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Vav2 vav 2 oncogene [ Mus musculus (house mouse) ]

Gene ID: 22325, updated on 21-May-2016
Official Symbol
Vav2provided by MGI
Official Full Name
vav 2 oncogeneprovided by MGI
Primary source
MGI:MGI:102718
See related
Ensembl:ENSMUSG00000009621 Vega:OTTMUSG00000012034
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Vav-2; AI847175; 2810040F13Rik
Summary
This gene encodes a member of the Vav family of Rho guanine nucleotide exchange factors. Vav family proteins are involved in the development and activation of lymphocytes, and the encoded protein may also be involved in angiogenesis. Disruption of this gene in mice is associated with heart, artery, and kidney defects, as well as tachycardia and hypertension. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2015]
Orthologs
Location:
2 A3; 2 19.36 cM
Exon count:
30
Annotation release Status Assembly Chr Location
105 current GRCm38.p3 (GCF_000001635.23) 2 NC_000068.7 (27262104..27427608, complement)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 2 NC_000068.6 (27119155..27282345, complement)

Chromosome 2 - NC_000068.7Genomic Context describing neighboring genes Neighboring gene dopamine beta hydroxylase Neighboring gene sarcosine dehydrogenase Neighboring gene predicted gene, 20071 Neighboring gene microRNA 7578 Neighboring gene bromodomain containing 3

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
Rho guanyl-nucleotide exchange factor activity IEA
Inferred from Electronic Annotation
more info
 
epidermal growth factor receptor binding IPI
Inferred from Physical Interaction
more info
PubMed 
guanyl-nucleotide exchange factor activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
guanyl-nucleotide exchange factor activity ISO
Inferred from Sequence Orthology
more info
 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
angiogenesis IEA
Inferred from Electronic Annotation
more info
 
cell migration IGI
Inferred from Genetic Interaction
more info
PubMed 
cell projection assembly IGI
Inferred from Genetic Interaction
more info
PubMed 
intracellular signal transduction IEA
Inferred from Electronic Annotation
more info
 
lamellipodium assembly IGI
Inferred from Genetic Interaction
more info
PubMed 
positive regulation of phosphatidylinositol 3-kinase activity IGI
Inferred from Genetic Interaction
more info
PubMed 
regulation of GTPase activity ISO
Inferred from Sequence Orthology
more info
 
regulation of Rho protein signal transduction IEA
Inferred from Electronic Annotation
more info
 
regulation of blood coagulation ISO
Inferred from Sequence Orthology
more info
 
regulation of gene expression ISO
Inferred from Sequence Orthology
more info
 
small GTPase mediated signal transduction IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
Preferred Names
guanine nucleotide exchange factor VAV2

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_009500.2NP_033526.1  guanine nucleotide exchange factor VAV2

    See identical proteins and their annotated locations for NP_033526.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the functional protein.
    Source sequence(s)
    AI847175, AL772282, BC053060, U37017
    Consensus CDS
    CCDS15827.1
    UniProtKB/Swiss-Prot
    Q60992
    UniProtKB/TrEMBL
    Q7TSI6
    Related
    ENSMUSP00000062782, OTTMUSP00000012940, ENSMUST00000056176, OTTMUST00000028609
    Conserved Domains (7) summary
    cd10406
    Location:657759
    SH2_Vav2; Src homology 2 (SH2) domain found in the Vav2 proteins
    cd11977
    Location:809866
    SH3_VAV2_2; C-terminal (or second) Src homology 3 domain of VAV2 protein
    cd11980
    Location:580639
    SH3_VAV2_1; First Src homology 3 domain of VAV2 protein
    cd00014
    Location:2118
    CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...
    cd00029
    Location:514561
    C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
    cd00160
    Location:194369
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cd01223
    Location:384506
    PH_Vav; Vav pleckstrin homology (PH) domain

RNA

  1. NR_133905.1 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks a 5' exon and contains several additional exons, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AI847175, AL772282, BC053060

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 105 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p3 C57BL/6J

Genomic

  1. NC_000068.7 Reference GRCm38.p3 C57BL/6J

    Range
    27262104..27427608 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006497858.1XP_006497921.1  

    See identical proteins and their annotated locations for XP_006497921.1

    Conserved Domains (7) summary
    cd10406
    Location:657759
    SH2_Vav2; Src homology 2 (SH2) domain found in the Vav2 proteins
    cd11977
    Location:780837
    SH3_VAV2_2; C-terminal (or second) Src homology 3 domain of VAV2 protein
    cd11980
    Location:580639
    SH3_VAV2_1; First Src homology 3 domain of VAV2 protein
    cd00014
    Location:2118
    CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...
    cd00029
    Location:514561
    C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
    cd00160
    Location:194369
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cd01223
    Location:384506
    PH_Vav; Vav pleckstrin homology (PH) domain
  2. XM_006497856.1XP_006497919.1  

    Conserved Domains (7) summary
    cd10406
    Location:662764
    SH2_Vav2; Src homology 2 (SH2) domain found in the Vav2 proteins
    cd11977
    Location:814871
    SH3_VAV2_2; C-terminal (or second) Src homology 3 domain of VAV2 protein
    cd11980
    Location:585644
    SH3_VAV2_1; First Src homology 3 domain of VAV2 protein
    cd00014
    Location:2118
    CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...
    cd00029
    Location:519566
    C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
    cd00160
    Location:194369
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cd01223
    Location:384511
    PH_Vav; Vav pleckstrin homology (PH) domain
  3. XM_006497854.1XP_006497917.1  

    Related
    ENSMUSP00000138964, OTTMUSP00000065545, ENSMUST00000185188, OTTMUST00000028610
    Conserved Domains (7) summary
    cd10406
    Location:667769
    SH2_Vav2; Src homology 2 (SH2) domain found in the Vav2 proteins
    cd11977
    Location:819876
    SH3_VAV2_2; C-terminal (or second) Src homology 3 domain of VAV2 protein
    cd11980
    Location:590649
    SH3_VAV2_1; First Src homology 3 domain of VAV2 protein
    cd00014
    Location:2118
    CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...
    cd00029
    Location:524571
    C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
    cd00160
    Location:199374
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cd01223
    Location:389516
    PH_Vav; Vav pleckstrin homology (PH) domain

Alternate Mm_Celera

Genomic

  1. AC_000024.1 Alternate Mm_Celera

    Range
    26966692..27129427 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)