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Txk TXK tyrosine kinase [ Mus musculus (house mouse) ]

Gene ID: 22165, updated on 21-May-2016
Official Symbol
Txkprovided by MGI
Official Full Name
TXK tyrosine kinaseprovided by MGI
Primary source
MGI:MGI:102960
See related
Ensembl:ENSMUSG00000054892 Vega:OTTMUSG00000054700
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Rlk; Btkl; PTK4; PTK-RL-18; A130089B16Rik
Orthologs
Location:
5 C3.2; 5 38.44 cM
Exon count:
15
Annotation release Status Assembly Chr Location
105 current GRCm38.p3 (GCF_000001635.23) 5 NC_000071.6 (72695978..72752992, complement)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 5 NC_000071.5 (73087217..73144012, complement)

Chromosome 5 - NC_000071.6Genomic Context describing neighboring genes Neighboring gene cyclic nucleotide gated channel alpha 1 Neighboring gene predicted gene 5297 Neighboring gene NIPA-like domain containing 1 Neighboring gene tec protein tyrosine kinase Neighboring gene SLAIN motif family, member 2

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
ATP binding IEA
Inferred from Electronic Annotation
more info
 
DNA binding IEA
Inferred from Electronic Annotation
more info
 
RNA polymerase II core promoter proximal region sequence-specific DNA binding ISO
Inferred from Sequence Orthology
more info
 
RNA polymerase II regulatory region DNA binding ISO
Inferred from Sequence Orthology
more info
 
kinase activity IEA
Inferred from Electronic Annotation
more info
 
non-membrane spanning protein tyrosine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
protein kinase activity IEA
Inferred from Electronic Annotation
more info
 
protein tyrosine kinase activity IEA
Inferred from Electronic Annotation
more info
 
transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding ISO
Inferred from Sequence Orthology
more info
 
transferase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
NK T cell differentiation IGI
Inferred from Genetic Interaction
more info
PubMed 
T cell receptor signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
activation of phospholipase C activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
adaptive immune response IMP
Inferred from Mutant Phenotype
more info
PubMed 
cytokine production IMP
Inferred from Mutant Phenotype
more info
PubMed 
immune system process IEA
Inferred from Electronic Annotation
more info
 
innate immune response IBA
Inferred from Biological aspect of Ancestor
more info
 
integrin-mediated signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
 
interferon-gamma production IGI
Inferred from Genetic Interaction
more info
PubMed 
interleukin-4 production IGI
Inferred from Genetic Interaction
more info
PubMed 
peptidyl-tyrosine autophosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
 
phosphorylation IEA
Inferred from Electronic Annotation
more info
 
positive regulation of interferon-gamma production ISO
Inferred from Sequence Orthology
more info
 
positive regulation of interferon-gamma-mediated signaling pathway ISO
Inferred from Sequence Orthology
more info
 
positive regulation of transcription from RNA polymerase II promoter ISO
Inferred from Sequence Orthology
more info
 
protein autophosphorylation ISO
Inferred from Sequence Orthology
more info
 
protein phosphorylation ISO
Inferred from Sequence Orthology
more info
 
regulation of cell proliferation IBA
Inferred from Biological aspect of Ancestor
more info
 
regulation of platelet activation IBA
Inferred from Biological aspect of Ancestor
more info
 
regulation of transcription from RNA polymerase II promoter ISO
Inferred from Sequence Orthology
more info
 
regulation of transcription, DNA-templated IEA
Inferred from Electronic Annotation
more info
 
tissue regeneration IBA
Inferred from Biological aspect of Ancestor
more info
 
transcription, DNA-templated IEA
Inferred from Electronic Annotation
more info
 
transmembrane receptor protein tyrosine kinase signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
 
Component Evidence Code Pubs
cytoplasm ISO
Inferred from Sequence Orthology
more info
 
extrinsic component of cytoplasmic side of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
membrane IEA
Inferred from Electronic Annotation
more info
 
nucleus ISO
Inferred from Sequence Orthology
more info
 
plasma membrane IEA
Inferred from Electronic Annotation
more info
 
Preferred Names
tyrosine-protein kinase TXK
Names
resting lymphocyte kinase
NP_001116226.1
NP_001276423.1
NP_001276424.1
NP_038726.2

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001122754.2NP_001116226.1  tyrosine-protein kinase TXK isoform 1

    See identical proteins and their annotated locations for NP_001116226.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes isoform 1.
    Source sequence(s)
    AC099698, AC122733, AK138786, U16145
    Consensus CDS
    CCDS51514.1
    UniProtKB/Swiss-Prot
    P42682
    Related
    ENSMUSP00000109234, OTTMUSP00000071727, ENSMUST00000113604, OTTMUST00000135585
    Conserved Domains (4) summary
    cd10398
    Location:143248
    SH2_Tec_Txk; Src homology 2 (SH2) domain found in Tec protein, Txk
    cd11907
    Location:85139
    SH3_TXK; Src Homology 3 domain of TXK, also called Resting lymphocyte kinase (Rlk)
    pfam07714
    Location:271520
    Pkinase_Tyr; Protein tyrosine kinase
    cl21453
    Location:266525
    PKc_like; Protein Kinases, catalytic domain
  2. NM_001289494.1NP_001276423.1  tyrosine-protein kinase TXK isoform 3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks an alternate in-frame exon, compared to variant 1. The encoded isoform (3) is shorter than isoform 1.
    Source sequence(s)
    AC099698, AC122733
    Consensus CDS
    CCDS80299.1
    UniProtKB/TrEMBL
    A0A0G2JG94
    Related
    ENSMUSP00000143476, OTTMUSP00000071729, ENSMUST00000197313, OTTMUST00000135589
    Conserved Domains (4) summary
    pfam07714
    Location:249498
    Pkinase_Tyr; Protein tyrosine kinase
    cl15255
    Location:126226
    SH2; Src homology 2 (SH2) domain
    cl17036
    Location:85127
    SH3; Src Homology 3 domain superfamily
    cl21453
    Location:244503
    PKc_like; Protein Kinases, catalytic domain
  3. NM_001289495.1NP_001276424.1  tyrosine-protein kinase TXK isoform 4

    See identical proteins and their annotated locations for NP_001276424.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) uses two alternate splice sites in the 5' region and initiates translation at a downstream in-frame start codon, compared to variant 1. The encoded isoform (4) has a shorter N-terminus than isoform 1.
    Source sequence(s)
    AC099698, AC122733, AK138786
    Consensus CDS
    CCDS80298.1
    UniProtKB/Swiss-Prot
    P42682
    Related
    ENSMUSP00000143002, OTTMUSP00000071730, ENSMUST00000198464, OTTMUST00000135590
    Conserved Domains (4) summary
    cd10398
    Location:89194
    SH2_Tec_Txk; Src homology 2 (SH2) domain found in Tec protein, Txk
    cd11907
    Location:3185
    SH3_TXK; Src Homology 3 domain of TXK, also called Resting lymphocyte kinase (Rlk)
    pfam07714
    Location:217466
    Pkinase_Tyr; Protein tyrosine kinase
    cl21453
    Location:212471
    PKc_like; Protein Kinases, catalytic domain
  4. NM_013698.3NP_038726.2  tyrosine-protein kinase TXK isoform 2

    See identical proteins and their annotated locations for NP_038726.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at an alternate start codon, compared to variant 1. The encoded isoform (2) has a distinct N-terminus but is the same size as isoform 1.
    Source sequence(s)
    AC122733, AK138786, BC137710, D43963
    Consensus CDS
    CCDS19334.1
    UniProtKB/TrEMBL
    B2RQ20
    Related
    ENSMUSP00000129397, OTTMUSP00000071728, ENSMUST00000169534, OTTMUST00000135588
    Conserved Domains (4) summary
    cd10398
    Location:143248
    SH2_Tec_Txk; Src homology 2 (SH2) domain found in Tec protein, Txk
    cd11907
    Location:85139
    SH3_TXK; Src Homology 3 domain of TXK, also called Resting lymphocyte kinase (Rlk)
    pfam07714
    Location:271520
    Pkinase_Tyr; Protein tyrosine kinase
    cl21453
    Location:266525
    PKc_like; Protein Kinases, catalytic domain

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 105 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p3 C57BL/6J

Genomic

  1. NC_000071.6 Reference GRCm38.p3 C57BL/6J

    Range
    72695978..72752992 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011240722.1XP_011239024.1  

    See identical proteins and their annotated locations for XP_011239024.1

    UniProtKB/Swiss-Prot
    P42682
    Conserved Domains (4) summary
    cd10398
    Location:89194
    SH2_Tec_Txk; Src homology 2 (SH2) domain found in Tec protein, Txk
    cd11907
    Location:3185
    SH3_TXK; Src Homology 3 domain of TXK, also called Resting lymphocyte kinase (Rlk)
    pfam07714
    Location:217466
    Pkinase_Tyr; Protein tyrosine kinase
    cl21453
    Location:212471
    PKc_like; Protein Kinases, catalytic domain

Alternate Mm_Celera

Genomic

  1. AC_000027.1 Alternate Mm_Celera

    Range
    69944742..70002868 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)