from Genetic Interaction
more info
PubMed 
establishment of planar polarity IMP
Inferred from Mutant Phenotype
more info
PubMed 
face development ISO
Inferred from Sequence Orthology
more info
 
genitalia development ISO
Inferred from Sequence Orthology
more info
 
heart looping IGI
Inferred from Genetic Interaction
more info
PubMed 
hematopoietic stem cell proliferation IDA
Inferred from Direct Assay
more info
PubMed 
hematopoietic stem cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
hematopoietic stem cell proliferation ISO
Inferred from Sequence Orthology
more info
 
hindgut morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
hypophysis morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
inner ear morphogenesis IDA
Inferred from Direct Assay
more info
PubMed 
inner ear morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
lateral sprouting involved in mammary gland duct morphogenesis IDA
Inferred from Direct Assay
more info
PubMed 
limb morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
lung development IMP
Inferred from Mutant Phenotype
more info
PubMed 
male gonad development IMP
Inferred from Mutant Phenotype
more info
PubMed 
mammary gland branching involved in thelarche IDA
Inferred from Direct Assay
more info
PubMed 
melanocyte proliferation IDA
Inferred from Direct Assay
more info
PubMed 
mesenchymal-epithelial cell signaling IMP
Inferred from Mutant Phenotype
more info
PubMed 
mesodermal to mesenchymal transition involved in gastrulation IGI
Inferred from Genetic Interaction
more info
PubMed 
midbrain development IDA
Inferred from Direct Assay
more info
PubMed 
midbrain development IGI
Inferred from Genetic Interaction
more info
PubMed 
midbrain dopaminergic neuron differentiation IDA
Inferred from Direct Assay
more info
PubMed 
midbrain dopaminergic neuron differentiation IGI
Inferred from Genetic Interaction
more info
PubMed 
midbrain dopaminergic neuron differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
midgut development IMP
Inferred from Mutant Phenotype
more info
PubMed 
morphogenesis of an epithelium IMP
Inferred from Mutant Phenotype
more info
PubMed 
multicellular organism development IEA
Inferred from Electronic Annotation
more info
 
negative chemotaxis IGI
Inferred from Genetic Interaction
more info
PubMed 
negative regulation of BMP signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of apoptotic process ISO
Inferred from Sequence Orthology
more info
 
negative regulation of axon extension involved in axon guidance IGI
Inferred from Genetic Interaction
more info
PubMed 
negative regulation of canonical Wnt signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
NOT negative regulation of canonical Wnt signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of canonical Wnt signaling pathway IGI
Inferred from Genetic Interaction
more info
PubMed 
negative regulation of canonical Wnt signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of canonical Wnt signaling pathway ISO
Inferred from Sequence Orthology
more info
 
negative regulation of cell proliferation in midbrain IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of epithelial cell proliferation IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of epithelial cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of fat cell differentiation ISO
Inferred from Sequence Orthology
more info
 
negative regulation of fibroblast growth factor receptor signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of melanin biosynthetic process IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of mesenchymal cell proliferation ISO
Inferred from Sequence Orthology
more info
 
negative regulation of prostatic bud formation IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of synapse assembly IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of transcription, DNA-templated ISO
Inferred from Sequence Orthology
more info
 
neural tube closure IGI
Inferred from Genetic Interaction
more info
PubMed 
neural tube development IGI
Inferred from Genetic Interaction
more info
PubMed 
neurogenesis IDA
Inferred from Direct Assay
more info
PubMed 
neuron projection morphogenesis IDA
Inferred from Direct Assay
more info
PubMed 
non-canonical Wnt signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
non-canonical Wnt signaling pathway TAS
Traceable Author Statement
more info
PubMed 
non-canonical Wnt signaling pathway via JNK cascade IMP
Inferred from Mutant Phenotype
more info
PubMed 
notochord morphogenesis IGI
Inferred from Genetic Interaction
more info
PubMed 
olfactory bulb interneuron development IMP
Inferred from Mutant Phenotype
more info
PubMed 
organ morphogenesis TAS
Traceable Author Statement
more info
PubMed 
palate development ISO
Inferred from Sequence Orthology
more info
 
paraxial mesoderm formation IGI
Inferred from Genetic Interaction
more info
PubMed 
pericardium morphogenesis IGI
Inferred from Genetic Interaction
more info
PubMed 
planar cell polarity pathway involved in axis elongation IGI
Inferred from Genetic Interaction
more info
PubMed 
planar cell polarity pathway involved in axis elongation IMP
Inferred from Mutant Phenotype
more info
PubMed 
planar cell polarity pathway involved in axon guidance IDA
Inferred from Direct Assay
more info
PubMed 
planar cell polarity pathway involved in axon guidance IMP
Inferred from Mutant Phenotype
more info
PubMed 
planar cell polarity pathway involved in cardiac muscle tissue morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
planar cell polarity pathway involved in cardiac right atrium morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
planar cell polarity pathway involved in gastrula mediolateral intercalation IGI
Inferred from Genetic Interaction
more info
PubMed 
planar cell polarity pathway involved in neural tube closure IMP
Inferred from Mutant Phenotype
more info
PubMed 
planar cell polarity pathway involved in outflow tract morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
planar cell polarity pathway involved in pericardium morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
planar cell polarity pathway involved in ventricular septum morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of GTPase activity IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of JNK cascade IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of JUN kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of JUN kinase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of NF-kappaB transcription factor activity ISO
Inferred from Sequence Orthology
more info
 
positive regulation of T cell chemotaxis ISO
Inferred from Sequence Orthology
more info
 
positive regulation of angiogenesis ISO
Inferred from Sequence Orthology
more info
 
positive regulation of cGMP metabolic process ISO
Inferred from Sequence Orthology
more info
 
positive regulation of cartilage development IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of cartilage development IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of cell proliferation IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of cell-cell adhesion ISO
Inferred from Sequence Orthology
more info
 
positive regulation of cell-cell adhesion mediated by cadherin IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of chemokine biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
positive regulation of cytokine production IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of cytokine secretion involved in immune response ISO
Inferred from Sequence Orthology
more info
 
positive regulation of endocytosis IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of endothelial cell migration ISO
Inferred from Sequence Orthology
more info
 
positive regulation of endothelial cell proliferation ISO
Inferred from Sequence Orthology
more info
 
positive regulation of epithelial cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of fibroblast proliferation ISO
Inferred from Sequence Orthology
more info
 
positive regulation of inflammatory response ISO
Inferred from Sequence Orthology
more info
 
positive regulation of interferon-gamma production IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of interleukin-1 beta secretion IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of interleukin-1 beta secretion ISO
Inferred from Sequence Orthology
more info
 
positive regulation of interleukin-6 production IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of interleukin-6 production ISO
Inferred from Sequence Orthology
more info
 
positive regulation of interleukin-8 secretion IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of macrophage activation ISO
Inferred from Sequence Orthology
more info
 
positive regulation of macrophage cytokine production ISO
Inferred from Sequence Orthology
more info
 
positive regulation of meiotic nuclear division IGI
Inferred from Genetic Interaction
more info
PubMed 
positive regulation of mesenchymal cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of neuron projection development IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of non-canonical Wnt signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of ossification ISO
Inferred from Sequence Orthology
more info
 
positive regulation of peptidyl-serine phosphorylation IGI
Inferred from Genetic Interaction
more info
PubMed 
positive regulation of peptidyl-threonine phosphorylation IGI
Inferred from Genetic Interaction
more info
PubMed 
positive regulation of protein binding IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of protein catabolic process ISO
Inferred from Sequence Orthology
more info
 
positive regulation of protein kinase C activity ISO
Inferred from Sequence Orthology
more info
 
positive regulation of protein kinase C signaling ISO
Inferred from Sequence Orthology
more info
 
positive regulation of protein kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of protein phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of response to cytokine stimulus ISO
Inferred from Sequence Orthology
more info
 
positive regulation of thymocyte apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of transcription from RNA polymerase II promoter ISO
Inferred from Sequence Orthology
more info
 
positive regulation of transcription, DNA-templated IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of transcription, DNA-templated ISO
Inferred from Sequence Orthology
more info
 
positive regulation of type I interferon-mediated signaling pathway ISO
Inferred from Sequence Orthology
more info
 
post-anal tail morphogenesis IGI
Inferred from Genetic Interaction
more info
PubMed 
post-anal tail morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
primitive streak formation IGI
Inferred from Genetic Interaction
more info
PubMed 
protein phosphorylation IGI
Inferred from Genetic Interaction
more info
PubMed 
regulation of branching involved in mammary gland duct morphogenesis IDA
Inferred from Direct Assay
more info
PubMed 
regulation of branching involved in mammary gland duct morphogenesis IGI
Inferred from Genetic Interaction
more info
PubMed 
regulation of cellular protein localization IDA
Inferred from Direct Assay
more info
PubMed 
regulation of protein localization IDA
Inferred from Direct Assay
more info
PubMed 
signal transduction TAS
Traceable Author Statement
more info
PubMed 
somite development IGI
Inferred from Genetic Interaction
more info
PubMed 
somitogenesis IGI
Inferred from Genetic Interaction
more info
PubMed 
tube closure IMP
Inferred from Mutant Phenotype
more info
PubMed 
type B pancreatic cell development IMP
Inferred from Mutant Phenotype
more info
PubMed 
urinary bladder development IMP
Inferred from Mutant Phenotype
more info
PubMed 
uterus development IMP
Inferred from Mutant Phenotype
more info
PubMed 
vagina development IMP
Inferred from Mutant Phenotype
more info
PubMed 
wound healing ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
cell surface IDA
Inferred from Direct Assay
more info
PubMed 
cytoplasm ISO
Inferred from Sequence Orthology
more info
 
extracellular region IEA
Inferred from Electronic Annotation
more info
 
extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
 
extracellular space ISO
Inferred from Sequence Orthology
more info
 
proteinaceous extracellular matrix IDA
Inferred from Direct Assay
more info
PubMed 
Preferred Names
protein Wnt-5a
Names
wingless-related MMTV integration site 5A

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001256224.1NP_001243153.1  protein Wnt-5a isoform 2 precursor

    See identical proteins and their annotated locations for NP_001243153.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) has multiple differences, compared to variant 1. These differences result in a distinct 5' UTR and cause translation initiation at a downstream start codon, compared to variant 1. The encoded protein (isoform 2) has a shorter N-terminus, compared to isoform 1.
    Source sequence(s)
    AK036824, CT025649
    Consensus CDS
    CCDS56946.1
    UniProtKB/Swiss-Prot
    P22725
    Related
    ENSMUSP00000107891, OTTMUSP00000023051, ENSMUST00000112272, OTTMUST00000049666
    Conserved Domains (1) summary
    smart00097
    Location:51360
    WNT1; found in Wnt-1
  2. NM_009524.3NP_033550.2  protein Wnt-5a isoform 1 precursor

    See identical proteins and their annotated locations for NP_033550.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    BC018425, BY721304, CT025649
    Consensus CDS
    CCDS26888.1
    UniProtKB/Swiss-Prot
    P22725
    Related
    ENSMUSP00000064878, OTTMUSP00000023050, ENSMUST00000063465, OTTMUST00000049665
    Conserved Domains (1) summary
    smart00097
    Location:71380
    WNT1; found in Wnt-1

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 105 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p3 C57BL/6J

Genomic

  1. NC_000080.6 Reference GRCm38.p3 C57BL/6J

    Range
    28505473..28527448
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006518925.2XP_006518988.1  

    See identical proteins and their annotated locations for XP_006518988.1

    UniProtKB/Swiss-Prot
    P22725
    Conserved Domains (1) summary
    smart00097
    Location:51360
    WNT1; found in Wnt-1
  2. XM_006518924.2XP_006518987.1  

    See identical proteins and their annotated locations for XP_006518987.1

    UniProtKB/Swiss-Prot
    P22725
    Conserved Domains (1) summary
    smart00097
    Location:51360
    WNT1; found in Wnt-1
  3. XM_006518926.2XP_006518989.1  

    See identical proteins and their annotated locations for XP_006518989.1

    Conserved Domains (1) summary
    smart00097
    Location:82391
    WNT1; found in Wnt-1
  4. XM_006518923.2XP_006518986.1  

    Conserved Domains (1) summary
    smart00097
    Location:84393
    WNT1; found in Wnt-1

Alternate Mm_Celera

Genomic

  1. AC_000036.1 Alternate Mm_Celera

    Range
    24754276..24774261
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)