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    AKD1 adenylate kinase domain containing 1 [ Homo sapiens ]

    Gene ID: 221264, updated on 11-May-2012

    Summary

    Official Symbol
    AKD1provided by HGNC
    Official Full Name
    adenylate kinase domain containing 1provided by HGNC
    Primary source
    HGNC:33814
    Locus tag
    hCG_2030702
    See related
    Ensembl:ENSG00000155085; HPRD:12871; Vega:OTTHUMG00000157658
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    AKD2; C6orf199; C6orf224; dJ70A9.1; RP1-70A9.1; FLJ16163; FLJ25791; FLJ34784; FLJ42177; MGC26954; MGC126763; MGC138153; MGC177059; MGC180194; MGC184281

    Genomic context

    Location :
    6q21
    Sequence :
    Chromosome: 6; NC_000006.11 (109814059..110012415, complement)
    See AKD1 in Epigenomics, MapViewer

    Chromosome 6 - NC_000006.11Genomic Context describing neighboring genes Neighboring gene microtubule associated monoxygenase, calponin and LIM domain containing 1 Neighboring gene zinc finger and BTB domain containing 24 Neighboring gene FIG4 homolog, SAC1 lipid phosphatase domain containing (S. cerevisiae) Neighboring gene G protein-coupled receptor 6

    Genomic regions, transcripts, and products

    Bibliography

    GeneRIFs: Gene References Into Functions What's a GeneRIF?

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description
    Chromosome 6 open reading frame 199 Q15121 PEA15    HPRD  PubMed  

    General gene information

    Markers

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    nucleobase-containing compound kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    nucleoside-triphosphatase activity IEA
    Inferred from Electronic Annotation
    more info
     
    nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    nucleobase-containing compound metabolic process IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    adenylate kinase domain-containing protein 1
    Names
    adenylate kinase domain-containing protein 1
    adenylate kinase domain containing 2

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001145128.2NP_001138600.2  adenylate kinase domain-containing protein 1 isoform 1

      Status: PROVISIONAL

      Description
      Transcript Variant: This variant (1) is the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AL109947, AL121788, AL133472, AL139391
      Consensus CDS
      CCDS55048.1
      UniProtKB/Swiss-Prot
      Q5TCS8
      Related
      ENSP00000410186, ENST00000424296
      Conserved Domains (5) summary
      cd01428
      Location:14131535
      Blast Score: 224
      ADK; Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for ...
      COG0563
      Location:14131598
      Blast Score: 181
      Adk; Adenylate kinase and related kinases [Nucleotide transport and metabolism]
      TIGR01351
      Location:33277
      Blast Score: 219
      adk; adenylate kinases
      cl00909
      Location:945987
      Blast Score: 96
      Ribosomal_L24e_L24; Ribosomal protein L24e/L24 is a ribosomal protein found in eukaryotes (L24) and in archaea (L24e, distinct from archaeal L24). L24e/L24 is located on the surface of the large subunit, adjacent to proteins L14 and L3, and near the translation factor ...
      cl09099
      Location:393426
      Blast Score: 90
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
    2. NM_145025.4NP_659462.1  adenylate kinase domain-containing protein 1 isoform 2

      Status: PROVISIONAL

      Description
      Transcript Variant: This variant (2) lacks multiple 3' exons, as compared to variant 1. The resulting isoform (2) is much shorter at the C-terminus, as compared to isoform 1.
      Source sequence(s)
      AK055538, BC022031
      Consensus CDS
      CCDS5077.1
      UniProtKB/Swiss-Prot
      Q5TCS8
      Related
      ENSP00000285397, OTTHUMP00000016973, ENST00000285397, OTTHUMT00000041765
      Conserved Domains (3) summary
      cd01428
      Location:33276
      Blast Score: 223
      ADK; Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for ...
      TIGR01351
      Location:33277
      Blast Score: 220
      adk; adenylate kinases
      cl09099
      Location:393419
      Blast Score: 82
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

    RefSeqs of Annotated Genomes: Build 37.3

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh37.p5 Primary Assembly

    Genomic

    1. NC_000006.11 Reference GRCh37.p5 Primary Assembly

      Range
      109814059..110012415, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate HuRef

    Genomic

    1. AC_000138.1 Alternate HuRef

      Range
      107380087..107578597, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001001706.2: Suppressed sequence

      Description
      NM_001001706.2: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the CDS appears to be partial at the 5' end.
    2. NM_173559.1: Suppressed sequence

      Description
      NM_173559.1: This RefSeq was permanently suppressed because the CDS was partial.

    Related Sequences

    Nucleotide Protein
    Heading Accession and Version
    genomic AL109947.19 (92010..128959) None
    genomic AL121788.17 CAI22498.1
      CAI22499.1
      CAI22500.1
    genomic AL133472.12 CAI19667.1
      CAI19668.1
    genomic AL139391.11 (100..8011) None
    genomic CH471051.2 EAW48333.1
      EAW48334.1
      EAW48335.1
      EAW48336.1
    genomic CH471051.2 EAW48333.1
      EAW48334.1
      EAW48335.1
      EAW48336.1
    mRNA AK055538.1 BAB70945.1
    mRNA AK098657.1 BAC05368.1
    mRNA AK124171.1 None
    mRNA AK131244.1 BAD18424.1
    mRNA AK315561.1 BAG37937.1
    mRNA AL832162.1 None
    mRNA BC022031.2 AAH22031.1
    mRNA BC087860.1 AAH87860.1
    mRNA BC101714.1 AAI01715.1
    mRNA BC111948.1 AAI11949.1
    mRNA BC143533.1 AAI43534.1
    mRNA DA106296.1 None
    mRNA DW009925.1 None
    other-genetic BC146443.1 AAI46444.1
    other-genetic BC153055.1 AAI53056.1
    other-genetic EU831612.1 ACE87212.1
    other-genetic EU831699.1 ACE86533.1
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q5TCS8.2 GenPept UniProtKB/Swiss-Prot:Q5TCS8
    Q5TDU3 GenPept UniProtKB/TrEMBL:Q5TDU3

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