Trpc1 transient receptor potential cation channel, subfamily C, member 1 [Mus musculus (house mouse)] - Gene

Summary

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Official Symbol: Trpc1provided by MGI
Official Full Name: transient receptor potential cation channel, subfamily C, member 1provided by MGI
Primary source: MGI:109528
See related: Ensembl:ENSMUSG00000032839
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Trp1; Mtrp1; Trrp1

Genomic context

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Location :: 9 E4; 9 50.2 cM

Sequence :: Chromosome: 9; NC_000075.6 (95706627..95750358, complement)

See Trpc1 in Epigenomics, MapViewer

Chromosome 9 - NC_000075.6 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence

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Bibliography

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GeneRIFs: Gene References Into Functions What's a GeneRIF?

mGluR5 activation of cation current-carrying TRPC channels plays an important role in governing the cycle-by-cycle variability of the respiratory rhythm.
Title: Metabotropic glutamate receptors (mGluR5) activate transient receptor potential canonical channels to improve the regularity of the respiratory rhythm generated by the pre-Bötzinger complex in mice.
TRPC1 attenuates receptor-mediated aortic contraction through activation and/or expression of smooth muscle BK(Ca) channels and participates in endothelial cell Ca(2+) influx and vasorelaxation of aorta.
Title: Role of TRPC1 and TRPC3 channels in contraction and relaxation of mouse thoracic aorta.
The data provided direct evidence that TRPC1 and Orai1 channels mediate capacitative calcium entry through activation of STIM1 in acute hypoxic mouse pulmonary arterial smooth muscle cells.
Title: TRPC1 and Orai1 interact with STIM1 and mediate capacitative Ca(2+) entry caused by acute hypoxia in mouse pulmonary arterial smooth muscle cells.
The suppression of TRPC1 expression arrested the adult neural progenitor cell cycle at G0/G1 phase.
Title: A TRPC1-mediated increase in store-operated Ca2+ entry is required for the proliferation of adult hippocampal neural progenitor cells.
TRPC1 is involved in regulating Ca2+ homeostasis and inhibiting the unfoled protein rsponse and thus contributes to neuronal survival after neurotoxin exposure.
Title: Neurotoxin-induced ER stress in mouse dopaminergic neurons involves downregulation of TRPC1 and inhibition of AKT/mTOR signaling.
the involvement of Trpc1 channels in skeletal muscle development in vitro and in vivo, and identify a Ca(2+)-dependent activation of the PI3K/Akt/mTOR/p70S6K pathway during myoblast differentiation and muscle regeneration.
Title: Trpc1 ion channel modulates phosphatidylinositol 3-kinase/Akt pathway during myoblast differentiation and muscle regeneration.
This study concluded that TRPC1 can be activated downstream of NMDA receptor activation and contribute to slow synaptic transmission in the olfactory bulb, including the calcium dynamics required for asynchronous release from the granule cell spine.
Title: NMDA receptor-dependent synaptic activation of TRPC channels in olfactory bulb granule cells.
Study concludes that mechanical injury of brain endothelial cells induces a rapid influx of calcium, mediated by TRPC1 and TRPP2 channels, which leads to NO synthesis and actin cytoskeletal rearrangement.
Title: Critical role of TRPP2 and TRPC1 channels in stretch-induced injury of blood-brain barrier endothelial cells.
The results suggested that TRPC1 may be important in the detection of innocuous mechanical force.
Title: TRPC1 contributes to light-touch sensation and mechanical responses in low-threshold cutaneous sensory neurons.
TRPC1 and TRPC4 can interact with STIM1 to form functional store-operated Ca(2+)-entry channels, which are essential for mediating Ca(2+) entry-dependent disruption of the endothelial barrier
Title: The Ca(2+) sensor stromal interaction molecule 1 (STIM1) is necessary and sufficient for the store-operated Ca(2+) entry function of transient receptor potential canonical (TRPC) 1 and 4 channels in endothelial cells.

Submit: New GeneRIF Correction See all (45)

Alleles

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Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (knock-out) (2) 1 citation

Interactions

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Products	Interactant	Other Gene	Source	Pubs	Description
NP_035773.1	NP_031587.1	Bmpr2	BIND	PubMed	BMPR-II interacts with Trpc1.
NP_035773.1	XP_283704.1	Enkur	BIND	PubMed	Enkurin interacts with TRPC1. This interaction was modeled on a demonstrated interaction between mouse Enkurin and human TRPC1.
BioGRID:204327	BioGRID:107127	BMPR2	BioGRID	PubMed	Affinity Capture-MS
BioGRID:204327	BioGRID:204330	Trpc4	BioGRID	PubMed	Affinity Capture-Western

Pathways from BioSystems

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Adaptive Immune System, organism-specific biosystem (from REACTOME)
Adaptive Immune System, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Antigen Activates B Cell Receptor Leading to Generation of Second Messengers, organism-specific biosystem (from REACTOME)
Antigen Activates B Cell Receptor Leading to Generation of Second Messengers, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Axon guidance, organism-specific biosystem (from REACTOME)
Axon guidance, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Developmental Biology, organism-specific biosystem (from REACTOME)
Developmental Biology, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Glutamatergic synapse, organism-specific biosystem (from KEGG)
Glutamatergic synapse, organism-specific biosystemGlutamate is the major excitatory neurotransmitter in the mammalian central nervous system(CNS). Glutamate is packaged into synaptic vesicles in the presynaptic terminal. Once released into the synap...
Glutamatergic synapse, conserved biosystem (from KEGG)
Glutamatergic synapse, conserved biosystemGlutamate is the major excitatory neurotransmitter in the mammalian central nervous system(CNS). Glutamate is packaged into synaptic vesicles in the presynaptic terminal. Once released into the synap...
Immune System, organism-specific biosystem (from REACTOME)
Immune System, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Netrin-1 signaling, organism-specific biosystem (from REACTOME)
Netrin-1 signaling, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Pancreatic secretion, organism-specific biosystem (from KEGG)
Pancreatic secretion, organism-specific biosystemThe pancreas performs both exocrine and endocrine functions. The exocrine pancreas consists of two parts, the acinar and duct cells. The primary functions of pancreatic acinar cells are to synthesiz...
Pancreatic secretion, conserved biosystem (from KEGG)
Pancreatic secretion, conserved biosystemThe pancreas performs both exocrine and endocrine functions. The exocrine pancreas consists of two parts, the acinar and duct cells. The primary functions of pancreatic acinar cells are to synthesiz...
Role of second messengers in netrin-1 signaling, organism-specific biosystem (from REACTOME)
Role of second messengers in netrin-1 signaling, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Serotonergic synapse, organism-specific biosystem (from KEGG)
Serotonergic synapse, organism-specific biosystemSerotonin (5-Hydroxytryptamine, 5-HT) is a monoamine neurotransmitter that plays important roles in physiological functions such as learning and memory, emotion, sleep, pain, motor function and endoc...
Signaling by the B Cell Receptor (BCR), organism-specific biosystem (from REACTOME)
Signaling by the B Cell Receptor (BCR), organism-specific biosystemcomputationally inferred pathway (not manually curated)

General gene information

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Markers

Trpc1 (e-PCR), detects polymorphism
- UniSTS:531238

Trrp1 (e-PCR), detects polymorphism
- UniSTS:144682

Trpc1 (e-PCR), detects polymorphism
- UniSTS:516709

Trpc1 (e-PCR), detects polymorphism
- UniSTS:516710

UniSTS:236220 (e-PCR)
- UniSTS:236220

Homology

Homologs of the Trpc1 gene: The Trpc1 gene is conserved in human, chimpanzee, Rhesus monkey, dog, cow, rat, chicken, and zebrafish.
Map Viewer (Human, Rat)
OrthoDB: The Hierarchical Catalog of Eukaryotic Orthologs

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
calcium channel activity	IEA Inferred from Electronic Annotation more info
cation channel activity	ISO Inferred from Sequence Orthology more info
inositol 1,4,5 trisphosphate binding	ISO Inferred from Sequence Orthology more info
ion channel activity	IEA Inferred from Electronic Annotation more info
ion channel binding	ISO Inferred from Sequence Orthology more info
protein binding	IPI Inferred from Physical Interaction more info	PubMed
store-operated calcium channel activity	IMP Inferred from Mutant Phenotype more info	PubMed

Process	Evidence Code	Pubs
calcium ion transmembrane transport	IMP Inferred from Mutant Phenotype more info	PubMed
calcium ion transport	IEA Inferred from Electronic Annotation more info
cytosolic calcium ion homeostasis	ISO Inferred from Sequence Orthology more info
ion transport	IEA Inferred from Electronic Annotation more info
positive regulation of release of sequestered calcium ion into cytosol	ISO Inferred from Sequence Orthology more info
response to calcium ion	ISO Inferred from Sequence Orthology more info
saliva secretion	IMP Inferred from Mutant Phenotype more info	PubMed
transmembrane transport	IEA Inferred from Electronic Annotation more info
transport	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
basolateral plasma membrane	IMP Inferred from Mutant Phenotype more info	PubMed
costamere	IDA Inferred from Direct Assay more info	PubMed
cytoplasm	IDA Inferred from Direct Assay more info	PubMed
integral to membrane	IEA Inferred from Electronic Annotation more info
membrane	IEA Inferred from Electronic Annotation more info
membrane raft	IDA Inferred from Direct Assay more info	PubMed
plasma membrane	ISO Inferred from Sequence Orthology more info
protein complex	IPI Inferred from Physical Interaction more info	PubMed
sarcomere	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: short transient receptor potential channel 1

Names: short transient receptor potential channel 1; TRP-1; trp-related protein 1; transient receptor protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_011643.2 → NP_035773.1 short transient receptor potential channel 1

Status: PROVISIONAL

Source sequence(s)

AC091531, AC157947

Consensus CDS

CCDS23411.1

UniProtKB/TrEMBL

B2RPS7

UniProtKB/Swiss-Prot

Q61056

Related

ENSMUSP00000057640, ENSMUST00000053785

Conserved Domains (3) summary

cd00204
Location:67 – 195
Blast Score: 113

ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...

pfam08344
Location:209 – 271
Blast Score: 270

TRP_2; Transient receptor ion channel II

TIGR00870
Location:64 – 790
Blast Score: 1243

trp; transient-receptor-potential calcium channel protein

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 103

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p1 C57BL/6J

Genomic

NC_000075.6 Reference GRCm38.p1 C57BL/6J

Range

95706627..95750358, complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Alternate Mm_Celera

Genomic

AC_000031.1 Alternate Mm_Celera

Range

95273759..95317486, complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Nucleotide		Protein	Strain
Heading	Accession and Version	Protein	Strain
genomic	AAHY01080731.1 (23954..67681)	None
genomic	AC091531.9 (114619..118023)	None	C57BL/6J
genomic	AC157947.2	None
genomic	CH466560.1	EDL20938.1	mixed
		EDL20939.1	mixed
		EDL20940.1	mixed
		EDL20941.1	mixed
mRNA	AF191551.1	AAF05725.1
mRNA	AK005144.1	None	C57BL/6J
mRNA	AK038676.1	None	C57BL/6J
mRNA	AK046014.1	None	C57BL/6J
mRNA	BC137581.1	AAI37582.1
mRNA	BC144726.1	AAI44727.1
mRNA	U40980.1	AAC52699.1
mRNA	U73625.1	AAB50622.1
mRNA	U95167.1	AAC53162.1
mRNA	U95168.1	None
mRNA	U95169.1	None