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    FCGR3B Fc fragment of IgG, low affinity IIIb, receptor (CD16b) [ Homo sapiens ]

    Gene ID: 2215, updated on 19-May-2012
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    Summary

    Official Symbol
    FCGR3Bprovided by HGNC
    Official Full Name
    Fc fragment of IgG, low affinity IIIb, receptor (CD16b)provided by HGNC
    Primary source
    HGNC:3620
    Locus tag
    RP11-25K21.3
    See related
    Ensembl:ENSG00000162747; HPRD:09951; MIM:610665; Vega:OTTHUMG00000074099
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    CD16; FCG3; CD16b; FCGR3; FCR-10; FCRIII; FCRIIIb
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    Genomic context

    Location :
    1q23
    Sequence :
    Chromosome: 1; NC_000001.10 (161592986..161601158, complement)
    See FCGR3B in Epigenomics, MapViewer

    Chromosome 1 - NC_000001.10Genomic Context describing neighboring genes Neighboring gene heat shock 70kDa protein 7 (HSP70B) Neighboring gene ribosomal protein S23 pseudogene Neighboring gene Fc fragment of IgG, low affinity IIb, receptor (CD32) Neighboring gene ribosomal protein L31 pseudogene 11

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    Genomic regions, transcripts, and products

    Go to nucleotideGraphics FASTA GenBank

    Go to reference sequence details
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    Bibliography

    Related articles in PubMed

    1. Genetic polymorphism of Fcγ-receptors IIa, IIIa and IIIb in South Indian patients with generalized aggressive periodontitis. Hans VM, et al. J Oral Sci, 2011 Dec. PMID 22167032.
    2. Human CD16+ and CD16- monocyte subsets display unique effector properties in inflammatory conditions in vivo. Aguilar-Ruiz SR, et al. J Leukoc Biol, 2011 Dec. PMID 21937707.
    3. FCGR3B*03 allele inheritance pattern in Brazilian families and some new variants of gene FCGR3B. Terzian CC, et al. Transfusion, 2012 Mar. PMID 21895673.
    4. Functional haplotypes of Fc gamma (Fcγ) receptor (FcγRIIA and FcγRIIIB) predict risk to repeated episodes of severe malarial anemia and mortality in Kenyan children. Ouma C, et al. Hum Genet, 2012 Feb. PMID 21818580.
    5. FCGR3B copy number variation is associated with systemic lupus erythematosus risk in Afro-Caribbeans. Molokhia M, et al. Rheumatology (Oxford), 2011 Jul. PMID 21296850.

    See all (137) citations in PubMed

    GeneRIFs: Gene References Into Functions What's a GeneRIF?

    1. NA2/NA2 and/or NA2 allele may be risk factors for generalized aggressive periodontitis in the population of South India
      Title: Genetic polymorphism of Fcγ-receptors IIa, IIIa and IIIb in South Indian patients with generalized aggressive periodontitis.
    2. In this Brazilian FCGR3B*03(+) group we found that the inheritance of FCGR3B*03 took place by a linkage to FCGR3B*02 or to FCGR3B*01.
      Title: FCGR3B*03 allele inheritance pattern in Brazilian families and some new variants of gene FCGR3B.
    3. Results here demonstrate that variation in the FcgammaR gene alters susceptibility to repeated episodes of SMA and mortality, as well as functional changes in IFN-gamma production.
      Title: Functional haplotypes of Fc gamma (Fcγ) receptor (FcγRIIA and FcγRIIIB) predict risk to repeated episodes of severe malarial anemia and mortality in Kenyan children.
    4. FCGR3B DNA copy number variation is associated with systemic lupus erythematosus risk in afro-caribbeans.
      Title: FCGR3B copy number variation is associated with systemic lupus erythematosus risk in Afro-Caribbeans.
    5. Monocyte subsets have specialized roles during inflammation: CD16-positive monocytes might undergo an immediate innate immune response, whereas CD16-negative monocytes could have a major role as antigen presenting cells.
      Title: Human CD16+ and CD16- monocyte subsets display unique effector properties in inflammatory conditions in vivo.
    6. Our results suggest that FcgammaRIIIb might not be a susceptibility gene for SLE and lupus nephritis.
      Title: Lack of association of FcγRIIIb polymorphisms with systemic lupus erythematosus: a meta-analysis.
    7. copy number associated with susceptibility to idiopathic pulmonary fibrosis
      Title: Copy number variation of FCGR3B is associated with susceptibility to idiopathic pulmonary fibrosis.
    8. IL-21 stimulates the production of IL-10 by CD4(+) T-cells. Secreted Il-10 maintains the expression of CD16 on monocytes.
      Title: Interleukin-21 maintains the expression of CD16 on monocytes via the production of IL-10 by human naïve CD4+ T cells.
    9. the neutrophil responses to stimuli that engage FcGR3B and FcGR2A, namely the phagocytosis of human IgG-opsonized zymosan and the responses to heat-aggregated IgGs
      Title: Fc gammaRIIIb triggers raft-dependent calcium influx in IgG-mediated responses in human neutrophils.
    10. FcgammaRIIIb NA1/2 polymorphisms are associated with idiopathic pulmonary fibrosis disease susceptibility but not with disease progression.
      Title: Fcγ receptor IIIb (CD16b) polymorphisms are associated with susceptibility to idiopathic pulmonary fibrosis.
    Submit: New GeneRIF Correction See all (67)
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    Phenotypes

    Review eQTL and phenotype association data in this region using PheGenI

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    HIV-1 protein interactions

    Protein Gene Interaction Pubs
    Tat tat HIV-1 Tat inhibits the rise in intracellular free calcium concentration in Natural Killer (NK) cells upon cross-linking of the adhesion molecule CD11a and the activation molecule CD16, indicating Tat is involved in the impairment of NK cell function PubMed

    Go to the HIV-1, Human Protein Interaction Database

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    Interactions

    Products Interactant Other Gene Complex Source Pubs Description
    NP_000561.2     BIND  PubMed FCGR3B (Fc fragment of IgG) interacts with ligand 5/9. 
    NP_000561.2     BIND  PubMed FCGR3B (Fc fragment of IgG) interacts with ligand 3/12. 
    O75015 P02743 APCS    HPRD  PubMed  
    O75015 P01857 IGHG1    HPRD  PubMed  
    BioGRID:108509 BioGRID:106822 APCS    BioGRID  PubMed Reconstituted Complex 
    BioGRID:108509 BioGRID:109721 IGHG1    BioGRID  PubMed Co-crystal Structure 
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    General gene information

    Markers

    Genotypes

    Pathways from BioSystems

    • Leishmaniasis, organism-specific biosystem (from KEGG)
      Leishmaniasis, organism-specific biosystemLeishmania is an intracellular protozoan parasite of macrophages that causes visceral, mucosal, and cutaneous diseases. The parasite is transmitted to humans by sandflies, where they survive and prol...
    • Leishmaniasis, conserved biosystem (from KEGG)
      Leishmaniasis, conserved biosystemLeishmania is an intracellular protozoan parasite of macrophages that causes visceral, mucosal, and cutaneous diseases. The parasite is transmitted to humans by sandflies, where they survive and prol...
    • Natural killer cell mediated cytotoxicity, organism-specific biosystem (from KEGG)
      Natural killer cell mediated cytotoxicity, organism-specific biosystemNatural killer (NK) cells are lymphocytes of the innate immune system that are involved in early defenses against both allogeneic (nonself) cells and autologous cells undergoing various forms of stre...
    • Natural killer cell mediated cytotoxicity, conserved biosystem (from KEGG)
      Natural killer cell mediated cytotoxicity, conserved biosystemNatural killer (NK) cells are lymphocytes of the innate immune system that are involved in early defenses against both allogeneic (nonself) cells and autologous cells undergoing various forms of stre...
    • Osteoclast differentiation, organism-specific biosystem (from KEGG)
      Osteoclast differentiation, organism-specific biosystemThe osteoclasts, multinucleared cells originating from the hematopoietic monocyte-macrophage lineage, are responsible for bone resorption. Osteoclastogenesis is mainly regulated by signaling pathways...
    • Osteoclast differentiation, conserved biosystem (from KEGG)
      Osteoclast differentiation, conserved biosystemThe osteoclasts, multinucleared cells originating from the hematopoietic monocyte-macrophage lineage, are responsible for bone resorption. Osteoclastogenesis is mainly regulated by signaling pathways...
    • Phagosome, organism-specific biosystem (from KEGG)
      Phagosome, organism-specific biosystemPhagocytosis is the process of taking in relatively large particles by a cell, and is a central mechanism in the tissue remodeling, inflammation, and defense against infectious agents. A phagosome is...
    • Phagosome, conserved biosystem (from KEGG)
      Phagosome, conserved biosystemPhagocytosis is the process of taking in relatively large particles by a cell, and is a central mechanism in the tissue remodeling, inflammation, and defense against infectious agents. A phagosome is...
    • Staphylococcus aureus infection, organism-specific biosystem (from KEGG)
      Staphylococcus aureus infection, organism-specific biosystemStaphylococcus aureus can cause multiple forms of infections ranging from superficial skin infections to food poisoning and life-threatening infections. The organism has several ways to divert the ef...
    • Staphylococcus aureus infection, conserved biosystem (from KEGG)
      Staphylococcus aureus infection, conserved biosystemStaphylococcus aureus can cause multiple forms of infections ranging from superficial skin infections to food poisoning and life-threatening infections. The organism has several ways to divert the ef...
    • Systemic lupus erythematosus, organism-specific biosystem (from KEGG)
      Systemic lupus erythematosus, organism-specific biosystemSystemic lupus erythematosus (SLE) is a prototypic autoimmune disease characterised by the production of IgG autoantibodies that are specific for self-antigens, such as DNA, nuclear proteins and cert...
    • Systemic lupus erythematosus, conserved biosystem (from KEGG)
      Systemic lupus erythematosus, conserved biosystemSystemic lupus erythematosus (SLE) is a prototypic autoimmune disease characterised by the production of IgG autoantibodies that are specific for self-antigens, such as DNA, nuclear proteins and cert...
    • Tuberculosis, organism-specific biosystem (from KEGG)
      Tuberculosis, organism-specific biosystemTuberculosis, or TB, is an infectious disease caused by Mycobacterium tuberculosis. One third of the world's population is thought to be infected with TB. About 90% of those infected result in latent...
    • Tuberculosis, conserved biosystem (from KEGG)
      Tuberculosis, conserved biosystemTuberculosis, or TB, is an infectious disease caused by Mycobacterium tuberculosis. One third of the world's population is thought to be infected with TB. About 90% of those infected result in latent...

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    IgG binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    immune response TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    anchored to membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    extracellular region IEA
    Inferred from Electronic Annotation
    more info
    		  
    plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
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    General protein information

    Preferred Names
    low affinity immunoglobulin gamma Fc region receptor III-B
    Names
    low affinity immunoglobulin gamma Fc region receptor III-B
    fc-gamma RIII
    fc-gamma RIIIb
    fc-gamma RIII-beta
    igG Fc receptor III-1
    Fc-gamma receptor IIIb (CD 16)
    Fc fragment of IgG, low affinity IIIb, receptor for (CD16)
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    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_000570.4 → NP_000561.3  low affinity immunoglobulin gamma Fc region receptor III-B isoform 2 precursor

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR, lacks a portion of the 5' coding region and uses a downstream, in-frame start codon, compared to variant 1. The encoded isoform (2) has a shorter N-terminus, compared to isoform 1.
      Source sequence(s)
      AJ581669, AL451067, BC128562, DA672751, J04162
      Consensus CDS
      CCDS41433.1
      UniProtKB/Swiss-Prot
      O75015
      Related
      ENSP00000294800, ENST00000294800
      Conserved Domains (2) summary
      cd05752
      Location:26 – 104
      Blast Score: 295
      Ig1_FcgammaR_like; Frst immunoglobulin (Ig)-like domain of Fcgamma-receptors (FcgammaRs) and similar proteins
      cd05753
      Location:108 – 190
      Blast Score: 371
      Ig2_FcgammaR_like; Second immunoglobulin (Ig)-like domain of Fcgamma-receptors (FcgammaRs) and similar proteins

    2. NM_001244753.1 → NP_001231682.1  low affinity immunoglobulin gamma Fc region receptor III-B isoform 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AJ581669, AL451067, DA669913, DC428645, DC428702, M24854, X16863
      UniProtKB/Swiss-Prot
      O75015
      Conserved Domains (2) summary
      cd05752
      Location:62 – 140
      Blast Score: 298
      Ig1_FcgammaR_like; Frst immunoglobulin (Ig)-like domain of Fcgamma-receptors (FcgammaRs) and similar proteins
      cd05753
      Location:144 – 226
      Blast Score: 378
      Ig2_FcgammaR_like; Second immunoglobulin (Ig)-like domain of Fcgamma-receptors (FcgammaRs) and similar proteins

    RefSeqs of Annotated Genomes: Build 37.3

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh37.p5 Primary Assembly

    Genomic

    1. NC_000001.10 Reference GRCh37.p5 Primary Assembly

      Range
      161592986..161601158, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate HuRef

    Genomic

    1. NW_001839829.1 Alternate HuRef

      Range
      5851..13447
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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    Related Sequences

    Nucleotide Protein
    Heading Accession and Version
    genomic AL451067.12 CAM15149.1
      CAM15150.1
    genomic Z46223.1 CAA86296.1
    mRNA AB025256.1 BAA83803.1
    mRNA AJ581669.1 CAE46408.1
    mRNA AK313219.1 None
    mRNA AK316565.1 BAG38154.1
    mRNA BC128562.1 AAI28563.1
    mRNA DA669913.1 None
    mRNA DA672751.1 None
    mRNA DA672763.1 None
    mRNA DC428645.1 None
    mRNA DC428702.1 None
    mRNA J04162.1 AAA35881.1
    mRNA M24854.1 AAA53507.1
    mRNA X07934.1 CAA30758.1
    mRNA X16863.1 CAA34753.1
    Protein Accession Links
    GenPept Link UniProtKB Link
    O75015.2 GenPept UniProtKB/Swiss-Prot:O75015
    Q9ULV2 GenPept UniProtKB/TrEMBL:Q9ULV2
    Q9UPY7 GenPept UniProtKB/TrEMBL:Q9UPY7
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    Additional Links

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Medical
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    Research Materials
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