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FCAR Fc fragment of IgA receptor [ Homo sapiens (human) ]

Gene ID: 2204, updated on 4-May-2015
Official Symbol
FCARprovided by HGNC
Official Full Name
Fc fragment of IgA receptorprovided by HGNC
Primary source
HGNC:HGNC:3608
See related
HPRD:00914; MIM:147045
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CD89; FcalphaRI; CTB-61M7.2
Summary
This gene is a member of the immunoglobulin gene superfamily and encodes a receptor for the Fc region of IgA. The receptor is a transmembrane glycoprotein present on the surface of myeloid lineage cells such as neutrophils, monocytes, macrophages, and eosinophils, where it mediates immunologic responses to pathogens. It interacts with IgA-opsonized targets and triggers several immunologic defense processes, including phagocytosis, antibody-dependent cell-mediated cytotoxicity, and stimulation of the release of inflammatory mediators. Multiple alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Jul 2008]
Orthologs
See FCAR in MapViewer
Location:
19q13.42
Exon count:
6
Annotation release Status Assembly Chr Location
107 current GRCh38.p2 (GCF_000001405.28) 19 NC_000019.10 (54874093..54891420)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (55385549..55401839)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene killer cell immunoglobulin-like receptor, two domains, short cytoplasmic tail, 4 Neighboring gene killer cell immunoglobulin-like receptor, three domains, long cytoplasmic tail, 2 Neighboring gene natural cytotoxicity triggering receptor 1 Neighboring gene NLR family, pyrin domain containing 7 Neighboring gene ribosomal protein L36a pseudogene 50 Neighboring gene NLR family, pyrin domain containing 2

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp120 env Preincubation of monocytes with HIV-1 gp120 depresses anti-CD3 antibody-induced T cell stimulation and Fc receptor-mediated phagocytosis PubMed

Go to the HIV-1, Human Interaction Database

  • Phagosome, organism-specific biosystem (from KEGG)
    Phagosome, organism-specific biosystemPhagocytosis is the process of taking in relatively large particles by a cell, and is a central mechanism in the tissue remodeling, inflammation, and defense against infectious agents. A phagosome is...
  • Phagosome, conserved biosystem (from KEGG)
    Phagosome, conserved biosystemPhagocytosis is the process of taking in relatively large particles by a cell, and is a central mechanism in the tissue remodeling, inflammation, and defense against infectious agents. A phagosome is...
  • Staphylococcus aureus infection, organism-specific biosystem (from KEGG)
    Staphylococcus aureus infection, organism-specific biosystemStaphylococcus aureus can cause multiple forms of infections ranging from superficial skin infections to food poisoning and life-threatening infections. The organism has several ways to divert the ef...
  • Staphylococcus aureus infection, conserved biosystem (from KEGG)
    Staphylococcus aureus infection, conserved biosystemStaphylococcus aureus can cause multiple forms of infections ranging from superficial skin infections to food poisoning and life-threatening infections. The organism has several ways to divert the ef...
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
IgA binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
immune response TAS
Traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
extracellular region IEA
Inferred from Electronic Annotation
more info
 
integral component of plasma membrane TAS
Traceable Author Statement
more info
PubMed 
plasma membrane IDA
Inferred from Direct Assay
more info
 
Preferred Names
immunoglobulin alpha Fc receptor
Names
immunoglobulin alpha Fc receptor
Fc alpha receptor
Fc fragment of IgA, receptor for

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_002000.3NP_001991.1  immunoglobulin alpha Fc receptor isoform a precursor

    See identical proteins and their annotated locations for NP_001991.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1, also known as a.1) represents the longest transcript and encodes the longest isoform (a).
    Source sequence(s)
    AC245128, AK290922, BC027953
    Consensus CDS
    CCDS12907.1
    UniProtKB/Swiss-Prot
    P24071
    Conserved Domains (2) summary
    cd05711
    Location:125215
    Ig_FcalphaRI; Immunoglobulin (IG)-like domain of of FcalphaRI
    cl11960
    Location:27120
    Ig; Immunoglobulin domain
  2. NM_133269.3NP_579803.1  immunoglobulin alpha Fc receptor isoform b precursor

    See identical proteins and their annotated locations for NP_579803.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2, also known as a.2, delta66EC2, or U06) uses an alternate in-frame splice site in the 3' coding region, compared to variant 1. The encoded isoform (b) is shorter than isoform a.
    Source sequence(s)
    AC245128, AK290922, U43774
    Consensus CDS
    CCDS42622.1
    UniProtKB/TrEMBL
    A0A024R4N4
    UniProtKB/Swiss-Prot
    P24071
    Conserved Domains (1) summary
    cl11960
    Location:125197
    Ig; Immunoglobulin domain
  3. NM_133271.3NP_579805.1  immunoglobulin alpha Fc receptor isoform c precursor

    See identical proteins and their annotated locations for NP_579805.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3, also known as a.3, Rla2, deltaE2, or U08) lacks an alternate in-frame exon in the 3' coding region, compared to variant 1. The encoded isoform (c) is shorter than isoform a.
    Source sequence(s)
    AC245128, AK290922, S82919
    Consensus CDS
    CCDS12908.1
    UniProtKB/Swiss-Prot
    P24071
    Conserved Domains (1) summary
    cl11960
    Location:27120
    Ig; Immunoglobulin domain
  4. NM_133272.3NP_579806.1  immunoglobulin alpha Fc receptor isoform d

    See identical proteins and their annotated locations for NP_579806.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4, also known as deltaS2 or U11) lacks an alternate in-frame exon in the 5' coding region, compared to variant 1. The encoded isoform (d) is shorter than isoform a.
    Source sequence(s)
    AC245128, AK290922, D87855
    Consensus CDS
    CCDS12909.1
    UniProtKB/Swiss-Prot
    P24071
    Conserved Domains (2) summary
    cd05711
    Location:113203
    Ig_FcalphaRI; Immunoglobulin (IG)-like domain of of FcalphaRI
    cl11960
    Location:15108
    Ig; Immunoglobulin domain
  5. NM_133273.3NP_579807.1  immunoglobulin alpha Fc receptor isoform e

    See identical proteins and their annotated locations for NP_579807.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5, also known as U10) lacks alternate in-frame exons in the 5' and 3' coding region, compared to variant 1. The encoded isoform (e) is shorter than isoform a.
    Source sequence(s)
    AC245128, AK290922, BC027953, BX643574
    Consensus CDS
    CCDS42624.1
    UniProtKB/Swiss-Prot
    P24071
    Conserved Domains (1) summary
    cl11960
    Location:15108
    Ig; Immunoglobulin domain
  6. NM_133274.3NP_579808.1  immunoglobulin alpha Fc receptor isoform f

    See identical proteins and their annotated locations for NP_579808.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (6, also known as U09) lacks an in-frame exon in the 5' coding region and uses an alternate splice site in the 3' coding region, which results in a frameshift, compared to variant 1. The encoded isoform (f) has a distinct C-terminus and is shorter than isoform a.
    Source sequence(s)
    AC245128, AK290922, D87857
    Consensus CDS
    CCDS42625.1
    UniProtKB/Swiss-Prot
    P24071
    Conserved Domains (1) summary
    cl11960
    Location:113180
    Ig; Immunoglobulin domain
  7. NM_133277.3NP_579811.1  immunoglobulin alpha Fc receptor isoform g

    See identical proteins and their annotated locations for NP_579811.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (7, also known as deltaS2ECl or L10) lacks two in-frame exons in the 5' coding region, compared to variant 1. The encoded isoform (g) is shorter than isoform a.
    Source sequence(s)
    AC245128, AK290922, D87861
    Consensus CDS
    CCDS12910.1
    UniProtKB/Swiss-Prot
    P24071
    Conserved Domains (1) summary
    cd05711
    Location:16106
    Ig_FcalphaRI; Immunoglobulin (IG)-like domain of of FcalphaRI
  8. NM_133278.3NP_579812.1  immunoglobulin alpha Fc receptor isoform h

    See identical proteins and their annotated locations for NP_579812.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (8, also known as deltaS266Ec2 or U13) lacks an in-frame exon in the 5' coding region and uses an alternate in-frame splice site in the 3' coding region, compared to variant 1. The encoded isoform (h) is shorter than isoform a.
    Source sequence(s)
    AC245128, AK290922, X92559
    Consensus CDS
    CCDS42623.1
    UniProtKB/TrEMBL
    A0A024R4R4
    UniProtKB/Swiss-Prot
    P24071
    Conserved Domains (1) summary
    cl11960
    Location:113185
    Ig; Immunoglobulin domain

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 107

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p2 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p2 Primary Assembly

    Range
    54874093..54891420
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011526625.1XP_011524927.1  

    See identical proteins and their annotated locations for XP_011524927.1

    Conserved Domains (2) summary
    cd05711
    Location:98188
    Ig_FcalphaRI; Immunoglobulin (IG)-like domain of of FcalphaRI
    cl11960
    Location:293
    Ig; Immunoglobulin domain
  2. XM_011526626.1XP_011524928.1  

    See identical proteins and their annotated locations for XP_011524928.1

    Conserved Domains (2) summary
    cd05711
    Location:98188
    Ig_FcalphaRI; Immunoglobulin (IG)-like domain of of FcalphaRI
    cl11960
    Location:293
    Ig; Immunoglobulin domain

Reference GRCh38.p2 ALT_REF_LOCI_2

Genomic

  1. NW_003571055.2 Reference GRCh38.p2 ALT_REF_LOCI_2

    Range
    519361..536649
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011547519.1XP_011545821.1  

    See identical proteins and their annotated locations for XP_011545821.1

    Conserved Domains (1) summary
    cd05711
    Location:28118
    Ig_FcalphaRI; Immunoglobulin (IG)-like domain of of FcalphaRI
  2. XM_011547517.1XP_011545819.1  

    See identical proteins and their annotated locations for XP_011545819.1

    Conserved Domains (2) summary
    cd05711
    Location:98188
    Ig_FcalphaRI; Immunoglobulin (IG)-like domain of of FcalphaRI
    cl11960
    Location:293
    Ig; Immunoglobulin domain
  3. XM_011547518.1XP_011545820.1  

    See identical proteins and their annotated locations for XP_011545820.1

    Conserved Domains (2) summary
    cd05711
    Location:98188
    Ig_FcalphaRI; Immunoglobulin (IG)-like domain of of FcalphaRI
    cl11960
    Location:293
    Ig; Immunoglobulin domain

Reference GRCh38.p2 ALT_REF_LOCI_7

Genomic

  1. NW_003571060.1 Reference GRCh38.p2 ALT_REF_LOCI_7

    Range
    778468..795785
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011548553.1XP_011546855.1  

    See identical proteins and their annotated locations for XP_011546855.1

    Conserved Domains (2) summary
    cd05711
    Location:98188
    Ig_FcalphaRI; Immunoglobulin (IG)-like domain of of FcalphaRI
    cl11960
    Location:293
    Ig; Immunoglobulin domain
  2. XM_011548554.1XP_011546856.1  

    See identical proteins and their annotated locations for XP_011546856.1

    Conserved Domains (2) summary
    cd05711
    Location:98188
    Ig_FcalphaRI; Immunoglobulin (IG)-like domain of of FcalphaRI
    cl11960
    Location:293
    Ig; Immunoglobulin domain

Reference GRCh38.p2 ALT_REF_LOCI_9

Genomic

  1. NT_187693.1 Reference GRCh38.p2 ALT_REF_LOCI_9

    Range
    856663..873900
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011548699.1XP_011547001.1  

    See identical proteins and their annotated locations for XP_011547001.1

    Conserved Domains (1) summary
    cd05711
    Location:28118
    Ig_FcalphaRI; Immunoglobulin (IG)-like domain of of FcalphaRI
  2. XM_011548697.1XP_011546999.1  

    See identical proteins and their annotated locations for XP_011546999.1

    Conserved Domains (2) summary
    cd05711
    Location:98188
    Ig_FcalphaRI; Immunoglobulin (IG)-like domain of of FcalphaRI
    cl11960
    Location:293
    Ig; Immunoglobulin domain
  3. XM_011548698.1XP_011547000.1  

    See identical proteins and their annotated locations for XP_011547000.1

    Conserved Domains (2) summary
    cd05711
    Location:98188
    Ig_FcalphaRI; Immunoglobulin (IG)-like domain of of FcalphaRI
    cl11960
    Location:293
    Ig; Immunoglobulin domain

Reference GRCh38.p2 ALT_REF_LOCI_10

Genomic

  1. NT_187636.1 Reference GRCh38.p2 ALT_REF_LOCI_10

    Range
    152..1425
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p2 ALT_REF_LOCI_23

Genomic

  1. NT_187671.1 Reference GRCh38.p2 ALT_REF_LOCI_23

    Range
    153040..170367
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011547554.1XP_011545856.1  

    See identical proteins and their annotated locations for XP_011545856.1

    Conserved Domains (2) summary
    cd05711
    Location:98188
    Ig_FcalphaRI; Immunoglobulin (IG)-like domain of of FcalphaRI
    cl11960
    Location:293
    Ig; Immunoglobulin domain
  2. XM_011547555.1XP_011545857.1  

    See identical proteins and their annotated locations for XP_011545857.1

    Conserved Domains (2) summary
    cd05711
    Location:98188
    Ig_FcalphaRI; Immunoglobulin (IG)-like domain of of FcalphaRI
    cl11960
    Location:293
    Ig; Immunoglobulin domain

Reference GRCh38.p2 ALT_REF_LOCI_26

Genomic

  1. NT_187674.1 Reference GRCh38.p2 ALT_REF_LOCI_26

    Range
    160113..177440
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011547562.1XP_011545864.1  

    See identical proteins and their annotated locations for XP_011545864.1

    Conserved Domains (2) summary
    cd05711
    Location:98188
    Ig_FcalphaRI; Immunoglobulin (IG)-like domain of of FcalphaRI
    cl11960
    Location:293
    Ig; Immunoglobulin domain
  2. XM_011547563.1XP_011545865.1  

    See identical proteins and their annotated locations for XP_011545865.1

    Conserved Domains (2) summary
    cd05711
    Location:98188
    Ig_FcalphaRI; Immunoglobulin (IG)-like domain of of FcalphaRI
    cl11960
    Location:293
    Ig; Immunoglobulin domain

Reference GRCh38.p2 ALT_REF_LOCI_27

Genomic

  1. NT_187675.1 Reference GRCh38.p2 ALT_REF_LOCI_27

    Range
    244332..261659
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011547566.1XP_011545868.1  

    See identical proteins and their annotated locations for XP_011545868.1

    Conserved Domains (2) summary
    cd05711
    Location:98188
    Ig_FcalphaRI; Immunoglobulin (IG)-like domain of of FcalphaRI
    cl11960
    Location:293
    Ig; Immunoglobulin domain
  2. XM_011547567.1XP_011545869.1  

    See identical proteins and their annotated locations for XP_011545869.1

    Conserved Domains (2) summary
    cd05711
    Location:98188
    Ig_FcalphaRI; Immunoglobulin (IG)-like domain of of FcalphaRI
    cl11960
    Location:293
    Ig; Immunoglobulin domain

Reference GRCh38.p2 ALT_REF_LOCI_28

Genomic

  1. NT_187676.1 Reference GRCh38.p2 ALT_REF_LOCI_28

    Range
    150043..167370
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011547573.1XP_011545875.1  

    See identical proteins and their annotated locations for XP_011545875.1

    Conserved Domains (2) summary
    cd05711
    Location:98188
    Ig_FcalphaRI; Immunoglobulin (IG)-like domain of of FcalphaRI
    cl11960
    Location:293
    Ig; Immunoglobulin domain
  2. XM_011547574.1XP_011545876.1  

    See identical proteins and their annotated locations for XP_011545876.1

    Conserved Domains (2) summary
    cd05711
    Location:98188
    Ig_FcalphaRI; Immunoglobulin (IG)-like domain of of FcalphaRI
    cl11960
    Location:293
    Ig; Immunoglobulin domain

Reference GRCh38.p2 ALT_REF_LOCI_29

Genomic

  1. NT_187677.1 Reference GRCh38.p2 ALT_REF_LOCI_29

    Range
    151460..168787
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011547578.1XP_011545880.1  

    See identical proteins and their annotated locations for XP_011545880.1

    Conserved Domains (2) summary
    cd05711
    Location:98188
    Ig_FcalphaRI; Immunoglobulin (IG)-like domain of of FcalphaRI
    cl11960
    Location:293
    Ig; Immunoglobulin domain
  2. XM_011547579.1XP_011545881.1  

    See identical proteins and their annotated locations for XP_011545881.1

    Conserved Domains (2) summary
    cd05711
    Location:98188
    Ig_FcalphaRI; Immunoglobulin (IG)-like domain of of FcalphaRI
    cl11960
    Location:293
    Ig; Immunoglobulin domain

Reference GRCh38.p2 ALT_REF_LOCI_30

Genomic

  1. NT_187683.1 Reference GRCh38.p2 ALT_REF_LOCI_30

    Range
    148311..165638
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011547803.1XP_011546105.1  

    See identical proteins and their annotated locations for XP_011546105.1

    Conserved Domains (2) summary
    cd05711
    Location:98188
    Ig_FcalphaRI; Immunoglobulin (IG)-like domain of of FcalphaRI
    cl11960
    Location:293
    Ig; Immunoglobulin domain
  2. XM_011547804.1XP_011546106.1  

    See identical proteins and their annotated locations for XP_011546106.1

    Conserved Domains (2) summary
    cd05711
    Location:98188
    Ig_FcalphaRI; Immunoglobulin (IG)-like domain of of FcalphaRI
    cl11960
    Location:293
    Ig; Immunoglobulin domain

Alternate CHM1_1.1

Genomic

  1. NC_018930.2 Alternate CHM1_1.1

    Range
    55379113..55396440
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_133279.2: Suppressed sequence

    Description
    NM_133279.2: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.
  2. NM_133280.1: Suppressed sequence

    Description
    NM_133280.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.