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PATL1 PAT1 homolog 1, processing body mRNA decay factor [ Homo sapiens (human) ]

Gene ID: 219988, updated on 26-May-2016
Official Symbol
PATL1provided by HGNC
Official Full Name
PAT1 homolog 1, processing body mRNA decay factorprovided by HGNC
Primary source
HGNC:HGNC:26721
See related
Ensembl:ENSG00000166889 HPRD:08214; MIM:614660; Vega:OTTHUMG00000167423
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
Pat1b; hPat1b
Orthologs
Location:
11q12.1
Exon count:
21
Annotation release Status Assembly Chr Location
107 current GRCh38.p2 (GCF_000001405.28) 11 NC_000011.10 (59636716..59669040, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (59404189..59436513, complement)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene oxysterol binding protein Neighboring gene microRNA 3162 Neighboring gene uncharacterized LOC101927226 Neighboring gene uncharacterized LOC105369318 Neighboring gene olfactory receptor family 10 subfamily V member 1

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

  • Deadenylation-dependent mRNA decay, organism-specific biosystem (from REACTOME)
    Deadenylation-dependent mRNA decay, organism-specific biosystemAfter undergoing rounds of translation, mRNA is normally destroyed by the deadenylation-dependent pathway. Though the trigger is unclear, deadenylation likely proceeds in two steps: one catalyzed by...
  • Decapping complex, organism-specific biosystem (from KEGG)
    Decapping complex, organism-specific biosystemStructural complex; Genetic information processing; RNA processing
  • Decapping complex, conserved biosystem (from KEGG)
    Decapping complex, conserved biosystemStructural complex; Genetic information processing; RNA processing
  • Gene Expression, organism-specific biosystem (from REACTOME)
    Gene Expression, organism-specific biosystemGene Expression covers the pathways by which genomic DNA is transcribed to yield RNA, the regulation of these transcription processes, and the pathways by which newly-made RNA Transcripts are process...
  • RNA degradation, organism-specific biosystem (from KEGG)
    RNA degradation, organism-specific biosystemThe correct processing, quality control and turnover of cellular RNA molecules are critical to many aspects in the expression of genetic information. In eukaryotes, two major pathways of mRNA decay e...
  • RNA degradation, conserved biosystem (from KEGG)
    RNA degradation, conserved biosystemThe correct processing, quality control and turnover of cellular RNA molecules are critical to many aspects in the expression of genetic information. In eukaryotes, two major pathways of mRNA decay e...
  • mRNA decay by 5' to 3' exoribonuclease, organism-specific biosystem (from REACTOME)
    mRNA decay by 5' to 3' exoribonuclease, organism-specific biosystemDegradation of mRNA from 5' to 3' occurs in three steps. First, the mRNA is bound at its 3' end by the Lsm1-7 complex. The bound Lsm1-7 may prevent nucleases from accessing the 3' end. Second, the 7-...
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Clone Names

  • FLJ36874, MGC125671, MGC125672

Gene Ontology Provided by GOA

Function Evidence Code Pubs
RNA binding IDA
Inferred from Direct Assay
more info
PubMed 
poly(A) RNA binding IDA
Inferred from Direct Assay
more info
PubMed 
poly(G) binding IDA
Inferred from Direct Assay
more info
PubMed 
poly(U) RNA binding IDA
Inferred from Direct Assay
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Component Evidence Code Pubs
colocalizes_with CCR4-NOT complex IDA
Inferred from Direct Assay
more info
PubMed 
PML body IEA
Inferred from Electronic Annotation
more info
 
cytoplasmic mRNA processing body IDA
Inferred from Direct Assay
more info
PubMed 
cytosol TAS
Traceable Author Statement
more info
 
intracellular membrane-bounded organelle IDA
Inferred from Direct Assay
more info
 
nuclear speck IEA
Inferred from Electronic Annotation
more info
 
Preferred Names
protein PAT1 homolog 1
Names
PAT1-like protein 1
protein PAT1 homolog b
protein associated with topoisomerase II homolog 1

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_152716.2NP_689929.2  protein PAT1 homolog 1

    See identical proteins and their annotated locations for NP_689929.2

    Status: VALIDATED

    Source sequence(s)
    BC111047, DC409866
    Consensus CDS
    CCDS44613.1
    UniProtKB/Swiss-Prot
    Q86TB9
    Related
    ENSP00000300146, OTTHUMP00000235907, ENST00000300146, OTTHUMT00000394559
    Conserved Domains (1) summary
    pfam09770
    Location:16638
    PAT1; Topoisomerase II-associated protein PAT1

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 107 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p2 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p2 Primary Assembly

    Range
    59636716..59669040 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005273834.1XP_005273891.1  

    See identical proteins and their annotated locations for XP_005273891.1

    Conserved Domains (1) summary
    pfam09770
    Location:16608
    PAT1; Topoisomerase II-associated protein PAT1
  2. XM_005273833.3XP_005273890.1  

    Conserved Domains (1) summary
    pfam09770
    Location:16638
    PAT1; Topoisomerase II-associated protein PAT1
  3. XM_011544811.1XP_011543113.1  

    See identical proteins and their annotated locations for XP_011543113.1

    Conserved Domains (1) summary
    pfam09770
    Location:1419
    PAT1; Topoisomerase II-associated protein PAT1
  4. XM_005273835.3XP_005273892.1  

    See identical proteins and their annotated locations for XP_005273892.1

    Conserved Domains (1) summary
    pfam09770
    Location:1419
    PAT1; Topoisomerase II-associated protein PAT1

Alternate CHM1_1.1

Genomic

  1. NC_018922.2 Alternate CHM1_1.1

    Range
    59270207..59302529 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)