DOK6 docking protein 6 [Homo sapiens] - Gene

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Summary

Official Symbol: DOK6provided by HGNC
Official Full Name: docking protein 6provided by HGNC
Primary source: HGNC:28301
See related: Ensembl:ENSG00000206052; HPRD:13244; MIM:611402
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: DOK5L; HsT3226; MGC20785
Summary: DOK6 is a member of the DOK (see DOK1; MIM 602919) family of intracellular adaptors that play a role in the RET (MIM 164761) signaling cascade (Crowder et al., 2004 [PubMed 15286081]).[supplied by OMIM, Mar 2008]

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Genomic context

Location :: 18q22.2

Sequence :: Chromosome: 18; NC_000018.9 (67068284..67516323)

See DOK6 in Epigenomics, MapViewer

Chromosome 18 - NC_000018.9 Genomic Context describing neighboring genes

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Genomic regions, transcripts, and products

Genomic Sequence

Go to nucleotideGraphics FASTA GenBank

Go to reference sequence details

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Bibliography

GeneRIFs: Gene References Into Functions What's a GeneRIF?

DOK-6 is involved in RET signaling with less influence when compared with DOK-1, DOK-4, and SHC.
Title: Analysis of DOK-6 function in downstream signaling of RET in human neuroblastoma cells.
Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)
Title: Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
Dok-6 binds to the phosphorylated Ret Tyr(1062) residue resulting in phosphorylation of tyrosine residue(s) located within the unique C terminus of Dok-6 predominantly through a Src-dependent mechanism
Title: Dok-6, a Novel p62 Dok family member, promotes Ret-mediated neurite outgrowth.

Submit: New GeneRIF Correction

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Phenotypes

Review eQTL and phenotype association data in this region using PheGenI

An integration of genome-wide association study and gene expression profiling to prioritize the discovery of novel susceptibility Loci for osteoporosis-related traits.

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description
Q6PKX4	P07949	RET		HPRD	PubMed
BioGRID:128636	BioGRID:111911	RET		BioGRID	PubMed	Affinity Capture-Western

Function	Evidence Code	Pubs
insulin receptor binding	IEA Inferred from Electronic Annotation more info

General protein information

Preferred Names: docking protein 6

Names: docking protein 6; downstream of tyrosine kinase 6

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NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_152721.5 → NP_689934.2 docking protein 6

Status: VALIDATED

Source sequence(s)

AC090231, AY599248, BC008583, BC019045, BX280184, DB480182

Consensus CDS

CCDS32841.1

UniProtKB/Swiss-Prot

Q6PKX4

Related

ENSP00000372160, ENST00000382713

Conserved Domains (2) summary

cd00821
Location:10 – 109
Blast Score: 109

PH; Pleckstrin homology (PH) domain

cd00824
Location:131 – 237
Blast Score: 310

PTBI; IRS-like phosphotyrosine-binding domain

RefSeqs of Annotated Genomes: Build 37.3

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh37.p5 Primary Assembly

Genomic

NC_000018.9 Reference GRCh37.p5 Primary Assembly

Range

67068284..67516323

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Alternate HuRef

Genomic

AC_000150.1 Alternate HuRef

Range

63951465..64234898

Download

GenBank, FASTA, Sequence Viewer (Graphics)

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Related Sequences

Nucleotide		Protein
Heading	Accession and Version	Protein
genomic	AC026585.9 (121392..172797)	None
genomic	AC068254.6	None
genomic	AC090231.7 (42544..168393)	None
genomic	AC119868.2	None
genomic	CH471117.1	EAW66514.1
mRNA	AK057795.1	BAB71577.1
mRNA	AL512695.1	None
mRNA	AY599248.1	AAT09770.1
mRNA	BC008583.1	AAH08583.3
mRNA	BC019045.2	AAH19045.2
mRNA	BC096744.1	AAH96744.1
mRNA	BX280184.1	None
mRNA	DB480182.1	None