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Trp73 transformation related protein 73 [ Mus musculus (house mouse) ]

Gene ID: 22062, updated on 28-May-2016
Official Symbol
Trp73provided by MGI
Official Full Name
transformation related protein 73provided by MGI
Primary source
MGI:MGI:1336991
See related
Ensembl:ENSMUSG00000029026 Vega:OTTMUSG00000010497
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
p73; Tp73; TAp73; deltaNp73
Summary
This gene encodes tumor protein p73, which is a member of the p53 family of transcription factors involved in cellular responses to stress and development. The family members include p53, p63, and p73 and have high sequence similarity to one another, which allows p63 and p73 to transactivate p53-responsive genes causing cell cycle arrest and apoptosis. The family members can interact with each other in many ways involving direct or indirect protein interactions, resulting in regulation of the same target gene promoters or regulation of each other's promoters. The p73 protein is expressed at very low levels in normal tissues and is differentially expressed in a number of tumors. The p73 gene expresses at least 35 mRNA variants due to the use of alternate promoters, alternate translation initiation sites, and multiple splice variations. Theoretically this can account for 29 different p73 isoforms; however, the biological validity and the full-length nature of most variants have not been determined. [provided by RefSeq, Jul 2008]
Orthologs
Location:
4 E2; 4 83.79 cM
Exon count:
18
Annotation release Status Assembly Chr Location
105 current GRCm38.p3 (GCF_000001635.23) 4 NC_000070.6 (154056249..154140208, complement)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 4 NC_000070.5 (153430358..153514317, complement)

Chromosome 4 - NC_000070.6Genomic Context describing neighboring genes Neighboring gene leucine rich repeat containing 47 Neighboring gene small integral membrane protein 1 Neighboring gene predicted gene, 31672 Neighboring gene coiled-coil domain containing 27 Neighboring gene WD repeat containing, antisense to Trp73 Neighboring gene predicted gene, 38459 Neighboring gene transformation related protein 63 regulated like

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

  • Alpha6-Beta4 Integrin Signaling Pathway, organism-specific biosystem (from WikiPathways)
    Alpha6-Beta4 Integrin Signaling Pathway, organism-specific biosystemIntegrins are cell surface heterodimeric protein complex consisting of one alpha and one beta chain. Integrins act as cell adhesion molecules as well as participate in cellular signaling. The ligands...
  • Apoptosis, organism-specific biosystem (from WikiPathways)
    Apoptosis, organism-specific biosystemApoptosis is a distinct form of cell death that is functionally and morphologically different from necrosis. Nuclear chromatin condensation, cytoplasmic shrinking, dilated endoplasmic reticulum, and ...
  • Gene Expression, organism-specific biosystem (from REACTOME)
    Gene Expression, organism-specific biosystemcomputationally inferred pathway (not manually curated)
  • Generic Transcription Pathway, organism-specific biosystem (from REACTOME)
    Generic Transcription Pathway, organism-specific biosystemcomputationally inferred pathway (not manually curated)
  • Hippo signaling pathway, organism-specific biosystem (from KEGG)
    Hippo signaling pathway, organism-specific biosystemHippo signaling is an evolutionarily conserved signaling pathway that controls organ size from flies to humans. In humans and mice, the pathway consists of the MST1 and MST2 kinases, their cofactor S...
  • Hippo signaling pathway, conserved biosystem (from KEGG)
    Hippo signaling pathway, conserved biosystemHippo signaling is an evolutionarily conserved signaling pathway that controls organ size from flies to humans. In humans and mice, the pathway consists of the MST1 and MST2 kinases, their cofactor S...
  • Measles, organism-specific biosystem (from KEGG)
    Measles, organism-specific biosystemMeasles virus (MV) is highly contagious virus that leads infant death worldwide. Humans are the unique natural reservoir for this virus. It causes severe immunosuppression favouring secondary bacteri...
  • Measles, conserved biosystem (from KEGG)
    Measles, conserved biosystemMeasles virus (MV) is highly contagious virus that leads infant death worldwide. Humans are the unique natural reservoir for this virus. It causes severe immunosuppression favouring secondary bacteri...
  • Neurotrophin signaling pathway, organism-specific biosystem (from KEGG)
    Neurotrophin signaling pathway, organism-specific biosystemNeurotrophins are a family of trophic factors involved in differentiation and survival of neural cells. The neurotrophin family consists of nerve growth factor (NGF), brain derived neurotrophic facto...
  • Neurotrophin signaling pathway, conserved biosystem (from KEGG)
    Neurotrophin signaling pathway, conserved biosystemNeurotrophins are a family of trophic factors involved in differentiation and survival of neural cells. The neurotrophin family consists of nerve growth factor (NGF), brain derived neurotrophic facto...
  • Regulation of TP53 Activity, organism-specific biosystem (from REACTOME)
    Regulation of TP53 Activity, organism-specific biosystemcomputationally inferred pathway (not manually curated)
  • Regulation of TP53 Activity through Association with Co-factors, organism-specific biosystem (from REACTOME)
    Regulation of TP53 Activity through Association with Co-factors, organism-specific biosystemcomputationally inferred pathway (not manually curated)
  • TGF-beta Receptor Signaling Pathway, organism-specific biosystem (from WikiPathways)
    TGF-beta Receptor Signaling Pathway, organism-specific biosystem
    TGF-beta Receptor Signaling Pathway
  • Transcriptional Regulation by TP53, organism-specific biosystem (from REACTOME)
    Transcriptional Regulation by TP53, organism-specific biosystemcomputationally inferred pathway (not manually curated)
  • p53 signaling pathway, organism-specific biosystem (from KEGG)
    p53 signaling pathway, organism-specific biosystemp53 activation is induced by a number of stress signals, including DNA damage, oxidative stress and activated oncogenes. The p53 protein is employed as a transcriptional activator of p53-regulated ge...
  • p53 signaling pathway, conserved biosystem (from KEGG)
    p53 signaling pathway, conserved biosystemp53 activation is induced by a number of stress signals, including DNA damage, oxidative stress and activated oncogenes. The p53 protein is employed as a transcriptional activator of p53-regulated ge...
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
RNA polymerase II core promoter proximal region sequence-specific DNA binding ISO
Inferred from Sequence Orthology
more info
 
RNA polymerase II transcription factor activity, sequence-specific DNA binding ISO
Inferred from Sequence Orthology
more info
 
chromatin binding IBA
Inferred from Biological aspect of Ancestor
more info
 
damaged DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
 
double-stranded DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
 
identical protein binding ISO
Inferred from Sequence Orthology
more info
 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
p53 binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein kinase binding ISO
Inferred from Sequence Orthology
more info
 
sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
 
sequence-specific DNA binding ISO
Inferred from Sequence Orthology
more info
 
transcription factor activity, sequence-specific DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
transcription factor activity, sequence-specific DNA binding ISO
Inferred from Sequence Orthology
more info
PubMed 
transcription factor binding ISO
Inferred from Sequence Orthology
more info
 
transcription regulatory region DNA binding ISO
Inferred from Sequence Orthology
more info
 
transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator IBA
Inferred from Biological aspect of Ancestor
more info
 
activation of MAPK activity ISO
Inferred from Sequence Orthology
more info
 
apoptotic process IEA
Inferred from Electronic Annotation
more info
 
cell cycle IEA
Inferred from Electronic Annotation
more info
 
cell cycle arrest IDA
Inferred from Direct Assay
more info
PubMed 
cellular response to DNA damage stimulus IMP
Inferred from Mutant Phenotype
more info
PubMed 
cellular response to DNA damage stimulus ISO
Inferred from Sequence Orthology
more info
 
cellular response to UV IBA
Inferred from Biological aspect of Ancestor
more info
 
cerebrospinal fluid secretion IMP
Inferred from Mutant Phenotype
more info
PubMed 
digestive tract morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
forebrain development IMP
Inferred from Mutant Phenotype
more info
PubMed 
hippocampus development IMP
Inferred from Mutant Phenotype
more info
PubMed 
inflammatory response IMP
Inferred from Mutant Phenotype
more info
PubMed 
intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator ISO
Inferred from Sequence Orthology
more info
 
mitotic G1 DNA damage checkpoint IBA
Inferred from Biological aspect of Ancestor
more info
 
negative regulation of JUN kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of cardiac muscle cell proliferation ISO
Inferred from Sequence Orthology
more info
PubMed 
negative regulation of cell proliferation ISO
Inferred from Sequence Orthology
more info
 
negative regulation of neuron apoptotic process IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of neuron apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of neuron differentiation ISO
Inferred from Sequence Orthology
more info
 
negative regulation of transcription from RNA polymerase II promoter IBA
Inferred from Biological aspect of Ancestor
more info
 
neuron development IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of apoptotic process ISO
Inferred from Sequence Orthology
more info
 
positive regulation of apoptotic signaling pathway IGI
Inferred from Genetic Interaction
more info
PubMed 
positive regulation of cell cycle arrest ISO
Inferred from Sequence Orthology
more info
 
positive regulation of cell size IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator IGI
Inferred from Genetic Interaction
more info
PubMed 
positive regulation of oligodendrocyte differentiation ISO
Inferred from Sequence Orthology
more info
 
positive regulation of transcription from RNA polymerase II promoter IBA
Inferred from Biological aspect of Ancestor
more info
 
positive regulation of transcription from RNA polymerase II promoter ISO
Inferred from Sequence Orthology
more info
 
positive regulation of transcription, DNA-templated IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of transcription, DNA-templated ISO
Inferred from Sequence Orthology
more info
PubMed 
post-embryonic development IMP
Inferred from Mutant Phenotype
more info
PubMed 
protein tetramerization IEA
Inferred from Electronic Annotation
more info
 
regulation of gene expression ISO
Inferred from Sequence Orthology
more info
PubMed 
regulation of mitotic cell cycle ISO
Inferred from Sequence Orthology
more info
PubMed 
regulation of neuron apoptotic process IGI
Inferred from Genetic Interaction
more info
PubMed 
regulation of transcription, DNA-templated IEA
Inferred from Electronic Annotation
more info
 
release of cytochrome c from mitochondria IDA
Inferred from Direct Assay
more info
PubMed 
response to X-ray IBA
Inferred from Biological aspect of Ancestor
more info
 
response to gamma radiation IBA
Inferred from Biological aspect of Ancestor
more info
 
transcription, DNA-templated IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
Golgi apparatus ISO
Inferred from Sequence Orthology
more info
 
cell junction ISO
Inferred from Sequence Orthology
more info
 
chromatin IBA
Inferred from Biological aspect of Ancestor
more info
 
chromatin ISO
Inferred from Sequence Orthology
more info
 
cytoplasm ISO
Inferred from Sequence Orthology
more info
 
cytosol IBA
Inferred from Biological aspect of Ancestor
more info
 
intracellular membrane-bounded organelle ISO
Inferred from Sequence Orthology
more info
 
nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 
nucleus ISO
Inferred from Sequence Orthology
more info
 
transcription factor complex IBA
Inferred from Biological aspect of Ancestor
more info
 

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001126330.1NP_001119802.1  tumor protein p73 isoform b

    See identical proteins and their annotated locations for NP_001119802.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) is an alternate promoter product; it lacks a few of 5' exons but has an alternate 5' exon, as compared to variant 1. The resulting isoform b, also known as DNp73alpha, has a shorter and different N-terminus, as compared to isoform a.
    Source sequence(s)
    AK014503, AK139633, Y19235
    Consensus CDS
    CCDS51397.1
    UniProtKB/Swiss-Prot
    Q9JJP2
    UniProtKB/TrEMBL
    Q9D6A3
    Related
    ENSMUSP00000114418, OTTMUSP00000011256, ENSMUST00000133533, OTTMUST00000024474
    Conserved Domains (4) summary
    cd08367
    Location:78257
    P53; P53 DNA-binding domain
    cd09571
    Location:440504
    SAM_tumor-p73; SAM domain of tumor-p73 proteins
    smart00454
    Location:444504
    SAM; Sterile alpha motif
    pfam07710
    Location:302337
    P53_tetramer; P53 tetramerization motif
  2. NM_001126331.1NP_001119803.1  tumor protein p73 isoform c

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) is an alternate promoter product; it lacks a few of 5' exons and two internal exons in the 3' region, but has an alternate 5' exon, as compared to variant 1. The resulting isoform c, also known as DNp73zeta, has a shorter and different N-terminus and lacks an internal segment in the C-terminal region, as compared to isoform a.
    Source sequence(s)
    AK014503, AK017412, AK139633
    Consensus CDS
    CCDS51396.1
    UniProtKB/Swiss-Prot
    Q9JJP2
    UniProtKB/TrEMBL
    Q9D6A3
    Related
    ENSMUSP00000095368, OTTMUSP00000053091, ENSMUST00000097762, OTTMUST00000095185
    Conserved Domains (4) summary
    cd08367
    Location:78257
    P53; P53 DNA-binding domain
    smart00454
    Location:353408
    SAM; Sterile alpha motif
    pfam07710
    Location:302337
    P53_tetramer; P53 tetramerization motif
    cl15755
    Location:353408
    SAM_superfamily; SAM (Sterile alpha motif )
  3. NM_011642.3NP_035772.2  tumor protein p73 isoform a

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes isoform a, also known as TAp73alpha.
    Source sequence(s)
    AB221594, AK014503, AL806525, Y19234
    Consensus CDS
    CCDS19009.2
    UniProtKB/Swiss-Prot
    Q9JJP2
    UniProtKB/TrEMBL
    Q9D6A3, Z4YK94
    Related
    ENSMUSP00000101269, OTTMUSP00000011255, ENSMUST00000105644, OTTMUST00000024473
    Conserved Domains (4) summary
    cd08367
    Location:126305
    P53; P53 DNA-binding domain
    cd09571
    Location:488552
    SAM_tumor-p73; SAM domain of tumor-p73 proteins
    smart00454
    Location:492552
    SAM; Sterile alpha motif
    pfam07710
    Location:350385
    P53_tetramer; P53 tetramerization motif

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 105 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p3 C57BL/6J

Genomic

  1. NC_000070.6 Reference GRCm38.p3 C57BL/6J

    Range
    154056249..154140208 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006538720.2XP_006538783.2  

    Conserved Domains (4) summary
    cd08367
    Location:137316
    P53; P53 DNA-binding domain
    cd09571
    Location:499563
    SAM_tumor-p73; SAM domain of tumor-p73 proteins
    smart00454
    Location:503563
    SAM; Sterile alpha motif
    pfam07710
    Location:361396
    P53_tetramer; P53 tetramerization motif
  2. XM_006538721.2XP_006538784.1  

    See identical proteins and their annotated locations for XP_006538784.1

    Conserved Domains (4) summary
    cd08367
    Location:56235
    P53; P53 DNA-binding domain
    cd09571
    Location:418482
    SAM_tumor-p73; SAM domain of tumor-p73 proteins
    smart00454
    Location:422482
    SAM; Sterile alpha motif
    pfam07710
    Location:280315
    P53_tetramer; P53 tetramerization motif
  3. XM_006538722.2XP_006538785.1  

    See identical proteins and their annotated locations for XP_006538785.1

    Conserved Domains (4) summary
    cd08367
    Location:56235
    P53; P53 DNA-binding domain
    cd09571
    Location:418482
    SAM_tumor-p73; SAM domain of tumor-p73 proteins
    smart00454
    Location:422482
    SAM; Sterile alpha motif
    pfam07710
    Location:280315
    P53_tetramer; P53 tetramerization motif
  4. XM_006538723.2XP_006538786.1  

    Conserved Domains (4) summary
    cd08367
    Location:4101
    P53; P53 DNA-binding domain
    cd09571
    Location:284348
    SAM_tumor-p73; SAM domain of tumor-p73 proteins
    smart00454
    Location:288348
    SAM; Sterile alpha motif
    pfam07710
    Location:146181
    P53_tetramer; P53 tetramerization motif

Alternate Mm_Celera

Genomic

  1. AC_000026.1 Alternate Mm_Celera

    Range
    156338953..156424405 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)