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Vegfb vascular endothelial growth factor B [ Mus musculus (house mouse) ]

Gene ID: 22340, updated on 8-May-2016
Official Symbol
Vegfbprovided by MGI
Official Full Name
vascular endothelial growth factor Bprovided by MGI
Primary source
MGI:MGI:106199
See related
Ensembl:ENSMUSG00000024962 Vega:OTTMUSG00000033015
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Vrf; VEGF-B
Orthologs
Location:
19; 19 B
Exon count:
7
Annotation release Status Assembly Chr Location
105 current GRCm38.p3 (GCF_000001635.23) 19 NC_000085.6 (6982472..6987651, complement)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 19 NC_000085.5 (7056962..7062141, complement)

Chromosome 19 - NC_000085.6Genomic Context describing neighboring genes Neighboring gene protein phosphatase 1, regulatory (inhibitor) subunit 14B Neighboring gene FK506 binding protein 2 Neighboring gene predicted gene, 41803 Neighboring gene DnaJ heat shock protein family (Hsp40) member C4 Neighboring gene predicted gene, 35838 Neighboring gene nudix (nucleoside diphosphate linked moiety X)-type motif 22

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
chemoattractant activity ISO
Inferred from Sequence Orthology
more info
 
growth factor activity IEA
Inferred from Electronic Annotation
more info
 
heparin binding IEA
Inferred from Electronic Annotation
more info
 
protein heterodimerization activity IPI
Inferred from Physical Interaction
more info
PubMed 
protein homodimerization activity IPI
Inferred from Physical Interaction
more info
PubMed 
vascular endothelial growth factor receptor 1 binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
angiogenesis IEA
Inferred from Electronic Annotation
more info
 
cardiac muscle contraction IMP
Inferred from Mutant Phenotype
more info
PubMed 
cell differentiation IEA
Inferred from Electronic Annotation
more info
 
coronary vasculature development IMP
Inferred from Mutant Phenotype
more info
PubMed 
heart development IMP
Inferred from Mutant Phenotype
more info
PubMed 
induction of positive chemotaxis ISO
Inferred from Sequence Orthology
more info
 
multicellular organism development IEA
Inferred from Electronic Annotation
more info
 
negative regulation of apoptotic process ISO
Inferred from Sequence Orthology
more info
 
negative regulation of gene expression ISO
Inferred from Sequence Orthology
more info
 
negative regulation of neuron apoptotic process ISO
Inferred from Sequence Orthology
more info
 
positive chemotaxis ISO
Inferred from Sequence Orthology
more info
 
positive regulation of ERK1 and ERK2 cascade ISO
Inferred from Sequence Orthology
more info
 
positive regulation of cell division IEA
Inferred from Electronic Annotation
more info
 
positive regulation of endothelial cell proliferation ISO
Inferred from Sequence Orthology
more info
 
positive regulation of mast cell chemotaxis ISO
Inferred from Sequence Orthology
more info
 
positive regulation of peptidyl-tyrosine phosphorylation ISO
Inferred from Sequence Orthology
more info
 
positive regulation of protein kinase B signaling ISO
Inferred from Sequence Orthology
more info
 
positive regulation of vascular endothelial growth factor receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
positive regulation of vascular wound healing ISO
Inferred from Sequence Orthology
more info
 
protein O-linked glycosylation IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
extracellular region IDA
Inferred from Direct Assay
more info
PubMed 
extracellular space ISO
Inferred from Sequence Orthology
more info
 
intracellular IDA
Inferred from Direct Assay
more info
PubMed 
membrane IEA
Inferred from Electronic Annotation
more info
 
Preferred Names
vascular endothelial growth factor B
Names
VEGF-related factor

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001185164.1NP_001172093.1  vascular endothelial growth factor B isoform Vegf-b167 precursor

    See identical proteins and their annotated locations for NP_001172093.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate splice site in the 3' coding region, compared to variant 1. This difference results in a frameshift and an isoform (Vegf-b167) with a shorter and distinct C-terminus, compared to isoform Vegf-b186.
    Source sequence(s)
    AK148188, BC046303, CF804631
    Consensus CDS
    CCDS50373.1
    UniProtKB/Swiss-Prot
    P49766
    Related
    ENSMUSP00000120860, OTTMUSP00000044142, ENSMUST00000130048, OTTMUST00000082367
    Conserved Domains (1) summary
    cd00135
    Location:45127
    PDGF; Platelet-derived and vascular endothelial growth factors (PDGF, VEGF) family domain; PDGF is a potent activator for cells of mesenchymal origin; PDGF-A and PDGF-B form AA and BB homodimers and an AB heterodimer; VEGF is a potent mitogen in embryonic and ...
  2. NM_011697.3NP_035827.1  vascular endothelial growth factor B isoform Vegf-b186 precursor

    See identical proteins and their annotated locations for NP_035827.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (Vegf-b186).
    Source sequence(s)
    AK148188, CF804631, U43836
    Consensus CDS
    CCDS29516.1
    UniProtKB/Swiss-Prot
    P49766
    Related
    ENSMUSP00000025914, OTTMUSP00000044141, ENSMUST00000025914, OTTMUST00000082366
    Conserved Domains (1) summary
    cd00135
    Location:45127
    PDGF; Platelet-derived and vascular endothelial growth factors (PDGF, VEGF) family domain; PDGF is a potent activator for cells of mesenchymal origin; PDGF-A and PDGF-B form AA and BB homodimers and an AB heterodimer; VEGF is a potent mitogen in embryonic and ...

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 105 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p3 C57BL/6J

Genomic

  1. NC_000085.6 Reference GRCm38.p3 C57BL/6J

    Range
    6982472..6987651 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate Mm_Celera

Genomic

  1. AC_000041.1 Alternate Mm_Celera

    Range
    6759390..6764564 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)