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Tpm1 tropomyosin 1, alpha [ Mus musculus (house mouse) ]

Gene ID: 22003, updated on 16-Apr-2014
Official Symbol
Tpm1provided by MGI
Official Full Name
tropomyosin 1, alphaprovided by MGI
Primary source
MGI:98809
See related
Ensembl:ENSMUSG00000032366; Vega:OTTMUSG00000020411
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
TM2; Tm3; Tmpa; Tpm-1; AA986836; AI854628; alpha-TM
Location :
9 C; 9 36.27 cM
Sequence :
Chromosome: 9; NC_000075.6 (67022590..67049401, complement)
See Tpm1 in Epigenomics, MapViewer

Chromosome 9 - NC_000075.6Genomic Context describing neighboring genes Neighboring gene ribosomal protein S27-like Neighboring gene lactamase, beta Neighboring gene uncharacterized LOC102632609 Neighboring gene uncharacterized LOC102632852 Neighboring gene uncharacterized LOC102632690 Neighboring gene uncharacterized LOC102632936

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (Floxed/Frt) (1) 
  • Targeted (knock-out) (2)  1 citation
  • Adrenergic signaling in cardiomyocytes, organism-specific biosystem (from KEGG)
    Adrenergic signaling in cardiomyocytes, organism-specific biosystemCardiac myocytes express at least six subtypes of adrenergic receptor (AR) which include three subtypes of beta-AR (beta-1, beta-2, beta-3) and three subtypes of the alpha-1-AR (alpha-1A, alpha-1B, a...
  • Adrenergic signaling in cardiomyocytes, conserved biosystem (from KEGG)
    Adrenergic signaling in cardiomyocytes, conserved biosystemCardiac myocytes express at least six subtypes of adrenergic receptor (AR) which include three subtypes of beta-AR (beta-1, beta-2, beta-3) and three subtypes of the alpha-1-AR (alpha-1A, alpha-1B, a...
  • Cardiac muscle contraction, organism-specific biosystem (from KEGG)
    Cardiac muscle contraction, organism-specific biosystemContraction of the heart is a complex process initiated by the electrical excitation of cardiac myocytes (excitation-contraction coupling, ECC). In cardiac myocytes, Ca2+ influx induced by activation...
  • Cardiac muscle contraction, conserved biosystem (from KEGG)
    Cardiac muscle contraction, conserved biosystemContraction of the heart is a complex process initiated by the electrical excitation of cardiac myocytes (excitation-contraction coupling, ECC). In cardiac myocytes, Ca2+ influx induced by activation...
  • Dilated cardiomyopathy, organism-specific biosystem (from KEGG)
    Dilated cardiomyopathy, organism-specific biosystemDilated cardiomyopathy (DCM) is a heart muscle disease characterised by dilation and impaired contraction of the left or both ventricles that results in progressive heart failure and sudden cardiac d...
  • Dilated cardiomyopathy, conserved biosystem (from KEGG)
    Dilated cardiomyopathy, conserved biosystemDilated cardiomyopathy (DCM) is a heart muscle disease characterised by dilation and impaired contraction of the left or both ventricles that results in progressive heart failure and sudden cardiac d...
  • Hypertrophic cardiomyopathy (HCM), organism-specific biosystem (from KEGG)
    Hypertrophic cardiomyopathy (HCM), organism-specific biosystemHypertrophic cardiomyopathy (HCM) is a primary myocardial disorder with an autosomal dominant pattern of inheritance that is characterized by hypertrophy of the left ventricles with histological feat...
  • Hypertrophic cardiomyopathy (HCM), conserved biosystem (from KEGG)
    Hypertrophic cardiomyopathy (HCM), conserved biosystemHypertrophic cardiomyopathy (HCM) is a primary myocardial disorder with an autosomal dominant pattern of inheritance that is characterized by hypertrophy of the left ventricles with histological feat...
  • MicroRNAs in cancer, organism-specific biosystem (from KEGG)
    MicroRNAs in cancer, organism-specific biosystemMicroRNA (miRNA) is a cluster of small non-encoding RNA molecules of 21 - 23 nucleotides in length, which controls gene expression post-transcriptionally either via the degradation of target mRNAs or...
  • MicroRNAs in cancer, conserved biosystem (from KEGG)
    MicroRNAs in cancer, conserved biosystemMicroRNA (miRNA) is a cluster of small non-encoding RNA molecules of 21 - 23 nucleotides in length, which controls gene expression post-transcriptionally either via the degradation of target mRNAs or...
  • Striated Muscle Contraction, organism-specific biosystem (from WikiPathways)
    Striated Muscle Contraction, organism-specific biosystem
    Striated Muscle Contraction
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
actin binding ISO
Inferred from Sequence Orthology
more info
 
actin filament binding ISO
Inferred from Sequence Orthology
more info
 
protein N-terminus binding ISO
Inferred from Sequence Orthology
more info
 
protein homodimerization activity ISO
Inferred from Sequence Orthology
more info
 
structural constituent of cytoskeleton TAS
Traceable Author Statement
more info
PubMed 
Process Evidence Code Pubs
actin filament capping ISO
Inferred from Sequence Orthology
more info
 
cardiac muscle contraction IMP
Inferred from Mutant Phenotype
more info
PubMed 
cardiac muscle contraction ISO
Inferred from Sequence Orthology
more info
 
embryo development IMP
Inferred from Mutant Phenotype
more info
PubMed 
in utero embryonic development IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of ATPase activity ISO
Inferred from Sequence Orthology
more info
 
positive regulation of heart rate by epinephrine IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of ATPase activity ISO
Inferred from Sequence Orthology
more info
 
ventricular cardiac muscle tissue morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
cytoskeleton IEA
Inferred from Electronic Annotation
more info
 
colocalizes_with filamentous actin IDA
Inferred from Direct Assay
more info
PubMed 
muscle thin filament tropomyosin TAS
Traceable Author Statement
more info
PubMed 
myofibril IDA
Inferred from Direct Assay
more info
PubMed 
protein complex ISO
Inferred from Sequence Orthology
more info
 
Preferred Names
tropomyosin alpha-1 chain
Names
tropomyosin alpha-1 chain
tropomyosin-1
alpha tropomyosin
alpha-tropomyosin

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001164248.1NP_001157720.1  tropomyosin alpha-1 chain isoform 1

    See proteins identical to NP_001157720.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) differs in the 3' UTR and coding sequence compared to variant 3. Variants 1-6 encode isoforms of the same size but of differing aa sequence.
    Source sequence(s)
    AC166370
    Consensus CDS
    CCDS52845.1
    UniProtKB/Swiss-Prot
    P58771
    UniProtKB/TrEMBL
    Q545Y3
    Related
    ENSMUSP00000109315, OTTMUSP00000022207, ENSMUST00000113685, OTTMUST00000048448
    Conserved Domains (2) summary
    pfam00261
    Location:48284
    Blast Score: 606
    Tropomyosin; Tropomyosin
    pfam12718
    Location:7153
    Blast Score: 254
    Tropomyosin_1; Tropomyosin like
  2. NM_001164249.1NP_001157721.1  tropomyosin alpha-1 chain isoform 2

    See proteins identical to NP_001157721.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon and has another alternate in-frame exon compared to variant 3. Variants 1-6 encode isoforms of the same size but of differing aa sequence.
    Source sequence(s)
    AC166370
    Consensus CDS
    CCDS52848.1
    UniProtKB/TrEMBL
    B7ZNL3
    Related
    ENSMUSP00000109335, OTTMUSP00000022210, ENSMUST00000113705, OTTMUST00000048452
    Conserved Domains (2) summary
    pfam00261
    Location:48284
    Blast Score: 555
    Tropomyosin; Tropomyosin
    pfam12718
    Location:7153
    Blast Score: 208
    Tropomyosin_1; Tropomyosin like
  3. NM_001164250.1NP_001157722.1  tropomyosin alpha-1 chain isoform 4

    See proteins identical to NP_001157722.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) lacks an alternate exon and contains another alternate exon compared to variant 3. Variants 1-6 encode isoforms of the same size but of differing aa sequence.
    Source sequence(s)
    AC166370
    Consensus CDS
    CCDS52846.1
    UniProtKB/TrEMBL
    E9Q450
    Related
    ENSMUSP00000109327, OTTMUSP00000022209, ENSMUST00000113697, OTTMUST00000048451
    Conserved Domains (2) summary
    pfam00261
    Location:48284
    Blast Score: 567
    Tropomyosin; Tropomyosin
    pfam12718
    Location:7153
    Blast Score: 254
    Tropomyosin_1; Tropomyosin like
  4. NM_001164251.1NP_001157723.1  tropomyosin alpha-1 chain isoform 5

    See proteins identical to NP_001157723.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) differs in the 3' UTR and coding sequence, lacks an alternate internal exon, and contains another alternate internal exon compared to variant 3. Variants 1-6 encode isoforms of the same size but of differing aa sequence.
    Source sequence(s)
    AC166370
    Consensus CDS
    CCDS52847.1
    UniProtKB/TrEMBL
    Q8BP43
    Related
    ENSMUSP00000051888, OTTMUSP00000022208, ENSMUST00000050905, OTTMUST00000048449
    Conserved Domains (2) summary
    pfam00261
    Location:48284
    Blast Score: 589
    Tropomyosin; Tropomyosin
    pfam12718
    Location:7153
    Blast Score: 254
    Tropomyosin_1; Tropomyosin like
  5. NM_001164252.1NP_001157724.1  tropomyosin alpha-1 chain isoform 6

    See proteins identical to NP_001157724.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (6) differs in the 5' UTR and coding sequence compared to variant 3. Variants 1-6 encode isoforms of the same size but of differing aa sequence.
    Source sequence(s)
    AC166370
    Consensus CDS
    CCDS52841.1
    UniProtKB/TrEMBL
    G5E8R1
    Related
    ENSMUSP00000109325, OTTMUSP00000022218, ENSMUST00000113695, OTTMUST00000048461
    Conserved Domains (2) summary
    pfam00261
    Location:12248
    Blast Score: 582
    Tropomyosin; Tropomyosin
    cl19113
    Location:12117
    Blast Score: 141
    ApoLp-III_like; Apolipophorin-III and similar insect proteins
  6. NM_001164253.1NP_001157725.1  tropomyosin alpha-1 chain isoform 7

    See proteins identical to NP_001157725.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (7) differs in the 5' UTR and coding sequence, lacks an alternate internal exon, and contains another alternate internal exon compared to variant 3. Variants 7 and 8 encode isoforms of the same size but of differing aa sequence.
    Source sequence(s)
    AC166370
    Consensus CDS
    CCDS52843.1
    UniProtKB/TrEMBL
    G5E8R2
    Related
    ENSMUSP00000109326, OTTMUSP00000022217, ENSMUST00000113696, OTTMUST00000048460
    Conserved Domains (2) summary
    pfam00261
    Location:12248
    Blast Score: 566
    Tropomyosin; Tropomyosin
    cl19113
    Location:12117
    Blast Score: 141
    ApoLp-III_like; Apolipophorin-III and similar insect proteins
  7. NM_001164254.1NP_001157726.1  tropomyosin alpha-1 chain isoform 8

    See proteins identical to NP_001157726.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (8) differs in the 5' and 3' UTRs as well as the 5' and 3' coding sequences compared to variant 3. Variants 7 and 8 encode isoforms of the same size but of differing aa sequence.
    Source sequence(s)
    AC166370
    Conserved Domains (2) summary
    pfam00261
    Location:12248
    Blast Score: 605
    Tropomyosin; Tropomyosin
    cl19113
    Location:12117
    Blast Score: 141
    ApoLp-III_like; Apolipophorin-III and similar insect proteins
  8. NM_001164255.1NP_001157727.1  tropomyosin alpha-1 chain isoform 9

    See proteins identical to NP_001157727.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (9) differs in the 3' UTR and coding sequence compared to variant 3. The resulting isoform (9) has a shorter and distinct C-terminus compared to isoform 3.
    Source sequence(s)
    AC166370
    Consensus CDS
    CCDS52844.1
    UniProtKB/TrEMBL
    E9Q452
    Conserved Domains (2) summary
    pfam00261
    Location:48280
    Blast Score: 569
    Tropomyosin; Tropomyosin
    pfam12718
    Location:7153
    Blast Score: 254
    Tropomyosin_1; Tropomyosin like
  9. NM_001164256.1NP_001157728.1  tropomyosin alpha-1 chain isoform 10

    See proteins identical to NP_001157728.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (10) differs in the 5' and 3' UTRs as well as the 5' and 3' coding sequences compared to variant 3. The resulting isoform (10) has shorter and distinct N- and C-termini compared to isoform 3.
    Source sequence(s)
    AC166370
    Consensus CDS
    CCDS52842.1
    UniProtKB/TrEMBL
    G5E8R0
    Conserved Domains (2) summary
    pfam00261
    Location:12244
    Blast Score: 562
    Tropomyosin; Tropomyosin
    cl19113
    Location:12117
    Blast Score: 141
    ApoLp-III_like; Apolipophorin-III and similar insect proteins
  10. NM_024427.4NP_077745.2  tropomyosin alpha-1 chain isoform 3

    See proteins identical to NP_077745.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) represents one of the longest transcripts and encodes one of the longest isoforms (3). Variants 1-6 encode isoforms of the same size but of differing aa sequence.
    Source sequence(s)
    AC166370
    Consensus CDS
    CCDS23311.1
    UniProtKB/Swiss-Prot
    P58771
    UniProtKB/TrEMBL
    Q564G1
    Related
    ENSMUSP00000109337, OTTMUSP00000022205, ENSMUST00000113707, OTTMUST00000048446
    Conserved Domains (2) summary
    pfam00261
    Location:48284
    Blast Score: 587
    Tropomyosin; Tropomyosin
    pfam12718
    Location:7153
    Blast Score: 254
    Tropomyosin_1; Tropomyosin like

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 104

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p2 C57BL/6J

Genomic

  1. NC_000075.6

    Range
    67022590..67049401, complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006511044.1XP_006511107.1  

    See proteins identical to XP_006511107.1

    UniProtKB/TrEMBL
    E9Q448
    Related
    ENSMUSP00000109331, OTTMUSP00000022212, ENSMUST00000113701, OTTMUST00000048455
    Conserved Domains (1) summary
    pfam00261
    Location:48284
    Blast Score: 388
    Tropomyosin; Tropomyosin
  2. XM_006511045.1XP_006511108.1  

    Conserved Domains (2) summary
    pfam00261
    Location:48280
    Blast Score: 537
    Tropomyosin; Tropomyosin
    pfam12718
    Location:7153
    Blast Score: 208
    Tropomyosin_1; Tropomyosin like
  3. XM_006511046.1XP_006511109.1  

    Conserved Domains (2) summary
    pfam00261
    Location:48280
    Blast Score: 512
    Tropomyosin; Tropomyosin
    pfam12718
    Location:7153
    Blast Score: 208
    Tropomyosin_1; Tropomyosin like
  4. XM_006511051.1XP_006511114.1  

    See proteins identical to XP_006511114.1

    UniProtKB/TrEMBL
    E9Q453
    Conserved Domains (1) summary
    pfam00261
    Location:12244
    Blast Score: 432
    Tropomyosin; Tropomyosin
  5. XM_006511040.1XP_006511103.1  

    UniProtKB/TrEMBL
    E9Q454
    Conserved Domains (2) summary
    pfam00261
    Location:48259
    Blast Score: 600
    Tropomyosin; Tropomyosin
    pfam12718
    Location:7153
    Blast Score: 265
    Tropomyosin_1; Tropomyosin like
  6. XM_006511039.1XP_006511102.1  

    Conserved Domains (2) summary
    pfam00261
    Location:48259
    Blast Score: 562
    Tropomyosin; Tropomyosin
    pfam12718
    Location:7153
    Blast Score: 221
    Tropomyosin_1; Tropomyosin like
  7. XM_006511042.1XP_006511105.1  

    See proteins identical to XP_006511105.1

    Conserved Domains (2) summary
    pfam00261
    Location:48284
    Blast Score: 571
    Tropomyosin; Tropomyosin
    pfam12718
    Location:7153
    Blast Score: 208
    Tropomyosin_1; Tropomyosin like
  8. XM_006511043.1XP_006511106.1  

    Conserved Domains (2) summary
    pfam00261
    Location:48284
    Blast Score: 553
    Tropomyosin; Tropomyosin
    pfam12718
    Location:7153
    Blast Score: 208
    Tropomyosin_1; Tropomyosin like
  9. XM_006511049.1XP_006511112.1  

    UniProtKB/TrEMBL
    E9Q455
    Related
    ENSMUSP00000109316, OTTMUSP00000022216, ENSMUST00000113686, OTTMUST00000048459
    Conserved Domains (2) summary
    pfam00261
    Location:12223
    Blast Score: 604
    Tropomyosin; Tropomyosin
    cl19113
    Location:12117
    Blast Score: 158
    ApoLp-III_like; Apolipophorin-III and similar insect proteins
  10. XM_006511041.1XP_006511104.1  

    See proteins identical to XP_006511104.1

    Conserved Domains (1) summary
    pfam00261
    Location:48284
    Blast Score: 430
    Tropomyosin; Tropomyosin
  11. XM_006511050.1XP_006511113.1  

    See proteins identical to XP_006511113.1

    Conserved Domains (1) summary
    pfam00261
    Location:12248
    Blast Score: 478
    Tropomyosin; Tropomyosin
  12. XM_006511036.1XP_006511099.1  

    Conserved Domains (2) summary
    pfam00261
    Location:48262
    Blast Score: 600
    Tropomyosin; Tropomyosin
    pfam12718
    Location:7153
    Blast Score: 266
    Tropomyosin_1; Tropomyosin like
  13. XM_006511038.1XP_006511101.1  

    Conserved Domains (3) summary
    pfam00261
    Location:48262
    Blast Score: 580
    Tropomyosin; Tropomyosin
    pfam12718
    Location:7153
    Blast Score: 272
    Tropomyosin_1; Tropomyosin like
    cl19296
    Location:105272
    Blast Score: 83
    GBP; Guanylate-binding protein, N-terminal domain
  14. XM_006511035.1XP_006511098.1  

    Conserved Domains (2) summary
    pfam00261
    Location:48262
    Blast Score: 561
    Tropomyosin; Tropomyosin
    pfam12718
    Location:7153
    Blast Score: 221
    Tropomyosin_1; Tropomyosin like
  15. XM_006511037.1XP_006511100.1  

    Conserved Domains (3) summary
    pfam00261
    Location:48262
    Blast Score: 541
    Tropomyosin; Tropomyosin
    pfam12718
    Location:7153
    Blast Score: 226
    Tropomyosin_1; Tropomyosin like
    cl19296
    Location:105272
    Blast Score: 84
    GBP; Guanylate-binding protein, N-terminal domain
  16. XM_006511048.1XP_006511111.1  

    Conserved Domains (3) summary
    pfam00261
    Location:12226
    Blast Score: 584
    Tropomyosin; Tropomyosin
    cl19113
    Location:12117
    Blast Score: 162
    ApoLp-III_like; Apolipophorin-III and similar insect proteins
    cl19296
    Location:69236
    Blast Score: 85
    GBP; Guanylate-binding protein, N-terminal domain
  17. XM_006511047.1XP_006511110.1  

    Conserved Domains (2) summary
    pfam00261
    Location:12226
    Blast Score: 603
    Tropomyosin; Tropomyosin
    cl19113
    Location:12117
    Blast Score: 158
    ApoLp-III_like; Apolipophorin-III and similar insect proteins

RNA

  1. XR_379413.1 RNA Sequence

  2. XR_379412.1 RNA Sequence

Alternate Mm_Celera

Genomic

  1. AC_000031.1 Alternate Mm_Celera

    Range
    64256822..64283903, complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

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