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    FOXK1 forkhead box K1 [ Homo sapiens ]

    Gene ID: 221937, updated on 11-May-2012
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    Summary

    Official Symbol
    FOXK1provided by HGNC
    Official Full Name
    forkhead box K1provided by HGNC
    Primary source
    HGNC:23480
    See related
    Ensembl:ENSG00000164916; HPRD:18750; Vega:OTTHUMG00000151739
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    FOXK1L; FLJ14977
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    Genomic context

    Location :
    7p22.1
    Sequence :
    Chromosome: 7; NC_000007.13 (4721930..4811074)
    See FOXK1 in Epigenomics, MapViewer

    Chromosome 7 - NC_000007.13Genomic Context describing neighboring genes Neighboring gene ribosomal protein L21 pseudogene 72 Neighboring gene NIF3 NGG1 interacting factor 3-like 1 (S. cerevisiae) Neighboring gene sidekick cell adhesion molecule 1 Neighboring gene small nucleolar RNA, C/D box 13 pseudogene 2 Neighboring gene microRNA 4656 Neighboring gene adaptor-related protein complex 5, zeta 1 subunit Neighboring gene Ras association and DIL domains Neighboring gene poly(A) polymerase beta (testis specific)

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    Genomic regions, transcripts, and products

    Go to nucleotideGraphics FASTA GenBank

    Go to reference sequence details
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    Bibliography

    Related articles in PubMed

    1. Mapping a dynamic innate immunity protein interaction network regulating type I interferon production. Li S, et al. Immunity, 2011 Sep 23. PMID 21903422.
    2. The ubiquitin carboxyl hydrolase BAP1 forms a ternary complex with YY1 and HCF-1 and is a critical regulator of gene expression. Yu H, et al. Mol Cell Biol, 2010 Nov. PMID 20805357.
    3. Network organization of the human autophagy system. Behrends C, et al. Nature, 2010 Jul 1. PMID 20562859.
    4. The deubiquitinating enzyme BAP1 regulates cell growth via interaction with HCF-1. Machida YJ, et al. J Biol Chem, 2009 Dec 4. PMID 19815555.
    5. Defining the human deubiquitinating enzyme interaction landscape. Sowa ME, et al. Cell, 2009 Jul 23. PMID 19615732.

    See all (15) citations in PubMed

    See citations in PubMed for homologs of this gene provided by HomoloGene

    GeneRIFs: Gene References Into Functions What's a GeneRIF?

    1. crystallographic analysis of the FOXK1a-DNA complex
      Title: Crystal structure of the human FOXK1a-DNA complex and its implications on the diverse binding specificity of winged helix/forkhead proteins.
    Submit: New GeneRIF Correction
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    Phenotypes

    Review eQTL and phenotype association data in this region using PheGenI

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    Interactions

    Products Interactant Other Gene Complex Source Pubs Description
    BioGRID:128769 BioGRID:127557 AMOT    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:128769 BioGRID:113911 BAP1    BioGRID  PubMed Affinity Capture-MS; Co-purification 
    BioGRID:128769 BioGRID:122669 FYCO1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:128769 BioGRID:109868 IRF2    BioGRID  PubMed Affinity Capture-MS; Reconstituted Complex 
    BioGRID:128769 BioGRID:113361 YWHAB    BioGRID  PubMed Affinity Capture-MS 
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    General gene information

    Markers

    Genotypes

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    DNA binding, bending IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    double-stranded DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    magnesium ion binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    sequence-specific DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    sequence-specific distal enhancer binding RNA polymerase II transcription factor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    transcription factor binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    cell differentiation IEA
    Inferred from Electronic Annotation
    more info
    		  
    embryo development IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    muscle organ development IEA
    Inferred from Electronic Annotation
    more info
    		  
    negative regulation of cell growth IEA
    Inferred from Electronic Annotation
    more info
    		  
    negative regulation of transcription, DNA-dependent IEA
    Inferred from Electronic Annotation
    more info
    		  
    pattern specification process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    positive regulation of transcription, DNA-dependent IEA
    Inferred from Electronic Annotation
    more info
    		  
    regulation of sequence-specific DNA binding transcription factor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    regulation of transcription from RNA polymerase II promoter IEA
    Inferred from Electronic Annotation
    more info
    		  
    tissue development IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    nucleolus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    NOT nucleolus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    transcription factor complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
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    General protein information

    Preferred Names
    forkhead box protein K1
    Names
    forkhead box protein K1
    MNF
    myocyte nuclear factor
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    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001037165.1 → NP_001032242.1  forkhead box protein K1

      Status: VALIDATED

      Source sequence(s)
      AC092610, AW205747, BC038434, CB959941
      Consensus CDS
      CCDS34591.1
      UniProtKB/Swiss-Prot
      P85037
      Related
      ENSP00000328720, OTTHUMP00000200456, ENST00000328914, OTTHUMT00000323729
      Conserved Domains (2) summary
      cd00059
      Location:305 – 382
      Blast Score: 354
      FH; Forkhead (FH), also known as a "winged helix". FH is named for the Drosophila fork head protein, a transcription factor which promotes terminal rather than segmental development. This family of transcription factor domains, which bind to B-DNA as ...
      cd00060
      Location:116 – 203
      Blast Score: 133
      FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...

    RefSeqs of Annotated Genomes: Build 37.3

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh37.p5 Primary Assembly

    Genomic

    1. NC_000007.13 Reference GRCh37.p5 Primary Assembly

      Range
      4721930..4811074
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate HuRef

    Genomic

    1. AC_000139.1 Alternate HuRef

      Range
      4638801..4727921
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate CRA_TCAGchr7v2

    Genomic

    1. AC_000068.1 Alternate CRA_TCAGchr7v2

      Range
      4768285..4857429
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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    Related Sequences

    Nucleotide Protein
    Heading Accession and Version
    genomic AC072054.10 (129314..152036) None
    genomic AC092428.4 None
    genomic AC092610.1 None
    genomic CH471144.1 EAW87291.1
    mRNA AK027883.1 None
    mRNA AK122663.1 BAG53651.1
    mRNA AK302243.1 BAG63595.1
    mRNA AW205747.1 None
    mRNA BC038434.1 None
    mRNA CB959941.1 None
    other-genetic BC169199.1 None
    Protein Accession Links
    GenPept Link UniProtKB Link
    P85037.1 GenPept UniProtKB/Swiss-Prot:P85037
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    Additional Links

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Molecular Biology Databases
    Research Materials
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