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Tpm1 tropomyosin 1, alpha [ Mus musculus (house mouse) ]

Gene ID: 22003, updated on 21-Feb-2015
Official Symbol
Tpm1provided by MGI
Official Full Name
tropomyosin 1, alphaprovided by MGI
Primary source
MGI:MGI:98809
See related
Ensembl:ENSMUSG00000032366; Vega:OTTMUSG00000020411
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
TM2; Tm3; Tmpa; Tpm-1; AA986836; AI854628; alpha-TM
Orthologs
See Tpm1 in MapViewer
Location:
9 C; 9 36.27 cM
Exon count:
15
Annotation release Status Assembly Chr Location
105 current GRCm38.p3 (GCF_000001635.23) 9 NC_000075.6 (67022590..67049401, complement)

Chromosome 9 - NC_000075.6Genomic Context describing neighboring genes Neighboring gene ribosomal protein S27-like Neighboring gene lactamase, beta Neighboring gene predicted gene, 30639 Neighboring gene uncharacterized LOC102632690 Neighboring gene predicted gene, 19299 Neighboring gene uncharacterized LOC105245015

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

  • Adrenergic signaling in cardiomyocytes, organism-specific biosystem (from KEGG)
    Adrenergic signaling in cardiomyocytes, organism-specific biosystemCardiac myocytes express at least six subtypes of adrenergic receptor (AR) which include three subtypes of beta-AR (beta-1, beta-2, beta-3) and three subtypes of the alpha-1-AR (alpha-1A, alpha-1B, a...
  • Adrenergic signaling in cardiomyocytes, conserved biosystem (from KEGG)
    Adrenergic signaling in cardiomyocytes, conserved biosystemCardiac myocytes express at least six subtypes of adrenergic receptor (AR) which include three subtypes of beta-AR (beta-1, beta-2, beta-3) and three subtypes of the alpha-1-AR (alpha-1A, alpha-1B, a...
  • Cardiac muscle contraction, organism-specific biosystem (from KEGG)
    Cardiac muscle contraction, organism-specific biosystemContraction of the heart is a complex process initiated by the electrical excitation of cardiac myocytes (excitation-contraction coupling, ECC). In cardiac myocytes, Ca2+ influx induced by activation...
  • Cardiac muscle contraction, conserved biosystem (from KEGG)
    Cardiac muscle contraction, conserved biosystemContraction of the heart is a complex process initiated by the electrical excitation of cardiac myocytes (excitation-contraction coupling, ECC). In cardiac myocytes, Ca2+ influx induced by activation...
  • Dilated cardiomyopathy, organism-specific biosystem (from KEGG)
    Dilated cardiomyopathy, organism-specific biosystemDilated cardiomyopathy (DCM) is a heart muscle disease characterised by dilation and impaired contraction of the left or both ventricles that results in progressive heart failure and sudden cardiac d...
  • Dilated cardiomyopathy, conserved biosystem (from KEGG)
    Dilated cardiomyopathy, conserved biosystemDilated cardiomyopathy (DCM) is a heart muscle disease characterised by dilation and impaired contraction of the left or both ventricles that results in progressive heart failure and sudden cardiac d...
  • Hypertrophic cardiomyopathy (HCM), organism-specific biosystem (from KEGG)
    Hypertrophic cardiomyopathy (HCM), organism-specific biosystemHypertrophic cardiomyopathy (HCM) is a primary myocardial disorder with an autosomal dominant pattern of inheritance that is characterized by hypertrophy of the left ventricles with histological feat...
  • Hypertrophic cardiomyopathy (HCM), conserved biosystem (from KEGG)
    Hypertrophic cardiomyopathy (HCM), conserved biosystemHypertrophic cardiomyopathy (HCM) is a primary myocardial disorder with an autosomal dominant pattern of inheritance that is characterized by hypertrophy of the left ventricles with histological feat...
  • MicroRNAs in cancer, organism-specific biosystem (from KEGG)
    MicroRNAs in cancer, organism-specific biosystemMicroRNA (miRNA) is a cluster of small non-encoding RNA molecules of 21 - 23 nucleotides in length, which controls gene expression post-transcriptionally either via the degradation of target mRNAs or...
  • MicroRNAs in cancer, conserved biosystem (from KEGG)
    MicroRNAs in cancer, conserved biosystemMicroRNA (miRNA) is a cluster of small non-encoding RNA molecules of 21 - 23 nucleotides in length, which controls gene expression post-transcriptionally either via the degradation of target mRNAs or...
  • Muscle contraction, organism-specific biosystem (from REACTOME)
    Muscle contraction, organism-specific biosystemcomputationally inferred pathway (not manually curated)
  • Smooth Muscle Contraction, organism-specific biosystem (from REACTOME)
    Smooth Muscle Contraction, organism-specific biosystemcomputationally inferred pathway (not manually curated)
  • Striated Muscle Contraction, organism-specific biosystem (from REACTOME)
    Striated Muscle Contraction, organism-specific biosystemcomputationally inferred pathway (not manually curated)
  • Striated Muscle Contraction, organism-specific biosystem (from WikiPathways)
    Striated Muscle Contraction, organism-specific biosystem
    Striated Muscle Contraction
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
actin binding ISO
Inferred from Sequence Orthology
more info
 
actin filament binding ISO
Inferred from Sequence Orthology
more info
 
protein N-terminus binding ISO
Inferred from Sequence Orthology
more info
 
protein homodimerization activity ISO
Inferred from Sequence Orthology
more info
 
structural constituent of cytoskeleton TAS
Traceable Author Statement
more info
PubMed 
Process Evidence Code Pubs
actin filament capping ISO
Inferred from Sequence Orthology
more info
 
cardiac muscle contraction IMP
Inferred from Mutant Phenotype
more info
PubMed 
cardiac muscle contraction ISO
Inferred from Sequence Orthology
more info
 
embryo development IMP
Inferred from Mutant Phenotype
more info
PubMed 
in utero embryonic development IMP
Inferred from Mutant Phenotype
more info
PubMed 
muscle filament sliding ISO
Inferred from Sequence Orthology
more info
 
negative regulation of cell migration ISO
Inferred from Sequence Orthology
more info
 
positive regulation of ATPase activity ISO
Inferred from Sequence Orthology
more info
 
positive regulation of cell adhesion ISO
Inferred from Sequence Orthology
more info
 
positive regulation of heart rate by epinephrine IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of stress fiber assembly ISO
Inferred from Sequence Orthology
more info
 
regulation of ATPase activity ISO
Inferred from Sequence Orthology
more info
 
ruffle organization ISO
Inferred from Sequence Orthology
more info
 
ventricular cardiac muscle tissue morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
wound healing ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
cytoskeleton IEA
Inferred from Electronic Annotation
more info
 
colocalizes_with filamentous actin IDA
Inferred from Direct Assay
more info
PubMed 
muscle thin filament tropomyosin TAS
Traceable Author Statement
more info
PubMed 
myofibril IDA
Inferred from Direct Assay
more info
PubMed 
protein complex ISO
Inferred from Sequence Orthology
more info
 
Preferred Names
tropomyosin alpha-1 chain
Names
tropomyosin alpha-1 chain
alpha tropomyosin
alpha-tropomyosin
tropomyosin-1

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001164248.1NP_001157720.1  tropomyosin alpha-1 chain isoform Tpm1.1st

    See proteins identical to NP_001157720.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (Tpm1.1, also known as variant 1) differs in the 3' UTR and coding sequence compared to variant Tpm1.6. The encoded isoform (Tpm1.1st) is the same length, but has an alternate C-terminus, compared to isoform Tpm1.6cy.
    Source sequence(s)
    AC166370
    Consensus CDS
    CCDS52845.1
    UniProtKB/Swiss-Prot
    P58771
    UniProtKB/TrEMBL
    Q545Y3
    Related
    ENSMUSP00000109315, OTTMUSP00000022207, ENSMUST00000113685, OTTMUST00000048448
    Conserved Domains (2) summary
    pfam00261
    Location:48284
    Tropomyosin; Tropomyosin
    pfam12718
    Location:7153
    Tropomyosin_1; Tropomyosin like
  2. NM_001164249.1NP_001157721.1  tropomyosin alpha-1 chain isoform Tpm1.2st

    See proteins identical to NP_001157721.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (Tpm1.2, also known as variant 2) lacks an in-frame exon and has an alternate in-frame exon compared to variant Tpm1.6. The encoded isoform (Tpm1.2st) is the same length but has a short region of sequence differences, compared to isoform Tpm1.6cy.
    Source sequence(s)
    AC166370
    Consensus CDS
    CCDS52848.1
    UniProtKB/TrEMBL
    B7ZNL3
    Related
    ENSMUSP00000109335, OTTMUSP00000022210, ENSMUST00000113705, OTTMUST00000048452
    Conserved Domains (2) summary
    pfam00261
    Location:48284
    Tropomyosin; Tropomyosin
    pfam12718
    Location:7153
    Tropomyosin_1; Tropomyosin like
  3. NM_001164250.1NP_001157722.1  tropomyosin alpha-1 chain isoform Tpm1.7cy

    See proteins identical to NP_001157722.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (Tpm1.7, also known as variant 4) lacks an exon and contains another alternate exon compared to variant Tpm1.6. The encoded isoform (Tpm1.7cy) is the same length but has short regions of sequence differences and an alternate C-terminus, compared to isoform Tpm1.6cy.
    Source sequence(s)
    AC166370
    Consensus CDS
    CCDS52846.1
    UniProtKB/TrEMBL
    E9Q450
    Related
    ENSMUSP00000109327, OTTMUSP00000022209, ENSMUST00000113697, OTTMUST00000048451
    Conserved Domains (2) summary
    pfam00261
    Location:48284
    Tropomyosin; Tropomyosin
    pfam12718
    Location:7153
    Tropomyosin_1; Tropomyosin like
  4. NM_001164251.1NP_001157723.1  tropomyosin alpha-1 chain isoform Tpm1.5cy

    See proteins identical to NP_001157723.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (Tpm1.5, also known as variant 5) differs in the 3' UTR and coding sequence, lacks internal exon, and contains another alternate internal exon compared to variant Tpm1.6. The encoded isoform (Tpm1.5cy) is the same length but has short regions of sequence differences, compared to isoform Tpm1.6cy.
    Source sequence(s)
    AC166370
    Consensus CDS
    CCDS52847.1
    UniProtKB/TrEMBL
    Q8BP43
    Related
    ENSMUSP00000051888, OTTMUSP00000022208, ENSMUST00000050905, OTTMUST00000048449
    Conserved Domains (2) summary
    pfam00261
    Location:48284
    Tropomyosin; Tropomyosin
    pfam12718
    Location:7153
    Tropomyosin_1; Tropomyosin like
  5. NM_001164252.1NP_001157724.1  tropomyosin alpha-1 chain isoform Tpm1.8cy

    See proteins identical to NP_001157724.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (Tpm1.8, also known as variant 6) differs in the 5' UTR and coding sequence compared to variant Tpm1.6. The encoded isoform (Tpm1.8cy) has an alternate N-terminus compared to isoform Tpm1.6cy.
    Source sequence(s)
    AC166370
    Consensus CDS
    CCDS52841.1
    UniProtKB/TrEMBL
    G5E8R1
    Related
    ENSMUSP00000109325, OTTMUSP00000022218, ENSMUST00000113695, OTTMUST00000048461
    Conserved Domains (2) summary
    pfam00261
    Location:12248
    Tropomyosin; Tropomyosin
    cl19113
    Location:12117
    ApoLp-III_like; Apolipophorin-III and similar insect proteins
  6. NM_001164253.1NP_001157725.1  tropomyosin alpha-1 chain isoform Tpm1.9cy

    See proteins identical to NP_001157725.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (Tpm1.9, also known as variant 7) differs in the 5' UTR and coding sequence, lacks an alternate internal exon, and contains another alternate internal exon compared to variant Tpm1.6. The encoded isoform (Tpm1.9cy) has an alternate N-terminus, has a short internal region of sequence differences and is shorter, compared to isoform Tpm1.6cy.
    Source sequence(s)
    AC166370
    Consensus CDS
    CCDS52843.1
    UniProtKB/TrEMBL
    G5E8R2
    Related
    ENSMUSP00000109326, OTTMUSP00000022217, ENSMUST00000113696, OTTMUST00000048460
    Conserved Domains (2) summary
    pfam00261
    Location:12248
    Tropomyosin; Tropomyosin
    cl19113
    Location:12117
    ApoLp-III_like; Apolipophorin-III and similar insect proteins
  7. NM_001164254.1NP_001157726.1  tropomyosin alpha-1 chain isoform Tpm1.13

    See proteins identical to NP_001157726.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (Tpm1.13, also known as variant 8) differs in the 5' and 3' UTRs as well as the 5' and 3' coding sequences compared to variant Tpm1.6. The encoded isoform (Tpm1.13) has alternate N- and C- termini and is shorter, compared to isoform Tpm1.6cy.
    Source sequence(s)
    AC166370
    Conserved Domains (2) summary
    pfam00261
    Location:12248
    Tropomyosin; Tropomyosin
    cl19113
    Location:12117
    ApoLp-III_like; Apolipophorin-III and similar insect proteins
  8. NM_001164255.1NP_001157727.1  tropomyosin alpha-1 chain isoform Tpm1.10br

    See proteins identical to NP_001157727.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (Tpm1.10, also known as variant 9) differs in the 3' UTR and coding sequence compared to variant Tpm1.6. The resulting isoform (9) has a shorter and distinct C-terminus compared to isoform Tpm1.6cy.
    Source sequence(s)
    AC166370
    Consensus CDS
    CCDS52844.1
    UniProtKB/TrEMBL
    E9Q452
    Conserved Domains (2) summary
    pfam00261
    Location:48280
    Tropomyosin; Tropomyosin
    pfam12718
    Location:7153
    Tropomyosin_1; Tropomyosin like
  9. NM_001164256.1NP_001157728.1  tropomyosin alpha-1 chain isoform Tpm1.12br

    See proteins identical to NP_001157728.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (Tpm1.12, also known as variant 10) differs in the 5' and 3' UTRs as well as the 5' and 3' coding sequences compared to variant Tpm1.6. The resulting isoform (Tpm1.12br) has shorter and distinct N- and C-termini compared to isoform Tpm1.6cy.
    Source sequence(s)
    AC166370
    Consensus CDS
    CCDS52842.1
    UniProtKB/TrEMBL
    G5E8R0
    Conserved Domains (2) summary
    pfam00261
    Location:12244
    Tropomyosin; Tropomyosin
    cl19113
    Location:12117
    ApoLp-III_like; Apolipophorin-III and similar insect proteins
  10. NM_024427.4NP_077745.2  tropomyosin alpha-1 chain isoform Tpm1.6cy

    See proteins identical to NP_077745.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (Tpm1.6, also known as variant 3) represents one of the longest transcripts and encodes one of the longest isoforms (Tpm1.6cy).
    Source sequence(s)
    AC166370
    Consensus CDS
    CCDS23311.1
    UniProtKB/Swiss-Prot
    P58771
    UniProtKB/TrEMBL
    Q564G1
    Related
    ENSMUSP00000109337, OTTMUSP00000022205, ENSMUST00000113707, OTTMUST00000048446
    Conserved Domains (2) summary
    pfam00261
    Location:48284
    Tropomyosin; Tropomyosin
    pfam12718
    Location:7153
    Tropomyosin_1; Tropomyosin like

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 105

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p3 C57BL/6J

Genomic

  1. NC_000075.6 Reference GRCm38.p3 C57BL/6J

    Range
    67022590..67049401
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006511044.1XP_006511107.1  

    See proteins identical to XP_006511107.1

    UniProtKB/TrEMBL
    E9Q448
    Related
    ENSMUSP00000109331, OTTMUSP00000022212, ENSMUST00000113701, OTTMUST00000048455
    Conserved Domains (2) summary
    pfam00261
    Location:48284
    Tropomyosin; Tropomyosin
    pfam12718
    Location:7153
    Tropomyosin_1; Tropomyosin like
  2. XM_006511045.1XP_006511108.1  

    Conserved Domains (2) summary
    pfam00261
    Location:48280
    Tropomyosin; Tropomyosin
    pfam12718
    Location:7153
    Tropomyosin_1; Tropomyosin like
  3. XM_006511046.1XP_006511109.1  

    Conserved Domains (2) summary
    pfam00261
    Location:48280
    Tropomyosin; Tropomyosin
    pfam12718
    Location:7153
    Tropomyosin_1; Tropomyosin like
  4. XM_006511051.2XP_006511114.1  

    See proteins identical to XP_006511114.1

    UniProtKB/TrEMBL
    E9Q453
    Conserved Domains (2) summary
    pfam00261
    Location:12244
    Tropomyosin; Tropomyosin
    cl19113
    Location:12117
    ApoLp-III_like; Apolipophorin-III and similar insect proteins
  5. XM_006511040.2XP_006511103.1  

    UniProtKB/TrEMBL
    E9Q454
    Conserved Domains (2) summary
    pfam00261
    Location:48259
    Tropomyosin; Tropomyosin
    pfam12718
    Location:7153
    Tropomyosin_1; Tropomyosin like
  6. XM_011242715.1XP_011241017.1  

    Conserved Domains (2) summary
    pfam00261
    Location:48259
    Tropomyosin; Tropomyosin
    pfam12718
    Location:7153
    Tropomyosin_1; Tropomyosin like
  7. XM_006511039.2XP_006511102.1  

    Conserved Domains (2) summary
    pfam00261
    Location:48259
    Tropomyosin; Tropomyosin
    pfam12718
    Location:7153
    Tropomyosin_1; Tropomyosin like
  8. XM_006511042.2XP_006511105.1  

    See proteins identical to XP_006511105.1

    Conserved Domains (2) summary
    pfam00261
    Location:48284
    Tropomyosin; Tropomyosin
    pfam12718
    Location:7153
    Tropomyosin_1; Tropomyosin like
  9. XM_011242714.1XP_011241016.1  

    Conserved Domains (2) summary
    pfam00261
    Location:48259
    Tropomyosin; Tropomyosin
    pfam12718
    Location:7153
    Tropomyosin_1; Tropomyosin like
  10. XM_006511043.2XP_006511106.1  

    Conserved Domains (2) summary
    pfam00261
    Location:48284
    Tropomyosin; Tropomyosin
    pfam12718
    Location:7153
    Tropomyosin_1; Tropomyosin like
  11. XM_006511049.2XP_006511112.1  

    UniProtKB/TrEMBL
    E9Q455
    Related
    ENSMUSP00000109316, OTTMUSP00000022216, ENSMUST00000113686, OTTMUST00000048459
    Conserved Domains (2) summary
    pfam00261
    Location:12223
    Tropomyosin; Tropomyosin
    cl19113
    Location:12117
    ApoLp-III_like; Apolipophorin-III and similar insect proteins
  12. XM_011242716.1XP_011241018.1  

    See proteins identical to XP_011241018.1

    Conserved Domains (2) summary
    pfam00261
    Location:12223
    Tropomyosin; Tropomyosin
    cl22427
    Location:12117
    Tropomyosin_1; Tropomyosin like
  13. XM_006511041.1XP_006511104.1  

    See proteins identical to XP_006511104.1

    Conserved Domains (2) summary
    pfam00261
    Location:48284
    Tropomyosin; Tropomyosin
    pfam12718
    Location:7153
    Tropomyosin_1; Tropomyosin like
  14. XM_006511050.1XP_006511113.1  

    See proteins identical to XP_006511113.1

    Conserved Domains (2) summary
    pfam00261
    Location:12248
    Tropomyosin; Tropomyosin
    cl19113
    Location:12117
    ApoLp-III_like; Apolipophorin-III and similar insect proteins

RNA

  1. XR_379413.1 RNA Sequence

  2. XR_379412.2 RNA Sequence

Alternate Mm_Celera

Genomic

  1. AC_000031.1 Alternate Mm_Celera

    Range
    64256822..64283903
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)