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Vil1 villin 1 [ Mus musculus (house mouse) ]

Gene ID: 22349, updated on 28-May-2016
Official Symbol
Vil1provided by MGI
Official Full Name
villin 1provided by MGI
Primary source
MGI:MGI:98930
See related
Ensembl:ENSMUSG00000026175 Vega:OTTMUSG00000021741
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Vil
Orthologs
Location:
1 38.54 cM; 1 C5
Exon count:
21
Annotation release Status Assembly Chr Location
105 current GRCm38.p3 (GCF_000001635.23) 1 NC_000067.6 (74409191..74435560)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 1 NC_000067.5 (74455958..74482134)

Chromosome 1 - NC_000067.6Genomic Context describing neighboring genes Neighboring gene solute carrier family 11 (proton-coupled divalent metal ion transporters), member 1 Neighboring gene CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase 1 Neighboring gene microRNA 26b Neighboring gene ubiquitin specific peptidase 37 Neighboring gene RCD1 required for cell differentiation 1 homolog Neighboring gene phospholipase C, delta 4 Neighboring gene zinc finger protein 142

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Markers

Homology

Clone Names

  • MGC143974

Gene Ontology Provided by MGI

Function Evidence Code Pubs
actin binding IEA
Inferred from Electronic Annotation
more info
 
actin filament binding ISO
Inferred from Sequence Orthology
more info
 
calcium ion binding ISO
Inferred from Sequence Orthology
more info
 
cysteine-type endopeptidase inhibitor activity involved in apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
identical protein binding ISO
Inferred from Sequence Orthology
more info
 
lysophosphatidic acid binding ISO
Inferred from Sequence Orthology
more info
 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
phosphatidylinositol-4,5-bisphosphate binding ISO
Inferred from Sequence Orthology
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein homodimerization activity ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
actin filament capping ISO
Inferred from Sequence Orthology
more info
 
actin filament depolymerization ISO
Inferred from Sequence Orthology
more info
 
actin filament polymerization ISO
Inferred from Sequence Orthology
more info
 
actin filament severing ISO
Inferred from Sequence Orthology
more info
 
actin nucleation IEA
Inferred from Electronic Annotation
more info
 
apoptotic process IEA
Inferred from Electronic Annotation
more info
 
barbed-end actin filament capping ISO
Inferred from Sequence Orthology
more info
 
cellular response to epidermal growth factor stimulus ISO
Inferred from Sequence Orthology
more info
 
cellular response to hepatocyte growth factor stimulus IDA
Inferred from Direct Assay
more info
PubMed 
cytoplasmic actin-based contraction involved in cell motility ISO
Inferred from Sequence Orthology
more info
 
cytoskeleton organization IEA
Inferred from Electronic Annotation
more info
 
epidermal growth factor receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
intestinal D-glucose absorption IGI
Inferred from Genetic Interaction
more info
PubMed 
NOT microvillus assembly IGI
Inferred from Genetic Interaction
more info
PubMed 
positive regulation of actin filament bundle assembly ISO
Inferred from Sequence Orthology
more info
 
positive regulation of actin filament depolymerization ISO
Inferred from Sequence Orthology
more info
 
positive regulation of cell migration ISO
Inferred from Sequence Orthology
more info
 
positive regulation of epithelial cell migration ISO
Inferred from Sequence Orthology
more info
 
positive regulation of establishment of protein localization to plasma membrane IGI
Inferred from Genetic Interaction
more info
PubMed 
positive regulation of lamellipodium morphogenesis ISO
Inferred from Sequence Orthology
more info
 
positive regulation of multicellular organism growth IGI
Inferred from Genetic Interaction
more info
PubMed 
regulation of actin nucleation ISO
Inferred from Sequence Orthology
more info
 
regulation of cell shape ISO
Inferred from Sequence Orthology
more info
 
regulation of lamellipodium morphogenesis IDA
Inferred from Direct Assay
more info
PubMed 
regulation of microvillus length IGI
Inferred from Genetic Interaction
more info
PubMed 
regulation of wound healing IDA
Inferred from Direct Assay
more info
PubMed 
response to bacterium ISO
Inferred from Sequence Orthology
more info
 
terminal web assembly IGI
Inferred from Genetic Interaction
more info
PubMed 
Component Evidence Code Pubs
actin filament bundle ISO
Inferred from Sequence Orthology
more info
 
brush border IDA
Inferred from Direct Assay
more info
PubMed 
brush border TAS
Traceable Author Statement
more info
PubMed 
cell projection IEA
Inferred from Electronic Annotation
more info
 
cytoplasm IEA
Inferred from Electronic Annotation
more info
 
cytoskeleton IEA
Inferred from Electronic Annotation
more info
 
extracellular exosome ISO
Inferred from Sequence Orthology
more info
 
filopodium IDA
Inferred from Direct Assay
more info
PubMed 
filopodium ISO
Inferred from Sequence Orthology
more info
 
filopodium tip IDA
Inferred from Direct Assay
more info
PubMed 
lamellipodium IDA
Inferred from Direct Assay
more info
PubMed 
lamellipodium ISO
Inferred from Sequence Orthology
more info
 
microvillus IDA
Inferred from Direct Assay
more info
PubMed 
microvillus ISO
Inferred from Sequence Orthology
more info
 
nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
plasma membrane ISO
Inferred from Sequence Orthology
more info
 
ruffle ISO
Inferred from Sequence Orthology
more info
 

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_009509.2NP_033535.2  villin-1

    See identical proteins and their annotated locations for NP_033535.2

    Status: VALIDATED

    Source sequence(s)
    AI663456, AK027908, BB871941, BY426484
    Consensus CDS
    CCDS15049.1
    UniProtKB/Swiss-Prot
    Q62468
    UniProtKB/TrEMBL
    Q8CEJ4
    Related
    ENSMUSP00000027366, OTTMUSP00000024309, ENSMUST00000027366, OTTMUST00000051580
    Conserved Domains (7) summary
    smart00153
    Location:792827
    VHP; Villin headpiece domain
    cd11288
    Location:513603
    gelsolin_S5_like; Gelsolin sub-domain 5-like domain found in gelsolin, severin, villin, and related proteins
    cd11289
    Location:136225
    gelsolin_S2_like; Gelsolin sub-domain 2-like domain found in gelsolin, severin, villin, and related proteins
    cd11290
    Location:17121
    gelsolin_S1_like; Gelsolin sub-domain 1-like domain found in gelsolin, severin, villin, and related proteins
    cd11291
    Location:619715
    gelsolin_S6_like; Gelsolin sub-domain 6-like domain found in gelsolin, severin, villin, and related proteins
    cd11292
    Location:250348
    gelsolin_S3_like; Gelsolin sub-domain 3-like domain found in gelsolin, severin, villin, and related proteins
    cd11293
    Location:392492
    gelsolin_S4_like; Gelsolin sub-domain 4-like domain found in gelsolin, severin, villin, and related proteins

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 105 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p3 C57BL/6J

Genomic

  1. NC_000067.6 Reference GRCm38.p3 C57BL/6J

    Range
    74409191..74435560
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011238478.1XP_011236780.1  

    Conserved Domains (7) summary
    smart00153
    Location:863898
    VHP; Villin headpiece domain
    cd11288
    Location:584674
    gelsolin_S5_like; Gelsolin sub-domain 5-like domain found in gelsolin, severin, villin, and related proteins
    cd11289
    Location:207296
    gelsolin_S2_like; Gelsolin sub-domain 2-like domain found in gelsolin, severin, villin, and related proteins
    cd11290
    Location:88192
    gelsolin_S1_like; Gelsolin sub-domain 1-like domain found in gelsolin, severin, villin, and related proteins
    cd11291
    Location:690786
    gelsolin_S6_like; Gelsolin sub-domain 6-like domain found in gelsolin, severin, villin, and related proteins
    cd11292
    Location:321419
    gelsolin_S3_like; Gelsolin sub-domain 3-like domain found in gelsolin, severin, villin, and related proteins
    cd11293
    Location:463563
    gelsolin_S4_like; Gelsolin sub-domain 4-like domain found in gelsolin, severin, villin, and related proteins

Alternate Mm_Celera

Genomic

  1. AC_000023.1 Alternate Mm_Celera

    Range
    74966841..74993216
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)