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Wnt1 wingless-type MMTV integration site family, member 1 [ Mus musculus (house mouse) ]

Gene ID: 22408, updated on 24-May-2016
Official Symbol
Wnt1provided by MGI
Official Full Name
wingless-type MMTV integration site family, member 1provided by MGI
Primary source
MGI:MGI:98953
See related
Ensembl:ENSMUSG00000022997 Vega:OTTMUSG00000020981
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
sw; Int-1; Wnt-1; swaying
Orthologs
Location:
15 54.65 cM; 15 F1-F3
Exon count:
5
Annotation release Status Assembly Chr Location
105 current GRCm38.p3 (GCF_000001635.23) 15 NC_000081.6 (98788074..98793837)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 15 NC_000081.5 (98620288..98624261)

Chromosome 15 - NC_000081.6Genomic Context describing neighboring genes Neighboring gene ADP-ribosylation factor 3 Neighboring gene wingless-type MMTV integration site family, member 10B Neighboring gene dendrin Neighboring gene protein kinase, AMP-activated, gamma 1 non-catalytic subunit

Related articles in PubMed

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
cytokine activity IDA
Inferred from Direct Assay
more info
PubMed 
frizzled binding IBA
Inferred from Biological aspect of Ancestor
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein domain specific binding IPI
Inferred from Physical Interaction
more info
PubMed 
receptor agonist activity IDA
Inferred from Direct Assay
more info
PubMed 
receptor binding TAS
Traceable Author Statement
more info
PubMed 
transcription regulatory region DNA binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
BMP signaling pathway ISO
Inferred from Sequence Orthology
more info
PubMed 
Spemann organizer formation IMP
Inferred from Mutant Phenotype
more info
PubMed 
T cell differentiation in thymus IDA
Inferred from Direct Assay
more info
PubMed 
Wnt signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
Wnt signaling pathway ISO
Inferred from Sequence Orthology
more info
 
bone development ISO
Inferred from Sequence Orthology
more info
 
branching involved in ureteric bud morphogenesis IGI
Inferred from Genetic Interaction
more info
PubMed 
canonical Wnt signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
canonical Wnt signaling pathway IGI
Inferred from Genetic Interaction
more info
PubMed 
canonical Wnt signaling pathway ISO
Inferred from Sequence Orthology
more info
 
canonical Wnt signaling pathway NAS
Non-traceable Author Statement
more info
PubMed 
canonical Wnt signaling pathway involved in midbrain dopaminergic neuron differentiation IDA
Inferred from Direct Assay
more info
PubMed 
canonical Wnt signaling pathway involved in negative regulation of apoptotic process ISO
Inferred from Sequence Orthology
more info
 
cell proliferation in midbrain IDA
Inferred from Direct Assay
more info
PubMed 
cell-cell signaling IDA
Inferred from Direct Assay
more info
PubMed 
cell-cell signaling TAS
Traceable Author Statement
more info
PubMed 
central nervous system morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
cerebellum development IMP
Inferred from Mutant Phenotype
more info
PubMed 
cerebellum formation IMP
Inferred from Mutant Phenotype
more info
PubMed 
diencephalon development IGI
Inferred from Genetic Interaction
more info
PubMed 
dopaminergic neuron differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
dopaminergic neuron differentiation TAS
Traceable Author Statement
more info
PubMed 
embryonic axis specification IMP
Inferred from Mutant Phenotype
more info
PubMed 
embryonic brain development IDA
Inferred from Direct Assay
more info
PubMed 
forebrain anterior/posterior pattern specification IGI
Inferred from Genetic Interaction
more info
PubMed 
hematopoietic stem cell proliferation IDA
Inferred from Direct Assay
more info
PubMed 
hepatocyte differentiation ISO
Inferred from Sequence Orthology
more info
 
inner ear morphogenesis IGI
Inferred from Genetic Interaction
more info
PubMed 
metencephalon development IMP
Inferred from Mutant Phenotype
more info
PubMed 
midbrain development IDA
Inferred from Direct Assay
more info
PubMed 
midbrain development IMP
Inferred from Mutant Phenotype
more info
PubMed 
midbrain dopaminergic neuron differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
midbrain-hindbrain boundary development IMP
Inferred from Mutant Phenotype
more info
PubMed 
midbrain-hindbrain boundary maturation during brain development IMP
Inferred from Mutant Phenotype
more info
PubMed 
multicellular organism development IEA
Inferred from Electronic Annotation
more info
 
myoblast fusion IDA
Inferred from Direct Assay
more info
PubMed 
myoblast fusion IGI
Inferred from Genetic Interaction
more info
PubMed 
myotube differentiation IGI
Inferred from Genetic Interaction
more info
PubMed 
negative regulation of BMP signaling pathway ISO
Inferred from Sequence Orthology
more info
 
negative regulation of cell aging ISO
Inferred from Sequence Orthology
more info
 
negative regulation of cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of cell-cell adhesion ISO
Inferred from Sequence Orthology
more info
 
negative regulation of cell-substrate adhesion ISO
Inferred from Sequence Orthology
more info
 
negative regulation of fat cell differentiation IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of fat cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of transforming growth factor beta receptor signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
neurogenesis IDA
Inferred from Direct Assay
more info
PubMed 
neuron fate commitment IMP
Inferred from Mutant Phenotype
more info
PubMed 
neuron fate determination IMP
Inferred from Mutant Phenotype
more info
PubMed 
organ morphogenesis TAS
Traceable Author Statement
more info
PubMed 
organ regeneration ISO
Inferred from Sequence Orthology
more info
 
positive regulation of Notch signaling pathway ISO
Inferred from Sequence Orthology
more info
 
positive regulation of canonical Wnt signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of cell proliferation IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of cell proliferation ISO
Inferred from Sequence Orthology
more info
 
positive regulation of dermatome development ISO
Inferred from Sequence Orthology
more info
 
positive regulation of fibroblast proliferation ISO
Inferred from Sequence Orthology
more info
 
positive regulation of insulin-like growth factor receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
positive regulation of lamellipodium assembly ISO
Inferred from Sequence Orthology
more info
 
positive regulation of protein phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of sequence-specific DNA binding transcription factor activity IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of transcription from RNA polymerase II promoter IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of transcription from RNA polymerase II promoter IGI
Inferred from Genetic Interaction
more info
PubMed 
positive regulation of transcription from RNA polymerase II promoter NAS
Non-traceable Author Statement
more info
PubMed 
positive regulation of transcription, DNA-templated IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of transcription, DNA-templated ISO
Inferred from Sequence Orthology
more info
 
signal transduction TAS
Traceable Author Statement
more info
PubMed 
signal transduction in response to DNA damage ISO
Inferred from Sequence Orthology
more info
 
spinal cord association neuron differentiation IGI
Inferred from Genetic Interaction
more info
PubMed 
ubiquitin-dependent SMAD protein catabolic process IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
Wnt signalosome IC
Inferred by Curator
more info
PubMed 
cell surface IDA
Inferred from Direct Assay
more info
PubMed 
cytoplasm ISO
Inferred from Sequence Orthology
more info
 
extracellular region IDA
Inferred from Direct Assay
more info
PubMed 
extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
 
proteinaceous extracellular matrix IEA
Inferred from Electronic Annotation
more info
 
Preferred Names
proto-oncogene Wnt-1
Names
proto-oncogene Int-1
proto-oncogene protein Wnt-1
wingless-related MMTV integration site 1

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_021279.4NP_067254.1  proto-oncogene Wnt-1 precursor

    See identical proteins and their annotated locations for NP_067254.1

    Status: VALIDATED

    Source sequence(s)
    AC156543, AK141669
    Consensus CDS
    CCDS27807.1
    UniProtKB/Swiss-Prot
    P04426
    UniProtKB/TrEMBL
    Q3UR96
    Related
    ENSMUSP00000023734, OTTMUSP00000023019, ENSMUST00000023734, OTTMUST00000049616
    Conserved Domains (1) summary
    smart00097
    Location:60370
    WNT1; found in Wnt-1

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 105 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p3 C57BL/6J

Genomic

  1. NC_000081.6 Reference GRCm38.p3 C57BL/6J

    Range
    98788074..98793837
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006520890.2XP_006520953.1  

    See identical proteins and their annotated locations for XP_006520953.1

    UniProtKB/Swiss-Prot
    P04426
    UniProtKB/TrEMBL
    Q3UR96
    Conserved Domains (1) summary
    smart00097
    Location:60370
    WNT1; found in Wnt-1

Alternate Mm_Celera

Genomic

  1. AC_000037.1 Alternate Mm_Celera

    Range
    100939306..100943279
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)