FER fer (fps/fes related) tyrosine kinase [Homo sapiens] - Gene

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Summary

Official Symbol: FERprovided by HGNC
Official Full Name: fer (fps/fes related) tyrosine kinaseprovided by HGNC
Primary source: HGNC:3655
See related: Ensembl:ENSG00000151422; HPRD:01491; MIM:176942; Vega:OTTHUMG00000128751
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: TYK3; PPP1R74
Summary: Fer protein is a member of the FPS/FES family of nontransmembrane receptor tyrosine kinases. It regulates cell-cell adhesion and mediates signaling from the cell surface to the cytoskeleton via growth factor receptors. [provided by RefSeq, Jul 2008]

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Genomic context

Location :: 5q21

Sequence :: Chromosome: 5; NC_000005.9 (108083523..108523373)

See FER in Epigenomics, MapViewer

Chromosome 5 - NC_000005.9 Genomic Context describing neighboring genes

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Genomic regions, transcripts, and products

Genomic Sequence

Go to nucleotideGraphics FASTA GenBank

Go to reference sequence details

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Bibliography

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The A allele of SNP rs10447248 in the FER locus was nominally associated with lower MMW (P = 0.016) but was not associated with LMW (P > 0.05) adiponectin levels
Title: Novel locus FER is associated with serum HMW adiponectin levels.
Overexpression of FER from a cDNA confers quinacrine resistance to several different types of cancer cell lines.
Title: FER tyrosine kinase (FER) overexpression mediates resistance to quinacrine through EGF-dependent activation of NF-kappaB.
tyrosine phosphorylation of RhoGDIalpha by Fer as a mechanism to regulate binding of RhoGDIalpha to Rac
Title: The Fer tyrosine kinase regulates interactions of Rho GDP-Dissociation Inhibitor α with the small GTPase Rac.
Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
Title: Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study.
Observational study of gene-disease association. (HuGE Navigator)
Title: Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.
FER plays a role in the invasion and metastasis of hepatocellular carcinoma cells.
Title: Identification of tyrosine-phosphorylated proteins associated with metastasis and functional analysis of FER in human hepatocellular carcinoma cells.
FerT coexist in the acroplaxome with phosphorylated cortactin, a regulator of F-actin dynamics[Fer testis ]
Title: Expression of Fer testis (FerT) tyrosine kinase transcript variants and distribution sites of FerT during the development of the acrosome-acroplaxome-manchette complex in rat spermatids.
Overexpression of Fer enhanced lamellipodia formation and cell migration in a manner dependent on PLD activity and the PA-FX interaction.
Title: The tyrosine kinase Fer is a downstream target of the PLD-PA pathway that regulates cell migration.
Results suggest that Fer may allow a bypass of focal adhesion kinase-related cell anchorage dependency for intracellular signal transduction in hepatocytes.
Title: Specific tyrosine phosphorylation of focal adhesion kinase mediated by Fer tyrosine kinase in suspended hepatocytes.
Fer tyrosine kinase level correlates with the development of prostate cancer and aggressiveness of prostate cancer cell lines
Title: The Fer tyrosine kinase cooperates with interleukin-6 to activate signal transducer and activator of transcription 3 and promote human prostate cancer cell growth.

Submit: New GeneRIF Correction See all (13)

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Phenotypes

Review eQTL and phenotype association data in this region using PheGenI

Novel Locus FER Is Associated With Serum HMW Adiponectin Levels.

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Products	Interactant	Other Gene	Source	Pubs	Description
P16591	Calmodulin 1	CALM1	HPRD	PubMed
P16591	P35222	CTNNB1	HPRD	PubMed
P16591	O60716	CTNND1	HPRD	PubMed
P16591	Q14247	CTTN	HPRD	PubMed
P16591	P00533	EGFR	HPRD	PubMed
P16591	P16591	FER	HPRD	PubMed
P16591	P16591	FER	HPRD	PubMed
P16591	P35568	IRS1	HPRD	PubMed
P16591	P23458	JAK1	HPRD	PubMed
P16591	P14923	JUP	HPRD	PubMed
P16591	P40763	STAT3	HPRD	PubMed
P16591	P82094	TMF1	HPRD	PubMed
P16591	P31946	YWHAB	HPRD	PubMed
BioGRID:108532	BioGRID:107434	CDH1	BioGRID	PubMed	Reconstituted Complex
BioGRID:108532	BioGRID:107880	CTNNB1	BioGRID	PubMed	Biochemical Activity
BioGRID:108532	BioGRID:108332	CTTN	BioGRID	PubMed	Affinity Capture-Western; Biochemical Activity; Co-fractionation
BioGRID:108532	BioGRID:108099	DNM1	BioGRID	PubMed	Co-fractionation
BioGRID:108532	BioGRID:108122	DNM2	BioGRID	PubMed	Co-fractionation
BioGRID:108532	BioGRID:117515	DNM3	BioGRID	PubMed	Co-fractionation
BioGRID:108532	BioGRID:108276	EGFR	BioGRID	PubMed	Affinity Capture-Western
BioGRID:108532	BioGRID:108532	FER	BioGRID	PubMed	Biochemical Activity
BioGRID:108532	BioGRID:112965	TMF1	BioGRID	PubMed	Biochemical Activity; Two-hybrid

Function	Evidence Code	Pubs
ATP binding	IEA Inferred from Electronic Annotation more info
Rab GTPase binding	IEA Inferred from Electronic Annotation more info
actin binding	IEA Inferred from Electronic Annotation more info
cadherin binding	IEA Inferred from Electronic Annotation more info
epidermal growth factor receptor binding	IDA Inferred from Direct Assay more info
gamma-catenin binding	IEA Inferred from Electronic Annotation more info
lipid binding	IDA Inferred from Direct Assay more info	PubMed
non-membrane spanning protein tyrosine kinase activity	IDA Inferred from Direct Assay more info	PubMed
nucleotide binding	IEA Inferred from Electronic Annotation more info
protein kinase binding	IEA Inferred from Electronic Annotation more info
protein tyrosine kinase activity	TAS Traceable Author Statement more info	PubMed

Process	Evidence Code	Pubs
cell adhesion	IEA Inferred from Electronic Annotation more info
chemotaxis	IEA Inferred from Electronic Annotation more info
intracellular signal transduction	TAS Traceable Author Statement more info	PubMed
microtubule cytoskeleton organization	IMP Inferred from Mutant Phenotype more info	PubMed
negative regulation of mast cell activation involved in immune response	ISS Inferred from Sequence or Structural Similarity more info
peptidyl-tyrosine phosphorylation	IDA Inferred from Direct Assay more info	PubMed
platelet-derived growth factor receptor signaling pathway	TAS Traceable Author Statement more info	PubMed
positive regulation of NF-kappaB transcription factor activity	IMP Inferred from Mutant Phenotype more info
positive regulation of actin filament polymerization	IMP Inferred from Mutant Phenotype more info	PubMed
positive regulation of cell migration	IMP Inferred from Mutant Phenotype more info	PubMed
positive regulation of cell proliferation	TAS Traceable Author Statement more info
protein autophosphorylation	IDA Inferred from Direct Assay more info	PubMed
protein phosphorylation	TAS Traceable Author Statement more info	PubMed
regulation of epidermal growth factor receptor signaling pathway	IMP Inferred from Mutant Phenotype more info
regulation of lamellipodium assembly	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
colocalizes_with actin cytoskeleton	IDA Inferred from Direct Assay more info	PubMed
cell cortex	IEA Inferred from Electronic Annotation more info
colocalizes_with cell junction	IDA Inferred from Direct Assay more info	PubMed
cytoplasm	IDA Inferred from Direct Assay more info	PubMed
cytosol	TAS Traceable Author Statement more info
extrinsic to internal side of plasma membrane	IDA Inferred from Direct Assay more info	PubMed
colocalizes_with lamellipodium	IDA Inferred from Direct Assay more info	PubMed
colocalizes_with microtubule cytoskeleton	IDA Inferred from Direct Assay more info	PubMed
colocalizes_with nuclear chromatin	IDA Inferred from Direct Assay more info	PubMed
nucleus	IEA Inferred from Electronic Annotation more info
plasma membrane	IEA Inferred from Electronic Annotation more info

General protein information

Preferred Names: tyrosine-protein kinase Fer

Names: tyrosine-protein kinase Fer; p94-Fer; tyrosine kinase 3; phosphoprotein NCP94; proto-oncogene c-Fer; feline encephalitis virus-related kinase FER; protein phosphatase 1, regulatory subunit 74; fujinami poultry sarcoma/Feline sarcoma-related protein Fer

NP_005237.2

EC 2.7.10.2

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NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

NG_011445.1 RefSeqGene

Range

5001..444851

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_005246.2 → NP_005237.2 tyrosine-protein kinase Fer

Status: REVIEWED

Source sequence(s)

BC017060, J03358

Consensus CDS

CCDS4098.1

UniProtKB/Swiss-Prot

P16591

UniProtKB/TrEMBL

Q05DA5

Related

ENSP00000281092, OTTHUMP00000158945, ENST00000281092, OTTHUMT00000250664

Conserved Domains (4) summary

cd05085
Location:567 – 816
Blast Score: 1330

PTKc_Fer; Catalytic domain of the Protein Tyrosine Kinase, Fer

cd07686
Location:5 – 238
Blast Score: 1081

F-BAR_Fer; The F-BAR (FES-CIP4 Homology and Bin/Amphiphysin/Rvs) domain of Fer (Fes related) tyrosine kinase

cd10361
Location:453 – 538
Blast Score: 299

SH2_Fps_family; Src homology 2 (SH2) domain found in feline sarcoma, Fujinami poultry sarcoma, and fes-related (Fes/Fps/Fer) proteins

pfam07714
Location:563 – 814
Blast Score: 1053

Pkinase_Tyr; Protein tyrosine kinase

RefSeqs of Annotated Genomes: Build 37.3

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh37.p5 Primary Assembly

Genomic

NC_000005.9 Reference GRCh37.p5 Primary Assembly

Range

108083523..108523373

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Alternate HuRef

Genomic

AC_000137.1 Alternate HuRef

Range

103255853..103696708

Download

GenBank, FASTA, Sequence Viewer (Graphics)

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Related Sequences

Nucleotide		Protein
Heading	Accession and Version	Protein
genomic	AC008871.5 (102019..174137)	None
genomic	AC008955.6 (8301..104069)	None
genomic	AC010228.8	None
genomic	AC011421.2 (52150..87186)	None
genomic	AC034207.6	None
genomic	AC109481.3	None
genomic	AC116428.1 (3802..86475)	None
genomic	CH471086.2	EAW49054.1
		EAW49055.1
		EAW49056.1
mRNA	AK293376.1	BAG56888.1
mRNA	AK296874.1	BAG59436.1
mRNA	AK299855.1	BAG61714.1
mRNA	AK315234.1	BAG37661.1
mRNA	BC017060.1	AAH17060.1
mRNA	BC058030.1	AAH58030.1
mRNA	J03358.1	AAA61190.1
other-genetic	BC141559.1	AAI41560.1

Protein Accession	Links
Protein Accession	GenePept Link	UniProtKB Link
P16591.2	GenPept	UniProtKB/Swiss-Prot:P16591
Q05DA5	GenPept	UniProtKB/TrEMBL:Q05DA5
Q6PEJ9	GenPept	UniProtKB/TrEMBL:Q6PEJ9