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    Top3b topoisomerase (DNA) III beta [ Mus musculus (house mouse) ]

    Gene ID: 21976, updated on 18-May-2013
    Official Symbol
    Top3bprovided by MGI
    Official Full Name
    topoisomerase (DNA) III betaprovided by MGI
    Primary source
    MGI:1333803
    See related
    Ensembl:ENSMUSG00000022779; Vega:OTTMUSG00000027460
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
    Location :
    16; 16 B1
    Sequence :
    Chromosome: 16; NC_000082.6 (16870891..16892986)
    See Top3b in Epigenomics, MapViewer

    Chromosome 16 - NC_000082.6Genomic Context describing neighboring genes Neighboring gene immunoglobulin lambda-like polypeptide 1 Neighboring gene pre-B lymphocyte gene 1 Neighboring gene protein phosphatase 1F (PP2C domain containing) Neighboring gene predicted gene 6438

    Go to nucleotideGraphics FASTA GenBank

    Go to reference sequence details

    Related articles in PubMed

    1. A conditional knockout resource for the genome-wide study of mouse gene function. Skarnes WC, et al. Nature, 2011 Jun 15. PMID 21677750.
    2. A high-resolution anatomical atlas of the transcriptome in the mouse embryo. Diez-Roux G, et al. PLoS Biol, 2011 Jan 18. PMID 21267068.
    3. Large-scale gene trapping in C57BL/6N mouse embryonic stem cells. Hansen GM, et al. Genome Res, 2008 Oct. PMID 18799693.
    4. Defective p53 engagement after the induction of DNA damage in cells deficient in topoisomerase 3beta. Mohanty S, et al. Proc Natl Acad Sci U S A, 2008 Apr 1. PMID 18367668.
    5. EUCOMM--the European conditional mouse mutagenesis program. Friedel RH, et al. Brief Funct Genomic Proteomic, 2007 Sep. PMID 17967808.

    See all (24) citations in PubMed

    See citations in PubMed for homologs of this gene provided by HomoloGene

    GeneRIFs: Gene References Into Functions What's a GeneRIF?

    1. suggest an unanticipated role for Top3beta beyond DNA repair in the activation of cellular responses to DNA damage
      Title: Defective p53 engagement after the induction of DNA damage in cells deficient in topoisomerase 3beta.
    2. DNA topoisomerase III beta has a role in infertility and aneuploidy
      Title: Infertility and aneuploidy in mice lacking a type IA DNA topoisomerase III beta.
    3. Chromosomal abnormalities in top3beta(-/-) mice might lead to a persistent increase in apoptotic cells, which might in turn lead to the progression of autoimmunity
      Title: Development of autoimmunity in mice lacking DNA topoisomerase 3beta.
    Submit: New GeneRIF Correction
    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Bloom's syndrome complex, organism-specific biosystem (from KEGG)
      Bloom's syndrome complex, organism-specific biosystemStructural complex; Genetic information processing; Repair system
    • Fanconi anemia pathway, organism-specific biosystem (from KEGG)
      Fanconi anemia pathway, organism-specific biosystemThe Fanconi anemia pathway is required for the efficient repair of damaged DNA, especially interstrand cross-links (ICLs). DNA ICL is directly recognized by FANCM and associated proteins, that recrui...
    • Fanconi anemia pathway, conserved biosystem (from KEGG)
      Fanconi anemia pathway, conserved biosystemThe Fanconi anemia pathway is required for the efficient repair of damaged DNA, especially interstrand cross-links (ICLs). DNA ICL is directly recognized by FANCM and associated proteins, that recrui...
    • Homologous recombination, organism-specific biosystem (from KEGG)
      Homologous recombination, organism-specific biosystemHomologous recombination (HR) is essential for the accurate repair of DNA double-strand breaks (DSBs), potentially lethal lesions. HR takes place in the late S-G2 phase of the cell cycle and involves...
    • Homologous recombination, conserved biosystem (from KEGG)
      Homologous recombination, conserved biosystemHomologous recombination (HR) is essential for the accurate repair of DNA double-strand breaks (DSBs), potentially lethal lesions. HR takes place in the late S-G2 phase of the cell cycle and involves...

    Markers

    Genotypes

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    DNA topoisomerase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    DNA topoisomerase type I activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    isomerase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    DNA topological change IEA
    Inferred from Electronic Annotation
    more info
    		  
    chromosome segregation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    chromosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    condensed chromosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Preferred Names
    DNA topoisomerase 3-beta-1
    Names
    DNA topoisomerase 3-beta-1
    Topo III beta
    DNA topoisomerase III beta-1
    NP_035754.1

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_011624.2 → NP_035754.1  DNA topoisomerase 3-beta-1

      Status: PROVISIONAL

      Source sequence(s)
      BC031723
      Consensus CDS
      CCDS27990.1
      UniProtKB/TrEMBL
      Q3UJF5
      UniProtKB/Swiss-Prot
      Q9Z321
      Related
      ENSMUSP00000023465, OTTMUSP00000034277, ENSMUST00000023465, OTTMUST00000067954
      Conserved Domains (3) summary
      COG0550
      Location:3 – 600
      Blast Score: 1050
      TopA; Topoisomerase IA [DNA replication, recombination, and repair]
      cd00186
      Location:172 – 593
      Blast Score: 1022
      TOP1Ac; DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA ...
      cd03362
      Location:3 – 167
      Blast Score: 461
      TOPRIM_TopoIA_TopoIII; TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving ...

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 103

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p1 C57BL/6J

    Genomic

    1. NC_000082.6 Reference GRCm38.p1 C57BL/6J

      Range
      16870891..16892986
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate Mm_Celera

    Genomic

    1. AC_000038.1 Alternate Mm_Celera

      Range
      17442801..17464977
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    genomic AAHY01126094.1 (5106..26152) None
    genomic AAHY01126095.1 None
    genomic AC166832.2 (38247..60342) None
    genomic CH466521.1 EDK97430.1 mixed
      EDK97431.1 mixed
      EDK97432.1 mixed
    mRNA AB013603.1 BAA34227.1 BALB/c
    mRNA AB045324.1 BAA97984.1
    mRNA AK041159.1 None C57BL/6J
    mRNA AK079765.1 None C57BL/6J
    mRNA AK144709.1 BAE26026.1
    mRNA AK146475.1 BAE27200.1 C57BL/6J
    mRNA AK163716.1 None C57BL/6J
    mRNA AK163796.1 None C57BL/6J
    mRNA AK178271.1 None
    mRNA AK180059.1 None
    mRNA AK197171.1 None
    mRNA AK205914.1 None
    mRNA BC006614.1 None FVB/N
    mRNA BC031723.1 AAH31723.1 FVB/N-3
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9Z321.1 GenPept UniProtKB/Swiss-Prot:Q9Z321

    Additional Links

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Molecular Biology Databases
    Research Materials
    Tools
    Miscellaneous

      Supplemental Content

      Table of contents

      Related information

      • Order cDNA clone
        Order cDNA clone
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        BioProjects related to a gene
      • BioSystems
        BioSystems
      • CCDS
        Links from Gene to CCDS are established if a gene encodes a protein sequence that is a member of a Consensus CDS (CCDS).
      • Conserved Domains
        Conserved Domain Database Links between Entrez Gene and Conserved Domain Database (CDD) are calculated from the domains annotated by the CDD group on Reference Sequence proteins.
      • Full text in PMC
        PMC links
      • Full text in PMC_nucleotide
        Full text in PubMedCentral identified from shared sequence links
      • Genome
        Genome records having the gene annotated on corresponding genomic reference sequence.
      • GEO Profiles
        Related GEO
      • HomoloGene
        Links between HomoloGene and Gene are provided by the HomoloGene group when a gene is included in a HomoloGene record.
      • Map Viewer
        These links are maintained by the Map Viewer group and are provided when a GeneID is annotated on a map for the same species.
      • Nucleotide
        Link to related Nucleotide entry
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        Related Probe entry
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        Link to related protein entry
      • PubChem Compound
        PubChem Compounds
      • PubChem Substance
        PubChem Substances
      • PubMed
        Links between Gene and PubMed are the result of the following: 1. Manual curation within NCBI. Part of the process of generating a REVIEWED RefSeq is an analysis of the current literature. Papers that are seminal in defining the gene, its sequence, and its function are added to the record at that time. Alert users point out gaps or errors in papers associated with a Gene record. These messages are reviewed and implemented as required. 2. Integration of information from other public databases. Gene integrates gene-citation from resources external to NCBI such as model organism-specific databases, Gene Ontology (GO), groups curating interactions, and sequence databases. The assumption in using these source is that they report citations specific to a gene in a known species. Gene does not process citations from OMIM automatically, because many of citations in OMIM refer to studies of genes in species other than human.
      • PubMed (GeneRIF)
        GeneRIF -- Gene Reference Into Function Staff of the Index Section in the National Library of Medicine review the current literature. When they find articles focused on the structure and function of a gene, they write a brief summary of the impact of the paper and make the connection between the citation (PubMed) and Gene. An interface exists for interested users to submit such data as well. http://www.ncbi.nlm.nih.gov/projects/GeneRIF/GeneRIFhelp.html
      • PubMed(nucleotide/PMC)
        Citations in PubMed identified from shared sequence and PMC links.
      • RefSeq Proteins
        Link to Protein RefSeqs
      • RefSeq RNAs
        Link to Nucleotide RefSeq RNAs
      • SNP
        Related SNP records
      • SNP: GeneView
        SNPs linked from GeneView
      • Taxonomy
        Link to related taxonomy entry
      • UniGene
        Links are provided between Gene and UniGene when both databases calculate links to the same mRNA record (gi).
      • UniSTS
        Related UniSTS records

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