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    Tpm1 tropomyosin 1, alpha [ Mus musculus (house mouse) ]

    Gene ID: 22003, updated on 18-May-2013
    Official Symbol
    Tpm1provided by MGI
    Official Full Name
    tropomyosin 1, alphaprovided by MGI
    Primary source
    MGI:98809
    See related
    Ensembl:ENSMUSG00000032366; Vega:OTTMUSG00000020411
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    TM2; Tm3; Tmpa; Tpm-1; AA986836; AI854628; alpha-TM
    Location :
    9 C; 9 36.27 cM
    Sequence :
    Chromosome: 9; NC_000075.6 (67022593..67049213, complement)
    See Tpm1 in Epigenomics, MapViewer

    Chromosome 9 - NC_000075.6Genomic Context describing neighboring genes Neighboring gene ribosomal protein S27-like Neighboring gene lactamase, beta Neighboring gene predicted gene, 19299 Neighboring gene talin 2 Neighboring gene microRNA 190

    Go to nucleotideGraphics FASTA GenBank

    Go to reference sequence details

    Related articles in PubMed

    1. Tropomyosin dephosphorylation results in compensated cardiac hypertrophy. Schulz EM, et al. J Biol Chem, 2012 Dec 28. PMID 23148217.
    2. RBM4 promotes pancreas cell differentiation and insulin expression. Lin JC, et al. Mol Cell Biol, 2013 Jan. PMID 23129807.
    3. Identification of atrogin-1-targeted proteins during the myostatin-induced skeletal muscle wasting. Lokireddy S, et al. Am J Physiol Cell Physiol, 2012 Sep 1. PMID 22673621.
    4. Epigenetic repression of cardiac progenitor gene expression by Ezh2 is required for postnatal cardiac homeostasis. Delgado-Olguín P, et al. Nat Genet, 2012 Jan 22. PMID 22267199.
    5. Iroquois homeobox gene 3 establishes fast conduction in the cardiac His-Purkinje network. Zhang SS, et al. Proc Natl Acad Sci U S A, 2011 Aug 16. PMID 21825130.

    See all (76) citations in PubMed

    See citations in PubMed for homologs of this gene provided by HomoloGene

    GeneRIFs: Gene References Into Functions What's a GeneRIF?

    1. Tropomyosin dephosphorylation results in myocyte hypertrophy with increases in SERCA2a expression.
      Title: Tropomyosin dephosphorylation results in compensated cardiac hypertrophy.
    2. The results identify a novel mode of myofilament desensitization to Ca(2+) associated with a DCM linked switch in TPM1-kappa.
      Title: Expression of tropomyosin-κ induces dilated cardiomyopathy and depresses cardiac myofilament tension by mechanisms involving cross-bridge dependent activation and altered tropomyosin phosphorylation.
    3. Developed mouse model of familial hypertrophic cardiomyopathy with a mutation in the thin filament protein alpha-tropomyosin.
      Title: Rescue of tropomyosin-induced familial hypertrophic cardiomyopathy mice by transgenesis.
    4. Two transgenic lines of mutated alpha-TM demonstrated alterations in myocardial contractility differently.
      Title: Charged residue alterations in the inner-core domain and carboxy-terminus of alpha-tropomyosin differentially affect mouse cardiac muscle contractility.
    5. the N terminus is a critical determinant of TM1 functions, which in turn determines the organization of stress fibers.
      Title: N terminus is essential for tropomyosin functions: N-terminal modification disrupts stress fiber organization and abolishes anti-oncogenic effects of tropomyosin-1.
    6. A point mutation in alpha-TM causes a disease similar to familial hypertophic cardiomyopahy.
      Title: A mouse model of familial hypertrophic cardiomyopathy caused by a alpha-tropomyosin mutation.
    7. PTB interacting protein raver1 regulates alpha-tropomyosin alternative splicing.
      Title: The PTB interacting protein raver1 regulates alpha-tropomyosin alternative splicing.
    8. charge changes at the carboxy-terminal of alpha-TM alter the functional characteristics of the heart at both the whole organ and myofilament levels.
      Title: Charged residue changes in the carboxy-terminus of alpha-tropomyosin alter mouse cardiac muscle contractility.
    9. signaling by alpha-tropomyosin may have a role in familial hypertrophic cardiomyopathy
      Title: Altered signaling surrounding the C-lobe of cardiac troponin C in myofilaments containing an alpha-tropomyosin mutation linked to familial hypertrophic cardiomyopathy.
    10. Chronic activation of p38alpha MAPK directly depresses sarcomeric function in association with decreased phosphorylation of alpha-tropomyosin.
      Title: p38-MAPK induced dephosphorylation of alpha-tropomyosin is associated with depression of myocardial sarcomeric tension and ATPase activity.
    Submit: New GeneRIF Correction
    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (Floxed/Frt) (1) 
    • Targeted (knock-out) (2)  1 citation
    Products Interactant Other Gene Complex Source Pubs Description
    BioGRID:204291 BioGRID:212401 Fbxo32    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:204291 BioGRID:200268 Htt    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:204291 BioGRID:200780 Invs    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:204291 BioGRID:207938 Pdlim5    BioGRID  PubMed Affinity Capture-Western 
    • Cardiac muscle contraction, organism-specific biosystem (from KEGG)
      Cardiac muscle contraction, organism-specific biosystemContraction of the heart is a complex process initiated by the electrical excitation of cardiac myocytes (excitation-contraction coupling, ECC). In cardiac myocytes, Ca2+ influx induced by activation...
    • Cardiac muscle contraction, conserved biosystem (from KEGG)
      Cardiac muscle contraction, conserved biosystemContraction of the heart is a complex process initiated by the electrical excitation of cardiac myocytes (excitation-contraction coupling, ECC). In cardiac myocytes, Ca2+ influx induced by activation...
    • Dilated cardiomyopathy, organism-specific biosystem (from KEGG)
      Dilated cardiomyopathy, organism-specific biosystemDilated cardiomyopathy (DCM) is a heart muscle disease characterised by dilation and impaired contraction of the left or both ventricles that results in progressive heart failure and sudden cardiac d...
    • Dilated cardiomyopathy, conserved biosystem (from KEGG)
      Dilated cardiomyopathy, conserved biosystemDilated cardiomyopathy (DCM) is a heart muscle disease characterised by dilation and impaired contraction of the left or both ventricles that results in progressive heart failure and sudden cardiac d...
    • Hypertrophic cardiomyopathy (HCM), organism-specific biosystem (from KEGG)
      Hypertrophic cardiomyopathy (HCM), organism-specific biosystemHypertrophic cardiomyopathy (HCM) is a primary myocardial disorder with an autosomal dominant pattern of inheritance that is characterized by hypertrophy of the left ventricles with histological feat...
    • Hypertrophic cardiomyopathy (HCM), conserved biosystem (from KEGG)
      Hypertrophic cardiomyopathy (HCM), conserved biosystemHypertrophic cardiomyopathy (HCM) is a primary myocardial disorder with an autosomal dominant pattern of inheritance that is characterized by hypertrophy of the left ventricles with histological feat...
    • Striated Muscle Contraction, organism-specific biosystem (from WikiPathways)
      Striated Muscle Contraction, organism-specific biosystem
      Striated Muscle Contraction

    Markers

    Genotypes

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    actin binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    actin filament binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    cytoskeletal protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    protein N-terminus binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    protein homodimerization activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    structural constituent of cytoskeleton TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Process Evidence Code Pubs
    actin filament capping ISO
    Inferred from Sequence Orthology
    more info
    		  
    cardiac muscle contraction IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    cardiac muscle contraction ISO
    Inferred from Sequence Orthology
    more info
    		  
    embryo development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    in utero embryonic development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    positive regulation of ATPase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    positive regulation of heart rate by epinephrine IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    regulation of ATPase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    sarcomere organization ISO
    Inferred from Sequence Orthology
    more info
    		  
    ventricular cardiac muscle tissue morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    ventricular cardiac muscle tissue morphogenesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    actin cytoskeleton ISO
    Inferred from Sequence Orthology
    more info
    		  
    bleb ISO
    Inferred from Sequence Orthology
    more info
    		  
    cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
    		  
    colocalizes_with filamentous actin IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    muscle thin filament tropomyosin TAS
    Traceable Author Statement
    more info
    		 PubMed 
    myofibril IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    protein complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    ruffle membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    stress fiber ISO
    Inferred from Sequence Orthology
    more info
    		  
    Preferred Names
    tropomyosin alpha-1 chain
    Names
    tropomyosin alpha-1 chain
    tropomyosin-1
    alpha tropomyosin
    alpha-tropomyosin

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001164248.1 → NP_001157720.1  tropomyosin alpha-1 chain isoform 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) differs in the 3' UTR and coding sequence compared to variant 3. Variants 1-6 encode isoforms of the same size but of differing aa sequence.
      Source sequence(s)
      AC166370
      Consensus CDS
      CCDS52845.1
      UniProtKB/Swiss-Prot
      P58771
      UniProtKB/TrEMBL
      Q545Y3
      Related
      ENSMUSP00000109315, OTTMUSP00000022207, ENSMUST00000113685, OTTMUST00000048448
      Conserved Domains (1) summary
      pfam00261
      Location:48 – 284
      Blast Score: 502
      Tropomyosin; Tropomyosin

    2. NM_001164249.1 → NP_001157721.1  tropomyosin alpha-1 chain isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an alternate in-frame exon and has another alternate in-frame exon compared to variant 3. Variants 1-6 encode isoforms of the same size but of differing aa sequence.
      Source sequence(s)
      AC166370
      Consensus CDS
      CCDS52848.1
      UniProtKB/TrEMBL
      B7ZNL3
      Related
      ENSMUSP00000109335, OTTMUSP00000022210, ENSMUST00000113705, OTTMUST00000048452
      Conserved Domains (1) summary
      pfam00261
      Location:48 – 284
      Blast Score: 407
      Tropomyosin; Tropomyosin

    3. NM_001164250.1 → NP_001157722.1  tropomyosin alpha-1 chain isoform 4

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) lacks an alternate exon and contains another alternate exon compared to variant 3. Variants 1-6 encode isoforms of the same size but of differing aa sequence.
      Source sequence(s)
      AC166370
      Consensus CDS
      CCDS52846.1
      UniProtKB/TrEMBL
      E9Q450
      Related
      ENSMUSP00000109327, OTTMUSP00000022209, ENSMUST00000113697, OTTMUST00000048451
      Conserved Domains (1) summary
      pfam00261
      Location:48 – 284
      Blast Score: 462
      Tropomyosin; Tropomyosin

    4. NM_001164251.1 → NP_001157723.1  tropomyosin alpha-1 chain isoform 5

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5) differs in the 3' UTR and coding sequence, lacks an alternate internal exon, and contains another alternate internal exon compared to variant 3. Variants 1-6 encode isoforms of the same size but of differing aa sequence.
      Source sequence(s)
      AC166370
      Consensus CDS
      CCDS52847.1
      UniProtKB/TrEMBL
      Q8BP43
      Related
      ENSMUSP00000051888, OTTMUSP00000022208, ENSMUST00000050905, OTTMUST00000048449
      Conserved Domains (1) summary
      pfam00261
      Location:48 – 284
      Blast Score: 484
      Tropomyosin; Tropomyosin

    5. NM_001164252.1 → NP_001157724.1  tropomyosin alpha-1 chain isoform 6

      Status: VALIDATED

      Description
      Transcript Variant: This variant (6) differs in the 5' UTR and coding sequence compared to variant 3. Variants 1-6 encode isoforms of the same size but of differing aa sequence.
      Source sequence(s)
      AC166370
      Consensus CDS
      CCDS52841.1
      UniProtKB/TrEMBL
      G5E8R1
      Related
      ENSMUSP00000109325, OTTMUSP00000022218, ENSMUST00000113695, OTTMUST00000048461
      Conserved Domains (1) summary
      pfam00261
      Location:12 – 248
      Blast Score: 470
      Tropomyosin; Tropomyosin

    6. NM_001164253.1 → NP_001157725.1  tropomyosin alpha-1 chain isoform 7

      Status: VALIDATED

      Description
      Transcript Variant: This variant (7) differs in the 5' UTR and coding sequence, lacks an alternate internal exon, and contains another alternate internal exon compared to variant 3. Variants 7 and 8 encode isoforms of the same size but of differing aa sequence.
      Source sequence(s)
      AC166370
      Consensus CDS
      CCDS52843.1
      UniProtKB/TrEMBL
      G5E8R2
      Related
      ENSMUSP00000109326, OTTMUSP00000022217, ENSMUST00000113696, OTTMUST00000048460
      Conserved Domains (1) summary
      pfam00261
      Location:12 – 248
      Blast Score: 453
      Tropomyosin; Tropomyosin

    7. NM_001164254.1 → NP_001157726.1  tropomyosin alpha-1 chain isoform 8

      Status: VALIDATED

      Description
      Transcript Variant: This variant (8) differs in the 5' and 3' UTRs as well as the 5' and 3' coding sequences compared to variant 3. Variants 7 and 8 encode isoforms of the same size but of differing aa sequence.
      Source sequence(s)
      AC166370
      Related
      ENSMUSP00000109316, OTTMUSP00000022216, ENSMUST00000113686, OTTMUST00000048459
      Conserved Domains (1) summary
      pfam00261
      Location:12 – 248
      Blast Score: 493
      Tropomyosin; Tropomyosin

    8. NM_001164255.1 → NP_001157727.1  tropomyosin alpha-1 chain isoform 9

      Status: VALIDATED

      Description
      Transcript Variant: This variant (9) differs in the 3' UTR and coding sequence compared to variant 3. The resulting isoform (9) has a shorter and distinct C-terminus compared to isoform 3.
      Source sequence(s)
      AC166370
      Consensus CDS
      CCDS52844.1
      UniProtKB/TrEMBL
      E9Q452
      Conserved Domains (1) summary
      pfam00261
      Location:48 – 280
      Blast Score: 459
      Tropomyosin; Tropomyosin

    9. NM_001164256.1 → NP_001157728.1  tropomyosin alpha-1 chain isoform 10

      Status: VALIDATED

      Description
      Transcript Variant: This variant (10) differs in the 5' and 3' UTRs as well as the 5' and 3' coding sequences compared to variant 3. The resulting isoform (10) has shorter and distinct N- and C-termini compared to isoform 3.
      Source sequence(s)
      AC166370
      Consensus CDS
      CCDS52842.1
      UniProtKB/TrEMBL
      G5E8R0
      Conserved Domains (1) summary
      pfam00261
      Location:12 – 244
      Blast Score: 450
      Tropomyosin; Tropomyosin

    10. NM_024427.4 → NP_077745.2  tropomyosin alpha-1 chain isoform 3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) represents one of the longest transcripts and encodes one of the longest isoforms (3). Variants 1-6 encode isoforms of the same size but of differing aa sequence.
      Source sequence(s)
      AC166370
      Consensus CDS
      CCDS23311.1
      UniProtKB/Swiss-Prot
      P58771
      UniProtKB/TrEMBL
      Q564G1
      Related
      ENSMUSP00000109337, OTTMUSP00000022205, ENSMUST00000113707, OTTMUST00000048446
      Conserved Domains (1) summary
      pfam00261
      Location:48 – 284
      Blast Score: 479
      Tropomyosin; Tropomyosin

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 103

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p1 C57BL/6J

    Genomic

    1. NC_000075.6 Reference GRCm38.p1 C57BL/6J

      Range
      67022593..67049213, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate Mm_Celera

    Genomic

    1. AC_000031.1 Alternate Mm_Celera

      Range
      64256822..64283903, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    genomic AAHY01079001.1 (7991..17276) None
    genomic AAHY01079002.1 None
    genomic AAHY01079003.1 None
    genomic AC166370.3 (152718..179338) None
    genomic CH466522.1 EDL26140.1 mixed
      EDL26141.1 mixed
      EDL26142.1 mixed
      EDL26143.1 mixed
      EDL26144.1 mixed
      EDL26145.1 mixed
      EDL26146.1 mixed
      EDL26147.1 mixed
      EDL26148.1 mixed
      EDL26149.1 mixed
      EDL26150.1 mixed
      EDL26151.1 mixed
    genomic X68775.1 None Domesticus-A2G
    mRNA AK002271.1 BAB21978.1 C57BL/6J
    mRNA AK003175.1 BAB22620.1 C57BL/6J
    mRNA AK029384.1 None C57BL/6J
    mRNA AK032942.1 BAC28093.1 C57BL/6J
    mRNA AK077713.1 BAC36973.1 C57BL/6J
    mRNA AK083087.1 None C57BL/6J
    mRNA AK168640.1 BAE40499.1 C57BL/6J
    mRNA AK168783.1 BAE40617.1 C57BL/6J
    mRNA AK169188.1 BAE40964.1 C57BL/6J
    mRNA AK190148.1 None
    mRNA AK193361.1 None
    mRNA AK210663.1 None
    mRNA AK215633.1 None
    mRNA AK216548.1 None
    mRNA BC026720.1 None FVB/N
    mRNA BC131643.1 AAI31644.1
    mRNA BC132035.1 AAI32036.1
    mRNA BC132037.1 AAI32038.1
    mRNA BC145307.1 AAI45308.1
    mRNA M22479.1 AAA40483.1
    mRNA X64831.1 CAA46043.1 A2G
    Protein Accession Links
    GenPept Link UniProtKB Link
    P58771.1 GenPept UniProtKB/Swiss-Prot:P58771

    Additional Links

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Molecular Biology Databases
    Research Materials
    Tools
    Miscellaneous

      Supplemental Content

      Table of contents

      Related information

      • Order cDNA clone
        Order cDNA clone
      • BioProjects
        BioProjects related to a gene
      • BioSystems
        BioSystems
      • CCDS
        Links from Gene to CCDS are established if a gene encodes a protein sequence that is a member of a Consensus CDS (CCDS).
      • Conserved Domains
        Conserved Domain Database Links between Entrez Gene and Conserved Domain Database (CDD) are calculated from the domains annotated by the CDD group on Reference Sequence proteins.
      • dbVar
        Link from Gene to dbVar
      • Full text in PMC
        PMC links
      • Full text in PMC_nucleotide
        Full text in PubMedCentral identified from shared sequence links
      • Genome
        Genome records having the gene annotated on corresponding genomic reference sequence.
      • GEO Profiles
        Related GEO
      • HomoloGene
        Links between HomoloGene and Gene are provided by the HomoloGene group when a gene is included in a HomoloGene record.
      • Map Viewer
        These links are maintained by the Map Viewer group and are provided when a GeneID is annotated on a map for the same species.
      • Nucleotide
        Link to related Nucleotide entry
      • Probe
        Related Probe entry
      • Protein
        Link to related protein entry
      • PubChem Compound
        PubChem Compounds
      • PubChem Substance
        PubChem Substances
      • PubMed
        Links between Gene and PubMed are the result of the following: 1. Manual curation within NCBI. Part of the process of generating a REVIEWED RefSeq is an analysis of the current literature. Papers that are seminal in defining the gene, its sequence, and its function are added to the record at that time. Alert users point out gaps or errors in papers associated with a Gene record. These messages are reviewed and implemented as required. 2. Integration of information from other public databases. Gene integrates gene-citation from resources external to NCBI such as model organism-specific databases, Gene Ontology (GO), groups curating interactions, and sequence databases. The assumption in using these source is that they report citations specific to a gene in a known species. Gene does not process citations from OMIM automatically, because many of citations in OMIM refer to studies of genes in species other than human.
      • PubMed (GeneRIF)
        GeneRIF -- Gene Reference Into Function Staff of the Index Section in the National Library of Medicine review the current literature. When they find articles focused on the structure and function of a gene, they write a brief summary of the impact of the paper and make the connection between the citation (PubMed) and Gene. An interface exists for interested users to submit such data as well. http://www.ncbi.nlm.nih.gov/projects/GeneRIF/GeneRIFhelp.html
      • PubMed(nucleotide/PMC)
        Citations in PubMed identified from shared sequence and PMC links.
      • RefSeq Proteins
        Link to Protein RefSeqs
      • RefSeq RNAs
        Link to Nucleotide RefSeq RNAs
      • SNP
        Related SNP records
      • SNP: GeneView
        SNPs linked from GeneView
      • SNP: Genotype
        Gene Genotype Report
      • Taxonomy
        Link to related taxonomy entry
      • UniGene
        Links are provided between Gene and UniGene when both databases calculate links to the same mRNA record (gi).
      • UniSTS
        Related UniSTS records

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