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Tsg101 tumor susceptibility gene 101 [ Mus musculus (house mouse) ]

Gene ID: 22088, updated on 8-May-2016
Official Symbol
Tsg101provided by MGI
Official Full Name
tumor susceptibility gene 101provided by MGI
Primary source
MGI:MGI:106581
See related
Ensembl:ENSMUSG00000014402 Vega:OTTMUSG00000024345
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
CC2; AI255943
Orthologs
Location:
7; 7 B5
Exon count:
10
Annotation release Status Assembly Chr Location
105 current GRCm38.p3 (GCF_000001635.23) 7 NC_000073.6 (46889027..46919974, complement)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 7 NC_000073.5 (54144397..54175300, complement)

Chromosome 7 - NC_000073.6Genomic Context describing neighboring genes Neighboring gene lactate dehydrogenase A Neighboring gene predicted gene, 39011 Neighboring gene lactate dehydrogenase C Neighboring gene UEV and lactate/malate dehyrogenase domains Neighboring gene predicted gene, 39012 Neighboring gene thymosin, beta 10 pseudogene

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
calcium-dependent protein binding ISO
Inferred from Sequence Orthology
more info
 
ligand-dependent nuclear receptor transcription coactivator activity ISO
Inferred from Sequence Orthology
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein homodimerization activity ISO
Inferred from Sequence Orthology
more info
 
transcription corepressor activity IDA
Inferred from Direct Assay
more info
PubMed 
ubiquitin binding ISO
Inferred from Sequence Orthology
more info
 
ubiquitin protein ligase binding ISO
Inferred from Sequence Orthology
more info
 
virion binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
cell cycle IEA
Inferred from Electronic Annotation
more info
 
cell cycle arrest IDA
Inferred from Direct Assay
more info
PubMed 
cell differentiation IDA
Inferred from Direct Assay
more info
PubMed 
cell division IEA
Inferred from Electronic Annotation
more info
 
cellular protein modification process IEA
Inferred from Electronic Annotation
more info
 
endosome to lysosome transport ISO
Inferred from Sequence Orthology
more info
 
keratinocyte differentiation IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of cell proliferation IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of transcription, DNA-templated IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of exosomal secretion ISO
Inferred from Sequence Orthology
more info
 
positive regulation of ubiquitin-dependent endocytosis IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of viral budding via host ESCRT complex ISO
Inferred from Sequence Orthology
more info
 
positive regulation of viral process ISO
Inferred from Sequence Orthology
more info
 
positive regulation of viral release from host cell ISO
Inferred from Sequence Orthology
more info
 
protein monoubiquitination ISO
Inferred from Sequence Orthology
more info
 
protein transport IEA
Inferred from Electronic Annotation
more info
 
regulation of MAP kinase activity ISO
Inferred from Sequence Orthology
more info
 
regulation of cell growth IDA
Inferred from Direct Assay
more info
PubMed 
regulation of extracellular exosome assembly ISO
Inferred from Sequence Orthology
more info
 
regulation of growth IEA
Inferred from Electronic Annotation
more info
 
regulation of viral budding via host ESCRT complex ISO
Inferred from Sequence Orthology
more info
 
transport IEA
Inferred from Electronic Annotation
more info
 
ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway ISO
Inferred from Sequence Orthology
more info
 
viral budding IMP
Inferred from Mutant Phenotype
more info
PubMed 
viral budding ISO
Inferred from Sequence Orthology
more info
 
viral process IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
ESCRT I complex ISO
Inferred from Sequence Orthology
more info
 
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
cytoplasm ISO
Inferred from Sequence Orthology
more info
 
early endosome ISO
Inferred from Sequence Orthology
more info
 
endosome ISO
Inferred from Sequence Orthology
more info
 
endosome membrane ISO
Inferred from Sequence Orthology
more info
 
extracellular exosome ISO
Inferred from Sequence Orthology
more info
 
late endosome ISO
Inferred from Sequence Orthology
more info
 
membrane IEA
Inferred from Electronic Annotation
more info
 
nucleolus ISO
Inferred from Sequence Orthology
more info
 
nucleus IC
Inferred by Curator
more info
PubMed 
nucleus ISO
Inferred from Sequence Orthology
more info
 
plasma membrane ISO
Inferred from Sequence Orthology
more info
 
Preferred Names
tumor susceptibility gene 101 protein
Names
ESCRT-I complex subunit TSG101

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_021884.3NP_068684.1  tumor susceptibility gene 101 protein

    See identical proteins and their annotated locations for NP_068684.1

    Status: PROVISIONAL

    Source sequence(s)
    AK146602
    Consensus CDS
    CCDS21291.1
    UniProtKB/Swiss-Prot
    Q61187
    UniProtKB/TrEMBL
    Q3UCW0
    Related
    ENSMUSP00000014546, OTTMUSP00000029024, ENSMUST00000014546, OTTMUST00000059640
    Conserved Domains (3) summary
    pfam09454
    Location:316380
    Vps23_core; Vps23 core domain
    pfam05743
    Location:21139
    UEV; UEV domain
    cl03075
    Location:242307
    GrpE; nucleotide exchange factor GrpE

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 105 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p3 C57BL/6J

Genomic

  1. NC_000073.6 Reference GRCm38.p3 C57BL/6J

    Range
    46889027..46919974 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006540789.2XP_006540852.1  

    Conserved Domains (3) summary
    pfam09454
    Location:263327
    Vps23_core; Vps23 core domain
    pfam05743
    Location:21139
    UEV; UEV domain
    cl03075
    Location:189254
    GrpE; nucleotide exchange factor GrpE
  2. XM_006540788.2XP_006540851.1  

    Conserved Domains (3) summary
    pfam09454
    Location:281345
    Vps23_core; Vps23 core domain
    pfam05743
    Location:21104
    UEV; UEV domain
    cl03075
    Location:207272
    GrpE; nucleotide exchange factor GrpE
  3. XM_006540790.2XP_006540853.1  

    Conserved Domains (3) summary
    pfam09454
    Location:222286
    Vps23_core; Vps23 core domain
    cl03075
    Location:148213
    GrpE; nucleotide exchange factor GrpE
    cl00154
    Location:145
    UBCc; Ubiquitin-conjugating enzyme E2, catalytic (UBCc) domain. This is part of the ubiquitin-mediated protein degradation pathway in which a thiol-ester linkage forms between a conserved cysteine and the C-terminus of ubiquitin and complexes with ubiquitin ...

RNA

  1. XR_391333.2 RNA Sequence

Alternate Mm_Celera

Genomic

  1. AC_000029.1 Alternate Mm_Celera

    Range
    42369255..42400171 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)