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    Wbp2 WW domain binding protein 2 [ Mus musculus ]

    Gene ID: 22378, updated on 11-May-2012
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    Summary

    Official Symbol
    Wbp2provided by MGI
    Official Full Name
    WW domain binding protein 2provided by MGI
    Primary source
    MGI:104709
    Locus tag
    RP23-42F6.6
    See related
    Ensembl:ENSMUSG00000034341; Vega:OTTMUSG00000003690
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
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    Genomic context

    Location :
    11 E2; 11
    Sequence :
    Chromosome: 11; NC_000077.6 (116078573..116086964, complement)
    See Wbp2 in Epigenomics, MapViewer

    Chromosome 11 - NC_000077.6Genomic Context describing neighboring genes Neighboring gene unkempt homolog (Drosophila) Neighboring gene unc-13 homolog D (C. elegans) Neighboring gene tripartite motif-containing 47 Neighboring gene tripartite motif-containing 65

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    Genomic regions, transcripts, and products

    Go to nucleotideGraphics FASTA GenBank

    Go to reference sequence details
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    Bibliography

    Related articles in PubMed

    1. A conditional knockout resource for the genome-wide study of mouse gene function. Skarnes WC, et al. Nature, 2011 Jun 15. PMID 21677750.
    2. Tyrosine phosphorylation of transcriptional coactivator WW-domain binding protein 2 regulates estrogen receptor α function in breast cancer via the Wnt pathway. Lim SK, et al. FASEB J, 2011 Sep. PMID 21642474.
    3. Large-scale gene trapping in C57BL/6N mouse embryonic stem cells. Hansen GM, et al. Genome Res, 2008 Oct. PMID 18799693.
    4. Antisense transcription in the mammalian transcriptome. Katayama S, et al. Science, 2005 Sep 2. PMID 16141073.
    5. The transcriptional landscape of the mammalian genome. Carninci P, et al. Science, 2005 Sep 2. PMID 16141072.

    See all (18) citations in PubMed

    GeneRIFs: Gene References Into Functions What's a GeneRIF?

    1. This study established WBP2 as a tyrosine phosphorylation target of estrogen signaling via EGFR crosstalk.
      Title: Tyrosine phosphorylation of transcriptional coactivator WW-domain binding protein 2 regulates estrogen receptor α function in breast cancer via the Wnt pathway.
    Submit: New GeneRIF Correction
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    Interactions

    Products Interactant Other Gene Complex Source Pubs Description
    NP_058548.1 P46935 Nedd4    BIND  PubMed WBP-2 PY motifs interact with Nedd4 WW domains. 
    BioGRID:204546 BioGRID:115684 YAP1    BioGRID  PubMed Protein-peptide 
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    General gene information

    Genotypes

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    biological_process ND
    No biological Data available
    more info
    		  
    Component Evidence Code Pubs
    cellular_component ND
    No biological Data available
    more info
    		  
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    General protein information

    Preferred Names
    WW domain-binding protein 2
    Names
    WW domain-binding protein 2
    WBP-2
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    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_016852.2 → NP_058548.1  WW domain-binding protein 2

      Status: PROVISIONAL

      Source sequence(s)
      AL607108
      Consensus CDS
      CCDS25657.1
      UniProtKB/Swiss-Prot
      P97765
      UniProtKB/TrEMBL
      Q544A1
      Related
      ENSMUSP00000074204, OTTMUSP00000003889, ENSMUST00000074628, OTTMUST00000008000
      Conserved Domains (2) summary
      pfam10349
      Location:110 – 158
      Blast Score: 138
      WWbp; WW-domain ligand protein
      cl02671
      Location:15 – 84
      Blast Score: 108
      GRAM; GRAM domain

    RefSeqs of Annotated Genomes: Build 38.1

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38 C57BL/6J

    Genomic

    1. NC_000077.6 Reference GRCm38 C57BL/6J

      Range
      116078573..116086964, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate Mm_Celera

    Genomic

    1. AC_000033.1 Alternate Mm_Celera

      Range
      127840831..127849220, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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    Related Sequences

    Nucleotide Protein Strain
    Heading Accession and Version
    genomic AL607108.17 CAM24046.1
      CAM24047.1
    genomic CH466558.1 EDL34550.1 mixed
      EDL34551.1 mixed
      EDL34552.1 mixed
    mRNA AK004824.1 BAB23594.1 C57BL/6J
    mRNA AK043037.1 BAC31444.1 C57BL/6J
    mRNA AK079300.1 None C57BL/6J
    mRNA AK146572.1 BAE27268.1 C57BL/6J
    mRNA AK150018.1 BAE29243.1 C57BL/6J
    mRNA AK151368.1 BAE30342.1 C57BL/6J
    mRNA AK162810.1 BAE37064.1 C57BL/6J
    mRNA AK170317.1 BAE41712.1 NOD
    mRNA AK170474.1 BAE41819.1 NOD
    mRNA AK208273.1 None
    mRNA AK212316.1 None
    mRNA BC031908.1 AAH31908.1
    mRNA BC055058.1 AAH55058.1 FVB/N
    mRNA U40826.1 AAB40893.1
    Protein Accession Links
    GenPept Link UniProtKB Link
    P97765.1 GenPept UniProtKB/Swiss-Prot:P97765
    Q3TRG5 GenPept UniProtKB/TrEMBL:Q3TRG5
    Q544A1 GenPept UniProtKB/TrEMBL:Q544A1
    Q9DBP6 GenPept UniProtKB/TrEMBL:Q9DBP6
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    Additional Links

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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