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    SEMA3D sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3D [ Homo sapiens ]

    Gene ID: 223117, updated on 11-May-2012
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    Summary

    Official Symbol
    SEMA3Dprovided by HGNC
    Official Full Name
    sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3Dprovided by HGNC
    Primary source
    HGNC:10726
    Locus tag
    UNQ760/PRO1491
    See related
    Ensembl:ENSG00000153993; HPRD:15321; MIM:609907; Vega:OTTHUMG00000154569
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    coll-2; Sema-Z2; MGC39708
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    Genomic context

    Location :
    7q21.11
    Sequence :
    Chromosome: 7; NC_000007.13 (84624869..84751247, complement)
    See SEMA3D in Epigenomics, MapViewer

    Chromosome 7 - NC_000007.13Genomic Context describing neighboring genes Neighboring gene high mobility group nucleosomal binding domain 2 pseudogene 11 Neighboring gene heterogeneous nuclear ribonucleoprotein A1 pseudogene 8 Neighboring gene heat shock 70kDa protein 8 pseudogene Neighboring gene dynein, light chain, LC8-type 1 pseudogene Neighboring gene uncharacterized LOC100505913

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    Genomic regions, transcripts, and products

    Go to nucleotideGraphics FASTA GenBank

    Go to reference sequence details
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    Bibliography

    Related articles in PubMed

    1. Possible association of the semaphorin 3D gene (SEMA3D) with schizophrenia. Fujii T, et al. J Psychiatr Res, 2011 Jan. PMID 20684831.
    2. Polymorphisms in genes involved in neurodevelopment may be associated with altered brain morphology in schizophrenia: preliminary evidence. Gregório SP, et al. Psychiatry Res, 2009 Jan 30. PMID 19054571.
    3. Successful inhibition of tumor development by specific class-3 semaphorins is associated with expression of appropriate semaphorin receptors by tumor cells. Kigel B, et al. PLoS One, 2008 Sep 26. PMID 18818766.
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Gerhard DS, et al. Genome Res, 2004 Oct. PMID 15489334.
    5. Semaphorin profiling of periodontal fibroblasts and osteoblasts. Lallier TE. J Dent Res, 2004 Sep. PMID 15329371.

    See all (9) citations in PubMed

    See citations in PubMed for homologs of this gene provided by HomoloGene

    GeneRIFs: Gene References Into Functions What's a GeneRIF?

    1. This study provided strong evidence that SEMA3D confers susceptibility to schizophrenia, which could contribute to the neurodevelopmental impairments in the disorder.
      Title: Possible association of the semaphorin 3D gene (SEMA3D) with schizophrenia.
    2. Observational study of gene-disease association. (HuGE Navigator)
      Title: Possible association of the semaphorin 3D gene (SEMA3D) with schizophrenia.
    3. Sema3D inhibits tumor development from MDA-MB-231 and MDA-MB-435 cancer cells. It inhibits tumor angiogenesis in all of the formed tumors.
      Title: Successful inhibition of tumor development by specific class-3 semaphorins is associated with expression of appropriate semaphorin receptors by tumor cells.
    Submit: New GeneRIF Correction
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    Phenotypes

    Review eQTL and phenotype association data in this region using PheGenI

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    General gene information

    Markers

    Genotypes

    Homology

    Pathways from BioSystems

    • Axon guidance, organism-specific biosystem (from KEGG)
      Axon guidance, organism-specific biosystemAxon guidance represents a key stage in the formation of neuronal network. Axons are guided by a variety of guidance factors, such as netrins, ephrins, Slits, and semaphorins. These guidance cues are...
    • Axon guidance, conserved biosystem (from KEGG)
      Axon guidance, conserved biosystemAxon guidance represents a key stage in the formation of neuronal network. Axons are guided by a variety of guidance factors, such as netrins, ephrins, Slits, and semaphorins. These guidance cues are...

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    cell differentiation IEA
    Inferred from Electronic Annotation
    more info
    		  
    multicellular organismal development IEA
    Inferred from Electronic Annotation
    more info
    		  
    nervous system development IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    extracellular region IEA
    Inferred from Electronic Annotation
    more info
    		  
    membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
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    General protein information

    Preferred Names
    semaphorin-3D
    Names
    semaphorin-3D
    collapsin 2
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    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_152754.2 → NP_689967.2  semaphorin-3D precursor

      Status: VALIDATED

      Source sequence(s)
      AY358937, BC029590, BX648652
      Consensus CDS
      CCDS34676.1
      UniProtKB/Swiss-Prot
      O95025
      Related
      ENSP00000284136, OTTHUMP00000206138, ENST00000284136, OTTHUMT00000336084
      Conserved Domains (4) summary
      cd05871
      Location:596 – 686
      Blast Score: 420
      Ig_Semaphorin_classIII; Immunoglobulin (Ig)-like domain of class III semaphorin
      smart00630
      Location:86 – 507
      Blast Score: 1164
      Sema; semaphorin domain
      cd11252
      Location:61 – 534
      Blast Score: 2555
      Sema_3D; The Sema domain, a protein interacting module, of semaphorin 3D (Sema3D)
      cl02601
      Location:533 – 570
      Blast Score: 121
      PSI; Plexin repeat

    RefSeqs of Annotated Genomes: Build 37.3

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh37.p5 Primary Assembly

    Genomic

    1. NC_000007.13 Reference GRCh37.p5 Primary Assembly

      Range
      84624869..84751247, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate HuRef

    Genomic

    1. AC_000139.1 Alternate HuRef

      Range
      79234320..79360917, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate CRA_TCAGchr7v2

    Genomic

    1. AC_000068.1 Alternate CRA_TCAGchr7v2

      Range
      83956759..84083147, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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    Related Sequences

    Nucleotide Protein
    Heading Accession and Version
    genomic AC004957.1 (32096..158474) None
    genomic CH236949.1 EAL24184.1
    genomic CH471091.2 EAW76974.1
      EAW76975.1
      EAW76976.1
      EAW76977.1
    mRNA AK309116.1 None
    mRNA AY358937.1 AAQ89296.1
    mRNA BC029590.1 AAH29590.1
    mRNA BX648652.1 None
    other-genetic DQ891565.2 ABM82491.1
    other-genetic DQ894753.2 ABM85679.1
    Protein Accession Links
    GenPept Link UniProtKB Link
    O95025.2 GenPept UniProtKB/Swiss-Prot:O95025
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    Additional Links

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Molecular Biology Databases
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      Supplemental Content

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