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FCAR Fc fragment of IgA, receptor for [ Homo sapiens (human) ]

Gene ID: 2204, updated on 17-Apr-2014
Official Symbol
FCARprovided by HGNC
Official Full Name
Fc fragment of IgA, receptor forprovided by HGNC
Primary source
HGNC:3608
Locus tag
XXbac-BCX195L8.9
See related
Ensembl:ENSG00000186431; HPRD:00914; MIM:147045; Vega:OTTHUMG00000065936
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CD89
Summary
This gene is a member of the immunoglobulin gene superfamily and encodes a receptor for the Fc region of IgA. The receptor is a transmembrane glycoprotein present on the surface of myeloid lineage cells such as neutrophils, monocytes, macrophages, and eosinophils, where it mediates immunologic responses to pathogens. It interacts with IgA-opsonized targets and triggers several immunologic defense processes, including phagocytosis, antibody-dependent cell-mediated cytotoxicity, and stimulation of the release of inflammatory mediators. Multiple alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Jul 2008]
Location :
19q13.42
Sequence :
Chromosome: 19; NC_000019.10 (54874093..54890473)
See FCAR in Epigenomics, MapViewer

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene killer cell immunoglobulin-like receptor, two domains, short cytoplasmic tail, 4 Neighboring gene killer cell immunoglobulin-like receptor, three domains, long cytoplasmic tail, 2 Neighboring gene natural cytotoxicity triggering receptor 1 Neighboring gene NLR family, pyrin domain containing 7

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp120 env Preincubation of monocytes with HIV-1 gp120 depresses anti-CD3 antibody-induced T cell stimulation and Fc receptor-mediated phagocytosis PubMed

Go to the HIV-1, Human Protein Interaction Database

  • Phagosome, organism-specific biosystem (from KEGG)
    Phagosome, organism-specific biosystemPhagocytosis is the process of taking in relatively large particles by a cell, and is a central mechanism in the tissue remodeling, inflammation, and defense against infectious agents. A phagosome is...
  • Phagosome, conserved biosystem (from KEGG)
    Phagosome, conserved biosystemPhagocytosis is the process of taking in relatively large particles by a cell, and is a central mechanism in the tissue remodeling, inflammation, and defense against infectious agents. A phagosome is...
  • Staphylococcus aureus infection, organism-specific biosystem (from KEGG)
    Staphylococcus aureus infection, organism-specific biosystemStaphylococcus aureus can cause multiple forms of infections ranging from superficial skin infections to food poisoning and life-threatening infections. The organism has several ways to divert the ef...
  • Staphylococcus aureus infection, conserved biosystem (from KEGG)
    Staphylococcus aureus infection, conserved biosystemStaphylococcus aureus can cause multiple forms of infections ranging from superficial skin infections to food poisoning and life-threatening infections. The organism has several ways to divert the ef...
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
IgA binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
immune response TAS
Traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
extracellular region IEA
Inferred from Electronic Annotation
more info
 
integral component of plasma membrane TAS
Traceable Author Statement
more info
PubMed 
Preferred Names
immunoglobulin alpha Fc receptor
Names
immunoglobulin alpha Fc receptor
IgA Fc receptor
Fc alpha receptor

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_002000.2NP_001991.1  immunoglobulin alpha Fc receptor isoform a precursor

    See proteins identical to NP_001991.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1), also called deltaS3 and CD89, contains exons S1, S2, EC1, EC2, and TM/C and encodes isoform a.
    Source sequence(s)
    AC011501, X54150
    Consensus CDS
    CCDS12907.1
    UniProtKB/Swiss-Prot
    P24071
    Related
    ENSP00000347714, OTTHUMP00000068691, ENST00000355524, OTTHUMT00000141243
    Conserved Domains (2) summary
    cd05711
    Location:125215
    Blast Score: 372
    Ig_FcalphaRI; Immunoglobulin (IG)-like domain of of FcalphaRI
    cl11960
    Location:27120
    Blast Score: 142
    Ig; Immunoglobulin domain
  2. NM_133269.2NP_579803.1  immunoglobulin alpha Fc receptor isoform b precursor

    See proteins identical to NP_579803.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2), also called deltaS366EC2, CD89delta66EC2, and FcalphaRa.2, lacks the last 66 nt of exon EC2 as compared to variant 1. As a result, variant 2 encodes isoform b, which has the same N- and C-termini but which lacks 22 aa as compared to isoform a encoded by variant 1.
    Source sequence(s)
    AC011501, D87853
    Consensus CDS
    CCDS42622.1
    UniProtKB/Swiss-Prot
    P24071
    Conserved Domains (1) summary
    cl11960
    Location:125197
    Blast Score: 272
    Ig; Immunoglobulin domain
  3. NM_133271.2NP_579805.1  immunoglobulin alpha Fc receptor isoform c precursor

    See proteins identical to NP_579805.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3), also called deltaS3EC2, CD89deltaEC2, FcalphaRa.3, and FcalphaRla2 variant, lacks exon EC2 as compared to variant 1. As a result, variant 3 encodes isoform c, which has the same N- and C-termini but which lacks 96 aa as compared to isoform a encoded by variant 1.
    Source sequence(s)
    AC011501, D87854
    Consensus CDS
    CCDS12908.1
    UniProtKB/Swiss-Prot
    P24071
    Conserved Domains (1) summary
    cl11960
    Location:27120
    Blast Score: 143
    Ig; Immunoglobulin domain
  4. NM_133272.2NP_579806.1  immunoglobulin alpha Fc receptor isoform d

    See proteins identical to NP_579806.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4), also called deltaS2S3 and CD89deltaS2, lacks exon S2 as compared to variant 1. As a result, variant 4 encodes isoform d, which has the same N- and C-termini but which lacks 12 aa as compared to isoform a encoded by variant 1.
    Source sequence(s)
    AC011501, D87855
    Consensus CDS
    CCDS12909.1
    UniProtKB/Swiss-Prot
    P24071
    Conserved Domains (2) summary
    cd05711
    Location:113203
    Blast Score: 371
    Ig_FcalphaRI; Immunoglobulin (IG)-like domain of of FcalphaRI
    cl11960
    Location:15108
    Blast Score: 142
    Ig; Immunoglobulin domain
  5. NM_133273.2NP_579807.1  immunoglobulin alpha Fc receptor isoform e

    See proteins identical to NP_579807.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5), also called deltaS2S3EC2, lacks exons S2 and EC2 as compared to variant 1. As a result, variant 5 encodes isoform e, which has the same N- and C-termini but which lacks regions of 12 and 96 aa as compared to isoform a encoded by variant 1.
    Source sequence(s)
    AC011501, D87856
    Consensus CDS
    CCDS42624.1
    UniProtKB/Swiss-Prot
    P24071
    Conserved Domains (1) summary
    cl11960
    Location:15108
    Blast Score: 143
    Ig; Immunoglobulin domain
  6. NM_133274.2NP_579808.1  immunoglobulin alpha Fc receptor isoform f

    See proteins identical to NP_579808.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (6), also called deltaS2S374EC2, lacks exon S2 and the last 74 nt of exon EC2 as compared to variant 1. As a result, variant 6 encodes isoform f, which has the same N-terminus but different C-terminus and which lacks an internal 12 aa region as compared to isoform a encoded by variant 1.
    Source sequence(s)
    AC011501, D87857
    Consensus CDS
    CCDS42625.1
    UniProtKB/Swiss-Prot
    P24071
    Conserved Domains (1) summary
    cl11960
    Location:113180
    Blast Score: 242
    Ig; Immunoglobulin domain
  7. NM_133277.2NP_579811.1  immunoglobulin alpha Fc receptor isoform g

    See proteins identical to NP_579811.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (7), also called deltaS2S3EC1 and CD89deltaS2EC1, lacks exons S2 and EC1 as compared to variant 1. As a result, variant 7 encodes isoform g, which has the same N- and C-termini but which lacks a 109 aa region as compared to isoform a encoded by variant 1.
    Source sequence(s)
    AC011501, D87861
    Consensus CDS
    CCDS12910.1
    UniProtKB/Swiss-Prot
    P24071
    Conserved Domains (1) summary
    cd05711
    Location:16106
    Blast Score: 363
    Ig_FcalphaRI; Immunoglobulin (IG)-like domain of of FcalphaRI
  8. NM_133278.2NP_579812.1  immunoglobulin alpha Fc receptor isoform h

    See proteins identical to NP_579812.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (8), also called deltaS2S366EC2 and CD89deltaS266EC2, lacks exon S2 and the last 66 nt of exon EC2 as compared to variant 1. As a result, variant 8 encodes isoform h, which has the same N- and C-termini but which lacks regions of 12 and 22 aa as compared to isoform a encoded by variant 1.
    Source sequence(s)
    AC011501, D87862
    Consensus CDS
    CCDS42623.1
    UniProtKB/Swiss-Prot
    P24071
    Conserved Domains (1) summary
    cl11960
    Location:113185
    Blast Score: 270
    Ig; Immunoglobulin domain
  9. NM_133279.2NP_579813.1  immunoglobulin alpha Fc receptor isoform i precursor

    See proteins identical to NP_579813.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (9), also called alpha receptor b, lacks exon TM/C but contains 783 nt of sequence after exon EC2 that is present in the intron between exons EC2 and TM/C of variant 1. As a result, variant 9 encodes isoform i, which has the same N-terminus but a different C-terminus than isoform a encoded by variant 1.
    Source sequence(s)
    AC011501, CV029531, U56236
    Consensus CDS
    CCDS46180.1
    UniProtKB/Swiss-Prot
    P24071
    Related
    ENSP00000473814, OTTHUMP00000273172, ENST00000469767, OTTHUMT00000141248
    Conserved Domains (2) summary
    cd05711
    Location:125215
    Blast Score: 368
    Ig_FcalphaRI; Immunoglobulin (IG)-like domain of of FcalphaRI
    cl11960
    Location:27120
    Blast Score: 139
    Ig; Immunoglobulin domain

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 106

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38 ALT_REF_LOCI_10

Genomic

  1. NT_187636.1 Reference GRCh38 ALT_REF_LOCI_10

    Range
    152..1425, complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38 ALT_REF_LOCI_15

Genomic

  1. NT_187641.1 Reference GRCh38 ALT_REF_LOCI_15

    Range
    1474..7099, complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38 ALT_REF_LOCI_2

Genomic

  1. NW_003571055.2 Reference GRCh38 ALT_REF_LOCI_2

    Range
    519361..535702
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38 ALT_REF_LOCI_23

Genomic

  1. NT_187671.1 Reference GRCh38 ALT_REF_LOCI_23

    Range
    153040..169420
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38 ALT_REF_LOCI_26

Genomic

  1. NT_187674.1 Reference GRCh38 ALT_REF_LOCI_26

    Range
    160113..176493
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38 ALT_REF_LOCI_27

Genomic

  1. NT_187675.1 Reference GRCh38 ALT_REF_LOCI_27

    Range
    244332..260712
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38 ALT_REF_LOCI_28

Genomic

  1. NT_187676.1 Reference GRCh38 ALT_REF_LOCI_28

    Range
    150043..166423
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38 ALT_REF_LOCI_29

Genomic

  1. NT_187677.1 Reference GRCh38 ALT_REF_LOCI_29

    Range
    151460..167840
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38 ALT_REF_LOCI_30

Genomic

  1. NT_187683.1 Reference GRCh38 ALT_REF_LOCI_30

    Range
    148311..164691
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38 ALT_REF_LOCI_7

Genomic

  1. NW_003571060.1 Reference GRCh38 ALT_REF_LOCI_7

    Range
    778468..794838
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38 ALT_REF_LOCI_9

Genomic

  1. NT_187693.1 Reference GRCh38 ALT_REF_LOCI_9

    Range
    856663..872953
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38 Primary Assembly

    Range
    54874093..54890473
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate HuRef

Genomic

  1. AC_000151.1 Alternate HuRef

    Range
    51708188..51724488
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate CHM1_1.1

Genomic

  1. NC_018930.2 Alternate CHM1_1.1

    Range
    55379113..55395493
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_133280.1: Suppressed sequence

    Description
    NM_133280.1: This RefSeq was temporarily suppressed because currently there are not sufficient data to support this transcript and the transcript is a nonsense-mediated mRNA decay (NMD) candidate.

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